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Journal Articles

Peak ADAMTS13 activity to assess ADAMTS13 conformation and risk of relapse in immune-mediated thrombotic thrombocytopenic purpura

Nithya Prasannan, Bertina Dragunaite, Maryam Subhan, Mari Thomas, Rens de Groot, Deepak Singh, Karen Vanhoorelbeke, Marie Scully

Blood (2024) 143 (25): 2644–2653.

https://doi.org/10.1182/blood.2023023269

Published: 2024

Includes: Supplemental data

Journal Articles

Comparing the Impact of Rituximab Dosing on Longitudinal ADAMTS13 Parameters in TTP

Maryam Subhan, Nithya Prasannan, Bertina Dragunaite, Karen Vanhoorelbeke, Marie Scully, Mari Thomas

Blood (2023) 142 (Supplement 1): 694.

https://doi.org/10.1182/blood-2023-190542

Published: 2023

Journal Articles

ADAMTS13 Conformation and Immunoprofiles in Japanese Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura

Kazuya Sakai, Masanori Matsumoto, Laure De Waele, Charlotte Dekimpe, Eriko Hamada, Masayuki Kubo, Claudia Tersteeg, Simon F De Meyer, Karen Vanhoorelbeke

Blood (2022) 140 (Supplement 1): 2790–2791.

https://doi.org/10.1182/blood-2022-159415

Published: 2022

Journal Articles

Regulation of VWF Cleavage Is Mediated By Coupling ADAMTS13 D- and C- Domain Binding Sites

Joshua Muia, J. Cameron Barton, Kathryn L Smith, Karen Vanhoorelbeke, Veera V Manukonda, Anna Platt, Frida Miranda

Blood (2022) 140 (Supplement 1): 5580–5581.

https://doi.org/10.1182/blood-2022-168339

Published: 2022

Journal Articles

Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP

Bojing Shao, Christopher Hoover, Huiping Shi, Yuji Kondo, Robert H. Lee, Junmei Chen, Xindi Shan, Jianhua Song, J. Michael McDaniel, Meixiang Zhou, Samuel McGee, Karen Vanhoorelbeke, Wolfgang Bergmeier, José A. López, James N. George, Lijun Xia

Blood (2022) 139 (16): 2523–2533.

https://doi.org/10.1182/blood.2021012896

Published: 2022

Includes: Supplemental data

Journal Articles

Microlyse: a thrombolytic agent that targets VWF for clearance of microvascular thrombosis

Steven de Maat, Chantal C. Clark, Arjan D. Barendrecht, Simone Smits, Nadine D. van Kleef, Hinde El Otmani, Manon Waning, Marc van Moorsel, Michael Szardenings, Nicolas Delaroque, Kristof Vercruysse, Rolf T. Urbanus, Silvie Sebastian, Peter J. Lenting, Christoph Hagemeyer, Thomas Renné, Karen Vanhoorelbeke, Claudia Tersteeg, Coen Maas

Blood (2022) 139 (4): 597–607.

https://doi.org/10.1182/blood.2021011776

Published: 2022

Includes: Supplemental data

Journal Articles

N-glycan–mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP

Bogac Ercig, Nuno A. G. Graça, Kadri Kangro, Tom Arfman, Kanin Wichapong, Johana Hrdinová, Paul Kaijen, Floris P. J. van Alphen, Maartje van den Biggelaar, Karen Vanhoorelbeke, Agnès Veyradier, Paul Coppo, Chris Reutelingsperger, Gerry A. F. Nicolaes, Andres Männik, Jan Voorberg

Blood (2021) 137 (19): 2694–2698.

https://doi.org/10.1182/blood.2020007972

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

Open ADAMTS13, induced by antibodies, is a biomarker for subclinical immune-mediated thrombotic thrombocytopenic purpura

Blood (2020) 136 (3): 353–361.

https://doi.org/10.1182/blood.2019004221

Published: 2020

Includes: Supplemental data

Journal Articles

Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation

Joshua Muia, Jian Zhu, Suellen C. Greco, Karen Vanhoorelbeke, Garima Gupta, Lisa A. Westfield, J. Evan Sadler

Blood (2019) 133 (17): 1899–1908.

https://doi.org/10.1182/blood-2018-11-886275

Published: 2019

Includes: Supplemental data

Journal Articles

Exploring the “minimal” structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering

Jian Zhu, Joshua Muia, Garima Gupta, Lisa A. Westfield, Karen Vanhoorelbeke, Niraj H. Tolia, J. Evan Sadler

Blood (2019) 133 (17): 1909–1918.

https://doi.org/10.1182/blood-2018-11-886309

Published: 2019

Includes: Supplemental data

Journal Articles

Anti-CUB1 or Anti-Spacer Antibodies That Increase ADAMTS13 Activity Act By Allosterically Enhancing Metalloprotease Domain Function

An-Sofie Schelpe, Anastasis Petri, Nele Vandeputte, Hans Deckmyn, PhD, Simon F De Meyer, PhD, James TB Crawley, PhD, Karen Vanhoorelbeke, PhD

Blood (2018) 132 (Supplement 1): 23.

https://doi.org/10.1182/blood-2018-99-117061

Published: 2018

Journal Articles

Open ADAMTS13 Conformation in Immune-Mediated Thrombotic Thrombocytopenic Purpura Is Induced By Anti-ADAMTS13 Autoantibodies and Corresponds with an Ongoing ADAMTS13 Pathology

Blood (2018) 132 (Supplement 1): 222.

https://doi.org/10.1182/blood-2018-99-113762

Published: 2018

Journal Articles

Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura

Blood (2018) 132 (20): 2143–2153.

https://doi.org/10.1182/blood-2018-04-840090

Published: 2018

Includes: Supplemental data

Journal Articles

Presenting ADAMTS13 antibody and antigen levels predict prognosis in immune-mediated thrombotic thrombocytopenic purpura

Blood (2017) 130 (4): 466–471.

https://doi.org/10.1182/blood-2016-12-758656

Published: 2017

Journal Articles

N -acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura

Claudia Tersteeg, Jan Roodt, Walter J. Van Rensburg, Charlotte Dekimpe, Nele Vandeputte, Inge Pareyn, Aline Vandenbulcke, Barbara Plaimauer, Seb Lamprecht, Hans Deckmyn, José A. Lopez, Simon F. De Meyer, Karen Vanhoorelbeke

Blood (2017) 129 (8): 1030–1038.

https://doi.org/10.1182/blood-2016-09-738856

Published: 2017

Includes: Supplemental data

Journal Articles

Phylogenetic Analysis Identifies a Subset of ADAMTS13 Domains That Are Highly Conserved and Essential for Allosteric Regulation

Joshua Muia, PhD, Jian Zhu, PhD, Suellen Greco, DVM, Karen Vanhoorelbeke, PhD, Louis Deforche, PhD, Lisa Westfield, Garima Tyagi, PhD, J. Evan Sadler, MD PhD

Blood (2016) 128 (22): 1385.

https://doi.org/10.1182/blood.V128.22.1385.1385

Published: 2016

Journal Articles

The Hunt for the "Minimal" Structure of a Functional ADAMTS13: Study of Deletion Mutations of ADAMTS13 By Small-Angle X-Ray Scattering

Jian Zhu, PhD, Joshua Muia, PhD, Louis Deforche, PhD, Karen Vanhoorelbeke, PhD, Niraj H. Tolia, PhD, J. Evan Sadler, MD PhD

Blood (2016) 128 (22): 254.

https://doi.org/10.1182/blood.V128.22.254.254

Published: 2016

Journal Articles

Glycans of plasma ADAMTS13

Karen Vanhoorelbeke

Blood (2016) 128 (21): 2485–2486.

https://doi.org/10.1182/blood-2016-10-738773

Published: 2016

Journal Articles

ADAMTS13-mediated thrombolysis of t-PA–resistant occlusions in ischemic stroke in mice

Frederik Denorme, Friederike Langhauser, Linda Desender, Aline Vandenbulcke, Hanspeter Rottensteiner, Barbara Plaimauer, Olivier François, Tommy Andersson, Hans Deckmyn, Friedrich Scheiflinger, Christoph Kleinschnitz, Karen Vanhoorelbeke, Simon F. De Meyer

Blood (2016) 127 (19): 2337–2345.

https://doi.org/10.1182/blood-2015-08-662650

Published: 2016

Includes: Supplemental data

Journal Articles

Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice

Sebastien Verhenne, Frederik Denorme, Sarah Libbrecht, Aline Vandenbulcke, Inge Pareyn, Hans Deckmyn, Antoon Lambrecht, Bernhard Nieswandt, Christoph Kleinschnitz, Karen Vanhoorelbeke, Simon F. De Meyer

Blood (2015) 126 (14): 1715–1722.

https://doi.org/10.1182/blood-2015-03-632901

Published: 2015

Includes: Supplemental data

NARROW

Peak ADAMTS13 activity to assess ADAMTS13 conformation and risk of relapse in immune-mediated thrombotic thrombocytopenic purpura

Comparing the Impact of Rituximab Dosing on Longitudinal ADAMTS13 Parameters in TTP

ADAMTS13 Conformation and Immunoprofiles in Japanese Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura

Regulation of VWF Cleavage Is Mediated By Coupling ADAMTS13 D- and C- Domain Binding Sites

Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP

Microlyse: a thrombolytic agent that targets VWF for clearance of microvascular thrombosis

N-glycan–mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP

Open ADAMTS13, induced by antibodies, is a biomarker for subclinical immune-mediated thrombotic thrombocytopenic purpura

Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation

Exploring the “minimal” structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering

Anti-CUB1 or Anti-Spacer Antibodies That Increase ADAMTS13 Activity Act By Allosterically Enhancing Metalloprotease Domain Function

Open ADAMTS13 Conformation in Immune-Mediated Thrombotic Thrombocytopenic Purpura Is Induced By Anti-ADAMTS13 Autoantibodies and Corresponds with an Ongoing ADAMTS13 Pathology

Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura

Presenting ADAMTS13 antibody and antigen levels predict prognosis in immune-mediated thrombotic thrombocytopenic purpura

N -acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura

Phylogenetic Analysis Identifies a Subset of ADAMTS13 Domains That Are Highly Conserved and Essential for Allosteric Regulation

The Hunt for the "Minimal" Structure of a Functional ADAMTS13: Study of Deletion Mutations of ADAMTS13 By Small-Angle X-Ray Scattering

Glycans of plasma ADAMTS13

ADAMTS13-mediated thrombolysis of t-PA–resistant occlusions in ischemic stroke in mice

Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice

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American Society of Hematology

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ASH Publications

American Society of Hematology

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