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Journal Articles

The sickle erythrocyte yields another DAMP

Kevin R. Rarick, Kirkwood A. Pritchard, Jr

Blood (2021) 137 (22): 3010–3011.

https://doi.org/10.1182/blood.2021011143

Published: 2021

Journal Articles

Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease

Blood (2021) 137 (22): 3116–3126.

https://doi.org/10.1182/blood.2020009063

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

Oxphos Inhibition Induces Formation of Tunneling Nanotubes in AML Cells and Facilitates Mitochondrial Transfer from BM Stroma to AML That Contributes to Microenvironment-Mediated Drug-Resistance of AML

Blood (2019) 134 (Supplement_1): 911.

https://doi.org/10.1182/blood-2019-125007

Published: 2019

Journal Articles

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Jayna J Mistry, BSc, Christopher R Marlein, PhD, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Iain Macauley, PhD BSc, Naiara Beraza, PhD, Yu Sun, BSc, MSc, PhD, Adam Morfakis, BSc, Angela Patterson, PhD, Rebecca H Horton, Devina Divekar, Christopher J Morris, PhD, Anna Haestier, Bsc, PgD MBBS, MRCOG, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2019) 134 (Supplement_1): 2490.

https://doi.org/10.1182/blood-2019-128241

Published: 2019

Journal Articles

Hematological Presentation and Change in Clinical Phenotype during Follow-up in Pearson Syndrome

Ayami Yoshimi, MD PhD, Sarah C Grünert, MD, Holger Cario, MD PhD, Ute Gross-Wieltsch, MD, Udo Kontny, MD, Kyogo Suzuki, MD PhD, Stephan Lobitz, MD, Helen Wagner, MD, Irene Schmid, MD, Daniela Karall, MD, Arndt Borkhardt, MD, Miriam Erlacher, Peter Noellke, MPH, Charlotte M. Niemeyer, MD

Blood (2019) 134 (Supplement_1): 3746.

https://doi.org/10.1182/blood-2019-125199

Published: 2019

Journal Articles

Dual Targeting of Mitochondrial Unfolded Protein Response and BCL2 in Acute Myeloid Leukemia

Ran Zhao, BS, Sarah Zarabi, MD, Takenobu Nii, PhD, Ondrej Halgas, PhD, Yulia Jitkova, PhD, Vivian Ruvolo, Lauren Heese, Yuki Nishida, MD PhD, Gautam M. Borthakur, MD, Kensuke Kojima, MD PhD, Martin Stogniew, Wolfgang Oster, MD, Emil Pai, PhD, Eric Davis, MD, Hagop M. Kantarjian, MD, Aaron D Schimmer, MD PhD, Michael Andreeff, MD PhD, Jo Ishizawa, MD PhD

Blood (2019) 134 (Supplement_1): 2562.

https://doi.org/10.1182/blood-2019-127101

Published: 2019

Journal Articles

Daratumumab Inhibits AML Metabolic Capacity and Tumor Growth through Inhibition of CD38 Mediated Mitochondrial Transfer from Bone Marrow Stromal Cells to Blasts in the Leukemic Microenvironment

Jayna J Mistry, BSc, Charlotte Hellmich, MBBChir, Jamie A Moore, BSc, MSc, Christopher R Marlein, PhD, Genevra Pillinger, MB BS, Angela Collins, MBBS, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2019) 134 (Supplement_1): 1385.

https://doi.org/10.1182/blood-2019-128592

Published: 2019

Journal Articles

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

Grace A Ward, BS, Kathy McGraw, PhD, Amy F McLemore, M.S., Nghi B Lam, M.S., Hsin-An Hou, Benjamin S. Meyer, Alan F. List, MD

Blood (2019) 134 (Supplement_1): 774.

https://doi.org/10.1182/blood-2019-122358

Published: 2019

Journal Articles

Oxidized Mitochondrial DNA Is a Catalyst and Biomarker of Pyroptotic Cell Death in Myelodysplastic Syndromes

Grace A Ward, BS, Kathy L McGraw, PhD, Amy F McLemore, M.S., Farnoosh Abbas-Aghababazadeh, PhD, Hsin-An Hou, MD PhD, Thu Le Trinh, PhD, Nicole D. Vincelette, PhD, Benjamin S. Meyer, Alexis H Onimus, BS, Alexandra Calescibetta, Erika A Eksioglu, PhD MS, Sheng Wei, MD, Alan F. List, MD

Blood (2018) 132 (Supplement 1): 3076.

https://doi.org/10.1182/blood-2018-99-118493

Published: 2018

Journal Articles

Pkcε Is a Central Regulator of Mitochondrial Function and Metabolism in Acute Myeloid Leukemia

Daniela Di Marcantonio, PhD, Elena Masselli, MD, Esteban Martinez, BS, Daniela Araiza-Olivera, MD PhD, Giuliana Gobbi, PhD, Prisco Mirandola, PhD, Marco Vitale, MD, Stephen M. Sykes, PhD

Blood (2018) 132 (Supplement 1): 3926.

https://doi.org/10.1182/blood-2018-99-119758

Published: 2018

Journal Articles

Stressed Hematopoiesis Induces Mitochondrial Trafficking to Hematopoietic Stem Cells

Jayna J Mistry, BSc, Christopher Richard Marlein, BSc, Iain Macauley, PhD BSc, Rebecca H Horton, Adam Morfakis, BSc, Charlotte Hellmich, MBBChir, BSc, MRCP, Anna Haestier, Bsc, PgD MBBS, MRCOG, Kristian Bowles, MBBS, PhD, Stuart Rushworth, PhD BSc

Blood (2018) 132 (Supplement 1): 3849.

https://doi.org/10.1182/blood-2018-99-110930

Published: 2018

Journal Articles

Parenteral L-Arginine Improves Mitochondrial Function in Children with Sickle Cell Disease Admitted for Vaso-Occlusive Pain Episodes

Sruti Shiva, PhD, Lou Ann Brown, PhD, Y Wang, Carlton Dampier, MD, Amanda Watt, Vinita Tripathi, Amina Bhutta, MD, Polly Kumari, MD, Janet Figueroa, MPH, April Zmitrovich, MSW, MPH, Claudia R. Morris, MD

Blood (2018) 132 (Supplement 1): 508.

https://doi.org/10.1182/blood-2018-99-112666

Published: 2018

Journal Articles

Cell-Free Mitochondrial DNA Is Elevated in Sickle Cell Disease Patients, and Serve As a Potential Proinflammatory DAMP

Laxminath Tumburu, PhD, Shohini Ghosh-Choudhary, Emilia Alina Barbu, Simon Yang, Lauren D Harrison Ware, Ilker Tunc, PhD, Fayaz Tasaduck Seifuddin, Mehdi Pirooznia, MD PhD, Jun Zhu, PhD, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP

Blood (2018) 132 (Supplement 1): 1068.

https://doi.org/10.1182/blood-2018-99-118440

Published: 2018

Journal Articles

First-in-Human Mitochondrial Augmentation of Hematopoietic Stem Cells in Pearson Syndrome

Elad Jacoby, MD, Moriya Blumkin, PhD, Yair Anikster, MD PhD, Nira Varda-Bloom, PhD, Julia Pansheen, Omer Bar Yoseph, MD PhD, Noah Gruber, MD, Einat Lahav, MD, Michal J Besser, PhD, Jacob Schachter, MD, Noa Sher, PhD, Natalie Yivgi Ohana, PhD, Amos Toren, MD PhD

Blood (2018) 132 (Supplement 1): 1024.

https://doi.org/10.1182/blood-2018-99-113773

Published: 2018

Journal Articles

hnRNP U and DDX47 Are Novel FANCD2 Interactors That May Help to Resolve R-Loops during Mild Replication Stress

Yusuke Okamoto, MD, Masako Abe, Akiko Itaya, Junya Tomida, Akifumi Takaori-Kondo, MD PhD, Masato Taoka, Toshiaki Isobe, Minoru Takata, MD PhD

Blood (2018) 132 (Supplement 1): 1301.

https://doi.org/10.1182/blood-2018-99-112364

Published: 2018

Journal Articles

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

Asumi Yokota, PhD, Lulu Zhang, PhD, Xiaomei Yan, MD PhD, Xiaomin Feng, MD PhD, Lijun Wen, MS, George Freudiger, Maria Rife, Ally Woeste, Yoshihiro Hayashi, MD PhD, Gang Huang, PhD

Blood (2018) 132 (Supplement 1): 1311.

https://doi.org/10.1182/blood-2018-99-112529

Published: 2018

Journal Articles

All-Trans Retinoic Acid (ATRA) up-Regulates Cell Surface CD38 Expression Which Promotes Pro-Tumoral Mitochondrial Trafficking from Stromal Cells to Multiple Myeloma

Christopher Richard Marlein, BSc, Rebecca H Horton, Rachel E Piddock, BSc, Jayna J Mistry, BSc, Charlotte Hellmich, MBBChir, BSc, MRCP, Cesar A. Gomez, MD PhD FRCPath, Kristian Bowles, MBBS, PhD, Stuart Rushworth, PhD BSc

Blood (2018) 132 (Supplement 1): 3153.

https://doi.org/10.1182/blood-2018-99-110323

Published: 2018

Journal Articles

Increased Mitochondrial DNA in an ECMO Model Is Associated with Loss of Platelet Function

James Bynum, PhD, Andrew Meyer, MD MS, Daniel N Darlington, PhD, Colby McIntosh, BS, Grantham Peltier, MS, Ashley S Taylor, BA, Michael Meledeo, PhD, Andrew P. Cap, MD PhD

Blood (2017) 130 (Supplement 1): 1126.

https://doi.org/10.1182/blood.V130.Suppl_1.1126.1126

Published: 2017

Journal Articles

Mitochondria Are Transferred from Non-Malignant Stroma Cells to Malignant Plasma Cells, Via Tunnelling Nanotubules in a CD38 Dependent Mechanism, a Process That Promotes Myeloma Proliferation

Christopher Marlein, BSc, Rachel Piddock, BSc, Lyubov Zaitseva, PhD BSc, Martin Auger, MBBS, Kristian Bowles, MBBS, PhD, Stuart Rushworth, PhD BSc

Blood (2017) 130 (Supplement 1): 589.

https://doi.org/10.1182/blood.V130.Suppl_1.589.589

Published: 2017

Journal Articles

The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML

Dana Yehudai-Ofir, MD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Danny V. Jeyaraju, PhD, Xiaoming Wang, Thirushi Siriwardena, Yulia Jitkova, PhD, Aaron D. Schimmer, MDPhD, Biljana Rizoska, PhD, Paul Targett-Adams, PhD, Mark Albertella, PhD

Blood (2017) 130 (Supplement 1): 2524.

https://doi.org/10.1182/blood.V130.Suppl_1.2524.2524

Published: 2017

NARROW

The sickle erythrocyte yields another DAMP

Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease

Oxphos Inhibition Induces Formation of Tunneling Nanotubes in AML Cells and Facilitates Mitochondrial Transfer from BM Stroma to AML That Contributes to Microenvironment-Mediated Drug-Resistance of AML

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Hematological Presentation and Change in Clinical Phenotype during Follow-up in Pearson Syndrome

Dual Targeting of Mitochondrial Unfolded Protein Response and BCL2 in Acute Myeloid Leukemia

Daratumumab Inhibits AML Metabolic Capacity and Tumor Growth through Inhibition of CD38 Mediated Mitochondrial Transfer from Bone Marrow Stromal Cells to Blasts in the Leukemic Microenvironment

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

Oxidized Mitochondrial DNA Is a Catalyst and Biomarker of Pyroptotic Cell Death in Myelodysplastic Syndromes

Pkcε Is a Central Regulator of Mitochondrial Function and Metabolism in Acute Myeloid Leukemia

Stressed Hematopoiesis Induces Mitochondrial Trafficking to Hematopoietic Stem Cells

Parenteral L-Arginine Improves Mitochondrial Function in Children with Sickle Cell Disease Admitted for Vaso-Occlusive Pain Episodes

Cell-Free Mitochondrial DNA Is Elevated in Sickle Cell Disease Patients, and Serve As a Potential Proinflammatory DAMP

First-in-Human Mitochondrial Augmentation of Hematopoietic Stem Cells in Pearson Syndrome

hnRNP U and DDX47 Are Novel FANCD2 Interactors That May Help to Resolve R-Loops during Mild Replication Stress

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

All-Trans Retinoic Acid (ATRA) up-Regulates Cell Surface CD38 Expression Which Promotes Pro-Tumoral Mitochondrial Trafficking from Stromal Cells to Multiple Myeloma

Increased Mitochondrial DNA in an ECMO Model Is Associated with Loss of Platelet Function

Mitochondria Are Transferred from Non-Malignant Stroma Cells to Malignant Plasma Cells, Via Tunnelling Nanotubules in a CD38 Dependent Mechanism, a Process That Promotes Myeloma Proliferation

The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML

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American Society of Hematology

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ASH Publications

American Society of Hematology

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