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Journal Articles

Overexpression of MPL Causes Ruxolitinib-Resistance in Myeloproliferative Neoplasms with Calreticulin Frame-Shift Mutations

Shunichiro Yasuda, MD, Satoru Aoyama, MD, Ryoto Yoshimoto, Student, Watanabe Daisuke, MD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Ayako Nogami, MD PhD BPharm, Kouhei Yamamoto, Takeo Fujiwara, MD, Yoko Edahiro, MD PhD, Marito Araki, PhD, Norio Komatsu, MD PhD, Tetsuya Fukuda, MD PhD, Ayako Arai, MD PhD, Osamu Miura, MD, PhD, Norihiko Kawamata

Blood (2019) 134 (Supplement_1): 1690.

https://doi.org/10.1182/blood-2019-122652

Published: 2019

Journal Articles

Alternative Splicing and Intronic Polyadenylation Post-Transcriptionally Regulate CSF3R Via a Cryptic Exon

Lawrence J Druhan, PhD, Amanda Lance, MS, Alicia Hamilton, Nury M Steuerwald, PhD, Elise Tjaden, Belinda R Avalos, MD

Blood (2019) 134 (Supplement_1): 2462.

https://doi.org/10.1182/blood-2019-129102

Published: 2019

Journal Articles

Carfilzomib Induces Cardiotoxicity Via ß5/ß2-Specific Proteasome Subunit Inhibition Pattern

Max A Mendez-Lopez, MD, Andrej Besse, PhD, Bogdan Florea, PhD, Christian Zuppinger, PhD, Herman Overkleeft, PhD, Christoph Driessen, MD, Lenka Besse, PhD

Blood (2019) 134 (Supplement_1): 3110.

https://doi.org/10.1182/blood-2019-127987

Published: 2019

Journal Articles

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

Shuhei Asada, MD PhD, Susumu Goyama, MD PhD, Reina Takeda, MD, Keita Yamamoto, MD, Hiroko Kozuka-Hata, PhD, Masaaki Oyama, PhD, Daichi Inoue, MD PhD, Hiroaki Honda, MD PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 731.

https://doi.org/10.1182/blood-2019-125959

Published: 2019

Journal Articles

PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation

Mario Scarpa, PhD, Prerna Singh, MS, Shivani Kapoor, MS, Jonelle K. Lee, MS, Sandrine Niyongere, MD, Goutham Narla, MD PhD, Danilo Perrotti, MD PhD, Maria R. Baer, MD

Blood (2019) 134 (Supplement_1): 1276.

https://doi.org/10.1182/blood-2019-129011

Published: 2019

Journal Articles

Concurrent FLT3 Inhibitor and PP2A Activating Drug Treatment Induces Synergistic Cytotoxicity in Acute Myeloid Leukemia Cells with FLT3 Internal Tandem Duplication through Proteasomal Degradation of Pim-1 and c-Myc

Mario Scarpa, PhD, Shivani Kapoor, MS, Danilo Perrotti, MD PhD, Maria R. Baer, MD

Blood (2018) 132 (Supplement 1): 3951.

https://doi.org/10.1182/blood-2018-99-117609

Published: 2018

Journal Articles

Altered Splicing from a Mutated Alternate Branch Point Is Common in Severe Alpha-Spectrin Linked Inherited Anemia

Kimberly Lezon-Geyda, PhD, Vincent P Schulz, PhD, Yelena Maksimova, MS, Patrick G. Gallagher, MD

Blood (2018) 132 (Supplement 1): 503.

https://doi.org/10.1182/blood-2018-99-117752

Published: 2018

Journal Articles

Dual Inhibition of Aurora Kinase and BRD4 Leads to Improved Anti-Tumor Activity in Myc-Overexpressing Lymphoma Cells

Steven I Park, MD, Carolina Lin, Lawrence J Druhan, PhD, Michael B Foote, Trevor Parton, Natalie Ren, Steven P Angus, Aadra P Bhatt, Scott C Jaros, Nilanjan Ghosh, MD PhD, Ryan Jacobs, MD, Belinda Rene Avalos, MD, Dirk P Dittmer, PhD, Norman E. Sharpless, MD, Blossom A Damania

Blood (2017) 130 (Supplement 1): 4109.

https://doi.org/10.1182/blood.V130.Suppl_1.4109.4109

Published: 2017

Journal Articles

Aberrant Trafficking and Signal Propagation By the T618I CSF3R Mutant in Patients with Chronic Neutrophilic Leukemia

Lawrence J Druhan, PhD, Andrea Price, Amanda Lance, Alicia Hamilton, Judy Parsons, MT, Fei Guo, PhD, David M Foureau, PhD, Nury M Steuerwald, PhD, Belinda Rene Avalos, MD

Blood (2017) 130 (Supplement 1): 2941.

https://doi.org/10.1182/blood.V130.Suppl_1.2941.2941

Published: 2017

Journal Articles

Small Molecule Activators of Protein Phosphatase 2A (SMAPs) Cause c-Myc Degradation and Tumor Growth Suppression in Preclinical Models of Lymphoid Malignancies

Molly M Gallogly, MDPhD, Eric Yuan, MPhil, Sahar Mazhar, BA, Caroline Farrington, BA, Goutham Narla, MD PhD

Blood (2017) 130 (Supplement 1): 2819.

https://doi.org/10.1182/blood.V130.Suppl_1.2819.2819

Published: 2017

Journal Articles

Exportin-1 Connects Dynamic Transcription and Translation of Genotoxic Stress Genes in Diffuse Large B-Cell Lymphoma Patients

Rossella Marullo, MD PhD, Maria Revuelta, PhD, Nahuel Zamponi, PhD, Biljana Culjkovic, PhD, Shao Ning Yang, Haelee Ahn, Giorgio Inghirami, MD, Katherine L. B. Borden, PhD, Leandro Cerchietti, MD

Blood (2017) 130 (Supplement 1): 312.

https://doi.org/10.1182/blood.V130.Suppl_1.312.312

Published: 2017

Journal Articles

SF3B1 Mutation Causes Aberrant Splicing and Downregulation of PPP2R5A in Chronic Lymphocytic Leukemia

Qimei Han, MBBS, Libin Deng, PhD, Lirong Pei, Jeong-Hyeon Choi, PhD, Victor Jin, PhD, Huidong Shi

Blood (2017) 130 (Supplement 1): 2477.

https://doi.org/10.1182/blood.V130.Suppl_1.2477.2477

Published: 2017

Journal Articles

Inhibition of FLT3-ITD and Melk By Small Molecule Inhibitor OTS167 in FLT3 mutant Acute Myeloid Leukemia (AML)

Bartholomew Eisfelder, PhD, Houda Alachkar, PharmD, PhD, Margaret Colton, Noreen Fulton, BS, Olatoyosi Odenike, MD, Yusuke Nakamura, MD, Wendy Stock, MD

Blood (2017) 130 (Supplement 1): 2525.

https://doi.org/10.1182/blood.V130.Suppl_1.2525.2525

Published: 2017

Journal Articles

Protein Kinase C-Dependent Von Willebrand Factor Secretion Is a Dual-Phased Process That Originates from 2 Distinct Intracellular Compartments

Laura Knipe, Nicola Hellen, PhD, Ianina Conte, PhD, Marjon Mourik, PhD, Aina Masgrau-Fortuny, PhD, Bijal Patel, PhD, Sayibrinthan Vickneswaran, Matthew Hannah, PhD, Tom Carter, PhD, Ruben Bierings, PhD

Blood (2017) 130 (Supplement 1): 1020.

https://doi.org/10.1182/blood.V130.Suppl_1.1020.1020

Published: 2017

Journal Articles

Protein Synthesis Rates Regulate Tumor-Initiating Potential and Chemoresistance in Multiple Myeloma

Eun-Hee Park, PhD, Mehrnoosh Soori, PhD MSc, Qiuju Wang, MSc, Lukasz P. Gondek, MD PhD, William Matsui, MD, Christian B. Gocke, MD PhD

Blood (2017) 130 (Supplement 1): 4390.

https://doi.org/10.1182/blood.V130.Suppl_1.4390.4390

Published: 2017

Journal Articles

HDAC6 Inhibition Increases Translation of CD20 mRNA and Potentiates the Efficacy of Anti-CD20 Immunotherapy

Malgorzata Bobrowicz, MSc, Joanna Stachura, MSc, Michal Dwojak, DMD, Antoni Domagala, MD, Beata Pyrzynska, PhD, Elise Berthel, MSc, Nicole Dalla Venezia, PhD, Marta Siernicka, MSc, Malgorzata Firczuk, PhD, Magdalena Winiarska, PhD

Blood (2016) 128 (22): 1586.

https://doi.org/10.1182/blood.V128.22.1586.1586

Published: 2016

Journal Articles

Ribosome Profiling Uncovers Selective mRNA Translation Associated with eIF2 Phosphorylation in Erythrocyte Progenitors

Paolini Nahuel, MSc, Moore Kat, MSc, di Summa Franca, BSc, Fokkema Ivo, MSc, Jansen Sjoert, MSc, 't Hoen Peter-Bram, PhD, Marieke Von Lindern, PhD

Blood (2016) 128 (22): 1197.

https://doi.org/10.1182/blood.V128.22.1197.1197

Published: 2016

Journal Articles

Global and MYC-Specific Translation Is Enhanced in Activated Chronic Lymphocytic Leukemia Cells Carrying NOTCH1 C.7541_7542delct Mutations

Annalisa D'Avola, MSc, Alison Yeomans, PhD, Samantha Drennan, PhD, Matthew Rose-Zerilli, PhD, Jonathan C. Strefford, Freda K Stevenson, DPhil, Andrew J Steele, PhD, Graham Packham, PhD, Francesco Forconi, MD DM, PhD FRCPath

Blood (2016) 128 (22): 970.

https://doi.org/10.1182/blood.V128.22.970.970

Published: 2016

Journal Articles

A Dominant Mutation in Mitochondrial Unfoldase CLPX Results in Erythropoietic Protoporphyria

Yvette Y Yien, PhD, Gael Nicolas, PhD, Lisa van der Vorm, Laurent Gouya, MD PhD, Hector Begonia, Martin Kafina, Jean-Charles Deybach, MD PhD, Tania Baker, PhD, Julia Kardon, PhD, John D. Phillips, PhD, Hervé Puy, MD PhD, Barry H. Paw, MD, PhD

Blood (2016) 128 (22): 77.

https://doi.org/10.1182/blood.V128.22.77.77

Published: 2016

Journal Articles

Functional Link Between Heat Shock Protein HSP90alpha and Sirtuin 1 (SIRT1) in the Pathogenesis of Diffuse Large B Cell Lymphoma

Emilia Bialopiotrowicz, PhD, Tomasz Sewastianik, PhD, Monika Noyszewska-Kania, MSc, Maciej Szydlowski, PhD, Ewa Jablonska, PhD, Patryk Gorniak, PhD, Anna Polak, PhD, Przemyslaw Kiliszek, PhD, Krzysztof Warzocha, Przemyslaw Juszczynski, MD PhD

Blood (2016) 128 (22): 4120.

https://doi.org/10.1182/blood.V128.22.4120.4120

Published: 2016

NARROW

Overexpression of MPL Causes Ruxolitinib-Resistance in Myeloproliferative Neoplasms with Calreticulin Frame-Shift Mutations

Alternative Splicing and Intronic Polyadenylation Post-Transcriptionally Regulate CSF3R Via a Cryptic Exon

Carfilzomib Induces Cardiotoxicity Via ß5/ß2-Specific Proteasome Subunit Inhibition Pattern

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation

Concurrent FLT3 Inhibitor and PP2A Activating Drug Treatment Induces Synergistic Cytotoxicity in Acute Myeloid Leukemia Cells with FLT3 Internal Tandem Duplication through Proteasomal Degradation of Pim-1 and c-Myc

Altered Splicing from a Mutated Alternate Branch Point Is Common in Severe Alpha-Spectrin Linked Inherited Anemia

Dual Inhibition of Aurora Kinase and BRD4 Leads to Improved Anti-Tumor Activity in Myc-Overexpressing Lymphoma Cells

Aberrant Trafficking and Signal Propagation By the T618I CSF3R Mutant in Patients with Chronic Neutrophilic Leukemia

Small Molecule Activators of Protein Phosphatase 2A (SMAPs) Cause c-Myc Degradation and Tumor Growth Suppression in Preclinical Models of Lymphoid Malignancies

Exportin-1 Connects Dynamic Transcription and Translation of Genotoxic Stress Genes in Diffuse Large B-Cell Lymphoma Patients

SF3B1 Mutation Causes Aberrant Splicing and Downregulation of PPP2R5A in Chronic Lymphocytic Leukemia

Inhibition of FLT3-ITD and Melk By Small Molecule Inhibitor OTS167 in FLT3 mutant Acute Myeloid Leukemia (AML)

Protein Kinase C-Dependent Von Willebrand Factor Secretion Is a Dual-Phased Process That Originates from 2 Distinct Intracellular Compartments

Protein Synthesis Rates Regulate Tumor-Initiating Potential and Chemoresistance in Multiple Myeloma

HDAC6 Inhibition Increases Translation of CD20 mRNA and Potentiates the Efficacy of Anti-CD20 Immunotherapy

Ribosome Profiling Uncovers Selective mRNA Translation Associated with eIF2 Phosphorylation in Erythrocyte Progenitors

Global and MYC-Specific Translation Is Enhanced in Activated Chronic Lymphocytic Leukemia Cells Carrying NOTCH1 C.7541_7542delct Mutations

A Dominant Mutation in Mitochondrial Unfoldase CLPX Results in Erythropoietic Protoporphyria

Functional Link Between Heat Shock Protein HSP90alpha and Sirtuin 1 (SIRT1) in the Pathogenesis of Diffuse Large B Cell Lymphoma

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American Society of Hematology

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American Society of Hematology

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