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Journal Articles

Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer

Alexandre Slater, Ying Di, Joanne C. Clark, Natalie J. Jooss, Eleyna M. Martin, Fawaz Alenazy, Mark R. Thomas, Robert A. S. Ariëns, Andrew B. Herr, Natalie S. Poulter, Jonas Emsley, Steve P. Watson

Blood (2021) 137 (24): 3443–3453.

https://doi.org/10.1182/blood.2020009440

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Manasa K. Nayak, Madankumar Ghatge, Gagan D. Flora, Nirav Dhanesha, Manish Jain, Kathleen R. Markan, Matthew J. Potthoff, Steven R. Lentz, Anil K. Chauhan

Blood (2021) 137 (12): 1658–1668.

https://doi.org/10.1182/blood.2020007140

Published: 2021

Includes: Supplemental data

Journal Articles

Identification of amino acid residues that are crucial for FXIII-A intersubunit interactions and stability

Bojun Li, Hans P. Kohler, Verena Schroeder

Blood (2020) 135 (2): 145–152.

https://doi.org/10.1182/blood.2019002127

Published: 2020

Journal Articles

New Paradigms for the Mechanisms of Thrombopoietin Receptor Activation and Dysregulation By the JAK2 V617F Mutation

Stephan Wilmes, PhD, Maximillian Hafer, BSc, Tess A Stanly, Ignacio Moraga, PhD, Joni Vuorio, PhD, Chetan Poojari, PhD, Vivek Sharma, PhD, Sara Löchte, PhD, Katiuska Pulgar Prieto, BSc, Julie A Tucker, PhD, Stevan R Hubbard, PhD, K.Christopher Garcia, PhD, Ilpo Vattulainen, PhD, Ian Hitchcock, PhD, Jacob Piehler, PhD

Blood (2019) 134 (Supplement_1): 2962.

https://doi.org/10.1182/blood-2019-129234

Published: 2019

Journal Articles

The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction

Reinhard Schneppenheim, Natalie Hellermann, Maria A. Brehm, Ulrike Klemm, Tobias Obser, Volker Huck, Stefan W. Schneider, Cécile V. Denis, Alexander Tischer, Matthew Auton, Winfried März, Emma-Ruoqi Xu, Matthias Wilmanns, Rainer B. Zotz

Blood (2019) 133 (4): 356–365.

https://doi.org/10.1182/blood-2018-04-843425

Published: 2019

Includes: Multimedia, Supplemental data

Journal Articles

Comprehensive Genomic Analysis of IDH Inhibitor-Treated AML Samples Delineates Molecular Mechanisms of Differentiation and Heterogeneous Patterns of Acquired Resistance

Blood (2018) 132 (Supplement 1): 441.

https://doi.org/10.1182/blood-2018-99-116383

Published: 2018

Journal Articles

Plasma Derived FXIII Prophylaxis in Two Patients with Congenital FXIII Deficiency. Mexican Experience

Mara Toscano, MD

Blood (2018) 132 (Supplement 1): 5030.

https://doi.org/10.1182/blood-2018-99-119983

Published: 2018

Journal Articles

ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies

Francesca Zammarchi, Simon Corbett, Lauren Adams, Peter C. Tyrer, Konstantinos Kiakos, Narinder Janghra, Teresa Marafioti, Charles E. Britten, Carin E. G. Havenith, Simon Chivers, Francois D’Hooge, David G. Williams, Arnaud Tiberghien, Philip W. Howard, John A. Hartley, Patrick H. van Berkel

Blood (2018) 131 (10): 1094–1105.

https://doi.org/10.1182/blood-2017-10-813493

Published: 2018

Includes: Supplemental data

Journal Articles

Mitochondria-Targeted Effects of Water-Soluble Polyol-Methanofullerenes on Human Whole Blood Platelets, Lymphocytes and Granulocytes Ex Vivo

Gulzada Tarasova, PhDstudent, Natalia Kalacheva, PhD, Guzel Fazleeva, PhD, Valentina Gubskaya, PhD, Albert Rizvanov, DSc, PhD, Georgi Cherepnev, MD PhD

Blood (2017) 130 (Supplement 1): 4836.

https://doi.org/10.1182/blood.V130.Suppl_1.4836.4836

Published: 2017

Journal Articles

Unique Transmembrane Domain Interactions Differentially Modulate Platelet αIIbβ3 and αvβ3 Function

Rustem I. Litvinov, MD PhD, Marco Mravic, B.S., M.S., Hua Zhu, BS, John W. Weisel, PhD, William F. DeGrado, PhD, Joel S. Bennett, MD

Blood (2017) 130 (Supplement 1): 1019.

https://doi.org/10.1182/blood.V130.Suppl_1.1019.1019

Published: 2017

Journal Articles

A Phase 1b Study of Vadastuximab Talirine As Maintenance and in Combination with Standard Consolidation for Patients with Acute Myeloid Leukemia (AML)

Jay Yang, MD, Farhad Ravandi, MD, Anjali Advani, MD, Sumithira Vasu, MBBS, Roland B. Walter, MD PhD, Stefan Faderl, MD, Anthony S. Stein, MD, Harry P. Erba, MD PhD, Amir T. Fathi, MD, William B. Donnellan, MD, Moshe Y Levy, MD, Scott E. Smith, MD PhD, Brent L. Wood, MD PhD, Eric J. Feldman, MD, Jenna L Voellinger, PhD, Michael B. Maris, MD

Blood (2016) 128 (22): 340.

https://doi.org/10.1182/blood.V128.22.340.340

Published: 2016

Journal Articles

VWF Cleavage Products Inhibit Shear-Induced Self-Association

Shirin Feghhi, PhD, Alexander St. John, MD MS, Jeff Harris, Jennie Le, BS, Dominic W Chung, PhD, Junmei Chen, PhD, Jose A. Lopez, MD

Blood (2016) 128 (22): 3718.

https://doi.org/10.1182/blood.V128.22.3718.3718

Published: 2016

Journal Articles

hLL2-Cys-PBD, a New Site-Specifically Conjugated, Pyrrolobenzodiazepine (PBD) Dimer-Based Antibody Drug Conjugate (ADC) Targeting CD22-Expressing B-Cell Malignancies.

Francesca Zammarchi, PhD, Simon Corbett, Lauren Adams, Maria Mellinas-Gomez, PhD, Peter Tyrer, PhD, Sandamali Dissanayake, Simone Sims, Karin Havenith, PhD, Simon Chivers, PhD, David G Willimas, PhD, Philip W Howard, PhD, John A. Hartley, PhD, Patrick van Berkel, PhD

Blood (2016) 128 (22): 4176.

https://doi.org/10.1182/blood.V128.22.4176.4176

Published: 2016

Journal Articles

Adult hematopoietic stem cells lacking Hif-1α self-renew normally

Milica Vukovic, Catarina Sepulveda, Chithra Subramani, Amélie V. Guitart, Jasmine Mohr, Lewis Allen, Theano I. Panagopoulou, Jasmin Paris, Hannah Lawson, Arnaud Villacreces, Alejandro Armesilla-Diaz, Deniz Gezer, Tessa L. Holyoake, Peter J. Ratcliffe, Kamil R. Kranc

Blood (2016) 127 (23): 2841–2846.

https://doi.org/10.1182/blood-2015-10-677138

Published: 2016

Includes: Supplemental data

Journal Articles

von Willebrand factor is dimerized by protein disulfide isomerase

Svenja Lippok, Katra Kolšek, Achim Löf, Dennis Eggert, Willem Vanderlinden, Jochen P. Müller, Gesa König, Tobias Obser, Karoline Röhrs, Sonja Schneppenheim, Ulrich Budde, Carsten Baldauf, Camilo Aponte-Santamaría, Frauke Gräter, Reinhard Schneppenheim, Joachim O. Rädler, Maria A. Brehm

Blood (2016) 127 (9): 1183–1191.

https://doi.org/10.1182/blood-2015-04-641902

Published: 2016

Includes: Multimedia, Supplemental data

Journal Articles

Mechanistic and Pharmacodynamic Studies of Adct-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Michael J. Flynn, MD, Patrick H. van Berkel, PhD, Francesca Zammarchi, PhD, Peter C. Tyrer, PhD, Ayse U. Akarca, Narinder Janghra, Vishvesh Shende, PhD, Joseph Linares, Teresa Marafioti, MD, David G. Williams, PhD, Philip W. Howard, PhD, John A. Hartley, PhD

Blood (2015) 126 (23): 1559.

https://doi.org/10.1182/blood.V126.23.1559.1559

Published: 2015

Journal Articles

SGN-CD123A, a Pyrrolobenzodiazepine Dimer Linked Anti-CD123 Antibody Drug Conjugate, Demonstrates Effective Anti-Leukemic Activity in Multiple Preclinical Models of AML

May S.K. Sutherland, PhD, Changpu Yu, Roland B. Walter, MD PhD, Lori Westendorf, John Valliere-Douglass, PhD, Lucy Pan, PhD, Django Sussman, PhD, Martha Anderson, Weiping Zeng, Ivan Stone, Kerry Klussman, Michelle Ulrich, Mechthild Jonas, PhD, Peter Senter, PhD, Jonathan G. Drachman, MD, Dennis Benjamin, PhD

Blood (2015) 126 (23): 330.

https://doi.org/10.1182/blood.V126.23.330.330

Published: 2015

Journal Articles

SGN-CD33A in Combination with Hypomethylating Agents Is Highly Efficacious in Preclinical Models of AML

May S.K. Sutherland, PhD, Changpu Yu, Christine O'Day, PhD, Steve Alley, PhD, Martha Anderson, Kim Emmerton, Weipeng Zeng, Megan M. O'Meara, MD, Eric J. Feldman, MD, Dana A. Kennedy, Maureen C. Ryan, PhD, Dennis Benjamin, PhD

Blood (2015) 126 (23): 3785.

https://doi.org/10.1182/blood.V126.23.3785.3785

Published: 2015

Journal Articles

Lucky 13

David H. Farrell

Blood (2015) 126 (20): 2261–2262.

https://doi.org/10.1182/blood-2015-09-670471

Published: 2015

Journal Articles

FVIII-VWF dos-à-dos

Sriram Krishnaswamy

Blood (2015) 126 (8): 923–924.

https://doi.org/10.1182/blood-2015-06-652073

Published: 2015

NARROW

Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer

The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Identification of amino acid residues that are crucial for FXIII-A intersubunit interactions and stability

New Paradigms for the Mechanisms of Thrombopoietin Receptor Activation and Dysregulation By the JAK2 V617F Mutation

The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction

Comprehensive Genomic Analysis of IDH Inhibitor-Treated AML Samples Delineates Molecular Mechanisms of Differentiation and Heterogeneous Patterns of Acquired Resistance

Plasma Derived FXIII Prophylaxis in Two Patients with Congenital FXIII Deficiency. Mexican Experience

ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies

Mitochondria-Targeted Effects of Water-Soluble Polyol-Methanofullerenes on Human Whole Blood Platelets, Lymphocytes and Granulocytes Ex Vivo

Unique Transmembrane Domain Interactions Differentially Modulate Platelet αIIbβ3 and αvβ3 Function

A Phase 1b Study of Vadastuximab Talirine As Maintenance and in Combination with Standard Consolidation for Patients with Acute Myeloid Leukemia (AML)

VWF Cleavage Products Inhibit Shear-Induced Self-Association

hLL2-Cys-PBD, a New Site-Specifically Conjugated, Pyrrolobenzodiazepine (PBD) Dimer-Based Antibody Drug Conjugate (ADC) Targeting CD22-Expressing B-Cell Malignancies.

Adult hematopoietic stem cells lacking Hif-1α self-renew normally

von Willebrand factor is dimerized by protein disulfide isomerase

Mechanistic and Pharmacodynamic Studies of Adct-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

SGN-CD123A, a Pyrrolobenzodiazepine Dimer Linked Anti-CD123 Antibody Drug Conjugate, Demonstrates Effective Anti-Leukemic Activity in Multiple Preclinical Models of AML

SGN-CD33A in Combination with Hypomethylating Agents Is Highly Efficacious in Preclinical Models of AML

Lucky 13

FVIII-VWF dos-à-dos

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American Society of Hematology

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ASH Publications

American Society of Hematology

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