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Journal Articles

FVIII Proteins with a Modified Immunodominant T-Cell Epitope Exhibit Reduced Immunogenicity and Normal Procoagulant Activity

Ruth A. Ettinger, PhD, Joseph A. Liberman, PhD, Devi Gunasekera, BSSM, Eddie A. James, PhD, Arthur R. Thompson, MD PhD, Kathleen P. Pratt, PhD

Blood (2017) 130 (Supplement 1): 179.

https://doi.org/10.1182/blood.V130.Suppl_1.179.179

Published: 2017

Journal Articles

T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire

Ruth A. Ettinger, Pedro Paz, Eddie A. James, Devi Gunasekera, Fred Aswad, Arthur R. Thompson, Dana C. Matthews, Kathleen P. Pratt

Blood (2016) 128 (16): 2043–2054.

https://doi.org/10.1182/blood-2015-11-682468

Published: 2016

Includes: Supplemental data

Journal Articles

Factor VIII gene variants and inhibitor risk in African American hemophilia A patients

Devi Gunasekera, Ruth A. Ettinger, Shelley Nakaya Fletcher, Eddie A. James, Maochang Liu, John C. Barrett, Janice Withycombe, Dana C. Matthews, Melinda S. Epstein, Richard J. Hughes, Kathleen P. Pratt

Blood (2015) 126 (7): 895–904.

https://doi.org/10.1182/blood-2014-09-599365

Published: 2015

Includes: Supplemental data

Journal Articles

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

Yong Chan Kim, Ai-Hong Zhang, Yan Su, Sadiye Amcaoglu Rieder, Robert J. Rossi, Ruth A. Ettinger, Kathleen P. Pratt, Ethan M. Shevach, David W. Scott

Blood (2015) 125 (7): 1107–1115.

https://doi.org/10.1182/blood-2014-04-566786

Published: 2015

Includes: Supplemental data

Journal Articles

Factor VIII Gene Variants and Inhibitor Risk in African American Hemophilia a Patients

Devi Gunasekera, MD, Ruth A. Ettinger, PhD, Shelley Nakaya Fletcher, B.S., Eddie A. James, PhD, Maochang Liu, PhD, John C. Barrett, MD, Janice Withycombe, PhD, R.N., M.N., C.C.R.P., Dana C. Matthews, MD, Melinda S. Epstein, PhD, Richard J. Hughes, PhD, Kathleen P. Pratt, PhD

Blood (2014) 124 (21): 235.

https://doi.org/10.1182/blood.V124.21.235.235

Published: 2014

Journal Articles

High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance

Phuong-Cac T. Nguyen, Kenneth B. Lewis, Ruth A. Ettinger, Jason T. Schuman, Jasper C. Lin, John F. Healey, Shannon L. Meeks, Pete Lollar, Kathleen P. Pratt

Blood (2014) 123 (17): 2732–2739.

https://doi.org/10.1182/blood-2013-09-527275

Published: 2014

Includes: Supplemental data

Journal Articles

Generation and Functional Properties Of FVIII-Specific Human T Regulatory Cells: A Novel Approach Using Hemophilia A patient’s T Cell Receptors

Yongchan Kim, PhD, Yan Su, PhD, Robert J. Rossi, B.A., Ruth A. Ettinger, Ph.D., Kathleen P. Pratt, Ph.D., David William Scott, PhD, Ethan Shevach, MD

Blood (2013) 122 (21): 3568.

https://doi.org/10.1182/blood.V122.21.3568.3568

Published: 2013

Journal Articles

Factor VIII Proteins Having a Rationally Modified, Immunodominant T-Cell Epitope Demonstrate Normal Procoagulant Activity, Bind To VWF With High Affinity, and Are Markedly Less Stimulatory To FVIII-Specific Human T Cells

Ruth A. Ettinger, Ph.D., Eddie A. James, Ph.D., Komal Puranik, M.Sc., Arthur R. Thompson, M.D., Ph.D., Dana C. Matthews, M.D., Kathleen P. Pratt, Ph.D.

Blood (2013) 122 (21): 574.

https://doi.org/10.1182/blood.V122.21.574.574

Published: 2013

Journal Articles

Sequence-Modified Factor VIII Variants Having Reduced Immunogenicity

Ruth A. Ettinger, PhD, Melinda S. Epstein, PhD, Komal Puranik, MSc, Richard J. Hughes, PhD, Joseph A Liberman, BS, Eddie James, Ph.D., Tom E. Howard, MD, PhD, Shelley S. Cole, Ph.D., Dana C. Matthews, MD, Kathleen P. Pratt, PhD

Blood (2012) 120 (21): 39.

https://doi.org/10.1182/blood.V120.21.39.39

Published: 2012

Journal Articles

Potential Immunogenicity of Amino Acid Sequences Encoded by Ns-SNPs in Factor VIII,

Devi Gunasekera, PhD, Ruth A. Ettinger, Ph.D., Richard J. Hughes, Ph.D., Melinda S. Epstein, Ph.D., John C. Barrett, M.D., Alexis A. Thompson, MD, MPH, Janice Withycombe, Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2011) 118 (21): 3329.

https://doi.org/10.1182/blood.V118.21.3329.3329

Published: 2011

Journal Articles

Reduced Immunogenicity of FVIII Peptides by Rational Modifications of An Immunodominant T-Cell Epitope.

Ruth A. Ettinger, Ph.D., Joseph A. Liberman, B.S., Douglas C. Bolgiano, M.S., Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2009) 114 (22): 220.

https://doi.org/10.1182/blood.V114.22.220.220

Published: 2009

Journal Articles

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti–factor VIII immune responses

Ruth A. Ettinger, Eddie A. James, William W. Kwok, Arthur R. Thompson, Kathleen P. Pratt

Blood (2009) 114 (7): 1423–1428.

https://doi.org/10.1182/blood-2009-01-200725

Published: 2009

Journal Articles

HLA-DRB1*1101-Restricted T Cells from Two Unrelated Mild Hemophilia a Inhibitor Subjects with Missense Genotype R593C Respond to the Same Minimal Epitope.

Eddie A. James, Ph.D., Simon D. van Haren, Ruth A. Ettinger, Ph.D., Arthur R. Thompson, M.D., Ph.D., William W. Kwok, Ph.D., Jan Voorberg, Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 1212.

https://doi.org/10.1182/blood.V112.11.1212.1212

Published: 2008

Journal Articles

Identification of Specific Residues in a Human FVIII T-Cell Epitope That Are Essential for An HLA-DRA-DRB1*0101-Restricted T-Cell Response Associated with Inhibitor Development.

Joseph A. Liberman, Ruth A. Ettinger, Ph.D., Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 3396.

https://doi.org/10.1182/blood.V112.11.3396.3396

Published: 2008

Journal Articles

IL-17 Is Secreted by T-Cell Clones Isolated Following An Initial Peak Inhibitor Response to Factor VIIII, Suggesting Th17 Cells Play a Role in Inhibitor Development

Ruth A. Ettinger, Ph.D., Eddie James, Ph.D., William W. Kwok, Ph.D, Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 244.

https://doi.org/10.1182/blood.V112.11.244.244

Published: 2008

Journal Articles

Induction of ‘Tolerance’ in a T-Cell Clone from a Mild Hemophilia Patient

David W. Scott, PhD, Elizabeth Kadavil, MSc, Ai-Hong Zhang, MS, PhD, Ruth A. Ettinger, PhD, Kathleen Pratt, PhD

Blood (2008) 112 (11): 3526.

https://doi.org/10.1182/blood.V112.11.3526.3526

Published: 2008

Journal Articles

Epitope Identification and Generation of an Antigen-Specific T-Cell Clone in a Mild Hemophilia A Inhibitor Subject with Missense Genotype R593C.

Eddie A. James, PhD, Simon D. van Haren, Ruth A. Ettinger, Ph.D., Arthur R. Thompson, M.D., Ph.D., William W. Kwok, Ph.D., Jan Voorberg, Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2007) 110 (11): 1159.

https://doi.org/10.1182/blood.V110.11.1159.1159

Published: 2007

NARROW

FVIII Proteins with a Modified Immunodominant T-Cell Epitope Exhibit Reduced Immunogenicity and Normal Procoagulant Activity

T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire

Factor VIII gene variants and inhibitor risk in African American hemophilia A patients

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

Factor VIII Gene Variants and Inhibitor Risk in African American Hemophilia a Patients

High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance

Generation and Functional Properties Of FVIII-Specific Human T Regulatory Cells: A Novel Approach Using Hemophilia A patient’s T Cell Receptors

Factor VIII Proteins Having a Rationally Modified, Immunodominant T-Cell Epitope Demonstrate Normal Procoagulant Activity, Bind To VWF With High Affinity, and Are Markedly Less Stimulatory To FVIII-Specific Human T Cells

Sequence-Modified Factor VIII Variants Having Reduced Immunogenicity

Potential Immunogenicity of Amino Acid Sequences Encoded by Ns-SNPs in Factor VIII,

Reduced Immunogenicity of FVIII Peptides by Rational Modifications of An Immunodominant T-Cell Epitope.

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti–factor VIII immune responses

HLA-DRB1*1101-Restricted T Cells from Two Unrelated Mild Hemophilia a Inhibitor Subjects with Missense Genotype R593C Respond to the Same Minimal Epitope.

Identification of Specific Residues in a Human FVIII T-Cell Epitope That Are Essential for An HLA-DRA-DRB1*0101-Restricted T-Cell Response Associated with Inhibitor Development.

IL-17 Is Secreted by T-Cell Clones Isolated Following An Initial Peak Inhibitor Response to Factor VIIII, Suggesting Th17 Cells Play a Role in Inhibitor Development

Induction of ‘Tolerance’ in a T-Cell Clone from a Mild Hemophilia Patient

Epitope Identification and Generation of an Antigen-Specific T-Cell Clone in a Mild Hemophilia A Inhibitor Subject with Missense Genotype R593C.

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American Society of Hematology

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American Society of Hematology

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