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Journal Articles

Novel therapeutic approaches in thalassemias, sickle cell disease, and other red cell disorders

Valeria Maria Pinto, Filippo Mazzi, Lucia De Franceschi

Blood (2024) 144 (8): 853–866.

https://doi.org/10.1182/blood.2023022193

Published: 2024

Includes: Supplemental data

Journal Articles

An oral carbon monoxide–releasing molecule protects against acute hyperhemolysis in sickle cell disease

Kim Anh Nguyen, Alessandro Matte, Roberta Foresti, Enrica Federti, Laurent Kiger, Cécile Lefebvre, Hakim Hocini, Yanis Pelinski, Hiroaki Kitagishi, Laura Bencheikh, France Pirenne, Lucia de Franceschi, Roberto Motterlini, Pablo Bartolucci

Blood (2024) 143 (24): 2544–2558.

https://doi.org/10.1182/blood.2023023165

Published: 2024

Includes: Supplemental data

Journal Articles

17R-Resolvin D1 Improves Inflammatory Cardiomyopathy in a Mouse Model of Sickle Cell Disease

Enrica Federti, Domenico Mattoscio, Antonio Recchiuti, Alessandro Mattè, Maria Monti, Flora Cozzolino, Martina Ceci, Manuela Iezzi, Angela Siciliano, Veronica Riccardi, Alice Passarini, Carlo Brugnara, Lucia De Franceschi

Blood (2023) 142 (Supplement 1): 2496.

https://doi.org/10.1182/blood-2023-185603

Published: 2023

Journal Articles

Luspatercept in the Treatment of Beta Thalassemia in Italy: Lights and Shadows in Clinical Practice

Blood (2023) 142 (Supplement 1): 2475.

https://doi.org/10.1182/blood-2023-179747

Published: 2023

Journal Articles

Unraveling the Role of PIEZO1 in Stressed Erythropoiesis: Implications for Dyserythropoiesis and Potential Therapeutic Targets in Dehydrated Hereditary Stomatocytosis

Barbara Eleni Rosato, Vanessa D'Onofrio, Antonella Nostroso, Roberta Marra, Federica Maria Esposito, Maddalena Raia, Giuseppe D'Alterio, Mario Capasso, Lucia De Franceschi, Achille Iolascon, Roberta Russo, Immacolata Andolfo

Blood (2023) 142 (Supplement 1): 2446.

https://doi.org/10.1182/blood-2023-180833

Published: 2023

Journal Articles

Mitapivat Treatment Increases β-Thalassemic Erythroblasts Energy Production and Responsiveness to Oxidative Stress

Alessandro Mattè, Angelo D'Alessandro, Mariarita Bertoldi, Richard Huot Pozzetto, Giovanni Bisello, Andrea Mattarei, Alberto Ongaro, Alice Passarini, Angela Siciliano, Roberta Russo, Achille Iolascon, Carlo Brugnara, Lucia De Franceschi

Blood (2023) 142 (Supplement 1): 3850.

https://doi.org/10.1182/blood-2023-185681

Published: 2023

Journal Articles

Trials in Progress: The Randomized, Double-Blind, Placebo-Controlled Phase 1b CROSSWALK-a and Phase 2a CROSSWALK-c Trials - Crovalimab for the Treatment and Prevention of Vaso-Occlusive Episodes in Sickle Cell Disease

Marco Aurelio Salvino, Bulent Antmen, Frederick Chite Asirwa, Satheesh Chonat, Lucia De Franceschi, Perla Eleftheriou, Adlette Inati, Johnny Mahlangu, Erfan Nur, Salvador Payán-Pernía, Asad Charania, Diana Gradinaru, Allison Hsia, Yves Luder, Thomas Perretti, Sasha Srekovic, Pablo Bartolucci

Blood (2023) 142 (Supplement 1): 1158.

https://doi.org/10.1182/blood-2023-179858

Published: 2023

Journal Articles

Colchicine Protects Against Cardiomyopathy in Humanized Mouse Model for Sickle Cell Disease

Enrica Federti, Iana Iatcenko, Alessandra Ghigo, Alessandro Mattè, Veronica Riccardi, Immacolata Andolfo, Angela Siciliano, Filippo Mazzi, Manuela Stella, Luigi Robbiano, Valeria Pinto, Achille Iolascon, Gian Luca Forni, Lucia De Franceschi

Blood (2022) 140 (Supplement 1): 2513–2514.

https://doi.org/10.1182/blood-2022-163037

Published: 2022

Journal Articles

Resolvins Modulate Netosis and Autoimmunity in Sickle Cell Disease

Alessandro Mattè, Antonio Recchiuti, Enrica Federti, Filippo Mazzi, Jacopo Ceolan, Annamaria Porreca, Marta Di Nicola, Sofia Menotti, Stefano Alivernini, Carlo Brugnara, Lucia De Franceschi

Blood (2022) 140 (Supplement 1): 5399–5400.

https://doi.org/10.1182/blood-2022-166240

Published: 2022

Journal Articles

Premature aging of the immune system affects the response to SARS-CoV-2 mRNA vaccine in β-thalassemia: role of an additional dose

Blood (2022) 140 (15): 1735–1738.

https://doi.org/10.1182/blood.2022017594

Published: 2022

Includes: Supplemental data

Journal Articles

The Increased Burden of Sickle Cell Disease in Italy: Findings from the Greatalys (Generating Real world Evidence Across ITALy In SCD) Study

Lucia de Franceschi, Gian Luca Forni, Chiara Castiglioni, Claudia Condorelli, Diletta Valsecchi, Eleonora Premoli, Valentina Perrone, Luca Degli Esposti, Carina Andrea Fiocchi

Blood (2021) 138 (Supplement 1): 1950.

https://doi.org/10.1182/blood-2021-148273

Published: 2021

Journal Articles

Mitapivat Improves Transfusion Burden and Reduces Iron Overload in Thalassemic Mice

Alessandro Mattè, Penelope A. Kosinski, Enrica Federti, Lenny Dang, Angela Siciliano, Iana Iatcenko, Carlo Brugnara, Lucia De Franceschi

Blood (2021) 138 (Supplement 1): 2016.

https://doi.org/10.1182/blood-2021-153721

Published: 2021

Journal Articles

Nrf2 Plays a Key Role in Iron-Overload Cardiomyopathy

Enrica Federti, Francesca Vinchi, Iana Iatcenko, Alessandra Ghigo, Alessandro Mattè, Serge Cedrick, Angela Siciliano, Deborah Chiabrando, Emanuela Tolosano, S. Zebulon Vance, Veronica Riccardi, Immacolata Andolfo, Achille Iolascon, Lucia de Franceschi

Blood (2021) 138 (Supplement 1): 3068.

https://doi.org/10.1182/blood-2021-146157

Published: 2021

Journal Articles

Trial in Progress: The Randomized, Double-Blind, Placebo-Controlled Phase IIa CROSSWALK-c Trial Evaluating the Efficacy of Crovalimab As Adjunct Treatment in the Prevention of Vaso-Occlusive Episodes (VOEs) in Patients with Sickle Cell Disease (SCD)

Michael Callaghan, Kenneth I. Ataga, Lucia De Franceschi, Caterina Minniti, Nadiesh Balachandran, Diane-Charlotte Imbs, Thomas Perretti, Julia Ramos, Alexandre Sostelly, Pablo Bartolucci

Blood (2021) 138 (Supplement 1): 3111.

https://doi.org/10.1182/blood-2021-151222

Published: 2021

Journal Articles

Trial in Progress: The Randomized, Double-Blind, Placebo-Controlled Phase Ib CROSSWALK-a Trial Evaluating the Safety of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOEs) in Patients with Sickle Cell Disease (SCD)

Pablo Bartolucci, Kenneth I. Ataga, Michael U. Callaghan, Lucia De Franceschi, Caterina Minniti, Ari Alexandrou, Diane-Charlotte Imbs, Richard Fox, Himika Patel, Alexandre Sostelly, Jonathan Schimmel

Blood (2021) 138 (Supplement 1): 3108.

https://doi.org/10.1182/blood-2021-147854

Published: 2021

Journal Articles

The Pyruvate Kinase Activator Mitapivat Ameliorates Anemia and Prevents Iron Overload in a Mouse Model of Hereditary Spherocytosis

Alessandro Mattè, BSc,PhD, Wilson Anand, Enrica Federti, PhD, Charles Kung, PhD, Penelope A. Kosinski, MS, Veronica Riccardi, Iana Iatcenko, Lenny Dang, PhD, Christophe Leboeuf, Anne Janin, PhD, Carlo Brugnara, MD, Mohandas Narla, DSc, Lucia De Franceschi, MD

Blood (2020) 136 (Supplement 1): 29.

https://doi.org/10.1182/blood-2020-142232

Published: 2020

Journal Articles

COVID 19 and Hemoglobinopathies: Update of the Italian Experience

Irene Motta, MD, Valeria Maria Pinto, MD, Filomena Longo, MD, Federico Bonetti, MD, Elisa De Michele, MD, Alberto Piperno, MD, Lorella Pitrolo, MD, Micol Quaresima, MD, Michela Ribersani, MD, Margherita Migone De Amicis, MD, Manuela Balocco, MD, Barbara Gianesin, PhD, Giovanna Graziadei, MD, Maria Domenica Cappellini, MD, Lucia De Franceschi, MD, Antonio Piga, MD, Gian Luca Forni, MD

Blood (2020) 136 (Supplement 1): 17–18.

https://doi.org/10.1182/blood-2020-141610

Published: 2020

Journal Articles

Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion

Shin-Young Park, Alessandro Matte, Yookyung Jung, Jina Ryu, Wilson Babu Anand, Eun-Young Han, Min Liu, Carmine Carbone, Davide Melisi, Takashi Nagasawa, Joseph J. Locascio, Charles P. Lin, Leslie E. Silberstein, Lucia De Franceschi

Blood (2020) 135 (23): 2071–2084.

https://doi.org/10.1182/blood.2019002227

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Selecting ß-Thalassemia Patients for Gene Therapy: A Decision-Making Algorithm

Donatella Baronciani, MD, Maddalena Casale, MD, Lucia De Franceschi, MD, Giovanna Graziadei, MD, Filomena Longo, MD, Raffaella Origa, MD, Valeria Maria Pinto, MD, Paolo Rigano, MD, Monia Marchetti, MD, Antonia Gigante, Emanuele Angelucci, MD, Maria Domenica Cappellini, MD, Achille Iolascon, MD PhD, Antonio Piga, Gian Luca Forni

Blood (2019) 134 (Supplement_1): 972.

https://doi.org/10.1182/blood-2019-128320

Published: 2019

Journal Articles

Fyn Specifically Regulates the Activity of Red Cell Glucose-6-Phosphate-Dehydrogenase

Blood (2019) 134 (Supplement_1): 3527.

https://doi.org/10.1182/blood-2019-125709

Published: 2019

NARROW

Novel therapeutic approaches in thalassemias, sickle cell disease, and other red cell disorders

An oral carbon monoxide–releasing molecule protects against acute hyperhemolysis in sickle cell disease

17R-Resolvin D1 Improves Inflammatory Cardiomyopathy in a Mouse Model of Sickle Cell Disease

Luspatercept in the Treatment of Beta Thalassemia in Italy: Lights and Shadows in Clinical Practice

Unraveling the Role of PIEZO1 in Stressed Erythropoiesis: Implications for Dyserythropoiesis and Potential Therapeutic Targets in Dehydrated Hereditary Stomatocytosis

Mitapivat Treatment Increases β-Thalassemic Erythroblasts Energy Production and Responsiveness to Oxidative Stress

Trials in Progress: The Randomized, Double-Blind, Placebo-Controlled Phase 1b CROSSWALK-a and Phase 2a CROSSWALK-c Trials - Crovalimab for the Treatment and Prevention of Vaso-Occlusive Episodes in Sickle Cell Disease

Colchicine Protects Against Cardiomyopathy in Humanized Mouse Model for Sickle Cell Disease

Resolvins Modulate Netosis and Autoimmunity in Sickle Cell Disease

Premature aging of the immune system affects the response to SARS-CoV-2 mRNA vaccine in β-thalassemia: role of an additional dose

The Increased Burden of Sickle Cell Disease in Italy: Findings from the Greatalys (Generating Real world Evidence Across ITALy In SCD) Study

Mitapivat Improves Transfusion Burden and Reduces Iron Overload in Thalassemic Mice

Nrf2 Plays a Key Role in Iron-Overload Cardiomyopathy

Trial in Progress: The Randomized, Double-Blind, Placebo-Controlled Phase IIa CROSSWALK-c Trial Evaluating the Efficacy of Crovalimab As Adjunct Treatment in the Prevention of Vaso-Occlusive Episodes (VOEs) in Patients with Sickle Cell Disease (SCD)

Trial in Progress: The Randomized, Double-Blind, Placebo-Controlled Phase Ib CROSSWALK-a Trial Evaluating the Safety of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOEs) in Patients with Sickle Cell Disease (SCD)

The Pyruvate Kinase Activator Mitapivat Ameliorates Anemia and Prevents Iron Overload in a Mouse Model of Hereditary Spherocytosis

COVID 19 and Hemoglobinopathies: Update of the Italian Experience

Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion

Selecting ß-Thalassemia Patients for Gene Therapy: A Decision-Making Algorithm

Fyn Specifically Regulates the Activity of Red Cell Glucose-6-Phosphate-Dehydrogenase

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American Society of Hematology

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American Society of Hematology

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