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Journal Articles

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth

Cheuk Him Man, Francois E. Mercier, Nian Liu, Wentao Dong, Gregory Stephanopoulos, Li Jiang, Yookyung Jung, Charles P. Lin, Anskar Y. H. Leung, David T. Scadden

Blood (2022) 139 (4): 502–522.

https://doi.org/10.1182/blood.2021011563

Published: 2022

Includes: Supplemental data

Journal Articles

Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion

Shin-Young Park, Alessandro Matte, Yookyung Jung, Jina Ryu, Wilson Babu Anand, Eun-Young Han, Min Liu, Carmine Carbone, Davide Melisi, Takashi Nagasawa, Joseph J. Locascio, Charles P. Lin, Leslie E. Silberstein, Lucia De Franceschi

Blood (2020) 135 (23): 2071–2084.

https://doi.org/10.1182/blood.2019002227

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Embigin Regulates HSPC Homing and Quiescence and Acts As a Cell Surface Marker for a Niche Factor-Enriched Subset of Osteolineage Cells

Lev Silberstein, MDPhD, Peter V. Kharchenko, PhD, Youmna Sami Kfoury, PhD, Francois Mercier, MD FRCPC, Raphael Turcotte, Charles P. Lin, Ninib Baryawno, PhD, Nicolas Severe, Tiffany Tate, BS, Jonathan Hoggatt, PhD, David T. Scadden, MD

Blood (2015) 126 (23): 663.

https://doi.org/10.1182/blood.V126.23.663.663

Published: 2015

Journal Articles

Distinct Bone Marrow Blood Vessels Differentially Regulate Normal and Malignant Hematopoietic Stem and Progenitor Cells

Blood (2015) 126 (23): 664.

https://doi.org/10.1182/blood.V126.23.664.664

Published: 2015

Journal Articles

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning

Blood (2014) 124 (19): 2937–2947.

https://doi.org/10.1182/blood-2014-08-593426

Published: 2014

Includes: Supplemental data

Journal Articles

mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation

Oren Levy, Weian Zhao, Luke J. Mortensen, Sarah LeBlanc, Kyle Tsang, Moyu Fu, Joseph A. Phillips, Vinay Sagar, Priya Anandakumaran, Jessica Ngai, Cheryl H. Cui, Peter Eimon, Matthew Angel, Charles P. Lin, Mehmet Fatih Yanik, Jeffrey M. Karp

Blood (2013) 122 (14): e23–e32.

https://doi.org/10.1182/blood-2013-04-495119

Published: 2013

Includes: Supplemental data

Journal Articles

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

Abdel Kareem Azab, Jinsong Hu, Phong Quang, Feda Azab, Costas Pitsillides, Rana Awwad, Brian Thompson, Patricia Maiso, Jessica D. Sun, Charles P. Hart, Aldo M. Roccaro, Antonio Sacco, Hai T. Ngo, Charles P. Lin, Andrew L. Kung, Ruben D. Carrasco, Karin Vanderkerken, Irene M. Ghobrial

Blood (2012) 119 (24): 5782–5794.

https://doi.org/10.1182/blood-2011-09-380410

Published: 2012

Includes: Supplemental data

Journal Articles

P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment

Abdel Kareem Azab, Phong Quang, Feda Azab, Costas Pitsillides, Brian Thompson, Triona Chonghaile, John T. Patton, Patricia Maiso, Val Monrose, Antonio Sacco, Hai T. Ngo, Ludmila M. Flores, Charles P. Lin, John L. Magnani, Andrew L. Kung, Anthony Letai, Ruben Carrasco, Aldo M. Roccaro, Irene M. Ghobrial

Blood (2012) 119 (6): 1468–1478.

https://doi.org/10.1182/blood-2011-07-368050

Published: 2012

Includes: Supplemental data

Journal Articles

Defining the role of TORC1/2 in multiple myeloma

Patricia Maiso, Yi Liu, Brittany Morgan, Abdel Kareem Azab, Pingda Ren, Michel B. Martin, Yong Zhang, Yang Liu, Antonio Sacco, Hai Ngo, Feda Azab, Phong Quang, Scott J. Rodig, Charles P. Lin, Aldo M. Roccaro, Christian Rommel, Irene M. Ghobrial

Blood (2011) 118 (26): 6860–6870.

https://doi.org/10.1182/blood-2011-03-342394

Published: 2011

Includes: Supplemental data

Journal Articles

Engineered cell homing

Debanjan Sarkar, Joel A. Spencer, Joseph A. Phillips, Weian Zhao, Sebastian Schafer, Dawn P. Spelke, Luke J. Mortensen, Juan P. Ruiz, Praveen Kumar Vemula, Rukmani Sridharan, Sriram Kumar, Rohit Karnik, Charles P. Lin, Jeffrey M. Karp

Blood (2011) 118 (25): e184–e191.

https://doi.org/10.1182/blood-2010-10-311464

Published: 2011

Includes: Supplemental data

Journal Articles

Differential niche and Wnt requirements during acute myeloid leukemia progression

Steven W. Lane, Yingzi J. Wang, Cristina Lo Celso, Christine Ragu, Lars Bullinger, Stephen M. Sykes, Francesca Ferraro, Sebastian Shterental, Charles P. Lin, D. Gary Gilliland, David T. Scadden, Scott A. Armstrong, David A. Williams

Blood (2011) 118 (10): 2849–2856.

https://doi.org/10.1182/blood-2011-03-345165

Published: 2011

Includes: Supplemental data

Journal Articles

The Effect of the CXCR4 Inhibitors, AMD3100 and AMD3465, in Multiple Myeloma Cell Homing and Its Interaction with the Bone Marrow Microenvironment.

Judith M. Runnels, PhD, Abdel Kareem Azab, Bpharm, PhD, Costas Pitsillides, PhD, Jonathan Farag, Juwell Wu, Aldo M. Roccaro, MD, PhD, Patricia Maiso, PhD, Charles P. Lin, PhD, Irene M. Ghobrial, M.D.

Blood (2009) 114 (22): 1826.

https://doi.org/10.1182/blood.V114.22.1826.1826

Published: 2009

Journal Articles

Leukemia Stem Cells Are Resistant to In Vivo, Cell Non-Autonomous Wnt Inhibition.

Steven W. Lane, MD, Cristina Lo Celso, Stephen M Sykes, Sebastian Shterental, Mahnaz Paktinat, Charles P Lin, David A. Williams, MD, David T. Scadden, MD, D. Gary Gilliland, MD, PhD

Blood (2009) 114 (22): 1025.

https://doi.org/10.1182/blood.V114.22.1025.1025

Published: 2009

Journal Articles

Regulation of Rho GTPases by the Hematopoietic-Specific Guanine Nucleotide Exchange Factor Vav1 Is Critical for Hematopoietic Stem Cell Retention in the Endosteal Niche and Engraftment.

Abel Sanchez-Aguilera, Ph.D., Yun-Jung Lee, Ph.D., Cristina Lo Celso, Ph.D., Kristina Brumme, Charles P Lin, David T Scadden, MD, David A. Williams, MD

Blood (2009) 114 (22): 80.

https://doi.org/10.1182/blood.V114.22.80.80

Published: 2009

Journal Articles

Niche Induced Myelodysplasia and Secondary Hematopoietic Neoplasia Caused by Deletion of Dicer1 in Osteoprogenitor Cells.

Marc HGP Raaijmakers, MD, PhD, Siddhartha Mukherjee, M.D., Shangqin Guo, PhD, Tatsuya Kobayashi, PhD, Jesse Schoonmaker, Zinmar Aung, Benjamin L. Ebert, MD, DPhil, Fatima Al-Shahrour, Robert P Hasserjian, MD, Sonia Vallet, MD, Edward Scadden, Charles P Lin, David T. Scadden, MD

Blood (2009) 114 (22): 247.

https://doi.org/10.1182/blood.V114.22.247.247

Published: 2009

Journal Articles

Role of Selectins in the Pathogenesis of Multiple Myeloma.

Abdel Kareem Azab, Bpharm, PhD, Phong Quang, Feda Azab, BPharm, Costas M Pitsillides, John T Patton, Theodore Smith, Arun Sarkar, Judith M. Runnels, PhD, Aldo M. Roccaro, MD, PhD, Antonio Sacco, Hai T. Ngo, Molly R Melhem, Patricia Maiso, PhD, Kenneth C. Anderson, MD, Charles P. Lin, PhD, John L. Magnani, Irene M. Ghobrial, M.D.

Blood (2009) 114 (22): 951.

https://doi.org/10.1182/blood.V114.22.951.951

Published: 2009

Journal Articles

Role of Hypoxia in the Progression and Dissemination of Multiple Myeloma.

Abdel Kareem Azab, Bpharm, PhD, Phong Quang, Feda Azab, BPharm, Aldo M. Roccaro, MD, PhD, Antonio Sacco, Judith M. Runnels, PhD, Hai T. Ngo, Molly R Melhem, Patricia Maiso, PhD, Kenneth C. Anderson, MD, Charles P. Lin, PhD, Irene M. Ghobrial, M.D.

Blood (2009) 114 (22): 421.

https://doi.org/10.1182/blood.V114.22.421.421

Published: 2009

Journal Articles

Primary Waldesntrom Macroglobulinemia Cells Harbor Constitutive Activation of Akt, mTOR, Rictor and Raptor: Rational for Testing a Dual Inhibitor of the PI3K/Akt and mTOR Pathways in This Disease.

Aldo M. Roccaro, MD, PhD, Antonio Sacco, Emanuel N. Husu, Costas M Pitsillides, PhD, Steven Vesole, Abdel Kareem Azab, BPharm, PhD, Feda Azab, BPharm, Molly Melhem, Hai Ngo, Phong Quang, Patricia Maiso, PhD, Judith M. Runnels, PhD, Charles P. Lin, PhD, Kenneth C. Anderson, MD, Irene Ghobrial, M.D.

Blood (2009) 114 (22): 3843.

https://doi.org/10.1182/blood.V114.22.3843.3843

Published: 2009

Journal Articles

Persistence of Donor-Derived Protein in Host Myeloid Cells After Induced Rejection of Engrafted Allogeneic Bone Marrow Cells.

Toshiki Saito, MD, PhD, Joji Fujisaki, MD, Alicia Carlson, PhD, Charles P. Lin, PhD, Megan Sykes, MD, PhD

Blood (2009) 114 (22): 63.

https://doi.org/10.1182/blood.V114.22.63.63

Published: 2009

Journal Articles

RhoA and Rac1 GTPases play major and differential roles in stromal cell–derived factor-1–induced cell adhesion and chemotaxis in multiple myeloma

Abdel Kareem Azab, Feda Azab, Simona Blotta, Costas M. Pitsillides, Brian Thompson, Judith M. Runnels, Aldo M. Roccaro, Hai T. Ngo, Molly R. Melhem, Antonio Sacco, Xiaoying Jia, Kenneth C. Anderson, Charles P. Lin, Barrett J. Rollins, Irene M. Ghobrial

Blood (2009) 114 (3): 619–629.

https://doi.org/10.1182/blood-2009-01-199281

Published: 2009

Includes: Multimedia, Supplemental data

NARROW

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth

Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion

Embigin Regulates HSPC Homing and Quiescence and Acts As a Cell Surface Marker for a Niche Factor-Enriched Subset of Osteolineage Cells

Distinct Bone Marrow Blood Vessels Differentially Regulate Normal and Malignant Hematopoietic Stem and Progenitor Cells

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning

mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment

Defining the role of TORC1/2 in multiple myeloma

Engineered cell homing

Differential niche and Wnt requirements during acute myeloid leukemia progression

The Effect of the CXCR4 Inhibitors, AMD3100 and AMD3465, in Multiple Myeloma Cell Homing and Its Interaction with the Bone Marrow Microenvironment.

Leukemia Stem Cells Are Resistant to In Vivo, Cell Non-Autonomous Wnt Inhibition.

Regulation of Rho GTPases by the Hematopoietic-Specific Guanine Nucleotide Exchange Factor Vav1 Is Critical for Hematopoietic Stem Cell Retention in the Endosteal Niche and Engraftment.

Niche Induced Myelodysplasia and Secondary Hematopoietic Neoplasia Caused by Deletion of Dicer1 in Osteoprogenitor Cells.

Role of Selectins in the Pathogenesis of Multiple Myeloma.

Role of Hypoxia in the Progression and Dissemination of Multiple Myeloma.

Primary Waldesntrom Macroglobulinemia Cells Harbor Constitutive Activation of Akt, mTOR, Rictor and Raptor: Rational for Testing a Dual Inhibitor of the PI3K/Akt and mTOR Pathways in This Disease.

Persistence of Donor-Derived Protein in Host Myeloid Cells After Induced Rejection of Engrafted Allogeneic Bone Marrow Cells.

RhoA and Rac1 GTPases play major and differential roles in stromal cell–derived factor-1–induced cell adhesion and chemotaxis in multiple myeloma

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American Society of Hematology

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American Society of Hematology

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