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Stephen M Sykes
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Journal Articles

Assessment of T-Cell Receptor (TCR) Mediated T-Cell Activation in Acute Myeloid Leukemia at Diagnosis Has Implications for Risk Stratification and Response to Immune Checkpoint Inhibitors

Nancy BJ Arthur, Agata Gruszczynska, Ma Xenia G Illagan, Michael Prinsen, Sharon E Heath, Tasha Burton, Victoria Donaldson, Cara Lunn Shirai, Eric J. Duncavage, Amanda F Cashen, Geoffrey L Uy, David H Spencer, Stephen M Sykes, Timothy J Ley, Francesca Ferraro
Journal: Blood
Blood (2023) 142 (Supplement 1): 2928.
https://doi.org/10.1182/blood-2023-189573
Published: 2023
Journal Articles

Stathmin-1 Regulates Hematopoietic Stem Cell Mitochondrial and Cellular Function

Luana Chiquetto Paracatu, Qian Dong, Mia G Warmka, Liana Valin, Mousumi Chakraborty, Zev Greenberg, Nate Roundy, Christine RC Zhang, Grant A Challen, Cliff Luke, Wandy Beatty, Stephen M Sykes, Laura G. Schuettpelz
Journal: Blood
Blood (2023) 142 (Supplement 1): 4045.
https://doi.org/10.1182/blood-2023-189443
Published: 2023
Journal Articles

DNA polymerase θ protects leukemia cells from metabolically induced DNA damage

Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Katherine Sullivan-Reed, Paulina Podszywalow-Bartnicka, Kumaraswamy N. Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Srinivas Chatla, Konstantin Golovine, Jaroslav Jelinek, Tomasz Sliwinski, Jayashri Ghosh, Ksenia Matlawska-Wasowska, Gurushankar Chandramouly, Reza Nejati, Mariusz Wasik, Stephen M. Sykes, Katarzyna Piwocka, Emir Hadzijusufovic, Peter Valent, Richard T. Pomerantz, George Morton, Wayne Childers, Huaqing Zhao, Elisabeth M. Paietta, Ross L. Levine, Martin S. Tallman, Hugo F. Fernandez, Mark R. Litzow, Gaorav P. Gupta, Jean-Yves Masson, Tomasz Skorski
Journal: Blood
Blood (2023) 141 (19): 2372–2389.
https://doi.org/10.1182/blood.2022018428
Published: 2023
Includes: Supplemental data
Journal Articles

Acute Myeloid Leukemia Cells Rely on the Glycolytic Enzyme PGK1 to Support Energy Production and Amino Acid Metabolism

Liana Valin, Joice Kanefsky, Esteban Martinez, Jacklyn Huhn, Orsola Di Martino, Stephen M. Sykes, Judith Sokei
Journal: Blood
Blood (2022) 140 (Supplement 1): 8694–8695.
https://doi.org/10.1182/blood-2022-166659
Published: 2022
Journal Articles

MYC Influences mRNA Processing and Nuclear Export to Initiate Acute Myeloid Leukemia

Nancy Arthur, Keegan A Christensen, Kathleen Mannino, Stephen M. Sykes, Ashutosh Kumar, Nichole M Helton, Agata Gruszczynska, Timothy J Ley, Francesca Ferraro
Journal: Blood
Blood (2022) 140 (Supplement 1): 2960–2961.
https://doi.org/10.1182/blood-2022-166712
Published: 2022
Journal Articles

Transcriptional and Metabolic Profiling Reveals Alpha-Ketoglutarate As a Novel Mediator of Aberrant Platelet Activity and Inflammation in Myeloproliferative Neoplasms

Fan He, Angelo BA Laranjeira, Tim Kong, Katrina Bark, Alice Liu, Maggie J. Allen, Daniel AC Fisher, Mary Fulbright, LaYow Yu, Nina M. Lasky, Stephen M. Sykes, Angelo D'Alessandro, Jorge Di Paola, Stephen T Oh
Journal: Blood
Blood (2022) 140 (Supplement 1): 1095–1097.
https://doi.org/10.1182/blood-2022-167786
Published: 2022
Journal Articles

Identification of ATF4 As a Key Upstream Regulator of Acute Myeloid Leukemia Cell Metabolism

Jacklyn Huhn, Esteban Martinez, Joice Kanefsky, Aaron Goldman, Simone Sidoli, David Wiest, Stephen M. Sykes
Journal: Blood
Blood (2022) 140 (Supplement 1): 11838.
https://doi.org/10.1182/blood-2022-170467
Published: 2022
Journal Articles

Fatty Acid Desaturation Is a Metabolic Vulnerability of Acute Myeloid Leukemia Cells

Joice Kanefsky, Yorrick Jaspers, Esteban Martinez, Jacklyn Huhn, Daniela Di Marcoantonio, Stephan Kemp, David Wiest, Stephen M. Sykes
Journal: Blood
Blood (2022) 140 (Supplement 1): 5885–5886.
https://doi.org/10.1182/blood-2022-170721
Published: 2022
Journal Articles

DNA Polymerase Theta Protects Leukemia Cells from Metabolic-Induced DNA Damage

Umeshkumar M Vekariya, Katherine Sullivan-Reed, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Paulina Podszywalow-Bartnicka, Kumaraswamy Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Konstantin Golovine, Jaroslav Jelinek, Tomasz Sliwinski, Jayashri Ghosh, Ksenia Maslawska-Wasowska, Reza Nejati, Mariusz A Wasik, Stephen M. Sykes, Katarzyna Piwocka, Emir Hadzijusufovic, Peter Valent, Richard Pomerantz, George Morton, Wayne Childers, Huaqing Zhao, Elisabeth Paietta, Ross L. Levine, Martin S. Tallman, Hugo F Fernandez, Mark R. Litzow, Gaorav P Gupta, Jean-Yves Masson, Tomasz Skorski
Journal: Blood
Blood (2022) 140 (Supplement 1): 2972–2974.
https://doi.org/10.1182/blood-2022-156458
Published: 2022
Journal Articles

The Role of Stathmin-1 in the Regulation of Hematopoietic Stem Cells

Luana Chiquetto Paracatu, Qian Dong, Zev J. Greenberg, Liana Valin, Nate Roundy, Christine R Zhang, Grant A Challen, Cliff Luke, Stephen M. Sykes, Laura G. Schuettpelz
Journal: Blood
Blood (2022) 140 (Supplement 1): 5734–5735.
https://doi.org/10.1182/blood-2022-166665
Published: 2022
Journal Articles

The ERK2-DBP domain opposes pathogenesis of a mouse JAK2V617F-driven myeloproliferative neoplasm

Yong Zhang, Billy Truong, Shawn P. Fahl, Esteban Martinez, Kathy Q. Cai, Essel D. Al-Saleem, Yulan Gong, Dan A. Liebermann, Jonathan Soboloff, Roland Dunbrack, Ross L. Levine, Steven Fletcher, Dietmar Kappes, Stephen M. Sykes, Paul Shapiro, David L. Wiest
Journal: Blood
Blood (2022) 140 (4): 359–373.
https://doi.org/10.1182/blood.2021013068
Published: 2022
Includes: Supplemental data
Journal Articles

ERK2 Substrate Binding Domains Perform Opposing Roles in Pathogenesis of a JAK2V617F-Driven Myeloproliferative Neoplasm

Billy Truong, Yong Zhang, Shawn Fahl, Kathy Q Cai, Esteban Martinez, Essel D. Al-Saleem, Yulan Gong, Dan Liebermann, Jonathan Soboloff, Roland Dunbrack, Ross L. Levine, Dietmar J Kappes, Stephen M. Sykes, Paul Shapiro, David Wiest
Journal: Blood
Blood (2021) 138 (Supplement 1): 2547.
https://doi.org/10.1182/blood-2021-152063
Published: 2021
Journal Articles

TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska, Konstantin Golovine, Katherine Sullivan-Reed, Wangisa M.B. Dunuwille, Joseph Nacson, Michael Hulse, Lisa Beatrice Caruso, Zachary Gazze, Zhaorui Lian, Antonella Padella, Kumaraswamy Chitrala, Boris Bartholdy, Ksenia Matlawska-Wasowska, Daniela Di Marcantonio, Giorgia Simonetti, Georg Greiner, Stephen M. Sykes, Peter Valent, MD, Elisabeth M. Paietta, Hugo F Fernandez, Martin S. Tallman, MD, Mark Litzow, MD, Mark D. Minden, Jian Huang, Giovanni Martinelli, MD, George S. Vassiliou, MD PhD FRCPath, MRCP, Italo Tempera, Katarzyna Piwocka, Neil Johnson, Grant Challen, Tomasz Skorski, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4.
https://doi.org/10.1182/blood-2020-137658
Published: 2020
Journal Articles

NCAM1 supports therapy resistance and LSC function in AML

Stephen M. Sykes
Journal: Blood
Blood (2019) 133 (21): 2247–2248.
https://doi.org/10.1182/blood-2019-03-901017
Published: 2019
Journal Articles

Pkcε Is a Central Regulator of Mitochondrial Function and Metabolism in Acute Myeloid Leukemia

Daniela Di Marcantonio, PhD, Elena Masselli, MD, Esteban Martinez, BS, Daniela Araiza-Olivera, MD PhD, Giuliana Gobbi, PhD, Prisco Mirandola, PhD, Marco Vitale, MD, Stephen M. Sykes, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3926.
https://doi.org/10.1182/blood-2018-99-119758
Published: 2018
Journal Articles

JUN and ATF3 Regulate the Transcriptional Output of the Unfolded Protein Response to Support Acute Myeloid Leukemia

Stephen M. Sykes, PhD, Daniela Di Marcantonio, PhD, Esteban Martinez, BS, Jacqueline Huhn, BS, Anushk Gupta, Ritika Mistry
Journal: Blood
Blood (2018) 132 (Supplement 1): 1327.
https://doi.org/10.1182/blood-2018-99-119742
Published: 2018
Journal Articles

Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan-Reed, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Elizaveta A. Belyaeva, Alina Nersesyan, Marcin M. Machnicki, Monika Toma, Nicolas Chatain, Malgorzata Rydzanicz, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Sliwinski, Tomasz Stoklosa, Rafal Ploski, Thomas Fischer, Stephen M. Sykes, Steffen Koschmieder, Lars Bullinger, Peter Valent, Mariusz A. Wasik, Jian Huang, Tomasz Skorski
Journal: Blood
Blood (2018) 132 (1): 67–77.
https://doi.org/10.1182/blood-2018-02-834895
Published: 2018
Includes: Supplemental data
Journal Articles

Tyrosine Kinase Inhibitor-Induced Defects in DNA Repair Sensitize FLT3(ITD)-Positive Acute Myeloid Leukemia Quiescent and Proliferative Cells to PARP Inhibitors

Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Marcin M Machnicki, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Stoklosa, Thomas Fischer, Stephen M. Sykes, Steffen Koschmieder, Lars Bullinger, MD, Peter Valent, MD, Jian Huang, Tomasz Skorski
Journal: Blood
Blood (2017) 130 (Supplement 1): 2635.
https://doi.org/10.1182/blood.V130.Suppl_1.2635.2635
Published: 2017
Journal Articles

The RET Receptor Tyrosine Kinase Promotes Acute Myeloid Leukemia through Protection of FLT3-ITD Mutants from Autophagic Degradation

Saskia Rudat, MSc, Anja Pfaus, MSc, Claudia Bühler, MD, Sophie Rabe, MSc, Lars Bullinger, MD, Stefan Gröschel, MD, Stephen M. Sykes, PhD, Michael D. Milsom, PhD, Jana M. Ellegast, MD, Stefan Fröhling, MD, Claudia Scholl, MD
Journal: Blood
Blood (2016) 128 (22): 2849.
https://doi.org/10.1182/blood.V128.22.2849.2849
Published: 2016
Journal Articles

Ribosomal Protein L22 Loss Predisposes Stem Cells to Transformation By Altering Metabolism

Bryan Harris, BS, Shawn Fahl, Jaqueline Perrigoue, Stephen M. Sykes, PhD, Amit Verma, MD, David L Wiest, PhD
Journal: Blood
Blood (2016) 128 (22): 2733.
https://doi.org/10.1182/blood.V128.22.2733.2733
Published: 2016