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Journal Articles

The aptamer BT200 blocks interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1

Alain Chion, Ciara Byrne, Ferdows Atiq, Dearbhla Doherty, Sonia Aguila, Judicael Fazavana, Patricia Lopes, Ellie Karampini, Aamir Amin, Roger J. S. Preston, Ross I. Baker, Thomas A. J. McKinnon, Shuhao Zhu, James C. Gilbert, Jonas Emsley, Bernd Jilma, James S. O’Donnell

Blood (2024) 144 (13): 1445–1456.

https://doi.org/10.1182/blood.2024024055

Published: 2024

Includes: Supplemental data

Journal Articles

Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module

Nicholas A. Arce, Zoe Markham-Lee, Qian Liang, Shabir Najmudin, Emily R. Legan, Gabrielle Dean, Ally J. Su, Moriah S. Wilson, Robert F. Sidonio, Pete Lollar, Jonas Emsley, Renhao Li

Blood (2024) 143 (19): 1992–2004.

https://doi.org/10.1182/blood.2023022038

Published: 2024

Includes: Supplemental data

Journal Articles

First Validated Model of Zymogen Factor XII Provides Insights into Protein Assembly and Activation

Aleksandr Shamanaev, Mao-Fu Sun, Michal Ponczek, Jonas Emsley, David Gailani

Blood (2023) 142 (Supplement 1): 23.

https://doi.org/10.1182/blood-2023-190006

Published: 2023

Journal Articles

Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer

Alexandre Slater, Ying Di, Joanne C. Clark, Natalie J. Jooss, Eleyna M. Martin, Fawaz Alenazy, Mark R. Thomas, Robert A. S. Ariëns, Andrew B. Herr, Natalie S. Poulter, Jonas Emsley, Steve P. Watson

Blood (2021) 137 (24): 3443–3453.

https://doi.org/10.1182/blood.2020009440

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

Factor VIII/VWF complex caught on camera

Emma-Ruoqi Xu, Jonas Emsley

Blood (2021) 137 (21): 2865–2866.

https://doi.org/10.1182/blood.2021010716

Published: 2021

Journal Articles

Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery

Bubacarr G. Kaira, Alexandre Slater, Keith R. McCrae, Ingrid Dreveny, Ummay Sumya, Nicola J. Mutch, Mark Searle, Jonas Emsley

Blood (2020) 136 (14): 1685–1697.

https://doi.org/10.1182/blood.2020004818

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Plasma kallikrein's low gear

Jonas Emsley

Blood (2020) 135 (8): 518–519.

https://doi.org/10.1182/blood.2019004339

Published: 2020

Journal Articles

Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation

Ivan Ivanov, Anton Matafonov, Mao-fu Sun, Qiufang Cheng, S. Kent Dickeson, Ingrid M. Verhamme, Jonas Emsley, David Gailani

Blood (2017) 129 (11): 1527–1537.

https://doi.org/10.1182/blood-2016-10-744110

Published: 2017

Includes: Supplemental data

Journal Articles

A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain

Szu S. Wong, Søren Østergaard, Gareth Hall, Chan Li, Philip M. Williams, Henning Stennicke, Jonas Emsley

Blood (2016) 127 (23): 2915–2923.

https://doi.org/10.1182/blood-2015-10-676122

Published: 2016

Includes: Multimedia, Supplemental data

Journal Articles

FXa variants advance toward a therapy for bleeding

Jonas Emsley

Blood (2015) 126 (1): 6–7.

https://doi.org/10.1182/blood-2015-05-643395

Published: 2015

Journal Articles

Exploiting the kinetic interplay between GPIbα–VWF binding interfaces to regulate hemostasis and thrombosis

Jianchung Chen, Hairu Zhou, Alexander Diacovo, X. Long Zheng, Jonas Emsley, Thomas G. Diacovo

Blood (2014) 124 (25): 3799–3807.

https://doi.org/10.1182/blood-2014-04-569392

Published: 2014

Includes: Multimedia, Supplemental data

Journal Articles

Quaternary Organization of GPIb-IX Complex and Insights Into Bernard-Soulier Syndrome Revealed by the Crystal Structures of GPIbβ Ectodomain and a GPIbβ/GPIX Chimera

Paul A. McEwan, Ph.D., Wenjun Yang, PhD, Katherine H. Carr, Xi Mo, PhD, Xiaofeng Zheng, Renhao Li, PhD, Jonas Emsley, PhD

Blood (2011) 118 (21): 2195.

https://doi.org/10.1182/blood.V118.21.2195.2195

Published: 2011

Journal Articles

Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera

Paul A. McEwan, Wenjun Yang, Katherine H. Carr, Xi Mo, Xiaofeng Zheng, Renhao Li, Jonas Emsley

Blood (2011) 118 (19): 5292–5301.

https://doi.org/10.1182/blood-2011-05-356253

Published: 2011

Includes: Multimedia, Supplemental data

Journal Articles

Differential Pathogenesis of Bernard-Soulier Syndrome-Associated Mutations In the Platelet Glycoprotein Ibβ Ectodomain

Wenjun Yang, PhD, P.A McEwan, PhD, Xi Mo, PhD, Jonas Emsley, PhD, Renhao Li, PhD

Blood (2010) 116 (21): 3202.

https://doi.org/10.1182/blood.V116.21.3202.3202

Published: 2010

Journal Articles

Evidence against a protein in plasma that is a product of a factor XI mRNA splice variant missing exons 6 and 7

David Gailani, Mao-fu Sun, Qiufang Cheng, Anton Matafonov, Erik I. Tucker, Andras Gruber, Jonas Emsley

Blood (2010) 116 (7): 1185–1186.

https://doi.org/10.1182/blood-2010-01-265702

Published: 2010

Journal Articles

The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function

Brenda M. Luken, Luke Y. N. Winn, Jonas Emsley, David A. Lane, James T. B. Crawley

Blood (2010) 115 (23): 4910–4913.

https://doi.org/10.1182/blood-2009-12-257949

Published: 2010

Includes: Supplemental data

Journal Articles

Structure and function of factor XI

Jonas Emsley, Paul A. McEwan, David Gailani

Blood (2010) 115 (13): 2569–2577.

https://doi.org/10.1182/blood-2009-09-199182

Published: 2010

Includes: Supplemental data

Journal Articles

Glycoprotein Ibα inhibitor complex structure reveals a combined steric and allosteric mechanism of von Willebrand factor antagonism

Paul A. McEwan, Robert K. Andrews, Jonas Emsley

Blood (2009) 114 (23): 4883–4885.

https://doi.org/10.1182/blood-2009-05-224170

Published: 2009

Includes: Multimedia, Supplemental data

Journal Articles

Glycoprotein Ibalpha Inhibitor Complex Crystal Structure at High Resolution.

P.A Mcewan, Bsc, Phd, Robert K Andrews, Ph.D, Jonas Emsley, Bsc, Phd

Blood (2009) 114 (22): 774.

https://doi.org/10.1182/blood.V114.22.774.774

Published: 2009

NARROW

The aptamer BT200 blocks interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1

Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module

First Validated Model of Zymogen Factor XII Provides Insights into Protein Assembly and Activation

Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer

Factor VIII/VWF complex caught on camera

Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery

Plasma kallikrein's low gear

Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation

A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain

FXa variants advance toward a therapy for bleeding

Exploiting the kinetic interplay between GPIbα–VWF binding interfaces to regulate hemostasis and thrombosis

Quaternary Organization of GPIb-IX Complex and Insights Into Bernard-Soulier Syndrome Revealed by the Crystal Structures of GPIbβ Ectodomain and a GPIbβ/GPIX Chimera

Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera

Differential Pathogenesis of Bernard-Soulier Syndrome-Associated Mutations In the Platelet Glycoprotein Ibβ Ectodomain

Evidence against a protein in plasma that is a product of a factor XI mRNA splice variant missing exons 6 and 7

The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function

Structure and function of factor XI

Glycoprotein Ibα inhibitor complex structure reveals a combined steric and allosteric mechanism of von Willebrand factor antagonism

Glycoprotein Ibalpha Inhibitor Complex Crystal Structure at High Resolution.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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