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Journal Articles

Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module

Nicholas A. Arce, Zoe Markham-Lee, Qian Liang, Shabir Najmudin, Emily R. Legan, Gabrielle Dean, Ally J. Su, Moriah S. Wilson, Robert F. Sidonio, Pete Lollar, Jonas Emsley, Renhao Li

Blood (2024) 143 (19): 1992–2004.

https://doi.org/10.1182/blood.2023022038

Published: 2024

Includes: Supplemental data

Journal Articles

Platelet size matters

Renhao Li

Blood (2024) 143 (4): 298–300.

https://doi.org/10.1182/blood.2023023057

Published: 2024

Journal Articles

The Variable Heavy Chain Antibody Syn-VWFA1 Inhibits the Interaction of Platelets to Von Willebrand Factor in Solution but Not to Immobilized Von Willebrand Factor Thereby Inhibiting 3-Dimensional but Not 2-Dimensional Thrombus Formation

Dana Huskens, Lisa Nynke Van Der Vorm, Joke Konings, Nicholas Arce, Mark Roest, Philip G. De Groot, Renhao Li, Jasper A. Remijn, Bas De Laat

Blood (2023) 142 (Supplement 1): 1193.

https://doi.org/10.1182/blood-2023-177887

Published: 2023

Journal Articles

Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain

Emily R. Legan, Yi Liu, Nicholas A. Arce, Ernest T. Parker, Pete Lollar, X. Frank Zhang, Renhao Li

Blood (2023) 141 (10): 1221–1232.

https://doi.org/10.1182/blood.2022017239

Published: 2023

Includes: Supplemental data

Journal Articles

Autoinhibition of Mouse Von Willebrand Factor: Addressing the Species Compatibility between VWF and Gpibα in Humans and Mice

Nicholas A Arce, Renhao Li

Blood (2021) 138 (Supplement 1): 1002.

https://doi.org/10.1182/blood-2021-151138

Published: 2021

Journal Articles

Impediment of Gpibα-Mediated Platelet Clearance By an Anti-Gpibβ Antibody Derivative

Wenchun Chen, Moriah Simone Wilson, Yingchun Wang, Francois Lanza, Renhao Li

Blood (2021) 138 (Supplement 1): 1003.

https://doi.org/10.1182/blood-2021-150936

Published: 2021

Journal Articles

Nanobody Activators of Von Willebrand Factor Via Targeting Its Autoinhibitory Module

Nicholas A Arce, Ally J Su, Renhao Li

Blood (2021) 138 (Supplement 1): 2074.

https://doi.org/10.1182/blood-2021-151052

Published: 2021

Journal Articles

Characterization of Recombinant β2GPI Using Hydrogen-Deuterium Exchange and X-Ray Crystallography

Ravi Kumar Alluri, PhD, Nicholas Arce, Philip Klenotic, Chih Chia Su, PhD, Suman Kundu, MBA, Edward Yu, PhD, Renhao Li, PhD, Keith R McCrae, MD

Blood (2019) 134 (Supplement_1): 1105.

https://doi.org/10.1182/blood-2019-131386

Published: 2019

Journal Articles

Short-Acting Anti-VWF Aptamer Improves the Recovery and Survival, and Hemostatic Functions of Refrigerated Platelets

Wenchun Chen, PhD, Kayleigh M Voos, BS, Cassandra D Josephson, MD, Renhao Li, PhD

Blood (2018) 132 (Supplement 1): 741.

https://doi.org/10.1182/blood-2018-99-113955

Published: 2018

Journal Articles

Novel Antibodies Against Glycoprotein Ibα Inhibit Pulmonary Metastasis By Affecting Vwf-Gpibα Interaction

Qi Yingxue, Wenchun Chen, PhD, Ke Xu, Fengying Wu, Xuemei Fan, Shengxiang Ren, Junling Liu, Wei Deng, PhD, Jun Zhang, Renhao Li, PhD, Jianwen Liu, Xin Liang, PhD

Blood (2018) 132 (Supplement 1): 1133.

https://doi.org/10.1182/blood-2018-99-117613

Published: 2018

Journal Articles

A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice

Randolph Lyde, PhD, Hyunsook Ahn, Vincent Hayes, Sergei Zaistev, PhD, Shu-Wha Lin, PhD, Zaverio M. Ruggeri, MD, Renhao Li, PhD, Vladimir Muzykantov, Douglas B. Cines, MD, Mortimer Poncz, MD

Blood (2018) 132 (Supplement 1): 990.

https://doi.org/10.1182/blood-2018-99-115262

Published: 2018

Journal Articles

Mechanisms of platelet clearance and translation to improve platelet storage

M. Edward Quach, Wenchun Chen, Renhao Li

Blood (2018) 131 (14): 1512–1521.

https://doi.org/10.1182/blood-2017-08-743229

Published: 2018

Journal Articles

Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets

M. Edward Quach, Matthew A. Dragovich, Wenchun Chen, Anum K. Syed, Wenpeng Cao, Xin Liang, Wei Deng, Simon F. De Meyer, Guangheng Zhu, Jun Peng, Heyu Ni, Carolyn M. Bennett, Ming Hou, Jerry Ware, Hans Deckmyn, X. Frank Zhang, Renhao Li

Blood (2018) 131 (7): 787–796.

https://doi.org/10.1182/blood-2017-05-784975

Published: 2018

Includes: Supplemental data

Journal Articles

Mapping the Masked Region of the A1 Domain in Full-Length VWF

Wei Deng, PhD, Ernest T. Parker, BA, John S. Lollar, MD, Renhao Li, PhD

Blood (2017) 130 (Supplement 1): 3599.

https://doi.org/10.1182/blood.V130.Suppl_1.3599.3599

Published: 2017

Journal Articles

Calcium-Induced Conformational Changes in EF hands and Autoinhibitory Linker Region are Critical for Catalytic Activity of CalDAG-GEFI Towards the Small GTPase Rap1

Aaron Cook, Wei Deng, PhD, Renhao Li, PhD, John Sondek, PhD, Wolfgang Bergmeier, PhD

Blood (2017) 130 (Supplement 1): 3614.

https://doi.org/10.1182/blood.V130.Suppl_1.3614.3614

Published: 2017

Journal Articles

Twins actin’ differently

Renhao Li

Blood (2017) 130 (15): 1688–1689.

https://doi.org/10.1182/blood-2017-08-799767

Published: 2017

Journal Articles

Structural Basis for the Procofactor to Cofactor Transition in Human Factor V

Shekhar Kumar, PhD, Wei Deng, PhD, Steven Stayrook, PhD, Renhao Li, PhD, Rodney M. Camire, PhD, Sriram Krishnaswamy, PhD

Blood (2016) 128 (22): 253.

https://doi.org/10.1182/blood.V128.22.253.253

Published: 2016

Journal Articles

A Short N-Terminal Fragment in Front of the A1 Domain of Von Willebrand Factor Prevents the A1 from Binding the Platelet By Masking a Region Clustered By Type 2B VWD Mutations

Wei Deng, PhD, Yingchun Wang, PhD, Pete Lollar, MD, Renhao Li, PhD

Blood (2016) 128 (22): 553.

https://doi.org/10.1182/blood.V128.22.553.553

Published: 2016

Journal Articles

High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors

Glaivy Batsuli, Wei Deng, John F. Healey, Ernest T. Parker, W. Hunter Baldwin, Courtney Cox, Brenda Nguyen, Joerg Kahle, Christoph Königs, Renhao Li, Pete Lollar, Shannon L. Meeks

Blood (2016) 128 (16): 2055–2067.

https://doi.org/10.1182/blood-2016-02-701805

Published: 2016

Includes: Supplemental data

Journal Articles

Expanding the binding model of DITP

Renhao Li

Blood (2015) 126 (18): 2080–2081.

https://doi.org/10.1182/blood-2015-09-666586

Published: 2015

NARROW

Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module

Platelet size matters

The Variable Heavy Chain Antibody Syn-VWFA1 Inhibits the Interaction of Platelets to Von Willebrand Factor in Solution but Not to Immobilized Von Willebrand Factor Thereby Inhibiting 3-Dimensional but Not 2-Dimensional Thrombus Formation

Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain

Autoinhibition of Mouse Von Willebrand Factor: Addressing the Species Compatibility between VWF and Gpibα in Humans and Mice

Impediment of Gpibα-Mediated Platelet Clearance By an Anti-Gpibβ Antibody Derivative

Nanobody Activators of Von Willebrand Factor Via Targeting Its Autoinhibitory Module

Characterization of Recombinant β2GPI Using Hydrogen-Deuterium Exchange and X-Ray Crystallography

Short-Acting Anti-VWF Aptamer Improves the Recovery and Survival, and Hemostatic Functions of Refrigerated Platelets

Novel Antibodies Against Glycoprotein Ibα Inhibit Pulmonary Metastasis By Affecting Vwf-Gpibα Interaction

A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice

Mechanisms of platelet clearance and translation to improve platelet storage

Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets

Mapping the Masked Region of the A1 Domain in Full-Length VWF

Calcium-Induced Conformational Changes in EF hands and Autoinhibitory Linker Region are Critical for Catalytic Activity of CalDAG-GEFI Towards the Small GTPase Rap1

Twins actin’ differently

Structural Basis for the Procofactor to Cofactor Transition in Human Factor V

A Short N-Terminal Fragment in Front of the A1 Domain of Von Willebrand Factor Prevents the A1 from Binding the Platelet By Masking a Region Clustered By Type 2B VWD Mutations

High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors

Expanding the binding model of DITP

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American Society of Hematology

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ASH Publications

American Society of Hematology

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