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Journal Articles

RUNX-NFAT Axis As a Novel Therapeutic Target for AML and T Cell Immunity

Tatsuya Masuda, Master Degree, Hirohito Kubota, MD, Naoya Sakuramoto, Master Degree, Asuka Hada, Master Degree, Ayaka Horiuchi, Master Degree, Asami Sasaki, Master Degree, Kanako Takeda, Master Degree, Mizuho Takeda, Master Degree, Hidemasa Matsuo, Hiroshi Sugiyama, PhD, Souichi Adachi, MD PhD, Yasuhiko Kamikubo

Blood (2020) 136 (Supplement 1): 25–26.

https://doi.org/10.1182/blood-2020-143458

Published: 2020

Journal Articles

Autophagy Inhibition Enhances CDK4/6 Inhibitor-Induced Apoptosis in t(8;21) Acute Myeloid Leukemia Cells

Kana Nakatani, Hidemasa Matsuo, Yutarou Harata, Moe Higashitani, Asami Koyama, Mina Noura, Yoko Nishinaka-Arai, PhD, Yasuhiko Kamikubo, Souichi Adachi, MD PhD

Blood (2020) 136 (Supplement 1): 50.

https://doi.org/10.1182/blood-2020-133881

Published: 2020

Journal Articles

KRAS mutations Frequently Coexist with High-Risk MLL Fusions and Are Independent Adverse Prognostic Factors in MLL -Rearranged Acute Myeloid Leukemia

Blood (2020) 136 (Supplement 1): 28–29.

https://doi.org/10.1182/blood-2020-134648

Published: 2020

Journal Articles

Therapeutic Targeting of RUNX-NFATC2 Axis for Acute Promyelocytic Leukemia and T Cell Immunity

Hirohito Kubota, MD, Kana Furuichi, Tatsuya Masuda, Toshiya Tatsuta, Hidefumi Hiramatsu, MD PhD, Junko Takita, MD PhD, Sugiyama Hiroshi, PhD, Souichi Adachi, MD PhD, Yasuhiko Kamikubo, MD, PhD

Blood (2019) 134 (Supplement_1): 3359.

https://doi.org/10.1182/blood-2019-126428

Published: 2019

Journal Articles

Coexistence and Prognostic Significance of EVI1 Expression and Driver Mutations in KMT2A -Rearranged Acute Myeloid Leukemia

Hidemasa Matsuo, PhD, Kenichi Yoshida, MD PhD, Kana Nakatani, Yasuhiko Kamikubo, MD, PhD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Nobutaka Kiyokawa, MD PhD, Seishi Ogawa, MD PhD, Manja Meggendorfer, PhD, Claudia Haferlach, MD, Souichi Adachi, MD PhD

Blood (2019) 134 (Supplement_1): 1409.

https://doi.org/10.1182/blood-2019-124652

Published: 2019

Journal Articles

Recurrent Genomic Aberrations of D-Type Cyclins Are Therapeutic Targets of CDK4/6 Inhibitors in t(8;21) and MLL -Rearranged Acute Myeloid Leukemia

Blood (2018) 132 (Supplement 1): 2797.

https://doi.org/10.1182/blood-2018-99-111073

Published: 2018

Journal Articles

RUNX1 Enhances Leukemia Cell Engraftment in the Vascular Niche through up-Regulating E-Selectin

Chieko Tokushige, Ken Morita, MD, PhD, Shintaro Maeda, Hiroki Kiyose, Mina Noura, Tatsuki Kataoka, MD, PhD, Toshikazu Bando, PhD, Hiroshi Sugiyama, PhD, Yasuhiko Kamikubo, MD, PhD, Souichi Adachi, MD PhD

Blood (2017) 130 (Supplement 1): 1225.

https://doi.org/10.1182/blood.V130.Suppl_1.1225.1225

Published: 2017

Journal Articles

Cell-Autonomous Feedback Loop of RUNX1-p53-CBFB in Acute Myeloid Leukemia Cells

Mina Noura, Ken Morita, MD, PhD, Chieko Tokushige, Shintaro Maeda, Hiroki Kiyose, Toshikazu Bando, PhD, Kenichi Yoshida, MD PhD, Hidemasa Matsuo, Seishi Ogawa, MD PhD, Paul P. Liu, MD, PhD, Hiroshi Sugiyama, PhD, Yasuhiko Kamikubo, MD, PhD, Souichi Adachi, MD PhD

Blood (2017) 130 (Supplement 1): 1232.

https://doi.org/10.1182/blood.V130.Suppl_1.1232.1232

Published: 2017

Journal Articles

Role of RUNX1 in hematological malignancies

Raman Sood, Yasuhiko Kamikubo, Paul Liu

Blood (2017) 129 (15): 2070–2082.

https://doi.org/10.1182/blood-2016-10-687830

Published: 2017

Journal Articles

Paradoxical Enhancement of Leukemogenesis in Acute Myeloid Leukemia Cells with Moderately Attenuated RUNX1 Expressions

Kensho Suzuki, Ken Morita, MD, PhD, Shintaro Maeda, Hiroki Kiyose, Souichi Adachi, MD, PhD, Yasuhiko Kamikubo, MD, PhD

Blood (2016) 128 (22): 2710.

https://doi.org/10.1182/blood.V128.22.2710.2710

Published: 2016

Journal Articles

Cluster Regulation of RUNX Family By "Gene Switch" Triggers a Profound Tumor Regression of Diverse Origins

Ken Morita, MD, PhD, Kensho Suzuki, Shintaro Maeda, Yoshihide Mitsuda, Ayaka Yano, Yoshimi Yamada, Hiroki Kiyose, Chieko Tokushige, Paul P. Liu, MD PhD, Souichi Adachi, MD, PhD, Hiroshi Sugiyama, PhD, Yasuhiko Kamikubo, MD, PhD

Blood (2016) 128 (22): 443.

https://doi.org/10.1182/blood.V128.22.443.443

Published: 2016

Journal Articles

Targeting Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia with a Novel Transcriptional Inhibitor

Shintaro Maeda, Ken Morita, MD, PhD, Kensho Suzuki, Hiroshi Sugiyama, PhD, Souichi Adachi, MD, PhD, Yasuhiko Kamikubo, MD, PhD

Blood (2016) 128 (22): 2737.

https://doi.org/10.1182/blood.V128.22.2737.2737

Published: 2016

Journal Articles

Deciphering the Function of KLF4 as a Differentiation Inducer in Hematologic Malignancies

Hiroki Kiyose, Ken Morita, MD, PhD, Shintaro Maeda, Kensho Suzuki, Souichi Adachi, MD, PhD, Yasuhiko Kamikubo, MD, PhD

Blood (2016) 128 (22): 1546.

https://doi.org/10.1182/blood.V128.22.1546.1546

Published: 2016

Journal Articles

Prognostic Significance of CXCR4 Overexpression in Pediatric Acute Myeloid Leukemia with Low-Risk: A Report from the Japanese Pediatric Leukemia/Lymphoma Study Group

Hidemasa Matsuo, MS, Naomi Nakamura, MS, Daisuke Tomizawa, MD PhD, Akiko M. Saito, Nobutaka Kiyokawa, MDPhD, Keizo Horibe, MD PhD, Yoko Nishinaka-Arai, PhD, Mayu Tokumasu, MD, Hiroshi Itoh, MS, Yasuhiko Kamikubo, MD PhD, Hideki Nakayama, MD PhD, Akitoshi Kinoshita, MD PhD, Takashi Taga, MD PhD, Akio Tawa, MD PhD, Tomohiko Taki, MD PhD, Shiro Tanaka, PhD, Souichi Adachi, MD PhD

Blood (2015) 126 (23): 3814.

https://doi.org/10.1182/blood.V126.23.3814.3814

Published: 2015

Journal Articles

The C-terminus of CBFβ-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesis

Yasuhiko Kamikubo, R. Katherine Hyde, Ling Zhao, Lemlem Alemu, Cecilia Rivas, Lisa J. Garrett, P. Paul Liu

Blood (2013) 121 (4): 638–642.

https://doi.org/10.1182/blood-2012-06-434688

Published: 2013

Includes: Supplemental data

Journal Articles

Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples

Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka, Naoya Takayama, Makoto Otsu, Genta Nagae, Koki Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, Koji Eto, Hiroyuki Aburatani, Hiromitsu Nakauchi, Mineo Kurokawa

Blood (2012) 119 (26): 6234–6242.

https://doi.org/10.1182/blood-2011-07-367441

Published: 2012

Includes: Supplemental data

Journal Articles

KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice

Ling Zhao, Jan J. Melenhorst, Lemlem Alemu, Martha Kirby, Stacie Anderson, Maggie Kench, Shelley Hoogstraten-Miller, Lauren Brinster, Yasuhiko Kamikubo, D. Gary Gilliland, P. Paul Liu

Blood (2012) 119 (6): 1511–1521.

https://doi.org/10.1182/blood-2011-02-338210

Published: 2012

Includes: Supplemental data

Journal Articles

The C-Terminal of MYH11 Is Required for Cbfb-MYH11 Activity During Embryonic Hematopoiesis and Leukemogenesis

R. Katherine Hyde, PhD, Yasuhiko Kamikubo, Ling Zhao, MD, PhD, Lemlem Alemu, Lisa Garrett, Pu Paul Liu, MD, PhD

Blood (2011) 118 (21): 2472.

https://doi.org/10.1182/blood.V118.21.2472.2472

Published: 2011

Journal Articles

KIT with D816 Mutations Cooperates with CBFB-MYH11 for Leukemogenesis in Mice

Ling Zhao, MD, PhD, J. Joseph Melenhorst, PhD, Lemlem Alemu, Stacie Anderson, Martha Kirby, Shelley Hoogstraten-Miller, Lauren Brinster, Maggie Kench, Yasuhiko Kamikubo, D. Gary Gilliland, MD, PhD, Pu Paul Liu, MD, PhD

Blood (2011) 118 (21): 867.

https://doi.org/10.1182/blood.V118.21.867.867

Published: 2011

Journal Articles

Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19 ARF

Nahoko Nishimoto, Shunya Arai, Motoshi Ichikawa, Masahiro Nakagawa, Susumu Goyama, Keiki Kumano, Tsuyoshi Takahashi, Yasuhiko Kamikubo, Yoichi Imai, Mineo Kurokawa

Blood (2011) 118 (9): 2541–2550.

https://doi.org/10.1182/blood-2010-10-315440

Published: 2011

NARROW

RUNX-NFAT Axis As a Novel Therapeutic Target for AML and T Cell Immunity

Autophagy Inhibition Enhances CDK4/6 Inhibitor-Induced Apoptosis in t(8;21) Acute Myeloid Leukemia Cells

KRAS mutations Frequently Coexist with High-Risk MLL Fusions and Are Independent Adverse Prognostic Factors in MLL -Rearranged Acute Myeloid Leukemia

Therapeutic Targeting of RUNX-NFATC2 Axis for Acute Promyelocytic Leukemia and T Cell Immunity

Coexistence and Prognostic Significance of EVI1 Expression and Driver Mutations in KMT2A -Rearranged Acute Myeloid Leukemia

Recurrent Genomic Aberrations of D-Type Cyclins Are Therapeutic Targets of CDK4/6 Inhibitors in t(8;21) and MLL -Rearranged Acute Myeloid Leukemia

RUNX1 Enhances Leukemia Cell Engraftment in the Vascular Niche through up-Regulating E-Selectin

Cell-Autonomous Feedback Loop of RUNX1-p53-CBFB in Acute Myeloid Leukemia Cells

Role of RUNX1 in hematological malignancies

Paradoxical Enhancement of Leukemogenesis in Acute Myeloid Leukemia Cells with Moderately Attenuated RUNX1 Expressions

Cluster Regulation of RUNX Family By "Gene Switch" Triggers a Profound Tumor Regression of Diverse Origins

Targeting Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia with a Novel Transcriptional Inhibitor

Deciphering the Function of KLF4 as a Differentiation Inducer in Hematologic Malignancies

Prognostic Significance of CXCR4 Overexpression in Pediatric Acute Myeloid Leukemia with Low-Risk: A Report from the Japanese Pediatric Leukemia/Lymphoma Study Group

The C-terminus of CBFβ-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesis

Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples

KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice

The C-Terminal of MYH11 Is Required for Cbfb-MYH11 Activity During Embryonic Hematopoiesis and Leukemogenesis

KIT with D816 Mutations Cooperates with CBFB-MYH11 for Leukemogenesis in Mice

Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19 ARF

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American Society of Hematology

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ASH Publications

American Society of Hematology

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