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Journal Articles

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Blood (2019) 134 (Supplement_1): 531.

https://doi.org/10.1182/blood-2019-121996

Published: 2019

Journal Articles

Identification of Genetic Pathways Controlling Resistance to Standard Combination Chemotherapy in Acute Myeloid Leukemia

Victoria Y Ling, MBBS, William Godfrey, Sebastien Jacquelin, PhD, Jasmin Straube, PhD, Leanne T Cooper, Claudia Bruedigam, PhD, Siok-Keen Tey, MBBS PhDFRACP FRCPA, Lars Bullinger, MD, Marco J Herold, Megan Bywater, PhD, Steven W. Lane, MD PhD

Blood (2018) 132 (Supplement 1): 2771.

https://doi.org/10.1182/blood-2018-99-115729

Published: 2018

Journal Articles

Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms

Stefan Sonderegger, PhD MSc, Loretta Cerruti, BSc, Cedric Tremblay, PhD, Emma Toulmin, PhD, Jesslyn Saw, BSc, Tom Nebl, PhD, Katherine M Hannan, PhD, Steven W. Lane, MD PhD, Hendrik Falk, PhD, Ashwin Unnikrishnan, PhD, Paul Stupple, PhD, Ian Street, PhD, Stephen Jane, MDPhD, Rachel Altura, PhD, Benjamin Nicholson, PhD, David J. Curtis, MBBS,PhD

Blood (2018) 132 (Supplement 1): 53.

https://doi.org/10.1182/blood-2018-99-118406

Published: 2018

Journal Articles

Oncogenic-Drivers Dictate Immune Responses to Control Disease Progression in Acute Myeloid Leukaemia

Rebecca Austin, BSc, Megan Bywater, PhD, Jasmin Straube, PhD, Leanne T Cooper, Madeleine Headlam, PhD, Keyur Dave, PhD, Matthias Braun, PhD, Tobias Bald, PhD, Fernando Guimaraes, PhD, Sebastien Jacquelin, PhD, Matthew Witkowski, PhD, Iannis Aifantis, PhD, Geoffrey R Hill, MD PhD, Mark J Smyth, PhD, Steven W. Lane, MD PhD

Blood (2018) 132 (Supplement 1): 904.

https://doi.org/10.1182/blood-2018-99-112009

Published: 2018

Journal Articles

In Vivo Expansion of Recipient DC Leads to Deletion of Donor Alloreactive CD8 + T Cells and Is an Alternative to Post-Transplant Cyclophosphamide for the Prevention of Graft-Versus-Host Disease after BMT

Kate A Markey, MBBS, PhD, Rachel D Kuns, BSc, Daniel J Browne, BSc, Kate H Gartlan, PhD, Renee J Robb, PhD, J Paulo Martins, BSc, Andrea S Henden, MBBS, Simone A Minnie, BSc, Melody Cheong, PhD, Motoko Koyama, MD PhD, Mark J Smyth, PhD, Gabrielle T Belz, PhD, Thomas Brocker, PhD, Mariapia Degli-Esposti, PhD, Steven W. Lane, MD PhD, Geoff R Hill, MD

Blood (2017) 130 (Supplement 1): 4443.

https://doi.org/10.1182/blood.V130.Suppl_1.4443.4443

Published: 2017

Journal Articles

Integrated Molecular Analysis Identifies Replicative Stress As Sensitizer to Imetelstat Therapy in AML

Claudia Bruedigam, Amy H Porter, Brad Wackrow, Jasmin Straube, PhD, Leanne T Cooper, Axia Song, Stanley Chun-Wei Lee, PhD, Omar Abdel-Wahab, MD, Geoffrey R Hill, MD, Steven W. Lane, MD PhD

Blood (2017) 130 (Supplement 1): 798.

https://doi.org/10.1182/blood.V130.Suppl_1.798.798

Published: 2017

Journal Articles

Recipient CD8 + DC Delete Alloreactive Donor CTL and Promote Leukemic Relapse after Allogeneic BMT

Kate A Markey, MBBS, PhD, Rachel D Kuns, BSc, Renee J Robb, PhD, Motoko Koyama, MDPhD, Kate Helen Gartlan, PhD, Andrea S Henden, MBBS, Simone A Minnie, B Sc, Kelli P A Macdonald, PhD, Thomas Brocker, PhD, Gabrielle T Belz, PhD, Steven W. Lane, MD, Geoff R Hill, MD

Blood (2015) 126 (23): 4279.

https://doi.org/10.1182/blood.V126.23.4279.4279

Published: 2015

Journal Articles

Cdx2 Cooperates with Flt3-ITD to Induce Acute Myeloid Leukaemia in Mice

Therese Vu, BSc, Claudia Bruedigam, Axia Song, Solene Guignes, Rebecca Austin, Sebastien Jacquelin, Alistair Chalk, Carl Walkley, PhD BPharm, Claudia Scholl, Stefan Fröhling, MD, Steven W. Lane, MD

Blood (2015) 126 (23): 557.

https://doi.org/10.1182/blood.V126.23.557.557

Published: 2015

Journal Articles

SSB1/NABP2 and SSB2/NABP1 Have Essential and Overlapping Roles in Maintaining Hematopoietic Stem and Progenitor Cells

Wei Shi, PhD, Therese Vu, BSc, Glen Boyle, PhD, Fares Al-Ejeh, PhD, Tej Pandita, PhD, Krzysztof Ginalski, PhD, Maga Rowicka, PhD, Steven W. Lane, MD, Kum Kum Khanna, PhD

Blood (2015) 126 (23): 2405.

https://doi.org/10.1182/blood.V126.23.2405.2405

Published: 2015

Journal Articles

Inhibition of Telomerase with Imetelstat Is Detrimental to Leukemia Stem Cells in Acute Myeloid Leukemia (AML)

Claudia Bruedigam, Frederik Otzen Bagger, Florian H Heidel, MD, Catherine Kuhn, Solene Guignes, Axia Song, Rebecca Austin, Therese Vu, Erwin M Lee, PhD, Andrew S. Moore, MBBS, FRACP, PhD, Richard B. Lock, PhD, Lars Bullinger, MD PhD, Geoff R Hill, MD, Steven W Lane, MD PhD

Blood (2014) 124 (21): 2322.

https://doi.org/10.1182/blood.V124.21.2322.2322

Published: 2014

Journal Articles

Altered HSC Metabolism in Response to Stress Leads to De Novo dna Damage and Cellular Attrition

Blood (2014) 124 (21): 255.

https://doi.org/10.1182/blood.V124.21.255.255

Published: 2014

Journal Articles

Aberrant Activation of Epidermal Growth Factor Receptor in MPN May Respond to the Kinase Inhibitor Gefitinib

Debora A Casolari, PhD, Diana G Iarossi, BSc (Hons), Carolyn M Butcher, MMedSc(Hons), Sarah C Bray, PhD, Wendy T Parker, PhD, Chris N Hahn, PhD, Susan Branford, PhD, Peter Bardy, MD, Ian D Lewis, MBBS, PhD, Hamish S Scott, PhD, Steven W Lane, MD PhD, David M Ross, MBBS, PhD FRACP, FRCPA, Richard J D'Andrea, PhD

Blood (2014) 124 (21): 1882.

https://doi.org/10.1182/blood.V124.21.1882.1882

Published: 2014

Journal Articles

Inhibition Of Telomerase Is a Novel and Effective Therapy In MLL-Rearranged Acute Myeloid Leukemia (AML)

Claudia Bruedigam, Frederik Otzen Bagger, MSc, Catherine Paine Kuhn, Therese Vu, Rebecca Austin, Florian H Heidel, MD, Lars Bullinger, MD, PhD, Geoff R Hill, Scott A. Armstrong, MD, PhD, David A. Williams, MD, Steven W Lane, MD, PhD

Blood (2013) 122 (21): 2887.

https://doi.org/10.1182/blood.V122.21.2887.2887

Published: 2013

Journal Articles

IL3-Receptor Signaling Is Dispensable For The Generation and Maintenance Of Jak2V617F-Induced Myeloproliferative Neoplasm (MPN

Therese Vu, Claudia Bruedigam, Rebecca Austin, Catherine Paine-Kuhn, Hayley S. Ramshaw, PhD, Angel F. Lopez, MBBS, PhD, Geoff Hill, MD, Ann Mullally, MD, Steven W Lane, MD, PhD

Blood (2013) 122 (21): 2841.

https://doi.org/10.1182/blood.V122.21.2841.2841

Published: 2013

Journal Articles

HSC Exit From Dormancy Provokes De Novo DNA Damage, Leading To Bone Marrow Failure If Unresolved By The Fanconi Anemia Pathway

Dagmar Walter, PhD, Amelie Lier, Anja Geiselhart, Sina Huntscha, David Brocks, Irem Bayindir, Paul Kaschutnig, Peter Schmezer, PhD, Steven W Lane, MD, PhD, Marieke Essers, PhD, David A. Williams, MD, Andreas Trumpp, PhD, Michael D. Milsom, PhD

Blood (2013) 122 (21): 799.

https://doi.org/10.1182/blood.V122.21.799.799

Published: 2013

Journal Articles

Autophagy Is Required For Long-Term Hematopoietic Stem Cell (HSC) Function and G-CSF-Induced HSC Mobilization

Lucie Leveque, Therese Vu, Rachel D Kuns, Bianca E Teal, Mary Lor, Katie E Lineburg, Claudia Bruedigam, Frederik Otzen Bagger, Glen Boyle, PhD, Geoffrey R Hill, Kelli P A MacDonald, PhD, Steven W Lane, MD, PhD

Blood (2013) 122 (21): 892.

https://doi.org/10.1182/blood.V122.21.892.892

Published: 2013

Journal Articles

Depletion of Jak2V617F MPN Stem Cells by IFNα in a Murine Model of Polycythemia Vera

Ann Mullally, MD, Claudia Bruedigam, Dirk Heckl, Luke Poveromo, Florian H. Heidel, MD, Geoff Hill, MD, Benjamin L. Ebert, MD, PhD, Steven W. Lane, MD PhD

Blood (2012) 120 (21): 806.

https://doi.org/10.1182/blood.V120.21.806.806

Published: 2012

Journal Articles

Pak A Proteins Are Essential for Hematopoietic Stem/Progenitor Cell (HSC/P) Engraftment Through Regulation of Signaling Pathways Controlling HSC/P Proliferation, Survival, Migration, and the Actin Cytoskeleton

Adrienne M. Dorrance, PhD, Rachelle Kosoff, Meaghan McGuinness, Chad Harris, Serena De Vita, MD, PhD, Ronald Mathieu, Steven W. Lane, MD, Michael D. Milsom, PhD, Jonathan Chernoff, MD, PhD, David A. Williams, MD

Blood (2011) 118 (21): 917.

https://doi.org/10.1182/blood.V118.21.917.917

Published: 2011

Journal Articles

Characterizing the Disease-Initiating Cell Population In a Murine Model of Jak2V617F+ Myeloproliferative Neoplasm

Ann Mullally, MD, Steven W. Lane, MD, Luke Poveromo, Fatima Al-Shahrour, Jeffery Kutok, MD, PhD, Benjamin L. Ebert, MD, DPhil

Blood (2010) 116 (21): 317.

https://doi.org/10.1182/blood.V116.21.317.317

Published: 2010

Journal Articles

Leukemia Stem Cells Are Resistant to In Vivo, Cell Non-Autonomous Wnt Inhibition.

Steven W. Lane, MD, Cristina Lo Celso, Stephen M Sykes, Sebastian Shterental, Mahnaz Paktinat, Charles P Lin, David A. Williams, MD, David T. Scadden, MD, D. Gary Gilliland, MD, PhD

Blood (2009) 114 (22): 1025.

https://doi.org/10.1182/blood.V114.22.1025.1025

Published: 2009

NARROW

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Identification of Genetic Pathways Controlling Resistance to Standard Combination Chemotherapy in Acute Myeloid Leukemia

Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms

Oncogenic-Drivers Dictate Immune Responses to Control Disease Progression in Acute Myeloid Leukaemia

In Vivo Expansion of Recipient DC Leads to Deletion of Donor Alloreactive CD8 + T Cells and Is an Alternative to Post-Transplant Cyclophosphamide for the Prevention of Graft-Versus-Host Disease after BMT

Integrated Molecular Analysis Identifies Replicative Stress As Sensitizer to Imetelstat Therapy in AML

Recipient CD8 + DC Delete Alloreactive Donor CTL and Promote Leukemic Relapse after Allogeneic BMT

Cdx2 Cooperates with Flt3-ITD to Induce Acute Myeloid Leukaemia in Mice

SSB1/NABP2 and SSB2/NABP1 Have Essential and Overlapping Roles in Maintaining Hematopoietic Stem and Progenitor Cells

Inhibition of Telomerase with Imetelstat Is Detrimental to Leukemia Stem Cells in Acute Myeloid Leukemia (AML)

Altered HSC Metabolism in Response to Stress Leads to De Novo dna Damage and Cellular Attrition

Aberrant Activation of Epidermal Growth Factor Receptor in MPN May Respond to the Kinase Inhibitor Gefitinib

Inhibition Of Telomerase Is a Novel and Effective Therapy In MLL-Rearranged Acute Myeloid Leukemia (AML)

IL3-Receptor Signaling Is Dispensable For The Generation and Maintenance Of Jak2V617F-Induced Myeloproliferative Neoplasm (MPN

HSC Exit From Dormancy Provokes De Novo DNA Damage, Leading To Bone Marrow Failure If Unresolved By The Fanconi Anemia Pathway

Autophagy Is Required For Long-Term Hematopoietic Stem Cell (HSC) Function and G-CSF-Induced HSC Mobilization

Depletion of Jak2V617F MPN Stem Cells by IFNα in a Murine Model of Polycythemia Vera

Pak A Proteins Are Essential for Hematopoietic Stem/Progenitor Cell (HSC/P) Engraftment Through Regulation of Signaling Pathways Controlling HSC/P Proliferation, Survival, Migration, and the Actin Cytoskeleton

Characterizing the Disease-Initiating Cell Population In a Murine Model of Jak2V617F+ Myeloproliferative Neoplasm

Leukemia Stem Cells Are Resistant to In Vivo, Cell Non-Autonomous Wnt Inhibition.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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