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Journal Articles

The ability to cross the blood–cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

Blood (2016) 127 (16): 1998–2006.

https://doi.org/10.1182/blood-2015-08-665034

Published: 2016

Includes: Supplemental data

Journal Articles

The Sub-Clonal Complexity of STIL-TAL1 T-ALL

Caroline L Furness, MD, Marcela B Mansur, PhD, Victoria J Weston, PhD, Sarah Jenkinson, MSc, Frederik W van Delft, MDPhD, Lyndal Kearney, PhD, Ian Titley, PhD, Anthony M Ford, PhD, Rosemary E Gale, Pamela R Kearns, MBChB, PhD FRCPCH, Adolfo A. Ferrando, MD PhD, Christine J. Harrison, Nicola E Potter, PhD, Mel Greaves, FRS

Blood (2014) 124 (21): 3788.

https://doi.org/10.1182/blood.V124.21.3788.3788

Published: 2014

Journal Articles

Clonal Evolution and Sub-Clonal Architecture In Paediatric T-Cell Acute Lymphoblastic Leukaemia (T-ALL)

Caroline L Furness, MD, Marcela B Mansur, PhD, Victoria J Weston, PhD, Frederik W Van Delft, MD PhD, Christine J Harrison, PhD, Lyndal Kearney, PhD, Anthony M Ford, PhD, Pamela R Kearns, MBChB, PhD, FRCPCH, Nicola E Potter, PhD, Jean Soulier, MD, PhD, Adolfo A. Ferrando, MD, PhD, Mel Greaves, PhD, FRS

Blood (2013) 122 (21): 1366.

https://doi.org/10.1182/blood.V122.21.1366.1366

Published: 2013

Journal Articles

An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice

Blood (2013) 122 (21): 3866.

https://doi.org/10.1182/blood.V122.21.3866.3866

Published: 2013

Journal Articles

Inhibition of BRD4 Bromodomains Is a Potent Novel Strategy to Target Apoptosis Resistance in Paediatric ALL

David Da Costa, Victoria J Weston, PhD, Wenbin Wei, PhD, Angelo Agathanggelou, PhD, Eva Petermann, PhD, Stefan Knapp, PhD, Pamela R Kearns, BSc, MBBCh, MRCP, PhD, Tatjana Stankovic, MD, PhD

Blood (2011) 118 (21): 77.

https://doi.org/10.1182/blood.V118.21.77.77

Published: 2011

Journal Articles

Insight Into T-ALL Leukaemia Initiating Cells, Clonal Evolution and Impact of Treatment In Vivo Using Immune-Compromised Mouse Model,

Victoria J Weston, PhD, Tracey A Perry, BSc, Helen Roberts, BSc, Katie Brown, Shaun R Wilson, MBChB, MRCPCH, Pamela R Kearns, BSc, MBBCh, MRCP, PhD

Blood (2011) 118 (21): 3577.

https://doi.org/10.1182/blood.V118.21.3577.3577

Published: 2011

Journal Articles

Characterisation of Leukaemic Stem Cell Populations in Childhood AML Indicate Distinct Disease Subtypes with Diverse Clinical Features

Victoria J Weston, PhD, Tracey A Perry, BSc, Katie Brown, Shaun R Wilson, MBChB, MRCPCH, Pamela R Kearns, BSc, MBBCh, MRCP, PhD

Blood (2011) 118 (21): 1500.

https://doi.org/10.1182/blood.V118.21.1500.1500

Published: 2011

Journal Articles

Tyrosine Kinase Inhibitor Screen Identifies the Multikinase Inhibitor, Foretinib, As a Sensitisor of Treatment-resistant B-Precursor ALL to Core Chemotherapeutic Agents

Shaun R Wilson, MBChB, MRCPCH, Victoria J Weston, PhD, Tatjana Stankovic, MD, PhD, Pamela R Kearns, BSc, MBBCh, MRCP, PhD

Blood (2011) 118 (21): 1509.

https://doi.org/10.1182/blood.V118.21.1509.1509

Published: 2011

Journal Articles

The PARP inhibitor olaparib induces significant killing of ATM -deficient lymphoid tumor cells in vitro and in vivo

Victoria J. Weston, Ceri E. Oldreive, Anna Skowronska, David G. Oscier, Guy Pratt, Martin J. S. Dyer, Graeme Smith, Judy E. Powell, Zbigniew Rudzki, Pamela Kearns, Paul A. H. Moss, A. Malcolm R. Taylor, Tatjana Stankovic

Blood (2010) 116 (22): 4578–4587.

https://doi.org/10.1182/blood-2010-01-265769

Published: 2010

Includes: Supplemental data

Journal Articles

ATM Mutant Lymphoid Tumour Cells Exhibit Impaired Activation of the Redox-Sensitive Nrf2-ARE Detoxification Pathway and Are Differentially Sensitive to Nrf2-Activating Compounds

Victoria J Weston, PhD, Angelo Agathanggelou, PhD, Paul AH Moss, MD, PhD, Pamela R. Kearns, BSc, MBBCh, MRCP, PhD, A. Malcolm R Taylor, PhD, Tatjana Stankovic, MD, PhD

Blood (2010) 116 (21): 49.

https://doi.org/10.1182/blood.V116.21.49.49

Published: 2010

Journal Articles

The PIM Kinase Inhibitor K00135 Sensitizes Primary Acute Lymphoblastic Leukaemia (ALL) Cells to DNA-Damaging Agents

David Da Costa, Victoria J Weston, PhD, Stefan Knapp, PhD, A. Malcolm R Taylor, PhD, Pamela R. Kearns, BSc, MBBCh, MRCP, PhD, Tatjana Stankovic, MD, PhD

Blood (2010) 116 (21): 3238.

https://doi.org/10.1182/blood.V116.21.3238.3238

Published: 2010

Journal Articles

CLL Xenograft Models to Address the Impact of Single Gene Loss (ATM) on Proliferation and Cytotoxic Response

Ceri E Oldreive, PhD, Victoria J Weston, PhD, Paul AH Moss, MD, PhD, Guy Pratt, Pamela R. Kearns, BSc, MBBCh, MRCP, PhD, A. Malcolm R Taylor, PhD, Tatjana Stankovic, MD, PhD

Blood (2010) 116 (21): 2439.

https://doi.org/10.1182/blood.V116.21.2439.2439

Published: 2010

Journal Articles

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival

Azra J. Alvi, Belinda Austen, Victoria J. Weston, Christopher Fegan, David MacCallum, Athos Gianella-Borradori, David P. Lane, Mike Hubank, Judith E. Powell, Wenbin Wei, A. Malcolm R. Taylor, Paul A. H. Moss, Tatjana Stankovic

Blood (2005) 105 (11): 4484–4491.

https://doi.org/10.1182/blood-2004-07-2713

Published: 2005

Journal Articles

Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-κB survival pathway signaling

Victoria J. Weston, Belinda Austen, Wenbin Wei, Eliot Marston, Azra Alvi, Sarah Lawson, Philip J. Darbyshire, Mike Griffiths, Frank Hill, Jill R. Mann, Paul A. H. Moss, A. Malcolm R. Taylor, Tatjana Stankovic

Blood (2004) 104 (5): 1465–1473.

https://doi.org/10.1182/blood-2003-11-4039

Published: 2004

Journal Articles

Microarray analysis reveals that TP53 - and ATM -mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses

Tatjana Stankovic, Mike Hubank, Debbie Cronin, Grant S. Stewart, Danielle Fletcher, Colin R. Bignell, Azra J. Alvi, Belinda Austen, Victoria J. Weston, Christopher Fegan, Philip J. Byrd, Paul A. H. Moss, A. Malcolm R. Taylor

Blood (2004) 103 (1): 291–300.

https://doi.org/10.1182/blood-2003-04-1161

Published: 2004

NARROW

The ability to cross the blood–cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

The Sub-Clonal Complexity of STIL-TAL1 T-ALL

Clonal Evolution and Sub-Clonal Architecture In Paediatric T-Cell Acute Lymphoblastic Leukaemia (T-ALL)

An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice

Inhibition of BRD4 Bromodomains Is a Potent Novel Strategy to Target Apoptosis Resistance in Paediatric ALL

Insight Into T-ALL Leukaemia Initiating Cells, Clonal Evolution and Impact of Treatment In Vivo Using Immune-Compromised Mouse Model,

Characterisation of Leukaemic Stem Cell Populations in Childhood AML Indicate Distinct Disease Subtypes with Diverse Clinical Features

Tyrosine Kinase Inhibitor Screen Identifies the Multikinase Inhibitor, Foretinib, As a Sensitisor of Treatment-resistant B-Precursor ALL to Core Chemotherapeutic Agents

The PARP inhibitor olaparib induces significant killing of ATM -deficient lymphoid tumor cells in vitro and in vivo

ATM Mutant Lymphoid Tumour Cells Exhibit Impaired Activation of the Redox-Sensitive Nrf2-ARE Detoxification Pathway and Are Differentially Sensitive to Nrf2-Activating Compounds

The PIM Kinase Inhibitor K00135 Sensitizes Primary Acute Lymphoblastic Leukaemia (ALL) Cells to DNA-Damaging Agents

CLL Xenograft Models to Address the Impact of Single Gene Loss (ATM) on Proliferation and Cytotoxic Response

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival

Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-κB survival pathway signaling

Microarray analysis reveals that TP53 - and ATM -mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses

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American Society of Hematology

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ASH Publications

American Society of Hematology

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