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Journal Articles

Assessment of T-Cell Receptor (TCR) Mediated T-Cell Activation in Acute Myeloid Leukemia at Diagnosis Has Implications for Risk Stratification and Response to Immune Checkpoint Inhibitors

Nancy BJ Arthur, Agata Gruszczynska, Ma Xenia G Illagan, Michael Prinsen, Sharon E Heath, Tasha Burton, Victoria Donaldson, Cara Lunn Shirai, Eric J. Duncavage, Amanda F Cashen, Geoffrey L Uy, David H Spencer, Stephen M Sykes, Timothy J Ley, Francesca Ferraro

Blood (2023) 142 (Supplement 1): 2928.

https://doi.org/10.1182/blood-2023-189573

Published: 2023

Journal Articles

Spatial Organization of Hematopoietic Clones in the Bone Marrow of a Patient with Polycythemia Vera

Andrew L Young, Hannah C Davis, David H Spencer, Timothy J Ley, Stephen T Oh, Matthew J Walter, Grant A Challen

Blood (2022) 140 (Supplement 1): 2910–2911.

https://doi.org/10.1182/blood-2022-167351

Published: 2022

Journal Articles

Clonal Myeloid Heterogeneity in Older Autopsy Patients Determined By Multiple Bone Marrow Site Sequencing

Rohan Kodgule, Joshua Robinson, Sridhar Nonavinkere Srivatsan, Cara Lunn Shirai, Feiyu Du, Tianjiao Wang, Ajay Khanna, Catrina Fronick, Robert Fulton, David H Spencer, Matthew J Walter, Eric Duncavage

Blood (2022) 140 (Supplement 1): 2874–2875.

https://doi.org/10.1182/blood-2022-162624

Published: 2022

Journal Articles

Heterozygous variants of CLPB are a cause of severe congenital neutropenia

Julia T. Warren, Ryan R. Cupo, Peeradol Wattanasirakul, David H. Spencer, Adam E. Locke, Vahagn Makaryan, Audrey Anna Bolyard, Merideth L. Kelley, Natalie L. Kingston, James Shorter, Christine Bellanné-Chantelot, Jean Donadieu, David C. Dale, Daniel C. Link

Blood (2022) 139 (5): 779–791.

https://doi.org/10.1182/blood.2021010762

Published: 2022

Includes: Supplemental data

Journal Articles

DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults

Margaret A. Ferris, Amanda M. Smith, Sharon E. Heath, Eric J. Duncavage, Matthew Oberley, David Freyer, Robert Wynn, Sofia Douzgou, John M. Maris, Anne F. Reilly, Melinda D. Wu, Florence Choo, Roel B. Fiets, Saskia Koene, David H. Spencer, Christopher A. Miller, Marwan Shinawi, Timothy J. Ley

Blood (2022) 139 (3): 461–464.

https://doi.org/10.1182/blood.2021014052

Published: 2022

Includes: Supplemental data

Journal Articles

Characterization of WU-CART-007, an Allogeneic CD7-Targeted CAR-T Cell Therapy for T-Cell Malignancies

Tom Leedom, Alexander S. Hamil, Somayeh Pouyanfard, Jennifer Govero, Rachel Langland, Anna Ballard, Liz Schwarzkopf, Andrew Martens, Andrew Espenschied, Pooja Vinay, Michael James, Nitin Mahajan, David H Spencer, Kenneth M Chrobak, Matthew L Cooper, Ayman Kabakibi

Blood (2021) 138 (Supplement 1): 2772.

https://doi.org/10.1182/blood-2021-153150

Published: 2021

Journal Articles

Adverse Outcomes in Acute Myeloid Leukemia Are Associated with Tumor Cell-Mediated Immunosuppression

Blood (2021) 138 (Supplement 1): 800.

https://doi.org/10.1182/blood-2021-148645

Published: 2021

Journal Articles

Comparison of Deep Whole Exome Versus Targeted Gene Sequencing for Assessment of Persistent Molecular Disease in Acute Myeloid Leukemia Samples

Michael Slade, MDMS, Michelle O'Laughlin, Robert S Fulton, Eric J. Duncavage, MD, Timothy J Ley, MD, Meagan A. Jacoby, MD, David H Spencer, MD

Blood (2020) 136 (Supplement 1): 6–7.

https://doi.org/10.1182/blood-2020-133279

Published: 2020

Journal Articles

Deletions in BCP-ALL result in a TAD more FLT3

David H. Spencer

Blood (2020) 136 (8): 919–920.

https://doi.org/10.1182/blood.2020006607

Published: 2020

Journal Articles

Heterozygous Mutations of Clpb As a Newly Identified and Frequent Cause of Severe Congenital Neutropenia

Julia T Warren, MD PhD, Peeradol Wattanasirakul, David H Spencer, MD, Adam Locke, PhD, Vahagn Makaryan, MD, Audrey Anna Bolyard, RN, BS, Karl Welte, Julia Skokowa, MD PhD, David C. Dale, MD, Daniel C. Link, MD

Blood (2019) 134 (Supplement_1): 433.

https://doi.org/10.1182/blood-2019-129635

Published: 2019

Journal Articles

Whole Genome Bisulfite Sequencing of 63 Primary AML Samples Identifies a Unique DNA Hypermethylation Signature for Mutant IDH1/2 Cases That Is Different from That of TET2 Mutant AML

Ellie Wilson, BS, Nichole Helton, Catrina Fronick, BS, Robert Fulton, MS, John S. Welch, MD PhD, Timothy J Ley, MD, David H Spencer, MD

Blood (2019) 134 (Supplement_1): 3755.

https://doi.org/10.1182/blood-2019-122340

Published: 2019

Journal Articles

Homozygous Loss of a Critical CTCF Recognition Sequence in the HOXA gene Cluster Eliminates CTCF Binding but Does Not Appreciably Reduce HOXA9 expression in NPM1 Mutated AML Cells

Reza Ghasemi, PhD, Struthers B Heidi, David H Spencer, MD PhD

Blood (2018) 132 (Supplement 1): 2613.

https://doi.org/10.1182/blood-2018-99-119000

Published: 2018

Journal Articles

Extended Genetic Testing in Severe Congenital Neutropenia May Identify Mutations That Inform Therapy

Daniel C. Link, MD, Vahagn Makaryan, MD, David H Spencer, MDPhD, Jun Xia, PhD, Audrey Anna Bolyard, RN, BS, David C Dale, MD

Blood (2018) 132 (Supplement 1): 2401.

https://doi.org/10.1182/blood-2018-99-116712

Published: 2018

Journal Articles

Improving Risk Assessment of AML with a Precision Genomic Strategy to Assess Mutation Clearance

Blood (2018) 132 (Supplement 1): 5277.

https://doi.org/10.1182/blood-2018-99-114979

Published: 2018

Journal Articles

Whole-Genome Bisulfite Sequencing of Primary AML Cells with the DNMT3A R882H Mutation Identifies Regions of Focal Hypomethylation That Are Associated with Open Chromatin

David H. Spencer, MDPhD, Bilal Al-Khalil, David Russler-Germain, Tamara Lamprecht, Nicole Havey, Robert S. Fulton, Michelle O'Laughlin, BS, Catrina Fronick, Richard K. Wilson, PhD, Timothy J. Ley, MD

Blood (2014) 124 (21): 608.

https://doi.org/10.1182/blood.V124.21.608.608

Published: 2014

Journal Articles

DNMT3A R882H Overexpression Acts in a Dominant Negative Manner to Cause DNA Hypomethylation and Increased Susceptibility to Hematopoietic Malignancies in Transgenic Mice

Angela M. Verdoni, PhD, Christopher B Cole, Shamika Ketkar-Kulkarni, MS, Tamara Lamprecht, Nichole Havey, David H. Spencer, MDPhD, Timothy J. Ley, MD

Blood (2014) 124 (21): 609.

https://doi.org/10.1182/blood.V124.21.609.609

Published: 2014

Journal Articles

Whole Genome Bisulfite Sequencing of Purified Mouse Promyelocytes Reveals Differentially Methylated Regions in Cells Expressing PML-Rara

Shamika Ketkar-Kulkarni, MS, Christopher B Cole, David H. Spencer, MDPhD, Angela M. Verdoni, PhD, Nichole Havey, Tamara Lamprecht, Vincent Magrini, PhD, Ryan T Demeter, Richard K. Wilson, PhD, Timothy J Ley, MD

Blood (2014) 124 (21): 3531.

https://doi.org/10.1182/blood.V124.21.3531.3531

Published: 2014

Journal Articles

Comprehensive Analysis Of HOX Gene Expression and DNA Methylation From 189 Primary AMLs Demonstrates Canonical Patterns Associated With Hematopoietic Stem/Progenitors and Recurrent AML Mutations

David H Spencer, MD/PhD, Margaret A. Young, MD/PhD, Jeffery M. Klco, MD/PhD, Timothy J. Ley, MD

Blood (2013) 122 (21): 2496.

https://doi.org/10.1182/blood.V122.21.2496.2496

Published: 2013

Journal Articles

R882H DNMT3A Causes Dominant-Negative Inhibition Of WT DNMT3A

David A. Russler-Germain, B.S., David H Spencer, MD/PhD, Margaret A. Young, MD/PhD, Tamara Lamprecht, B.S., Chris Miller, PhD, Robert S. Fulton, Petra Gilmore, PhD, Reid Townsend, MD, PhD, Timothy J. Ley, MD

Blood (2013) 122 (21): 3812.

https://doi.org/10.1182/blood.V122.21.3812.3812

Published: 2013

Journal Articles

Dnmt3a is Required For Aberrant Self-Renewal Driven by PML-RARA

Christopher B Cole, Angela M. Verdoni, PhD, David H Spencer, MD/PhD, Timothy J. Ley, MD

Blood (2013) 122 (21): 477.

https://doi.org/10.1182/blood.V122.21.477.477

Published: 2013

NARROW

Assessment of T-Cell Receptor (TCR) Mediated T-Cell Activation in Acute Myeloid Leukemia at Diagnosis Has Implications for Risk Stratification and Response to Immune Checkpoint Inhibitors

Spatial Organization of Hematopoietic Clones in the Bone Marrow of a Patient with Polycythemia Vera

Clonal Myeloid Heterogeneity in Older Autopsy Patients Determined By Multiple Bone Marrow Site Sequencing

Heterozygous variants of CLPB are a cause of severe congenital neutropenia

DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults

Characterization of WU-CART-007, an Allogeneic CD7-Targeted CAR-T Cell Therapy for T-Cell Malignancies

Adverse Outcomes in Acute Myeloid Leukemia Are Associated with Tumor Cell-Mediated Immunosuppression

Comparison of Deep Whole Exome Versus Targeted Gene Sequencing for Assessment of Persistent Molecular Disease in Acute Myeloid Leukemia Samples

Deletions in BCP-ALL result in a TAD more FLT3

Heterozygous Mutations of Clpb As a Newly Identified and Frequent Cause of Severe Congenital Neutropenia

Whole Genome Bisulfite Sequencing of 63 Primary AML Samples Identifies a Unique DNA Hypermethylation Signature for Mutant IDH1/2 Cases That Is Different from That of TET2 Mutant AML

Homozygous Loss of a Critical CTCF Recognition Sequence in the HOXA gene Cluster Eliminates CTCF Binding but Does Not Appreciably Reduce HOXA9 expression in NPM1 Mutated AML Cells

Extended Genetic Testing in Severe Congenital Neutropenia May Identify Mutations That Inform Therapy

Improving Risk Assessment of AML with a Precision Genomic Strategy to Assess Mutation Clearance

Whole-Genome Bisulfite Sequencing of Primary AML Cells with the DNMT3A R882H Mutation Identifies Regions of Focal Hypomethylation That Are Associated with Open Chromatin

DNMT3A R882H Overexpression Acts in a Dominant Negative Manner to Cause DNA Hypomethylation and Increased Susceptibility to Hematopoietic Malignancies in Transgenic Mice

Whole Genome Bisulfite Sequencing of Purified Mouse Promyelocytes Reveals Differentially Methylated Regions in Cells Expressing PML-Rara

Comprehensive Analysis Of HOX Gene Expression and DNA Methylation From 189 Primary AMLs Demonstrates Canonical Patterns Associated With Hematopoietic Stem/Progenitors and Recurrent AML Mutations

R882H DNMT3A Causes Dominant-Negative Inhibition Of WT DNMT3A

Dnmt3a is Required For Aberrant Self-Renewal Driven by PML-RARA

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American Society of Hematology

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American Society of Hematology

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