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Journal Articles

A Novel Approach for Generating Platelet-Delivered FVIII: Role of Transient LRP1 Expression during Megakaryopoiesis

John Tkaczynski, BS, Randolph Lyde, PhD, Hyunsook Ahn, MSc, Francis Ayombil, PhD, Sara Borst, BS, Paul Gadue, PhD, Deborah L French, PhD, Denise Sabatino, PhD, Rodney M. Camire, PhD, Mortimer Poncz, MD

Blood (2019) 134 (Supplement_1): 1102.

https://doi.org/10.1182/blood-2019-124788

Published: 2019

Journal Articles

A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in α-Granules and Is Functional In Vivo in a Murine Model of Thrombosis

Hyunsook Ahn, MSc, John Tkaczynski, BS, Khalil Bdeir, PhD, Victoria Stepanova, Douglas B. Cines, MD, Mortimer Poncz, MD, Sergei Zaitsev

Blood (2019) 134 (Supplement_1): 3627.

https://doi.org/10.1182/blood-2019-124501

Published: 2019

Journal Articles

Blockade of Lipid Receptor GPR31 Suppresses Platelet Reactivity and Thrombosis with Minimal Effect on Hemostasis

Layla Van Doren, MD, Nga Nguyen, BSc, Chris Garzia, BSc, Elizabeth Fletcher, PhD, Ryan Stevenson, MD, David Jaramillo, MSc, Athan Kuliopulos, MD PhD, Lidija Covic, PhD

Blood (2019) 134 (Supplement_1): 1064.

https://doi.org/10.1182/blood-2019-126111

Published: 2019

Journal Articles

Phosphatidylinositol-3,4-Bisphosphate-Akt Signaling Pathway Promotes Platelet Activation

Jasna Marjanovic, Brad Rumancik, Luke Weber, Felix Wangmang, Dane Fickes, Dmitri Postnov, Dung Nguyen, Yoon Lee, Richard Ngo-Lam, Monita Wilson

Blood (2018) 132 (Supplement 1): 1131.

https://doi.org/10.1182/blood-2018-99-115066

Published: 2018

Journal Articles

Impaired GPVI Mediated Platelet Functional Responses and Signaling in CD45 Knockout Mice

Vaishali Inamdar, John Kostyak, PhD, Rachit Badolia, PhD, Carol Dangelmaier, Soochong Kim, PhD, Bhanukanth Manne, Satya P. Kunapuli, PhD

Blood (2016) 128 (22): 1355.

https://doi.org/10.1182/blood.V128.22.1355.1355

Published: 2016

Journal Articles

Infusion of Coagulation Factor VIII-Containing Induced Pluripotent Stem Cell (iPSC)-Derived Megakaryocytes (iMks) Shows Potential As Hemophilia a Treatment

Randolph B Lyde, Jr., BS, Hyunsook Ahn, Karen K Vo, BS, Danuta Jadwiga Jarocha, PhD, Li Zhai, BS, Spencer K. Sullivan, MD, Valder R Arruda, MD PhD, Denise E. Sabatino, PhD, Rodney M. Camire, PhD, Deborah French, PhD, Mortimer Poncz, MD

Blood (2016) 128 (22): 2559.

https://doi.org/10.1182/blood.V128.22.2559.2559

Published: 2016

Journal Articles

Evaluation of Two Structurally Distinct Novel Inhibitors of Apoptosis Signal-Regulating Kinase 1 (MAP3K5), As Potent Anti-Platelet Agents

Meghna U. Naik, M.Sc., Xi Chen, PhD, Brendan Bachman, M S, Ganesha Rai, PhD, David Maloney, PhD, Arjit Jadhav, PhD, Ulhas P. Naik, PhD FAHA

Blood (2016) 128 (22): 3833.

https://doi.org/10.1182/blood.V128.22.3833.3833

Published: 2016

Journal Articles

Apoptosis Signal-Regulating Kinase (ASK1) Regulates Thrombosis in Part By Regulating cPLA 2 phosphorylation-Dependent TxA 2 Generation

Pravin Patel, BA, Meghna U. Naik, M.Sc., Ulhas Naik, PhD

Blood (2016) 128 (22): 3719.

https://doi.org/10.1182/blood.V128.22.3719.3719

Published: 2016

Journal Articles

Humanized Von Willebrand Factor-Glycoprotein Ibα Interaction in Mouse Models of Hemostasis and Thrombosis

Sachiko Kanaji, MD PhD, Jennifer N Orje, Yuichi Kamikubo, PhD, Taisuke Kanaji, MD PhD, Jeremy Mattson, Alessandro Zarpellon, PhD, Scot A. Fahs, Rashmi Sood, PhD, Sandra L Haberichter, PhD, Zaverio M. Ruggeri, MD, Robert R Montgomery, MD

Blood (2016) 128 (22): 558.

https://doi.org/10.1182/blood.V128.22.558.558

Published: 2016

Journal Articles

Prothrombin Membrane Binding and Gla-Dependent Function Are Not Required for Effective Hemostasis In Vivo

Lindsey A. Greene, MD, Nabil K. Thalji, BS, Harlan Bradford, BA, Sriram Krishnaswamy, PhD MD, Rodney M. Camire, PhD

Blood (2015) 126 (23): 124.

https://doi.org/10.1182/blood.V126.23.124.124

Published: 2015

Journal Articles

A Single Amino Acid in the Gla Domain Mouse FVIIa Allows Its Binding to the Endothelial Protein C Receptor and Enhances Its Coagulant Activity In Vivo

Giulia Pavani, PhD, Lacramioara Ivanciu, PhD, Katherine A. Stafford, Paris Margaritis, DPhil

Blood (2015) 126 (23): 3489.

https://doi.org/10.1182/blood.V126.23.3489.3489

Published: 2015

Journal Articles

Targeting FVIII Expression to Platelets for Hemophilia A Gene Therapy Does Not Bare an Apparent Thrombosis Risk

Christina K Baumgartner, PhD, Jeremy G Mattson, Hartmut Weiler, Qizhen Shi, Robert R Montgomery

Blood (2015) 126 (23): 2264.

https://doi.org/10.1182/blood.V126.23.2264.2264

Published: 2015

Journal Articles

A Human-Specific, Platelet-Targeted, Thrombin-Activatable Urokinase (PLT/uPA-T) Demonstrates Selective Thromboprophylactic Properties in Two in Vivo Models

Hyun Sook Ahn, Rudy Fuentes, PhD, Vincent Hayes, Douglas B. Cines, MD, Vladimir R Muzykantov, MDPhD, Sergei V. Zaytsev, PhD, Mortimer Poncz, MD

Blood (2014) 124 (21): 579.

https://doi.org/10.1182/blood.V124.21.579.579

Published: 2014

Journal Articles

ASK1, a Novel Regulator of Thrombosis, Is Activated Downstream of G-Protein Coupled receptors in Human Platelets

Randall Derstine, MS, Meghna Ulhas Naik, MS, Ramya Turaga, PhD, Ulhas P Naik, PhD FAHA

Blood (2014) 124 (21): 4163.

https://doi.org/10.1182/blood.V124.21.4163.4163

Published: 2014

Journal Articles

Platelet Aggregation and Fibrin Deposition: The Yin and Yang of Thrombin Activity Regulation By Platelet Glycoprotein Ibα

Alessandro Zarpellon, PhD, Patrizia Marchese, PhD, Antonella Zampolli, Dr. Biol., Grazia Loredana Mendolicchio, MD PhD, Zaverio M. Ruggeri, MD

Blood (2014) 124 (21): 114.

https://doi.org/10.1182/blood.V124.21.114.114

Published: 2014

Journal Articles

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Mediate Synergistic Inhibition Of Platelet Aggregation In Combination With ADP/P2Y Antagonists

Gilbert Acevedo, BS, Brian R. Branchford, MD, Luke Law, BS, Christine Brzezinski, Susan Sather, Gary Brodsky, PhD, Deborah DeRyckere, Ph.D., Weihe Zhang, H. Shelton Earp, III, Stephen V Frye, Douglas K. Graham, MD, PhD, Jorge Di Paola, MD

Blood (2013) 122 (21): 3507.

https://doi.org/10.1182/blood.V122.21.3507.3507

Published: 2013

Journal Articles

Targeting The PI3K/AKT Pathway To Inhibit Platelet Activation and Thrombus Formation

Wenxiu Yi, BS, Wei Li, MS, Lijie Ren, MS, Xinliang Mao, MD, PhD, Li Zhu, MD, PhD

Blood (2013) 122 (21): 3513.

https://doi.org/10.1182/blood.V122.21.3513.3513

Published: 2013

Journal Articles

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Inhibit Platelet Aggregation In Vitro and Protect Mice From Arterial and Venous Thrombosis In Vivo

Gilbert Acevedo, BS, Brian R. Branchford, MD, Christine Brzezinski, Susan Sather, Gary Brodsky, PhD, Deborah DeRyckere, Ph.D., Weihe Zhang, Jing Liu, H. Shelton Earp, III, Xiaodong Wang, Stephen V Frye, Douglas K. Graham, MD, PhD, Jorge Di Paola, MD

Blood (2013) 122 (21): 2296.

https://doi.org/10.1182/blood.V122.21.2296.2296

Published: 2013

Journal Articles

Identification Of a Novel Small Molecule Inhibitor Of ASK1 As a Potent Anti-Platelet Agent

Meghna Ulhas Naik, MS, Maloney David, Ramya Turaga, Hidinori Ichijo, Ph.D, Ulhas P Naik, Ph.D. FAHA

Blood (2013) 122 (21): 20.

https://doi.org/10.1182/blood.V122.21.20.20

Published: 2013

Journal Articles

Pikfyve-Deficient Platelets Mediate Inflammation and Thrombosis by Releasing Aberrant Granules

Sang H Min, MD, Aae Suzuki, Liang Zhao, Ph.D., Lurong Lian, Timothy J. Stalker, PhD, John K. Choi, MD, PhD, Charles S. Abrams, MD

Blood (2012) 120 (21): 262.

https://doi.org/10.1182/blood.V120.21.262.262

Published: 2012

NARROW

A Novel Approach for Generating Platelet-Delivered FVIII: Role of Transient LRP1 Expression during Megakaryopoiesis

A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in α-Granules and Is Functional In Vivo in a Murine Model of Thrombosis

Blockade of Lipid Receptor GPR31 Suppresses Platelet Reactivity and Thrombosis with Minimal Effect on Hemostasis

Phosphatidylinositol-3,4-Bisphosphate-Akt Signaling Pathway Promotes Platelet Activation

Impaired GPVI Mediated Platelet Functional Responses and Signaling in CD45 Knockout Mice

Infusion of Coagulation Factor VIII-Containing Induced Pluripotent Stem Cell (iPSC)-Derived Megakaryocytes (iMks) Shows Potential As Hemophilia a Treatment

Evaluation of Two Structurally Distinct Novel Inhibitors of Apoptosis Signal-Regulating Kinase 1 (MAP3K5), As Potent Anti-Platelet Agents

Apoptosis Signal-Regulating Kinase (ASK1) Regulates Thrombosis in Part By Regulating cPLA 2 phosphorylation-Dependent TxA 2 Generation

Humanized Von Willebrand Factor-Glycoprotein Ibα Interaction in Mouse Models of Hemostasis and Thrombosis

Prothrombin Membrane Binding and Gla-Dependent Function Are Not Required for Effective Hemostasis In Vivo

A Single Amino Acid in the Gla Domain Mouse FVIIa Allows Its Binding to the Endothelial Protein C Receptor and Enhances Its Coagulant Activity In Vivo

Targeting FVIII Expression to Platelets for Hemophilia A Gene Therapy Does Not Bare an Apparent Thrombosis Risk

A Human-Specific, Platelet-Targeted, Thrombin-Activatable Urokinase (PLT/uPA-T) Demonstrates Selective Thromboprophylactic Properties in Two in Vivo Models

ASK1, a Novel Regulator of Thrombosis, Is Activated Downstream of G-Protein Coupled receptors in Human Platelets

Platelet Aggregation and Fibrin Deposition: The Yin and Yang of Thrombin Activity Regulation By Platelet Glycoprotein Ibα

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Mediate Synergistic Inhibition Of Platelet Aggregation In Combination With ADP/P2Y Antagonists

Targeting The PI3K/AKT Pathway To Inhibit Platelet Activation and Thrombus Formation

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Inhibit Platelet Aggregation In Vitro and Protect Mice From Arterial and Venous Thrombosis In Vivo

Identification Of a Novel Small Molecule Inhibitor Of ASK1 As a Potent Anti-Platelet Agent

Pikfyve-Deficient Platelets Mediate Inflammation and Thrombosis by Releasing Aberrant Granules

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American Society of Hematology

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American Society of Hematology

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