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Journal Articles

MLN0128, a Second-Generation mTOR Kinase Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML

Zhihong Zeng, MD, Rui-Yu Wang, MD PhD, Yuexi Shi, MD, Yihua Qiu, MD, Duncan H Mak, MS, Kevin Coombes, PhD, Suk Young Yoo, PhD, Katti Jessen, Yi Liu, PhD, Christian Rommel, PhD, Hagop M. Kantarjian, MD, Steven M. Kornblau, MD, David Fruman, PhD, Michael Andreeff, MD PhD, Marina Konopleva, MD PhD

Blood (2014) 124 (21): 3613.

https://doi.org/10.1182/blood.V124.21.3613.3613

Published: 2014

Journal Articles

MLN0128 (INK128), an Investigational Oral Dual TORC1/2 Inhibitor, in Patients (pts) with Relapsed or Refractory Multiple Myeloma (MM), Non-Hodgkin's Lymphoma (NHL), or Waldenstrom Macroglobulinemia (WM): Preliminary Results From a Phase 1 Dose-Escalation Study

Irene M. Ghobrial, MD, David Siegel, MD, PhD, Ravi Vij, MD, Jeffrey L Wolf, MD, Jesus G. Berdeja, MD, Jeffrey V. Matous, MD, Peter Lipman, PhD, Chirag Patel, MS, PhD, Trinh Le, Christian Rommel, PhD, Gregory Berk, MD

Blood (2012) 120 (21): 4038.

https://doi.org/10.1182/blood.V120.21.4038.4038

Published: 2012

Journal Articles

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

Zhihong Zeng, Yue Xi Shi, Twee Tsao, YiHua Qiu, Steven M. Kornblau, Keith A. Baggerly, Wenbin Liu, Katti Jessen, Yi Liu, Hagop Kantarjian, Christian Rommel, David A. Fruman, Michael Andreeff, Marina Konopleva

Blood (2012) 120 (13): 2679–2689.

https://doi.org/10.1182/blood-2011-11-393934

Published: 2012

Includes: Supplemental data

Journal Articles

Defining the role of TORC1/2 in multiple myeloma

Patricia Maiso, Yi Liu, Brittany Morgan, Abdel Kareem Azab, Pingda Ren, Michel B. Martin, Yong Zhang, Yang Liu, Antonio Sacco, Hai Ngo, Feda Azab, Phong Quang, Scott J. Rodig, Charles P. Lin, Aldo M. Roccaro, Christian Rommel, Irene M. Ghobrial

Blood (2011) 118 (26): 6860–6870.

https://doi.org/10.1182/blood-2011-03-342394

Published: 2011

Includes: Supplemental data

Journal Articles

The TOR Kinase Inhibitor INK128 Is Effective in Pre-B Acute Lymphoblastic Leukemia Models

David A Fruman, PhD, Matthew Robert Janes, MPH, Sharmila Mallya, MS, Collin C Vu, MD, Marie P. Shieh, MD, Michael B. Lilly, MD, Leonard S Sender, MD, Michael B Martin, PhD, Pingda Ren, PhD, Yi Liu, PhD, Christian Rommel, PhD

Blood (2011) 118 (21): 2585.

https://doi.org/10.1182/blood.V118.21.2585.2585

Published: 2011

Journal Articles

Role of TORC1 and TORC2 in Multiple Myeloma

Patricia Maiso, PhD, Yi Liu, PhD, Abdel Kareem Azab, PhD, BSPharm, Brittany Morgan, Feda Azab, BPharm, Antonio Sacco, BS, Michaela Reagan, PhD, Hai T Ngo, BS, Yang Liu, PhD, Yong Zhang, PhD, Charles Lin, PhD, Aldo M Roccaro, MD, PhD, Christian Rommel, PhD, Irene M. Ghobrial, MD

Blood (2011) 118 (21): 1815.

https://doi.org/10.1182/blood.V118.21.1815.1815

Published: 2011

Journal Articles

Dual Targeting of -TORC1 and -TORC2 as a New Strategy In the Treatment of Multiple Myeloma

Patricia Maiso, PhD, AbdelKareem Azab, PhD, Yang Liu, PhD, Yong Zhang, PhD, Feda Azab, Antonio Sacco, Hai T Ngo, Yi Liu, PhD, Brittany Morgan, Christian Rommel, PhD, Kenneth C. Anderson, MD, Aldo M. Roccaro, MD, PhD, Irene M. Ghobrial, MD

Blood (2010) 116 (21): 133.

https://doi.org/10.1182/blood.V116.21.133.133

Published: 2010

Journal Articles

Targeting mTORC1/2 by a mTOR Kinase Inhibitor (PP242) induces Apoptosis In AML Cells Under Conditions Mimicking Bone Marrow Microenvironment

Zhihong Zeng, Yuexi Shi, Twee Tsao, Yihua Qiu, Steven M. Kornblau, MD, Keith Baggerly, Wenbin Liu, Yi Liu, PhD, Christian Rommel, PhD, David A. Fruman, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD

Blood (2010) 116 (21): 778.

https://doi.org/10.1182/blood.V116.21.778.778

Published: 2010

Journal Articles

PI3Kgamma (PI3Kγ) is essential for efficient induction of CXCR3 on activated T cells

Joseph Barbi, Hannah E. Cummings, Bao Lu, Steve Oghumu, Thomas Rückle, Christian Rommel, William Lafuse, Caroline C. Whitacre, Abhay R. Satoskar

Blood (2008) 112 (8): 3048–3051.

https://doi.org/10.1182/blood-2008-02-135715

Published: 2008

Journal Articles

Inactivation of PI3Kγ and PI3Kδ distorts T-cell development and causes multiple organ inflammation

Hong Ji, Felix Rintelen, Caroline Waltzinger, Dominique Bertschy Meier, Antonio Bilancio, Wayne Pearce, Emilio Hirsch, Matthias P. Wymann, Thomas Rückle, Montserrat Camps, Bart Vanhaesebroeck, Klaus Okkenhaug, Christian Rommel

Blood (2007) 110 (8): 2940–2947.

https://doi.org/10.1182/blood-2007-04-086751

Published: 2007

Includes: Supplemental data

Journal Articles

T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling

Jonathan A. Deane, Michael G. Kharas, Jean S. Oak, Linda N. Stiles, Ji Luo, Travis I. Moore, Hong Ji, Christian Rommel, Lewis C. Cantley, Thomas E. Lane, David A. Fruman

Blood (2006) 109 (7): 2894–2902.

https://doi.org/10.1182/blood-2006-07-038620

Published: 2006

Journal Articles

Key role of the p110δ isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110δ function in B cells

Antonio Bilancio, Klaus Okkenhaug, Montserrat Camps, Juliet L. Emery, Thomas Ruckle, Christian Rommel, Bart Vanhaesebroeck

Blood (2006) 107 (2): 642–650.

https://doi.org/10.1182/blood-2005-07-3041

Published: 2006

Journal Articles

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

Alison M. Condliffe, Keith Davidson, Karen E. Anderson, Chris D. Ellson, Tom Crabbe, Klaus Okkenhaug, Bart Vanhaesebroeck, Martin Turner, Louise Webb, Matthias P. Wymann, Emilio Hirsch, Thomas Ruckle, Montserrat Camps, Christian Rommel, Shaun P. Jackson, Edwin R. Chilvers, Len R. Stephens, Phillip T. Hawkins

Blood (2005) 106 (4): 1432–1440.

https://doi.org/10.1182/blood-2005-03-0944

Published: 2005

Includes: Supplemental data

NARROW

MLN0128, a Second-Generation mTOR Kinase Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML

MLN0128 (INK128), an Investigational Oral Dual TORC1/2 Inhibitor, in Patients (pts) with Relapsed or Refractory Multiple Myeloma (MM), Non-Hodgkin's Lymphoma (NHL), or Waldenstrom Macroglobulinemia (WM): Preliminary Results From a Phase 1 Dose-Escalation Study

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

Defining the role of TORC1/2 in multiple myeloma

The TOR Kinase Inhibitor INK128 Is Effective in Pre-B Acute Lymphoblastic Leukemia Models

Role of TORC1 and TORC2 in Multiple Myeloma

Dual Targeting of -TORC1 and -TORC2 as a New Strategy In the Treatment of Multiple Myeloma

Targeting mTORC1/2 by a mTOR Kinase Inhibitor (PP242) induces Apoptosis In AML Cells Under Conditions Mimicking Bone Marrow Microenvironment

PI3Kgamma (PI3Kγ) is essential for efficient induction of CXCR3 on activated T cells

Inactivation of PI3Kγ and PI3Kδ distorts T-cell development and causes multiple organ inflammation

T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling

Key role of the p110δ isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110δ function in B cells

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

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American Society of Hematology

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American Society of Hematology

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