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Alain Chion
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Journal Articles

The aptamer BT200 blocks interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1

Alain Chion, Ciara Byrne, Ferdows Atiq, Dearbhla Doherty, Sonia Aguila, Judicael Fazavana, Patricia Lopes, Ellie Karampini, Aamir Amin, Roger J. S. Preston, Ross I. Baker, Thomas A. J. McKinnon, Shuhao Zhu, James C. Gilbert, Jonas Emsley, Bernd Jilma, James S. O’Donnell
Journal: Blood
Blood (2024) 144 (13): 1445–1456.
https://doi.org/10.1182/blood.2024024055
Published: 2024
Includes: Supplemental data
Journal Articles

Increased galactose expression and enhanced clearance in patients with low von Willebrand factor

Sonia Aguila, Michelle Lavin, Niall Dalton, Sean Patmore, Alain Chion, George D. Trahan, Kenneth L. Jones, Catriona Keenan, Teresa M. Brophy, Niamh M. O’Connell, Kevin Ryan, Mary Byrne, Margaret Nolan, Anjali Patel, Roger J. S. Preston, Paula James, Jorge Di Paola, Jamie M. O’Sullivan, James S. O’Donnell
Journal: Blood
Blood (2019) 133 (14): 1585–1596.
https://doi.org/10.1182/blood-2018-09-874636
Published: 2019
Includes: Supplemental data
Journal Articles

Defining the Molecular Mechanisms through Which the Macrophage Galactose Lectin (MGL) Receptor Regulates Von Willebrand Factor Clearance

Soracha E Ward, BSc, Jamie M O'Sullivan, Sonia Aguila Martinez, BSc, PhD, Clive Drakeford, BSc, Thomas Anthony Jude McKinnon, BSc, PhD, Alain Chion, BSc, PhD, James S O'Donnell, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 980.
https://doi.org/10.1182/blood-2018-99-114775
Published: 2018
Journal Articles

A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance

Brief Report
Soracha E. Ward, Jamie M. O’Sullivan, Clive Drakeford, Sonia Aguila, Christopher N. Jondle, Jyotika Sharma, Padraic G. Fallon, Teresa M. Brophy, Roger J. S. Preston, Paul Smyth, Orla Sheils, Alain Chion, James S. O’Donnell
Journal: Blood
Blood (2018) 131 (8): 911–916.
https://doi.org/10.1182/blood-2017-06-787853
Published: 2018
Includes: Supplemental data
Journal Articles

N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance

Alain Chion, Jamie M. O’Sullivan, Clive Drakeford, Gudmundur Bergsson, Niall Dalton, Sonia Aguila, Soracha Ward, Padraic G. Fallon, Teresa M. Brophy, Roger J. S. Preston, Lauren Brady, Orla Sheils, Michael Laffan, Thomas A. J. McKinnon, James S. O’Donnell
Journal: Blood
Blood (2016) 128 (15): 1959–1968.
https://doi.org/10.1182/blood-2016-04-709436
Published: 2016
Includes: Supplemental data
Journal Articles

A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria

Niamh O’Regan, Kristina Gegenbauer, Jamie M. O’Sullivan, Sanaz Maleki, Teresa M. Brophy, Niall Dalton, Alain Chion, Padraic G. Fallon, Georges E. Grau, Ulrich Budde, Owen P. Smith, Alister G. Craig, Roger J. S. Preston, James S. O’Donnell
Journal: Blood
Blood (2016) 127 (9): 1192–1201.
https://doi.org/10.1182/blood-2015-07-654921
Published: 2016
Includes: Supplemental data
Journal Articles

N-Linked Glycans within the A1A2A3 Domains of VWF Play a Critical Role in Modulating Macrophage-Mediated Clearance

Alain Chion, Jamie O'Sullivan, Gudmundur Bergsson, Sean Keyes, Orla Rawley, Padraic Fallon, PhD, Nico van Rooijen, PhD, Michael Laffan, MD, Thomas Anthony Jude McKinnon, PhD, Teresa Brophy, James S O'Donnell, MD PhD
Journal: Blood
Blood (2014) 124 (21): 469.
https://doi.org/10.1182/blood.V124.21.469.469
Published: 2014
Journal Articles

Identification Of Galectin-1 and Galectin-3 As Novel Binding Partners For Factor VIII

Jamie O' Sullivan, Orla Rawley, Vince Jenkins, PhD, Alain Chion, PhD, Teresa M Brophy, PhD, James S O'Donnell, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 28.
https://doi.org/10.1182/blood.V122.21.28.28
Published: 2013