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Journal Articles

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Martin K. Safo, PhD, Piyusha P Pagare, PhD, Mohini Ghatge, PhD, Carla Casu, PhD, Valentina Ghiaccio, PhD, Nancy Anabaraonye, Xiaomeng Xu, MS, Stefano Rivella, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Yan Zhang, PhD, Jürgen Venitz, MD PhD, Osheiza Abdulmalik, DVM

Blood (2019) 134 (Supplement_1): 73.

https://doi.org/10.1182/blood-2019-128646

Published: 2019

Journal Articles

Busulfan Pharmacogenetics and Drug Exposure in Cancer Patients Undergoing Hematopoietic Stem Cell Transplantation

Jai N Patel, PharmD, Issam Hamadeh, BS, Qing Zhang, PhD, Taylor Brown, BS, MS, Nury M Steuerwald, PhD, Alicia Hamilton, Lawrence J Druhan, PhD, Jiaxian He, MS, James T Symanowski, PhD, Mohammed J Hussain, MD, Jigar Trivedi, MSc, PharmD, Michael Richard Grunwald, MD, Nilanjan Ghosh, MD PhD, Belinda Rene Avalos, MD, Edward A Copelan, MD

Blood (2017) 130 (Supplement 1): 3215.

https://doi.org/10.1182/blood.V130.Suppl_1.3215.3215

Published: 2017

Journal Articles

Replication of Candidate SNP Survival Analyses and Gene-Based Tests of Association with Survival Outcomes after an Unrelated Donor Blood or Marrow Transplant: Results from the Discovery-BMT Study

Ezgi Karaesmen#, MS, Abbas Rizvi#, MS, Qianqian Zhu, PhD, Li Yan, PhD, Qian Liu, MA, Qiang Hu, PhD, Leah Preus, MS, Alyssa I. Clay, PhD, Song Liu, PhD, Daniel O. Stram, PhD, Loreall C. Pooler, MS, Xin Sheng, MS, Christopher A. Haiman, ScD, Xiaochun Zhu, MS, Stephen R. Spellman, MBS, Marcelo C. Pasquini, MD, Philip L. McCarthy, MD, Theresa Hahn, PhD, Lara E. Sucheston-Campbell, PhD

Blood (2016) 128 (22): 71.

https://doi.org/10.1182/blood.V128.22.71.71

Published: 2016

Journal Articles

Genetic Determinants of Busulfan Clearance and Outcomes in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation- Result of a Multicentric Prospective Study on Behalf of the Pediatric Disease Working Party of the European Blood and Marrow Transplantation Group

Blood (2014) 124 (21): 424.

https://doi.org/10.1182/blood.V124.21.424.424

Published: 2014

Journal Articles

CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia

Gillian G. Johnson, Ke Lin, Trevor F. Cox, Melanie Oates, David R. Sibson, Richard Eccles, Bryony Lloyd, Laura-Jayne Gardiner, Daniel F. Carr, Munir Pirmohamed, Jonathan C. Strefford, David G. Oscier, David Gonzalez de Castro, Monica Else, Daniel Catovsky, Andrew R. Pettitt

Blood (2013) 122 (26): 4253–4258.

https://doi.org/10.1182/blood-2013-07-516666

Published: 2013

Includes: Supplemental data

Journal Articles

Pharmacokinetics Of a Generic Formulation Of Intravenous Busulfan (BUCELON 60™) In Patients Undergoing Hematopoietic Stem Cell Transplantation

Ezhilpavai Mohanan, M.Sc, Salamun Desire, M.Sc, Sathya Mani, Gopinath Srinivasan, Biju George, MD, Vikram Mathews, MD, Alok Srivastava, MD, Poonkuzhali Balasubramanian, Ph.D

Blood (2013) 122 (21): 3280.

https://doi.org/10.1182/blood.V122.21.3280.3280

Published: 2013

Journal Articles

No Evidence Of Increased Cyclophosphamide Toxicity Associated With The Antiemetic Agent NEPA, a Fixed-Dose Combination Of Netupitant and Palonosetron

Lee Schwartzberg, MD, FACP, Cristina Oprean, MD, Servando Cardona-Huerta, MD, Giada Rizzi, M.Sc., Giorgia Rossi, MD, Marco Palmas, MD, Meinolf Karthaus, MD, Matti Aapro, MD

Blood (2013) 122 (21): 2949.

https://doi.org/10.1182/blood.V122.21.2949.2949

Published: 2013

Journal Articles

Identification of A Pharmacogenomic Profile Associated with High Sensitivity and Low Toxicity to a Combination of Gemtuzumab Ozogamicin Plus Fludarabine, Cytarabine, Idarubicin Regimen In CD33-Positive Acute Myeloid Leukemia (AML) Patients

Blood (2010) 116 (21): 967.

https://doi.org/10.1182/blood.V116.21.967.967

Published: 2010

Journal Articles

Trough Plasma Imatinib Levels and ABCG2 Polymorphisms Are Correlated with Optimal Cytogenetic Responses at 6 Months After Treatment with Standard Dose of Imatinib In Newly Diagnosed CML

Blood (2010) 116 (21): 2272.

https://doi.org/10.1182/blood.V116.21.2272.2272

Published: 2010

Journal Articles

Population Pharmacokinetics of Busulfan in Patients with Beta Thalassaemia Major Undergoing HSCT Reveals Body Weight, GSTA1 and CYP3A4 Promoter Polymorphisms as Main Covariates Explaining the Inter-Individual Variation.

Poonkuzhali Balasubramanian, Ph.D, John Carl Panetta, Ph.D, Salamun Desire, M.Sc, Shaji R Velayudhan, Ph.D, Vikram Mathews, MD, Biju George, MD, Auro Viswabandya, MD, Mammen Chandy, MD, Alok Srivastava, MD

Blood (2009) 114 (22): 3349.

https://doi.org/10.1182/blood.V114.22.3349.3349

Published: 2009

Journal Articles

Targeted Anti-Tumor Research of Mesenchymal Stem Cells Delivered Enzyme-Prodrug Gene CYP450 .

Jishi Wang, Yuan Yang, Wei Zhang, Pengxiang Guo

Blood (2009) 114 (22): 3582.

https://doi.org/10.1182/blood.V114.22.3582.3582

Published: 2009

Journal Articles

Polymorphisms in the CYP450 Genes Influences Regimen Related Toxicity and Outcome in Patients with Beta Thalassaemia Major Undergoing HSCT.

Poonkuzhali Balasubramanian, Ph.D, Salamun Desire, M.Sc, Vikram Mathews, MD, Kavitha M Lakshmi, M.Sc, Shaji R Velayudhan, Ph.D, Biju George, MD, Auro Viswabandya, MD, Mammen Chandy, MD, Alok Srivastava, MD

Blood (2009) 114 (22): 869.

https://doi.org/10.1182/blood.V114.22.869.869

Published: 2009

Journal Articles

Population Pharmacokinetics of Cyclophosphamide in Patients with Thalassaemia Major Undergoing HSCT Shows Body Weight, CYP450, GST and ALDH Polymorphisms as Covariates Explaining Inter-Individual Variation.

Poonkuzhali Balasubramanian, Ph.D, John Carl Panetta, Ph.D, Salamun Desire, M.Sc, Shaji R Velayudhan, Ph.D, Vikram Mathews, MD, Biju George, MD, Auro Viswabandya, Mammen Chandy, MD, Alok Srivastava, MD

Blood (2009) 114 (22): 1182.

https://doi.org/10.1182/blood.V114.22.1182.1182

Published: 2009

Journal Articles

Genetic Variations in CYP2B6 and Risk of Cyclophosphamide Toxicity in Patients Undergoing Myeloablative Stem Cell Transplantation.

Stacy E Melanson, MD, PhD, Joseph H. Antin, MD, Michael H. Court, PhD, Vincent Ho, Jerome Ritz, MD, Haesook T. Kim, Frank C Kuo, MD, PhD, Janina A Longtine, MD, Petr Jarolim, MD, PhD

Blood (2008) 112 (11): 3289.

https://doi.org/10.1182/blood.V112.11.3289.3289

Published: 2008

Journal Articles

The Pharmacogenetic Background of the Host Is An Independent Predictor of Outcome and Toxicity in Diffuse Large B Cell Lymphoma Treated with R-CHOP21

Davide Rossi, Silvia Rasi, Silvia Franceschetti, Daniela Capello, Andrea Castelli, Lorenzo De Paoli, Antonio Ramponi, Annalisa Chiappella, Enrico M. Pogliani, Umberto Vitolo, Ivo Kwee, Francesco Bertoni, Annarita Conconi, Gianluca Gaidano

Blood (2008) 112 (11): 480.

https://doi.org/10.1182/blood.V112.11.480.480

Published: 2008

Journal Articles

Drug Metabolism Gene Polymorphisms and the Risk of Hepatic Sinusoidal Obstruction Syndrome in Children with Inherited Diseases Receiving Haematopoietic Stem Cell Transplantation.

Juliana F. Fernandes, MD, Vanderson Rocha, MD, Raphael Porcher, Benedicte Neven, MD, Christophe Hue, Marli Tavela, Alain Fischer, MD, Marco Antonio Zago, MD, Marina Cavazzana-Calvo, MD

Blood (2007) 110 (11): 1980.

https://doi.org/10.1182/blood.V110.11.1980.1980

Published: 2007

Journal Articles

Genetic Polymorphisms of Gluthatione-S-Transferases in Two Different Populations of Fanconi Anaemia Patients.

Juliana F. Fernandes, MD, Vanderson Rocha, MD, Raphael Porcher, Marco Bittencourt, MD, Moema N. Santos, MD, Yulia Skvortsova, MD, Carmen Bonfim, MD, Marli Tavela, Gerard Socie, MD, Eliane Gluckman, MD, Ricardo Pasquini, MD, Marco Antonio Zago, MD

Blood (2007) 110 (11): 1981.

https://doi.org/10.1182/blood.V110.11.1981.1981

Published: 2007

Journal Articles

Different Prevalence of Drug Metabolism Gene Polymorphisms (GSTP and GSTT) in FA Patients Compared to a Normal Population.

Moema Nene Santos, MD, Vanderson Rocha, MD, PhD, Dalila Zanette, Pharm, Raphael Porcher, MS, Irina Ionescu, MD, Marli Tavela, Tech, Jean Soulier, MD, PhD, Thierry Leblanc, MD, Gustavo Fisher, MD, André Baruchel, MD, Marco Antonio Zago, MD, Eliane Gluckman, MD

Blood (2005) 106 (11): 106.

https://doi.org/10.1182/blood.V106.11.106.106

Published: 2005

Journal Articles

Pharmacogenetics of Cyclophosphamide in Patients with Beta Thalassemia Major Undergoing Bone Marrow Transplantation.

Balasubramanian Poonkuzhali, Ph.D., Desire Salamun, M.Sc, Ramachandran V. Shaji, Ph.D., Biju George, MD, DM, Vikram Mathews, MD, DM, Mammen Chandy, MD, Rajagopal Krishnamoorthy, Ph.D., Alok Srivastava, MD

Blood (2004) 104 (11): 99.

https://doi.org/10.1182/blood.V104.11.99.99

Published: 2004

Journal Articles

Pluripotent Unrestricted Somatic Stem Cells (USSC) from Cord Blood Generate Hepatocytes in Vivo, but In Vitro Convert into Immature Endodermal Precursors: The Critical Role of the Biological Niche.

Sandra Sensken, Juergen Enczmann, Ph.D., Thorsten Trapp, Ph.D., Esmail Zanjani, Ph.D., Peter Wernet, MD, Gesine Koegler, Ph.D.

Blood (2004) 104 (11): 3596.

https://doi.org/10.1182/blood.V104.11.3596.3596

Published: 2004

NARROW

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Busulfan Pharmacogenetics and Drug Exposure in Cancer Patients Undergoing Hematopoietic Stem Cell Transplantation

Replication of Candidate SNP Survival Analyses and Gene-Based Tests of Association with Survival Outcomes after an Unrelated Donor Blood or Marrow Transplant: Results from the Discovery-BMT Study

Genetic Determinants of Busulfan Clearance and Outcomes in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation- Result of a Multicentric Prospective Study on Behalf of the Pediatric Disease Working Party of the European Blood and Marrow Transplantation Group

CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia

Pharmacokinetics Of a Generic Formulation Of Intravenous Busulfan (BUCELON 60™) In Patients Undergoing Hematopoietic Stem Cell Transplantation

No Evidence Of Increased Cyclophosphamide Toxicity Associated With The Antiemetic Agent NEPA, a Fixed-Dose Combination Of Netupitant and Palonosetron

Identification of A Pharmacogenomic Profile Associated with High Sensitivity and Low Toxicity to a Combination of Gemtuzumab Ozogamicin Plus Fludarabine, Cytarabine, Idarubicin Regimen In CD33-Positive Acute Myeloid Leukemia (AML) Patients

Trough Plasma Imatinib Levels and ABCG2 Polymorphisms Are Correlated with Optimal Cytogenetic Responses at 6 Months After Treatment with Standard Dose of Imatinib In Newly Diagnosed CML

Population Pharmacokinetics of Busulfan in Patients with Beta Thalassaemia Major Undergoing HSCT Reveals Body Weight, GSTA1 and CYP3A4 Promoter Polymorphisms as Main Covariates Explaining the Inter-Individual Variation.

Targeted Anti-Tumor Research of Mesenchymal Stem Cells Delivered Enzyme-Prodrug Gene CYP450 .

Polymorphisms in the CYP450 Genes Influences Regimen Related Toxicity and Outcome in Patients with Beta Thalassaemia Major Undergoing HSCT.

Population Pharmacokinetics of Cyclophosphamide in Patients with Thalassaemia Major Undergoing HSCT Shows Body Weight, CYP450, GST and ALDH Polymorphisms as Covariates Explaining Inter-Individual Variation.

Genetic Variations in CYP2B6 and Risk of Cyclophosphamide Toxicity in Patients Undergoing Myeloablative Stem Cell Transplantation.

The Pharmacogenetic Background of the Host Is An Independent Predictor of Outcome and Toxicity in Diffuse Large B Cell Lymphoma Treated with R-CHOP21

Drug Metabolism Gene Polymorphisms and the Risk of Hepatic Sinusoidal Obstruction Syndrome in Children with Inherited Diseases Receiving Haematopoietic Stem Cell Transplantation.

Genetic Polymorphisms of Gluthatione-S-Transferases in Two Different Populations of Fanconi Anaemia Patients.

Different Prevalence of Drug Metabolism Gene Polymorphisms (GSTP and GSTT) in FA Patients Compared to a Normal Population.

Pharmacogenetics of Cyclophosphamide in Patients with Beta Thalassemia Major Undergoing Bone Marrow Transplantation.

Pluripotent Unrestricted Somatic Stem Cells (USSC) from Cord Blood Generate Hepatocytes in Vivo, but In Vitro Convert into Immature Endodermal Precursors: The Critical Role of the Biological Niche.

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American Society of Hematology

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American Society of Hematology

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