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Journal Articles

ANP32A Regulates Histone 3 Acetylation and Promotes Leukemogenesis in AML

Xuejing Yang, Xueqin Sun, PhD, Bin Lu, PhD, Qianfei Wang, PhD, Zan Huang, PhD
Journal: Blood
Blood (2016) 128 (22): 3917.
https://doi.org/10.1182/blood.V128.22.3917.3917
Published: 2016
Journal Articles

ANP32A Dysregulation Contributes to Abnormal Megakaryopoiesis in Acute Megakaryoblastic Leukemia

Xueqin Sun, PhD, Bin Lu, PhD, Zan Huang
Journal: Blood
Blood (2015) 126 (23): 1231.
https://doi.org/10.1182/blood.V126.23.1231.1231
Published: 2015
Journal Articles

ANP32A Dysregulation Involves Histone Modifications and Contributes to Myeloid Leukemia

Bin Lu, PhD, Xueqin Sun, PhD, John Crispino, PhD, Zan Huang
Journal: Blood
Blood (2015) 126 (23): 2456.
https://doi.org/10.1182/blood.V126.23.2456.2456
Published: 2015
Journal Articles

Tyrosine 599 Plays an Essential Role and Cooperates with Tyrosine 604 in MPL W515L-Indiced Myeloproliferative Neoplasms

Zan Huang, Chunjie Yu, PhDcandidate, Qiang Jeremy Wen, PhD MD, Qiong Yang, John Crispino, PhD, Demin Wang, PhD, Yuhong Chen
Journal: Blood
Blood (2014) 124 (21): 4580.
https://doi.org/10.1182/blood.V124.21.4580.4580
Published: 2014
Journal Articles

Novel Function Of Chromosome 7 Open Reading Frame 41 Gene To Promote Leukemic Megakaryocyte Differentiation By Modulating TPA-Induced MAPK/ERK, SAPK/JNK, and NF-κB Signaling

Xueqin Sun, Bin Lu, Zan Huang
Journal: Blood
Blood (2013) 122 (21): 1209.
https://doi.org/10.1182/blood.V122.21.1209.1209
Published: 2013
Journal Articles

Dysregulation of PSTPIP2 Due to Loss of GATA-1 Contributes to Aberrant Megakaryopoiesis

Lu Liu, Shangqin Liu, Sr., Qiang Jeremy Wen, MD, PhD, John Crispino, PhD, Zan Huang
Journal: Blood
Blood (2012) 120 (21): 854.
https://doi.org/10.1182/blood.V120.21.854.854
Published: 2012
Journal Articles

Inhibition of AKT Signaling Potently Inhibits the Growth of JAK and MPL-Mutant Cells in the Myeloproliferative Neoplasms In Vitro and In Vivo,

Irum Khan, MBBS, Zan Huang, PhD, Qiang Jeremy Wen, MD, PhD, Priya Koppikar, Ross L Levine, MD, Ayalew Tefferi, MD, John Crispino, PhD
Journal: Blood
Blood (2011) 118 (21): 3862.
https://doi.org/10.1182/blood.V118.21.3862.3862
Published: 2011
Journal Articles

FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis

Qi-Quan Huang, Harris Perlman, Zan Huang, Robert Birkett, Lixin Kan, Hemant Agrawal, Alexander Misharin, Sandeep Gurbuxani, John D. Crispino, Richard M. Pope
Journal: Blood
Blood (2010) 116 (23): 4968–4977.
https://doi.org/10.1182/blood-2009-11-252841
Published: 2010
Includes: Supplemental data
Journal Articles

Identification of a GATA Switch In Megakaryocytic Development.

Louis C Dore, Timothy M Chlon, Zan Huang, PhD, John Crispino, PhD
Journal: Blood
Blood (2010) 116 (21): 2605.
https://doi.org/10.1182/blood.V116.21.2605.2605
Published: 2010
Journal Articles

Inhibition of AKT Signaling Potently Inhibits Growth of MPL-Mutant Cells in the Myeloproliferative Neoplasms.

Zan Huang, PhD, Priya Koppikar, PhD, Thomas Mercher, Ph.D, Ross L. Levine, MD, John Crispino, PhD
Journal: Blood
Blood (2009) 114 (22): 1896.
https://doi.org/10.1182/blood.V114.22.1896.1896
Published: 2009
Journal Articles

Identification of Inducers of Megakaryocyte Polyploidization and Their Use as Targeted Differentiation Therapy for Acute Megakaryocytic Leukemia.

Qiang Wen, PhD, MD, Zan Huang, PhD, Sara Small, Niket Bubna, Frank An, PhD, Meghan Bliss-Moreau, Lynn Verplank, PhD, Tim Lewis, PhD, Monica Schenone, PhD, Nicola Tolliday, PhD, Chris Moore, Ann Carpenter, PhD, Thomas Mercher, Ph.D, Ross L. Levine, MD, Shai Izraeli, MD, Andrew Stern, PhD, Robert Gould, PhD, James E. Bradner, MD, John Crispino, PhD
Journal: Blood
Blood (2009) 114 (22): 792.
https://doi.org/10.1182/blood.V114.22.792.792
Published: 2009
Journal Articles

Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate

Stella T. Chou, Eugene Khandros, L. Charles Bailey, Kim E. Nichols, Christopher R. Vakoc, Yu Yao, Zan Huang, John D. Crispino, Ross C. Hardison, Gerd A. Blobel, Mitchell J. Weiss
Journal: Blood
Blood (2009) 114 (5): 983–994.
https://doi.org/10.1182/blood-2009-03-207944
Published: 2009
Includes: Supplemental data
Journal Articles

Survivin is not required for the endomitotic cell cycle of megakaryocytes

Brief Report
Qiang Wen, Cindy Leung, Zan Huang, Sara Small, Alagarsamy Lakku Reddi, Jonathan D. Licht, John D. Crispino
Journal: Blood
Blood (2009) 114 (1): 153–156.
https://doi.org/10.1182/blood-2008-11-190801
Published: 2009
Includes: Supplemental data
Journal Articles

GATA-2 Controls Proliferation of Megakaryocyte Progenitors and Its Expression Contributes to Human DS-AMKL.

Zan Huang, PhD, John Crispino, PhD
Journal: Blood
Blood (2008) 112 (11): 1380.
https://doi.org/10.1182/blood.V112.11.1380.1380
Published: 2008
Journal Articles

Survivin Is Required for Proliferation, but Not Polyploidization of Megakaryocytes.

Jeremy Q Wen, PhD, MD, Cindy Leung, PhD, Zan Huang, PhD, Sara Small, John Crispino, PhD
Journal: Blood
Blood (2008) 112 (11): 1328.
https://doi.org/10.1182/blood.V112.11.1328.1328
Published: 2008
Journal Articles

Graded Repression of PU.1 Expression by GATA Factors Influence Hematopoietic Progenitor Cell Fate

Stella T. Chou, MD, Charles Bailey, M.D., Yu Yao, Zan Huang, PhD, Kim Nichols, MD, John Crispino, PhD, Ross Hardison, Ph.D., Gerd Blobel, MD, PhD, Chris Vakoc, MD, PhD, Mitchell J. Weiss, M.D., Ph.D.
Journal: Blood
Blood (2008) 112 (11): 2469.
https://doi.org/10.1182/blood.V112.11.2469.2469
Published: 2008
Journal Articles

STAT1 Promotes Megakaryocytic Differentiation in a GATA-1-Independent Manner.

Zan Huang, PhD, John D. Crispino, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 1157.
https://doi.org/10.1182/blood.V108.11.1157.1157
Published: 2006