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Journal Articles

A Multicenter Nonrandom Clinical Study Using Induction Regimen of FLAG-IDA or Dae in Treatment of 101 Children with Newly Diagnosed CBF-AML in South of China: Clinical Responses and the Midterm Report of Survival

Xiaoqin Feng, Jian Li, MD, Chunfu Li, MD, Mincui Zheng, Honggui Xu, Yingyi He, MD& PhD, Changgang Li, MD, Hong Wen, Xiangling He, Lihua Yang, MD PhD

Blood (2019) 134 (Supplement_1): 3857.

https://doi.org/10.1182/blood-2019-126863

Published: 2019

Journal Articles

Prognostic Impact of Distinct Combinations of Molecular Mutations in AML Patients. Results of Two-Center International Cooperation Study

Olga Blau, MD PhD, Irina Martynkevich, MD PhD, Franziska Behrenbeck, Claudia D. Baldus, MD, Ekaterina Motiko, Sergei Voloshin, MD PhD, Antonio Pezzutto, MD PhD, Bernd Dorken, MD PhD, Igor Wolfgang Blau, MD PhD

Blood (2017) 130 (Supplement 1): 5111.

https://doi.org/10.1182/blood.V130.Suppl_1.5111.5111

Published: 2017

Journal Articles

Unravelling the Complexities of Hedgehog Mediated Signal Transduction in Acute Myeloid Leukaemia and Normal Haematopoiesis

Victoria Campbell, BSc hons, MBBS, MRCP, FRCPath, Anuradha Tarafdar, PhD, Edwina Dobbin, PhD, Gillian A. Horne, BSc hons, MBChB, MRCP, MRes, Laura Park, PhD, Colin Nixon, John R. Goodlad, MD FRCPath, Helen Wheadon, PhD, Mhairi Copland, PhD BSc, MB, ChB, MRCP, FRCPath

Blood (2016) 128 (22): 2881.

https://doi.org/10.1182/blood.V128.22.2881.2881

Published: 2016

Journal Articles

Study on the Pathogenesis and Clinical Significance of FLT3 and C-KIT Mutations in Core-Binding Factor AML

Aining Sun, PhD, Ji Shimeng, Suning Chen, Tongtong Zhang, Depei Wu, MD PhD

Blood (2016) 128 (22): 5236.

https://doi.org/10.1182/blood.V128.22.5236.5236

Published: 2016

Journal Articles

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation

Hamza Celik, Cates Mallaney, Alok Kothari, Elizabeth L. Ostrander, Elizabeth Eultgen, Andrew Martens, Christopher A. Miller, Jasreet Hundal, Jeffery M. Klco, Grant A. Challen

Blood (2015) 125 (4): 619–628.

https://doi.org/10.1182/blood-2014-08-594564

Published: 2015

Includes: Supplemental data

Journal Articles

Enforced Differentiation of Dnmt3a-Null Bone Marrow Leads to Failure with c-Kit Mutations Driving Leukemic Transformation

Hamza Celik, Cates Mallaney, Alok Kothari, Christopher A Miller, PhD, Jasreet Hundal, MS, Jeffery M. Klco, MDPhD, Grant A Challen, PhD

Blood (2014) 124 (21): 837.

https://doi.org/10.1182/blood.V124.21.837.837

Published: 2014

Journal Articles

APP Gene Is Correlated with C-KIT Mutations and Indicates Poor Disease Outcome in AML1-ETO-Positive Acute Myeloid Leukemia

Guopan Yu, MD, Ling Jiang, MDPhD, Fan Yi Meng, MD, Changxin Yin, Zhixiang Wang, MD, Hongsheng Zhou, MDPhD, Xuejie Jiang, MDPhD, Qingxiu Zhong, MD, Rui Cao, Libin Liao

Blood (2014) 124 (21): 942.

https://doi.org/10.1182/blood.V124.21.942.942

Published: 2014

Journal Articles

Molecular Mechanisms Underlying the Synergism of Erib and Hht in Treating t(8;21) AML with C-KIT mutations

Bing Chen, MD, PhD, Xin-Jie Chen, Sai-Juan Chen, MD, PhD

Blood (2014) 124 (21): 2332.

https://doi.org/10.1182/blood.V124.21.2332.2332

Published: 2014

Journal Articles

The D816V C-Kit Mutation Confers Higher Proliferation Activity By JAK-STAT and Src Family Kinase Pathways Compared to N822K C-Kit Mutation in Core-Binding Factor Acute Myeloid Leukemia

Ikuko Omori, MD, Hiroki Yamaguchi, MD PhD, Tomoaki Kitano, Noriko Miyake, PhD, Koichi Miyake, MD PhD, Koiti Inokuchi, PhD MD

Blood (2014) 124 (21): 2224.

https://doi.org/10.1182/blood.V124.21.2224.2224

Published: 2014

Journal Articles

Prevalence and Prognostic Significance of c-KIT Mutations in Core Binding Factor Acute Myeloid Leukemia: A Comprehensive Large-Scale Study from a Single Chinese Center

Ya-Zhen Qin, Honghu Zhu, Qian Jiang, Hao Jiang, Le-Ping Zhang, Jin-Lan Li, Ling-Di Li, Yan-Rong Liu, Yue-Yun Lai, Hong-Xia Shi, Bin Jiang, MD, Xiao-Jun Huang, MDPhD

Blood (2014) 124 (21): 1000.

https://doi.org/10.1182/blood.V124.21.1000.1000

Published: 2014

Journal Articles

In adults with t(8;21)AML, posttransplant RUNX1/RUNX1T1 -based MRD monitoring, rather than c-KIT mutations, allows further risk stratification

Yu Wang, De-Pei Wu, Qi-Fa Liu, Ya-Zhen Qin, Jing-Bo Wang, Lan-Ping Xu, Yan-Rong Liu, Hong-Hu Zhu, Jia Chen, Min Dai, Xiao-Jun Huang

Blood (2014) 124 (12): 1880–1886.

https://doi.org/10.1182/blood-2014-03-563403

Published: 2014

Journal Articles

PKC412 (Midostaurin) Is Safe and Highly Effective in Systemic Mastocytosis Patients: The Bologna Experience

Cristina Papayannidis, Mariachiara Abbenante, Sarah Parisi, Stefania Paolini, Ilaria Iacobucci, Federica Frabetti, Emanuela Ottaviani, Anna Ferrari, Viviana Guadagnuolo, Chiara Sartor, Simona Soverini, Caterina De Benedittis, Carmen Baldazzi, Nicoletta Testoni, Michele Baccarani, Giovanni Martinelli

Blood (2012) 120 (21): 1749.

https://doi.org/10.1182/blood.V120.21.1749.1749

Published: 2012

Journal Articles

Sequential Acquisition of AML1-ETO and c-Kit Mutation Leads to Formation of Human t(8;21) Acute Myelogenous Leukemia Stem Cells,

Takahiro Shima, MD, Yoshikane Kikushige, MD, Toshihiro Miyamoto, MD, PhD, Koichi Akashi, MD, PhD.

Blood (2011) 118 (21): 3584.

https://doi.org/10.1182/blood.V118.21.3584.3584

Published: 2011

Journal Articles

Genome-Wide Single-Nucleotide Polymorphism-Array Can Improve Prognostic Stratification of Core Binding Factor Acute Myeloid Leukemia, Especially in the Subgroup with Inv(16)/t(16;16) or without D816 C-KIT Mutation,

Jungwon Huh, Heeje Kim, Woo-Sung Min, Chul Won Jung, Hee-Jin Kim, Sun-Hee Kim, Yeo-Kyeoung Kim, Hyeoung Joon Kim, Joon Ho Moon, Sang Kyun Sohn, Sung Hyun Kim, Won Sik Lee, Jong-Ho Won, Yeung-Chul Mun, Hawk Kim, Jeeny Park, Dennis Dong Hwan Kim

Blood (2011) 118 (21): 3515.

https://doi.org/10.1182/blood.V118.21.3515.3515

Published: 2011

Journal Articles

New TET2 , ASXL1 and CBL Mutations Have Poor Prognostic Impact In Systemic Mastocytosis and Related Disorders

Fabiola Traina, MD, PhD, Ania Jankowska, MSC, Hideki Makishima, MD, PhD, Fred H. Hsieh, MD, Yingchun Han, PhD, Christine O'Keefe, PhD, Yuka Sugimoto, MD, PhD, Sanjay R. Mohan, MD, Hadrian Szpurka, PhD, Courtney Prince, Kathryn Guinta, MSC, Mikkael A. Sekeres, MD, MS, Matt Kalaycio, MD, Alan E. Lichtin, MD, Anjali S. Advani, MD, Edward Copelan, MD, Ronald Sobecks, MD, Jaroslaw P. Maciejewski, MD, PhD, FACP, Ramon V. Tiu, MD

Blood (2010) 116 (21): 3076.

https://doi.org/10.1182/blood.V116.21.3076.3076

Published: 2010

Journal Articles

Impact of RAS Mutations In Myelodysplastic Syndrome (MDS)

Aref Al-Kali, MD, Rajyalakshmi Luthra, PhD, Carlos E. Bueso-Ramos, MD, Sherry Pierce, RN, BS, Tapan Kadia, MD, Gautam Borthakur, MD, Zeev Estrov, MD, Elias Jabbour, MD, Stefan Faderl, MD, Farhad Ravandi, MD, Jorge Cortes, MD, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD

Blood (2010) 116 (21): 2926.

https://doi.org/10.1182/blood.V116.21.2926.2926

Published: 2010

Journal Articles

Mutational Analysis for IDH1 and IDH2 In Pediatric Leukemia

Mitsuteru Hiwatari, MD, PhD, Kentaro Oki, MD, Jyunko Takita, MD, PhD, Riki Nishimura, MD, Masashi Sanada, MD, PhD, Jun Okubo, MD, Masatoki Adachi, MD, Manabu Sotomatsu, MD, Akira Kikuchi, MD, PhD, Takashi Igarashi, MD, PhD, Yasuhide Hayashi, MD, PhD, Seishi Ogawa, MD, PhD

Blood (2010) 116 (21): 5106.

https://doi.org/10.1182/blood.V116.21.5106.5106

Published: 2010

Journal Articles

Pediatric mastocytosis–associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations

Ying Yang, Sébastien Létard, Laurence Borge, Amandine Chaix, Katia Hanssens, Sophie Lopez, Marina Vita, Pascal Finetti, Daniel Birnbaum, François Bertucci, Sophie Gomez, Paulo de Sepulveda, Patrice Dubreuil

Blood (2010) 116 (7): 1114–1123.

https://doi.org/10.1182/blood-2009-06-226027

Published: 2010

Includes: Supplemental data

Journal Articles

Highly Sensitive Quenching Probe (QProbe) Method Is Useful to Detect c-Kit Mutation and to Predict Relapse of t(8;21)(q22;q22) Acute Myeloid Leukemia.

Satoshi Wakita, Hiroki Yamaguchi, Yoshio Mitamura, Fumiko Kosaka, Koiti Inokuchi, Kazuo Dan

Blood (2009) 114 (22): 2646.

https://doi.org/10.1182/blood.V114.22.2646.2646

Published: 2009

Journal Articles

Prevalence and Prognostic Significance of c-KIT Mutations in Pediatric CBF AML Patients Enrolled on Serial CCG/COG Protocols.

Jessica Pollard, Todd Alonzo, Robert Gerbing, Rong Zeng, Betsy Hirsch, Susana Raimondi, Nyla Heerema, William Woods, Beverly Lange, Craig Hurwitz, Robert Arceci, Jerald Radich, Irwin Bernstein, Michael Heinrich, Soheil Meshinchi

Blood (2007) 110 (11): 1442.

https://doi.org/10.1182/blood.V110.11.1442.1442

Published: 2007

NARROW

A Multicenter Nonrandom Clinical Study Using Induction Regimen of FLAG-IDA or Dae in Treatment of 101 Children with Newly Diagnosed CBF-AML in South of China: Clinical Responses and the Midterm Report of Survival

Prognostic Impact of Distinct Combinations of Molecular Mutations in AML Patients. Results of Two-Center International Cooperation Study

Unravelling the Complexities of Hedgehog Mediated Signal Transduction in Acute Myeloid Leukaemia and Normal Haematopoiesis

Study on the Pathogenesis and Clinical Significance of FLT3 and C-KIT Mutations in Core-Binding Factor AML

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation

Enforced Differentiation of Dnmt3a-Null Bone Marrow Leads to Failure with c-Kit Mutations Driving Leukemic Transformation

APP Gene Is Correlated with C-KIT Mutations and Indicates Poor Disease Outcome in AML1-ETO-Positive Acute Myeloid Leukemia

Molecular Mechanisms Underlying the Synergism of Erib and Hht in Treating t(8;21) AML with C-KIT mutations

The D816V C-Kit Mutation Confers Higher Proliferation Activity By JAK-STAT and Src Family Kinase Pathways Compared to N822K C-Kit Mutation in Core-Binding Factor Acute Myeloid Leukemia

Prevalence and Prognostic Significance of c-KIT Mutations in Core Binding Factor Acute Myeloid Leukemia: A Comprehensive Large-Scale Study from a Single Chinese Center

In adults with t(8;21)AML, posttransplant RUNX1/RUNX1T1 -based MRD monitoring, rather than c-KIT mutations, allows further risk stratification

PKC412 (Midostaurin) Is Safe and Highly Effective in Systemic Mastocytosis Patients: The Bologna Experience

Sequential Acquisition of AML1-ETO and c-Kit Mutation Leads to Formation of Human t(8;21) Acute Myelogenous Leukemia Stem Cells,

Genome-Wide Single-Nucleotide Polymorphism-Array Can Improve Prognostic Stratification of Core Binding Factor Acute Myeloid Leukemia, Especially in the Subgroup with Inv(16)/t(16;16) or without D816 C-KIT Mutation,

New TET2 , ASXL1 and CBL Mutations Have Poor Prognostic Impact In Systemic Mastocytosis and Related Disorders

Impact of RAS Mutations In Myelodysplastic Syndrome (MDS)

Mutational Analysis for IDH1 and IDH2 In Pediatric Leukemia

Pediatric mastocytosis–associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations

Highly Sensitive Quenching Probe (QProbe) Method Is Useful to Detect c-Kit Mutation and to Predict Relapse of t(8;21)(q22;q22) Acute Myeloid Leukemia.

Prevalence and Prognostic Significance of c-KIT Mutations in Pediatric CBF AML Patients Enrolled on Serial CCG/COG Protocols.

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American Society of Hematology

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American Society of Hematology

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