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Journal Articles

Epigenetic Drug Combination Overcomes Bone Marrow Microenvironment-Induced Chemoprotection in Pediatric Acute Lymphoblastic Leukemia Via Modulation of CD81

Anthony Quagliano, BS, Anilkumar Gopalakrisnapillai, PhD, E. Anders Kolb, MD, Sonali Barwe, PhD MSc

Blood (2018) 132 (Supplement 1): 3957.

https://doi.org/10.1182/blood-2018-99-120275

Published: 2018

Journal Articles

Epigenetic Drug Combination Chemo-Sensitizes Pediatric AML By Reducing Cell Adhesion and Dislodging AML Cells from the Bone Marrow

Samantha Weber, BS, Anilkumar Gopalakrisnapillai, PhD, E. Anders Kolb, MD, Sonali Barwe, PhD MSc

Blood (2018) 132 (Supplement 1): 2637.

https://doi.org/10.1182/blood-2018-99-120321

Published: 2018

Journal Articles

Macrophage Involvement in the Response of Acute Myeloid Leukaemia to Chemotherapy

Thomas Keech, BSc, Crystal McGirr, Ingrid G Winkler, PhD, Jean-Pierre Levesque, PhD

Blood (2017) 130 (Supplement 1): 5069.

https://doi.org/10.1182/blood.V130.Suppl_1.5069.5069

Published: 2017

Journal Articles

Bone Marrow Stroma Protects FLT3 Acute Myeloid Leukemia (AML) through CYP3A4-Mediated Drug Metabolization of FLT3 Tyrosine Kinase Inhibitors (TKIs)

Yu-Ting Chang, MS, Daniela Hernandez, MD, Gabriel Ghiaur, MD PhD, Mark J. Levis, MD, Richard J. Jones, MD

Blood (2017) 130 (Supplement 1): 2519.

https://doi.org/10.1182/blood.V130.Suppl_1.2519.2519

Published: 2017

Journal Articles

Megakaryocytes Support Viability Proliferation and Protection of Primary Pre-B ALL Cells from Chemotherapy

Stephanie Nicole Shishido, PhD, EunJi Gang, MDPhD, Ruth Xu, Hye Na Kim, Yann Duchartre, PhD, Steven D. Mittelman, MDPhD, Hisham Abdel-Azim, MD, Matthew J Oberley, MDPhD, Nora Heisterkamp, PhD, Yong-Mi Kim, MDPhDMPH

Blood (2015) 126 (23): 3763.

https://doi.org/10.1182/blood.V126.23.3763.3763

Published: 2015

Journal Articles

Lymphocyte Function-Associated Antigen 3 (LFA-3): Key Factor of the Interactions Between Nurse-like-Cells and B Leukemic Cells from Chronic Lymphocytic Leukemia

Frederic Boissard, Jean Jacques Fournie, PhD, Loic Ysebaert, MDPhD, Mary Poupot, PhD

Blood (2014) 124 (21): 1955.

https://doi.org/10.1182/blood.V124.21.1955.1955

Published: 2014

Journal Articles

Combination of Tyrosine Kinase Inhibitor with β-Catenin/CBP Modulator C82 Reverses TKI Resistance, Eradicates Quiescent CML Stem/Progenitors Cells, and Overcomes MSC-Associated Microenvironmental Protection

Hongsheng Zhou, MDPhD, Po Yee Mak, Hong Mu, MD PhD, Duncan H Mak, MS, Hiroyuki Kouji, Marina Konopleva, MD PhD, Jorge E. Cortes, Michael Andreeff, MD PhD, Bing Z Carter, PhD

Blood (2014) 124 (21): 401.

https://doi.org/10.1182/blood.V124.21.401.401

Published: 2014

Journal Articles

Bortezomib Can Overcome Stroma-Mediated Chemotherapy Resistance in Acute Lymphoblastic Leukemia.

Ibraheem H. Motabi, MD, Julie Ritchey, Matthew Holt, John F. DiPersio, MD, PhD

Blood (2012) 120 (21): 2475.

https://doi.org/10.1182/blood.V120.21.2475.2475

Published: 2012

Journal Articles

Chemotherapy-Induced CXCR4 Modulation Predicts the In Vivo Efficacy of Plerixafor As a Chemosensitizer in Acute Leukemia

Edward Allan R. Sison, MD, Daniel Magoon, Li Li, PhD, Rachel E. Rau, MD, Colleen E. Annesley, MD, Donald Small, MD, PhD, Patrick A. Brown, MD

Blood (2011) 118 (21): 1410.

https://doi.org/10.1182/blood.V118.21.1410.1410

Published: 2011

Journal Articles

Drug Resistance Gene Therapy to Augment Allogeneic Transplantation for the Treatment of Leukemia Following Relapse

Melanie Wurm, DVM, PhD, Nathaniel Williams, BS, Christina Ironside, BS, Brian C Beard, PhD, Hans-Peter Kiem, MD

Blood (2011) 118 (21): 2050.

https://doi.org/10.1182/blood.V118.21.2050.2050

Published: 2011

Journal Articles

Efficient MGMTP140K-Mediated In Vivo Selection and Chemoprotection of Long-Term Repopulating Cells in Nonhuman Primates Following Reduced Intensity Conditioning.

Brian C Beard, PhD, Grant D Trobridge, PhD, Jeannine S McCune, Hans-Peter Kiem, MD

Blood (2009) 114 (22): 3572.

https://doi.org/10.1182/blood.V114.22.3572.3572

Published: 2009

Journal Articles

Preclinical Evaluation of Tysabri as a Novel Adjuvant Therapy against Drug Resistant B-ALL.

Yao-Te Hsieh, Enzi Jiang, MD, PhD, Carlton Scharman, Ella Waters, Eugene Park, Asha Kadavallore, Halvard Bonig, MA/MD, Yong-Mi Kim, MD, MPH, PhD

Blood (2009) 114 (22): 3089.

https://doi.org/10.1182/blood.V114.22.3089.3089

Published: 2009

Journal Articles

Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipients

Brian C. Beard, Reeteka Sud, Kirsten A. Keyser, Christina Ironside, Tobias Neff, Sabine Gerull, Grant D. Trobridge, Hans-Peter Kiem

Blood (2009) 113 (21): 5094–5103.

https://doi.org/10.1182/blood-2008-09-176412

Published: 2009

Includes: Supplemental data

Journal Articles

Efficient Gene Marking with a Clinical Gammaretrovirus Vector Expressing MGMTP140K in Baboons and Macaques

Brian C Beard, PhD, Megan L Welsh, MS, Grant D Trobridge, PhD, Hans-Peter Kiem, MD

Blood (2008) 112 (11): 3535.

https://doi.org/10.1182/blood.V112.11.3535.3535

Published: 2008

Journal Articles

Very High Expression of MGMT(P140K) Paradoxically Impairs Proliferation, In Vivo Selection and Protection of Transduced Hematopoietic Stem Cells.

Michael D. Milsom, PhD, Chad E. Harris, Axel Schambach, MD, PhD, Emily Broun, Moran Jerabek-Willemsen, Christopher Baum, MD, Thomas Moritz, MD, Geoffrey Margison, PhD, Jürgen Thomale, PhD, David A. Williams, MD

Blood (2007) 110 (11): 2588.

https://doi.org/10.1182/blood.V110.11.2588.2588

Published: 2007

Journal Articles

Retroviral Insertion and Temozolomide Selection Promote T-Cell Lymphomas in Tumor-Prone Mice.

Colin L. Sweeney, Yuan Lin, Stanton L. Gerson

Blood (2007) 110 (11): 2593.

https://doi.org/10.1182/blood.V110.11.2593.2593

Published: 2007

Journal Articles

Safety of MGMT Gene Transfer into Hematopoietic Progenitors: A Phase I Clinical Trial Using Retroviral Gene Transfer of G156A MGMT To Protect Hematopoiesis during BG Plus Alkylating Agent Treatment of Advanced Malignancies.

Jane S. Reese, Karen T. Lingas, Colin L. Sweeney, Joanna M. Brell, Stanton L. Gerson

Blood (2007) 110 (11): 500.

https://doi.org/10.1182/blood.V110.11.500.500

Published: 2007

Journal Articles

M2-10B4 Mesenchymal Stromal Cells Confer an In Vitro Protective Effect of Murine mCGPR/+ Acute Promyelocytic Leukemic Cells Against Chemotherapy.

Pablo A. Ramirez, MD, Michael P. Rettig, PhD, Matthew Holt, John F. DiPersio, MD, PhD

Blood (2007) 110 (11): 2844.

https://doi.org/10.1182/blood.V110.11.2844.2844

Published: 2007

Journal Articles

Oral Administration of PBI-1402 Significantly Reduces Erythropenia and Accelerates Peripheral Blood Recovery in Myeloablated Mice Post Transplantation.

Marie-Josée Morin, Gorazd Krosl, Mouna Lagraoui, Brigitte Grouix, Christopher Penney, Lyne Gagnon, Denis-Claude Roy

Blood (2006) 108 (11): 3201.

https://doi.org/10.1182/blood.V108.11.3201.3201

Published: 2006

Journal Articles

Transplantation of Hematopoietic and Endothelial Stem Cell Progenitors in Transgenic Zebrafish.

Hatem E. Sabaawy, MD, PhD, Lisa J. Embree, BS, Mizuki Azuma, PhD, Dennis D. Hickstein, MD

Blood (2006) 108 (11): 337.

https://doi.org/10.1182/blood.V108.11.337.337

Published: 2006

NARROW

Epigenetic Drug Combination Overcomes Bone Marrow Microenvironment-Induced Chemoprotection in Pediatric Acute Lymphoblastic Leukemia Via Modulation of CD81

Epigenetic Drug Combination Chemo-Sensitizes Pediatric AML By Reducing Cell Adhesion and Dislodging AML Cells from the Bone Marrow

Macrophage Involvement in the Response of Acute Myeloid Leukaemia to Chemotherapy

Bone Marrow Stroma Protects FLT3 Acute Myeloid Leukemia (AML) through CYP3A4-Mediated Drug Metabolization of FLT3 Tyrosine Kinase Inhibitors (TKIs)

Megakaryocytes Support Viability Proliferation and Protection of Primary Pre-B ALL Cells from Chemotherapy

Lymphocyte Function-Associated Antigen 3 (LFA-3): Key Factor of the Interactions Between Nurse-like-Cells and B Leukemic Cells from Chronic Lymphocytic Leukemia

Combination of Tyrosine Kinase Inhibitor with β-Catenin/CBP Modulator C82 Reverses TKI Resistance, Eradicates Quiescent CML Stem/Progenitors Cells, and Overcomes MSC-Associated Microenvironmental Protection

Bortezomib Can Overcome Stroma-Mediated Chemotherapy Resistance in Acute Lymphoblastic Leukemia.

Chemotherapy-Induced CXCR4 Modulation Predicts the In Vivo Efficacy of Plerixafor As a Chemosensitizer in Acute Leukemia

Drug Resistance Gene Therapy to Augment Allogeneic Transplantation for the Treatment of Leukemia Following Relapse

Efficient MGMTP140K-Mediated In Vivo Selection and Chemoprotection of Long-Term Repopulating Cells in Nonhuman Primates Following Reduced Intensity Conditioning.

Preclinical Evaluation of Tysabri as a Novel Adjuvant Therapy against Drug Resistant B-ALL.

Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipients

Efficient Gene Marking with a Clinical Gammaretrovirus Vector Expressing MGMTP140K in Baboons and Macaques

Very High Expression of MGMT(P140K) Paradoxically Impairs Proliferation, In Vivo Selection and Protection of Transduced Hematopoietic Stem Cells.

Retroviral Insertion and Temozolomide Selection Promote T-Cell Lymphomas in Tumor-Prone Mice.

Safety of MGMT Gene Transfer into Hematopoietic Progenitors: A Phase I Clinical Trial Using Retroviral Gene Transfer of G156A MGMT To Protect Hematopoiesis during BG Plus Alkylating Agent Treatment of Advanced Malignancies.

M2-10B4 Mesenchymal Stromal Cells Confer an In Vitro Protective Effect of Murine mCGPR/+ Acute Promyelocytic Leukemic Cells Against Chemotherapy.

Oral Administration of PBI-1402 Significantly Reduces Erythropenia and Accelerates Peripheral Blood Recovery in Myeloablated Mice Post Transplantation.

Transplantation of Hematopoietic and Endothelial Stem Cell Progenitors in Transgenic Zebrafish.

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American Society of Hematology

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American Society of Hematology

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