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Journal Articles

Cryo-EM structures of human coagulation factors V and Va

Eliza A. Ruben, Michael J. Rau, James A. J. Fitzpatrick, Enrico Di Cera

Blood (2021) 137 (22): 3137–3144.

https://doi.org/10.1182/blood.2021010684

Published: 2021

Includes: Supplemental data

Journal Articles

Structure of blood coagulation factor VIII in complex with an anti–C1 domain pathogenic antibody inhibitor

Joseph S. Gish, Lexi Jarvis, Kenneth C. Childers, Shaun C. Peters, Connor S. Garrels, Ian W. Smith, H. Trent Spencer, Christopher B. Doering, Pete Lollar, P. Clint Spiegel, Jr

Blood (2021) 137 (21): 2981–2986.

https://doi.org/10.1182/blood.2020008940

Published: 2021

Includes: Supplemental data

Journal Articles

FVIII Protein Is Not Detectable in Human PBMCs or Livers from Dogs with an Intron-22 Inversion Mutation: Implications for FVIII Immunogenicity and Tolerance

Devi Gunasekera, MBBS, Pooja Vir, PhD, Ahmad Faisal Karim, PhD, Margaret V. Ragni, MD MPH, Elizabeth P. Merricks, PhD, Timothy C. Nichols, MD, Kathleen P. Pratt, PhD

Blood (2019) 134 (Supplement_1): 630.

https://doi.org/10.1182/blood-2019-124880

Published: 2019

Journal Articles

Elispots and Ex Vivo Expansion of FVIII-Specific T-Cell Clones Confirm Specificity of CD4 + T-Cell Responses to Self-FVIII in Healthy Non-Hemophilic Blood Donors

Ahmad Faisal Karim, PhD, Pooja Vir, PhD, Devi Gunasekera, MBBS, Allen I. Stering, MD, Kenneth Lieuw, MD PhD, Kathleen P. Pratt, PhD

Blood (2019) 134 (Supplement_1): 2413.

https://doi.org/10.1182/blood-2019-124803

Published: 2019

Journal Articles

Contribution of Factor VIII A3 Domain Residues 1793-1795 to a Factor IXa-Interactive Site

Masahiro Takeyama, Keiji Nogami, MDPhD, Kana Sasai, Midori Shima, MD PhD

Blood (2018) 132 (Supplement 1): 1173.

https://doi.org/10.1182/blood-2018-99-113260

Published: 2018

Journal Articles

The 3.2 Angstrom Crystal Structure of a Bioengineered Factor VIII Construct Illustrates Two Conformations of the C2 Domain

Ian W Smith, MS, Anne d'Aquino, BS, Ernest T. Parker, Christopher B Doering, PhD, Paul C Spiegel, Jr., PhD

Blood (2018) 132 (Supplement 1): 21.

https://doi.org/10.1182/blood-2018-99-119083

Published: 2018

Journal Articles

Epitope Mapping of Inhibitor Patient Plasmas during Immune Tolerance Induction

Shannon L. Meeks, MD, Courtney Cox, MSc, W. Hunter Baldwin, BS

Blood (2017) 130 (Supplement 1): 2364.

https://doi.org/10.1182/blood.V130.Suppl_1.2364.2364

Published: 2017

Journal Articles

Mechanism of Tissue Factor (TF) Enhancing Factor (F)VIII Activity on FXa Generation in Initial Phase of Coagulation and Interaction Between TF and FVIII C2 Domain

Furukawa Shoko, Keiji Nogami, MD PhD, Kenichi Ogiwara, MD PhD, Midori Shima, MD PhD

Blood (2016) 128 (22): 1391.

https://doi.org/10.1182/blood.V128.22.1391.1391

Published: 2016

Journal Articles

Targeting FVIII-Specific B Cells Using BAR-Transduced Regulatory T Cells

Ai-Hong Zhang, PhD, Jeong Heon Yoon, PhD, Yong Chan Kim, PhD, David W. Scott, PhD

Blood (2016) 128 (22): 329.

https://doi.org/10.1182/blood.V128.22.329.329

Published: 2016

Journal Articles

The C Domain Mediates the Export of FVIII from the Endoplasmic Reticulum By Interacting with MCFD2

Zhigang Liu, PhD, Chunlei Zheng, PhD, Denise E. Sabatino, PhD, Bin Zhang, PhD

Blood (2016) 128 (22): 255.

https://doi.org/10.1182/blood.V128.22.255.255

Published: 2016

Journal Articles

Platelet Membranes and Activation Pathway Determine Inhibitory Activity of Anti-Factor VIII C2 Domain Antibodies

Madhumouli Chatterjee, PhD, Shannon L. Meeks, MD, Valerie Anne Novakovic, MS, Pete Lollar, MD, Gary E. Gilbert, MD

Blood (2016) 128 (22): 2567.

https://doi.org/10.1182/blood.V128.22.2567.2567

Published: 2016

Journal Articles

Factor VIII C2 Domain Epitopes Recognized By Classical and Non-Classical Anti-C2 Domain Monoclonal Antibodies Help Mediate FVIII Uptake By Dendritic Cells

Glaivy Batsuli, MD, Wallace Hunter Baldwin, BS, John F Healey, BS, Ernest T Parker, BS, Courtney Cox, MSc, Pete Lollar, MD, Shannon L. Meeks, MD

Blood (2016) 128 (22): 3762.

https://doi.org/10.1182/blood.V128.22.3762.3762

Published: 2016

Journal Articles

Identification of a Protein S-Interactive Site on the Factor VIII C2 Domain

Furukawa Shoko, Masahiro Takeyama, MD PhD, Midori Shima, MD PhD, Keiji Nogami, MD PhD

Blood (2016) 128 (22): 3763.

https://doi.org/10.1182/blood.V128.22.3763.3763

Published: 2016

Journal Articles

PBMCs from Hemophilia a Subjects with and without an Inhibitor Show Robust Cytokine Secretion in Response to Factor VIII C2 Domain Epitopes

Devi Gunasekera, MBBS, Debargh Kumar Dutta, PhD, Eddie A. James, PhD, Margaret V Ragni, Kathleen P. Pratt, PhD

Blood (2015) 126 (23): 2291.

https://doi.org/10.1182/blood.V126.23.2291.2291

Published: 2015

Journal Articles

FVIII-VWF dos-à-dos

Sriram Krishnaswamy

Blood (2015) 126 (8): 923–924.

https://doi.org/10.1182/blood-2015-06-652073

Published: 2015

Journal Articles

Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry

Po-Lin Chiu, George M. Bou-Assaf, Ekta Seth Chhabra, Melissa G. Chambers, Robert T. Peters, John D. Kulman, Thomas Walz

Blood (2015) 126 (8): 935–938.

https://doi.org/10.1182/blood-2015-04-641688

Published: 2015

Includes: Multimedia, Supplemental data

Journal Articles

The 1.7 Angstrom X-Ray Crystal Structure of the Porcine Factor VIII C2 Domain and Binding Analysis to Anti-Human C2 Domain Antibodies and Phospholipid Surfaces

Caileen M Brison, B.S., Steven M Mullen, B.S., Kira Podolsky, B.S., Shannon L Meeks, MD, Paul Clinton Spiegel, PhD

Blood (2014) 124 (21): 4235.

https://doi.org/10.1182/blood.V124.21.4235.4235

Published: 2014

Journal Articles

High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance

Phuong-Cac T. Nguyen, Kenneth B. Lewis, Ruth A. Ettinger, Jason T. Schuman, Jasper C. Lin, John F. Healey, Shannon L. Meeks, Pete Lollar, Kathleen P. Pratt

Blood (2014) 123 (17): 2732–2739.

https://doi.org/10.1182/blood-2013-09-527275

Published: 2014

Includes: Supplemental data

Journal Articles

Decrypting C2 inhibitors

Jan Voorberg, Henriët Meems

Blood (2014) 123 (17): 2601–2602.

https://doi.org/10.1182/blood-2014-03-562165

Published: 2014

Journal Articles

Rational design of small molecules targeting the C2 domain of coagulation factor VIII

Gerry A. F. Nicolaes, Mahesh Kulharia, Jan Voorberg, Paul H. Kaijen, Aleksandra Wroblewska, Simone Wielders, Roy Schrijver, Olivier Sperandio, Bruno O. Villoutreix

Blood (2014) 123 (1): 113–120.

https://doi.org/10.1182/blood-2013-05-503227

Published: 2014

Includes: Supplemental data

NARROW

Cryo-EM structures of human coagulation factors V and Va

Structure of blood coagulation factor VIII in complex with an anti–C1 domain pathogenic antibody inhibitor

FVIII Protein Is Not Detectable in Human PBMCs or Livers from Dogs with an Intron-22 Inversion Mutation: Implications for FVIII Immunogenicity and Tolerance

Elispots and Ex Vivo Expansion of FVIII-Specific T-Cell Clones Confirm Specificity of CD4 + T-Cell Responses to Self-FVIII in Healthy Non-Hemophilic Blood Donors

Contribution of Factor VIII A3 Domain Residues 1793-1795 to a Factor IXa-Interactive Site

The 3.2 Angstrom Crystal Structure of a Bioengineered Factor VIII Construct Illustrates Two Conformations of the C2 Domain

Epitope Mapping of Inhibitor Patient Plasmas during Immune Tolerance Induction

Mechanism of Tissue Factor (TF) Enhancing Factor (F)VIII Activity on FXa Generation in Initial Phase of Coagulation and Interaction Between TF and FVIII C2 Domain

Targeting FVIII-Specific B Cells Using BAR-Transduced Regulatory T Cells

The C Domain Mediates the Export of FVIII from the Endoplasmic Reticulum By Interacting with MCFD2

Platelet Membranes and Activation Pathway Determine Inhibitory Activity of Anti-Factor VIII C2 Domain Antibodies

Factor VIII C2 Domain Epitopes Recognized By Classical and Non-Classical Anti-C2 Domain Monoclonal Antibodies Help Mediate FVIII Uptake By Dendritic Cells

Identification of a Protein S-Interactive Site on the Factor VIII C2 Domain

PBMCs from Hemophilia a Subjects with and without an Inhibitor Show Robust Cytokine Secretion in Response to Factor VIII C2 Domain Epitopes

FVIII-VWF dos-à-dos

Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry

The 1.7 Angstrom X-Ray Crystal Structure of the Porcine Factor VIII C2 Domain and Binding Analysis to Anti-Human C2 Domain Antibodies and Phospholipid Surfaces

High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance

Decrypting C2 inhibitors

Rational design of small molecules targeting the C2 domain of coagulation factor VIII

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American Society of Hematology

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American Society of Hematology

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