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Journal Articles

Repurposing Nelarabine to Induce Differentiation of Acute Myeloid Leukemia

Hanying Wang, Xin He, MD, Feiteng Huang, MS, Haojie Dong, PhD, Wei Chen, PhD, Zheng Li, MS, Jie Sun, PhD, Yinghui Zhu, PhD, Lei Zhang, MD, Yuhui Wu, MD, Lifeng Feng, PhD, Jing Zhang, PhD, Samer Khaled, MD, Guido Marcucci, MD, David Sykes, MD PhD, Hongchuan Jin, MD PhD, Xian Wang, MD PhD, Ling Li, PhD

Blood (2020) 136 (Supplement 1): 26.

https://doi.org/10.1182/blood-2020-139922

Published: 2020

Journal Articles

CD25-Dependent Feedback Control of the B-Cell Receptor and Its Oncogenic Mimics in B-Cell Malignancies

Blood (2018) 132 (Supplement 1): 776.

https://doi.org/10.1182/blood-2018-99-117553

Published: 2018

Journal Articles

A Novel Full Length Anti-FLT3 CD3 Bispecific Antibody for the Treatment of Acute Myeloid Leukemia

Ivana Djuretic, PhD, Veena Krishnamoorthy, PhD, Cesar Sommer, PhD, Danielle E. Dettling, Kris Poulsen, Wei Chen, PhD, Wenyue Hu, PhD, Allison Given Chunyk, Kevin Lindquist, Shobha Potluri, PhD, Robert C Rickert, PhD, Barbra Sasu, PhD, Javier Chaparro-Riggers, PhD, Yik Andy Yeung, PhD

Blood (2018) 132 (Supplement 1): 1445.

https://doi.org/10.1182/blood-2018-99-119915

Published: 2018

Journal Articles

Inhibition of PRMT1 Mediated FLT3 Arginine Methylation As a Potent Therapeutic Strategy for MLL-r ALL

Yinghui Zhu, PhD, Xin He, PhD, Haojie Dong, PhD, Jie Sun, PhD, Hanying Wang, PhD, Lei Zhang, PhD, Yunan Miao, PhD, Jian Jin, PhD, Yudao Shen, PhD, Jianjun Chen, PhD, Markus Muschen, MD, Chun-Wei Chen, PhD, Marina Y. Konopleva, MD PhD, Weili Sun, MD PhD, Bin Zhang, PhD, Ya-Huei Kuo, PhD, Nadia Carlesso, MD PhD, Guido Marcucci, Ling Li, PhD

Blood (2018) 132 (Supplement 1): 892.

https://doi.org/10.1182/blood-2018-99-115139

Published: 2018

Journal Articles

High-Density CRISPR Scan Identifies Functional Regions of DOT1L That Mediate Therapeutic Response in MLL -r Leukemia

Chun-Wei Chen, PhD, Lu Yang, PhD, Xi Wang, PhD, Anthony Chan, PhD, Chris Delaney, Kazuya Miyashita, PhD, Yanchun Guo, MD PhD, Wen-Han Chang, PhD, Sandra Li, Sheela Pokharel, Hongzhi Li, PhD, Yadira Soto-Feliciano, Takayuki Hoshii, PhD, Scott A. Armstrong, MD PhD

Blood (2018) 132 (Supplement 1): 179.

https://doi.org/10.1182/blood-2018-179

Published: 2018

Journal Articles

A Phase II Study of Tacrolimus and Thymoglobulin, As Graft-Versus-Host-Disease Prophylaxis in Patients Undergoing Related Donor Allogeneic Hematopoietic Cell Transplantation

Dipenkumar Modi, MD, Wei Chen, PhD, Jang Hyejeong, Abhinav Deol, MD, Lois Ayash, MD, Alavi Asif, MD, Divaya Bhutani, Kendra Mellert, M.S.A.; C.C.R.P., Voravit Ratanatharathorn, MD, Joseph P. Uberti, MD, PhD

Blood (2016) 128 (22): 4579.

https://doi.org/10.1182/blood.V128.22.4579.4579

Published: 2016

Journal Articles

Two Novel Knock-in and Knock-out of Setd2 Alleles Cooperate with Mll-Af9 Knock-in Allele to Accelerate Leukemia Development

Yunzhu Dong, Yoshihiro Hayashi, MD PhD, Xiaomei Yan, MD PhD, Feng Xue, PhD, Wei Chen, PhD, Gang Huang, PhD

Blood (2015) 126 (23): 555.

https://doi.org/10.1182/blood.V126.23.555.555

Published: 2015

Journal Articles

A Selective and Potent Rock 2 Inhibitor (KD025) Decreases Human STAT3-Dependent IL-21 and IL-17 Production and Experimental Chronic Graft-Versus-Host Disease (cGVHD)

Alexandra Zanin-Zhorov, PhD, Ryan Flynn, Leo Luznik, MD, Angela Panoskaltsis-Mortari, PhD, Du Jing, Katelyn Goodman, Jonathan Weiss, PhD, Melanie Nyuydzefe, Wei Chen, PhD, Jonathan S Serody, MD, Kelli PA MacDonald, Geoffrey R Hill, John O'Shea, MD, Maria Roche, Sara Weiss, PhD, Samuel Waksal, PhD, Bruce R. Blazar, MD

Blood (2014) 124 (21): 540.

https://doi.org/10.1182/blood.V124.21.540.540

Published: 2014

Journal Articles

Hyperactive Ptpn11 Mutations Alters Leukemic Stem Cell Frequency through Mcl-1 Overexpression

Lili Chen, PhD, Wei Chen, PhD, Maria Mysliwski, Justin Serio, James Ropa, Fardokht Abulwerdi, Rebecca J. Chan, MD PhD, Jay P. Patel, Martin S. Tallman, MD, Elisabeth M. Paietta, PhD, Ari M Melnick, MD, Ross L. Levine, MD, Omar Abdel-Wahab, MD, Zaneta Nikolovska-Coleska, PhD, Andrew G. Muntean, PhD

Blood (2014) 124 (21): 3565.

https://doi.org/10.1182/blood.V124.21.3565.3565

Published: 2014

Journal Articles

A Novel Mutation In Bruton Tyrosine Kinase Confers Acquired Resistance To Ibrutinib (PCI-32765) In CLL

Richard R. Furman, MD, Shuhua Cheng, PhD, Pin Lu, MD, PhD, Menu Setty, Alexandar Perez, Ailin Guo, MD, PhD, Joelle Racchumi, BS, Jiao Ma, PhD, Morton Coleman, MD, Kabaleeswaran Venkataraman, PhD, Guozhou Xu, PhD, Wei Chen, PhD, Hao Wu, PhD, Betty Y. Chang, PhD, Christina Leslie, PhD, Y. Lynn Wang, MD, PhD

Blood (2013) 122 (21): 4914.

https://doi.org/10.1182/blood.V122.21.4914.4914

Published: 2013

Journal Articles

Low Incidence Of Severe Cgvhd and Late NRM In a Phase II Trial Of Thymoglobulin®, Tacrolimus and Sirolimus For Gvhd Prevention

Zaid Al-Kadhimi, MD, Alireza Eghtedar, MD, Zartash Gul, MD, Wei Chen, PhD, Daryn Smith, Abhinav Deol, MD, Muneer H. Abidi, MD, Lawrence G Lum, MD, DSc, Divaya Bhutani, MD, Lois Ayash, MD, Voravit Ratanatharathorn, MD, Joseph P. Uberti, MD, PhD

Blood (2013) 122 (21): 5471.

https://doi.org/10.1182/blood.V122.21.5471.5471

Published: 2013

Journal Articles

Myeloid Leukemia Cells With MLL partial Tandem Duplication Are Sensitive To Pharmacological Inhibition Of The H3K79 Methyltransferase DOT1L

Michael W.M. Kühn, MD, Michael Hadler, MSc, Scott R. Daigle, PhD, Chun-Wei Chen, PhD, Amit U. Sinha, PhD, Andrei V. Krivtsov, PhD, Edward J. Olhava, PhD, Michael A. Caligiuri, MD, James E Bradner, MD, Roy M. Pollock, PhD, Scott A. Armstrong, MD, PhD

Blood (2013) 122 (21): 1256.

https://doi.org/10.1182/blood.V122.21.1256.1256

Published: 2013

Journal Articles

Targeting β-arrestin2 Enhances Survival in a Murine Model of Chronic Myeloid Leukemia

Lindsay A.M. Rein, MD, Minyong Chen, PhD, Barbara S. Theriot, BS, James W. Wisler, MD, Laura M. Wingler, PhD, Richard T. Premont, PhD, Wei Chen, PhD, Julia K.L. Walker, PhD, Robert J. Lefkowitz, MD

Blood (2013) 122 (21): 857.

https://doi.org/10.1182/blood.V122.21.857.857

Published: 2013

Journal Articles

High Rates of Severe aGVHD with Tacrolimus and Mycophenolate Mofetil in a Large Cohort of Related and Unrelated Allogeneic Transplant Patients

Zaid Al-Kadhimi, MD, Zartash Gul, MD, Wei Chen, PhD, Daryn Smith, Abhinav Deol, MD, Muneer H. Abidi, MD, Lois Ayash, MD, Lawrence G Lum, MD, DSc, Voravit Ratanatharathorn, MD, Joseph P. Uberti, MD, PhD

Blood (2012) 120 (21): 1951.

https://doi.org/10.1182/blood.V120.21.1951.1951

Published: 2012

Journal Articles

A Prospective Phase II Trial: The Combination of Tacrolimus, Sirolimus, and Rabbit Anti-Thymocyte Globulin (Thymoglobulin® Thymo) to Prevent Acute Graft Vs. Host Disease (aGVHD) in Patients Receiving Unrelated Hematopoietic Stem Cell Transplantation (UHSCT)

Zaid Al-Kadhimi, MD, Zartash Gul, MD, Roberto Rodriguez, MD, Wei Chen, PhD, Alice Mitchell, BS, Muneer H. Abidi, MD, Lois Ayash, MD, Abhinav Deol, MD, Lawrence G Lum, MD, DSc, Voravit Ratanatharathorn, MD, Joseph P. Uberti, MD, PhD

Blood (2011) 118 (21): 4551.

https://doi.org/10.1182/blood.V118.21.4551.4551

Published: 2011

Journal Articles

The Combination of Tacrolimus (T), Sirolimus (S), and Rabbit Anti-Thymocyte Globulin (Thymoglobulin Thymo) to Prevent Acute Graft-Vs-Host Disease (aGVHD) in Patients (pts) Receiving Unrelated Hematopoietic Stem Cell Transplantation (UHSCT).

Zaid S Al-Kadhimi, M.D, Zartash Gul, MD, Lawrence G. Lum, MD, DSC, Lois Ayash, MD, Muneer H. Abidi, MD, Wei Chen, PhD, Alice Mitchell, BS, Voravit Ratanatharathorn, M.D, Joseph Uberti, M.D., Ph.D

Blood (2009) 114 (22): 2239.

https://doi.org/10.1182/blood.V114.22.2239.2239

Published: 2009

NARROW

Repurposing Nelarabine to Induce Differentiation of Acute Myeloid Leukemia

CD25-Dependent Feedback Control of the B-Cell Receptor and Its Oncogenic Mimics in B-Cell Malignancies

A Novel Full Length Anti-FLT3 CD3 Bispecific Antibody for the Treatment of Acute Myeloid Leukemia

Inhibition of PRMT1 Mediated FLT3 Arginine Methylation As a Potent Therapeutic Strategy for MLL-r ALL

High-Density CRISPR Scan Identifies Functional Regions of DOT1L That Mediate Therapeutic Response in MLL -r Leukemia

A Phase II Study of Tacrolimus and Thymoglobulin, As Graft-Versus-Host-Disease Prophylaxis in Patients Undergoing Related Donor Allogeneic Hematopoietic Cell Transplantation

Two Novel Knock-in and Knock-out of Setd2 Alleles Cooperate with Mll-Af9 Knock-in Allele to Accelerate Leukemia Development

A Selective and Potent Rock 2 Inhibitor (KD025) Decreases Human STAT3-Dependent IL-21 and IL-17 Production and Experimental Chronic Graft-Versus-Host Disease (cGVHD)

Hyperactive Ptpn11 Mutations Alters Leukemic Stem Cell Frequency through Mcl-1 Overexpression

A Novel Mutation In Bruton Tyrosine Kinase Confers Acquired Resistance To Ibrutinib (PCI-32765) In CLL

Low Incidence Of Severe Cgvhd and Late NRM In a Phase II Trial Of Thymoglobulin®, Tacrolimus and Sirolimus For Gvhd Prevention

Myeloid Leukemia Cells With MLL partial Tandem Duplication Are Sensitive To Pharmacological Inhibition Of The H3K79 Methyltransferase DOT1L

Targeting β-arrestin2 Enhances Survival in a Murine Model of Chronic Myeloid Leukemia

High Rates of Severe aGVHD with Tacrolimus and Mycophenolate Mofetil in a Large Cohort of Related and Unrelated Allogeneic Transplant Patients

A Prospective Phase II Trial: The Combination of Tacrolimus, Sirolimus, and Rabbit Anti-Thymocyte Globulin (Thymoglobulin® Thymo) to Prevent Acute Graft Vs. Host Disease (aGVHD) in Patients Receiving Unrelated Hematopoietic Stem Cell Transplantation (UHSCT)

The Combination of Tacrolimus (T), Sirolimus (S), and Rabbit Anti-Thymocyte Globulin (Thymoglobulin Thymo) to Prevent Acute Graft-Vs-Host Disease (aGVHD) in Patients (pts) Receiving Unrelated Hematopoietic Stem Cell Transplantation (UHSCT).

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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