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Journal Articles

Open ADAMTS13, induced by antibodies, is a biomarker for subclinical immune-mediated thrombotic thrombocytopenic purpura

Blood (2020) 136 (3): 353–361.

https://doi.org/10.1182/blood.2019004221

Published: 2020

Includes: Supplemental data

Journal Articles

Anti-CUB1 or Anti-Spacer Antibodies That Increase ADAMTS13 Activity Act By Allosterically Enhancing Metalloprotease Domain Function

An-Sofie Schelpe, Anastasis Petri, Nele Vandeputte, Hans Deckmyn, PhD, Simon F De Meyer, PhD, James TB Crawley, PhD, Karen Vanhoorelbeke, PhD

Blood (2018) 132 (Supplement 1): 23.

https://doi.org/10.1182/blood-2018-99-117061

Published: 2018

Journal Articles

Open ADAMTS13 Conformation in Immune-Mediated Thrombotic Thrombocytopenic Purpura Is Induced By Anti-ADAMTS13 Autoantibodies and Corresponds with an Ongoing ADAMTS13 Pathology

Blood (2018) 132 (Supplement 1): 222.

https://doi.org/10.1182/blood-2018-99-113762

Published: 2018

Journal Articles

Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque–triggered thrombus formation in humans

Kristina Busygina, Janina Jamasbi, Till Seiler, Hans Deckmyn, Christian Weber, Richard Brandl, Reinhard Lorenz, Wolfgang Siess

Blood (2018) 131 (24): 2605–2616.

https://doi.org/10.1182/blood-2017-09-808808

Published: 2018

Includes: Multimedia, Supplemental data

Journal Articles

Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets

M. Edward Quach, Matthew A. Dragovich, Wenchun Chen, Anum K. Syed, Wenpeng Cao, Xin Liang, Wei Deng, Simon F. De Meyer, Guangheng Zhu, Jun Peng, Heyu Ni, Carolyn M. Bennett, Ming Hou, Jerry Ware, Hans Deckmyn, X. Frank Zhang, Renhao Li

Blood (2018) 131 (7): 787–796.

https://doi.org/10.1182/blood-2017-05-784975

Published: 2018

Includes: Supplemental data

Journal Articles

N -acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura

Claudia Tersteeg, Jan Roodt, Walter J. Van Rensburg, Charlotte Dekimpe, Nele Vandeputte, Inge Pareyn, Aline Vandenbulcke, Barbara Plaimauer, Seb Lamprecht, Hans Deckmyn, José A. Lopez, Simon F. De Meyer, Karen Vanhoorelbeke

Blood (2017) 129 (8): 1030–1038.

https://doi.org/10.1182/blood-2016-09-738856

Published: 2017

Includes: Supplemental data

Journal Articles

ADAMTS13-mediated thrombolysis of t-PA–resistant occlusions in ischemic stroke in mice

Frederik Denorme, Friederike Langhauser, Linda Desender, Aline Vandenbulcke, Hanspeter Rottensteiner, Barbara Plaimauer, Olivier François, Tommy Andersson, Hans Deckmyn, Friedrich Scheiflinger, Christoph Kleinschnitz, Karen Vanhoorelbeke, Simon F. De Meyer

Blood (2016) 127 (19): 2337–2345.

https://doi.org/10.1182/blood-2015-08-662650

Published: 2016

Includes: Supplemental data

Journal Articles

Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice

Sebastien Verhenne, Frederik Denorme, Sarah Libbrecht, Aline Vandenbulcke, Inge Pareyn, Hans Deckmyn, Antoon Lambrecht, Bernhard Nieswandt, Christoph Kleinschnitz, Karen Vanhoorelbeke, Simon F. De Meyer

Blood (2015) 126 (14): 1715–1722.

https://doi.org/10.1182/blood-2015-03-632901

Published: 2015

Includes: Supplemental data

Journal Articles

Inhibition of von Willebrand factor–platelet glycoprotein Ib interaction prevents and reverses symptoms of acute acquired thrombotic thrombocytopenic purpura in baboons

Hendrik B. Feys, Jan Roodt, Nele Vandeputte, Inge Pareyn, Harald Mottl, Sam Hou, Seb Lamprecht, Walter J. Van Rensburg, Hans Deckmyn, Karen Vanhoorelbeke

Blood (2012) 120 (17): 3611–3614.

https://doi.org/10.1182/blood-2012-04-421248

Published: 2012

Includes: Supplemental data

Journal Articles

Model systems of genetically modified platelets

Tim Thijs, Hans Deckmyn, Katleen Broos

Blood (2012) 119 (7): 1634–1642.

https://doi.org/10.1182/blood-2011-10-381715

Published: 2012

Journal Articles

The CX3C chemokine fractalkine mediates platelet adhesion via the von Willebrand receptor glycoprotein Ib

Sascha Meyer dos Santos, Ute Klinkhardt, Klaus Scholich, Karen Nelson, Nadejda Monsefi, Hans Deckmyn, Karina Kuczka, Anita Zorn, Sebastian Harder

Blood (2011) 117 (18): 4999–5008.

https://doi.org/10.1182/blood-2011-02-335471

Published: 2011

Includes: Multimedia, Supplemental data

Journal Articles

Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow

Judith M. E. M. Cosemans, Saskia E. M. Schols, Lucia Stefanini, Susanne de Witt, Marion A. H. Feijge, Karly Hamulyák, Hans Deckmyn, Wolfgang Bergmeier, Johan W. M. Heemskerk

Blood (2011) 117 (2): 651–660.

https://doi.org/10.1182/blood-2010-01-262683

Published: 2011

Includes: Multimedia, Supplemental data

Journal Articles

Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function

Blood (2010) 116 (22): 4646–4656.

https://doi.org/10.1182/blood-2010-04-280925

Published: 2010

Includes: Supplemental data

Journal Articles

Thrombotic thrombocytopenic purpura directly linked with ADAMTS13 inhibition in the baboon ( Papio ursinus )

Hendrik B. Feys, Jan Roodt, Nele Vandeputte, Inge Pareyn, Seb Lamprecht, Walter J. van Rensburg, Patricia J. Anderson, Ulrich Budde, Vernon J. Louw, Philip N. Badenhorst, Hans Deckmyn, Karen Vanhoorelbeke

Blood (2010) 116 (12): 2005–2010.

https://doi.org/10.1182/blood-2010-04-280479

Published: 2010

Includes: Supplemental data

Journal Articles

Human platelets produced in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice upon transplantation of human cord blood CD34 + cells are functionally active in an ex vivo flow model of thrombosis

Isabelle I. Salles, Tim Thijs, Christine Brunaud, Simon F. De Meyer, Johan Thys, Karen Vanhoorelbeke, Hans Deckmyn

Blood (2009) 114 (24): 5044–5051.

https://doi.org/10.1182/blood-2009-02-205989

Published: 2009

Includes: Multimedia, Supplemental data

Journal Articles

Drug Inhibition of GPIb.

Hans Deckmyn, PhD, Simon F. De Meyer, PhD, Karen Vanhoorelbeke, PhD

Blood (2009) 114 (22): SCI-38.

https://doi.org/10.1182/blood.V114.22.SCI-38.SCI-38

Published: 2009

Journal Articles

Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura

Hendrik B. Feys, Inge Pareyn, Renee Vancraenenbroeck, Marc De Maeyer, Hans Deckmyn, Chris Van Geet, Karen Vanhoorelbeke

Blood (2009) 114 (21): 4749–4752.

https://doi.org/10.1182/blood-2009-07-230615

Published: 2009

Journal Articles

von Willebrand factor to the rescue

Simon F. De Meyer, Hans Deckmyn, Karen Vanhoorelbeke

Blood (2009) 113 (21): 5049–5057.

https://doi.org/10.1182/blood-2008-10-165621

Published: 2009

Journal Articles

Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins

Marie N. O'Connor, Isabelle I. Salles, Ana Cvejic, Nicholas A. Watkins, Adam Walker, Stephen F. Garner, Chris I. Jones, Iain C. Macaulay, Michael Steward, Jaap-Jan Zwaginga, Sarah L. Bray, Frank Dudbridge, Bernard de Bono, Alison H. Goodall, Hans Deckmyn, Derek L. Stemple, Willem H. Ouwehand

Blood (2009) 113 (19): 4754–4762.

https://doi.org/10.1182/blood-2008-06-162693

Published: 2009

Includes: Multimedia, Supplemental data

Journal Articles

Deficiency of von Willebrand factor protects mice from ischemic stroke

Christoph Kleinschnitz, Simon F. De Meyer, Tobias Schwarz, Madeleine Austinat, Karen Vanhoorelbeke, Bernhard Nieswandt, Hans Deckmyn, Guido Stoll

Blood (2009) 113 (15): 3600–3603.

https://doi.org/10.1182/blood-2008-09-180695

Published: 2009

Includes: Supplemental data

NARROW

Open ADAMTS13, induced by antibodies, is a biomarker for subclinical immune-mediated thrombotic thrombocytopenic purpura

Anti-CUB1 or Anti-Spacer Antibodies That Increase ADAMTS13 Activity Act By Allosterically Enhancing Metalloprotease Domain Function

Open ADAMTS13 Conformation in Immune-Mediated Thrombotic Thrombocytopenic Purpura Is Induced By Anti-ADAMTS13 Autoantibodies and Corresponds with an Ongoing ADAMTS13 Pathology

Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque–triggered thrombus formation in humans

Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets

N -acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura

ADAMTS13-mediated thrombolysis of t-PA–resistant occlusions in ischemic stroke in mice

Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice

Inhibition of von Willebrand factor–platelet glycoprotein Ib interaction prevents and reverses symptoms of acute acquired thrombotic thrombocytopenic purpura in baboons

Model systems of genetically modified platelets

The CX3C chemokine fractalkine mediates platelet adhesion via the von Willebrand receptor glycoprotein Ib

Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow

Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function

Thrombotic thrombocytopenic purpura directly linked with ADAMTS13 inhibition in the baboon ( Papio ursinus )

Human platelets produced in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice upon transplantation of human cord blood CD34 + cells are functionally active in an ex vivo flow model of thrombosis

Drug Inhibition of GPIb.

Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura

von Willebrand factor to the rescue

Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins

Deficiency of von Willebrand factor protects mice from ischemic stroke

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American Society of Hematology

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