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Journal Articles

Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells

May Daher, Rafet Basar, Elif Gokdemir, Natalia Baran, Nadima Uprety, Ana Karen Nunez Cortes, Mayela Mendt, Lucila Nassif Kerbauy, Pinaki P. Banerjee, Mayra Shanley, Nobuhiko Imahashi, Li Li, Francesca Lorraine Wei Inng Lim, Mohsen Fathi, Ali Rezvan, Vakul Mohanty, Yifei Shen, Hila Shaim, Junjun Lu, Gonca Ozcan, Emily Ensley, Mecit Kaplan, Vandana Nandivada, Mustafa Bdiwi, Sunil Acharya, Yuanxin Xi, Xinhai Wan, Duncan Mak, Enli Liu, Xin Ru Jiang, Sonny Ang, Luis Muniz-Feliciano, Ye Li, Jing Wang, Shahram Kordasti, Nedyalko Petrov, Navin Varadarajan, David Marin, Lorenzo Brunetti, Richard J. Skinner, Shangrong Lyu, Leiser Silva, Rolf Turk, Mollie S. Schubert, Garrett R. Rettig, Matthew S. McNeill, Gavin Kurgan, Mark A. Behlke, Heng Li, Natalie W. Fowlkes, Ken Chen, Marina Konopleva, Richard E. Champlin, Elizabeth J. Shpall, Katayoun Rezvani

Blood (2021) 137 (5): 624–636.

https://doi.org/10.1182/blood.2020007748

Published: 2021

Includes: Supplemental data

Journal Articles

Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity

Livingstone Fultang, Sarah Booth, Orli Yogev, Barbara Martins da Costa, Vanessa Tubb, Silvia Panetti, Victoria Stavrou, Ugo Scarpa, Andris Jankevics, Gavin Lloyd, Andrew Southam, Steven P. Lee, Warwick B. Dunn, Louis Chesler, Francis Mussai, Carmela De Santo

Blood (2020) 136 (10): 1155–1160.

https://doi.org/10.1182/blood.2019004500

Published: 2020

Includes: Supplemental data

Journal Articles

Donor cell engineering with GSK3 inhibitor–loaded nanoparticles enhances engraftment after in utero transplantation

Stavros P. Loukogeorgakis, Camila G. Fachin, Andre I. B. S. Dias, Haiying Li, Li Tang, Aimee G. Kim, Jesse D. Vrecenak, John D. Stratigis, Nicholas J. Ahn, Ilana Nissim, Izhtak Nissim, Antonio F. Moron, Jose L. Martins, William H. Peranteau, Paolo De Coppi, Darrell J. Irvine, Alan W. Flake

Blood (2019) 134 (22): 1983–1995.

https://doi.org/10.1182/blood.2019001037

Published: 2019

Includes: Supplemental data

Journal Articles

Engineering a Hematopoietic Stem Cell Niche By Revitalizing Mesenchymal Stem Cells with Five Transcription Factors

Fumio Nakahara, MD PhD, Sandra Pinho, PhD, Daniel K. Borger, MS, Qiaozhi Wei, PhD, Maria Maryanovich, PhD, Ali H. Zahalka, Masako Suzuki, Cristian Cruz, Zichen Wang, Chunliang Xu, PhD, Philip Boulais, PhD, Avi Ma'ayan, John M. Greally, MB, PhD, Paul S. Frenette, MD

Blood (2019) 134 (Supplement_1): 5004.

https://doi.org/10.1182/blood-2019-125045

Published: 2019

Journal Articles

Engineering Naturally Occurring CD7 Negative Cells for the Immunotherapy of CD7 Positive Leukemia

Abdullah Freiwan, MSc, Abishek Vaidya, MS, Caitlin Zebley, MD, Yiping Fan, PhD, Deanna Langfitt, PhD, Benjamin Youngblood, PhD, Maksim Mamonkin, PhD, Stephen Gottschalk, MD, Mireya Paulina Velasquez, MD

Blood (2019) 134 (Supplement_1): 868.

https://doi.org/10.1182/blood-2019-124903

Published: 2019

Journal Articles

Stringent Small Molecule Dose Requirements for the Optimal Expansion of Hematopoietic Stem Cells Revealed By Predictive Analytics and Xenotransplants

Javed K Manesia, PhD, Sakhar Almoflehi, Roya Pasha, Suria Jahan, MSc, John Blake, PhD, Julie Audet, PhD, Nicolas Pineault, PhD

Blood (2019) 134 (Supplement_1): 1185.

https://doi.org/10.1182/blood-2019-128692

Published: 2019

Journal Articles

Next Generation CRISPR Gene-Edited and Off-the-Shelf Virus-Specific T-Cells for the Immunocompromised Patient

Blood (2019) 134 (Supplement_1): 1944.

https://doi.org/10.1182/blood-2019-125276

Published: 2019

Journal Articles

Combining CAR Engineering and CIS Checkpoint Deletion in NK Cells for the Treatment of B Cell Hematologic Malignancies

Blood (2019) 134 (Supplement_1): 1936.

https://doi.org/10.1182/blood-2019-126739

Published: 2019

Journal Articles

Integrated Single Cell Transcriptomics Defines an Engineered Niche Supporting Hematopoietic Stem Cell Development Ex Vivo

Brandon Hadland, MD PhD, Barbara Varnum-Finney, PhD, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-Mckay, Dana Jackson, Shahin Rafii, MD, Cole Trapnell, PhD, Irwin D. Bernstein, MD

Blood (2019) 134 (Supplement_1): 3699.

https://doi.org/10.1182/blood-2019-126109

Published: 2019

Journal Articles

Ex vivo Engineering of Platelets

Koji Eto, MD

Blood (2019) 134 (Supplement_1): SCI-6.

https://doi.org/10.1182/blood-2019-121116

Published: 2019

Journal Articles

F-Deletion Non-Integrating Measles Virus Vector: A Promising Tool for T-Cell Engineering and Naive iPSCs Generation

Jiyuan Liao, PhD, Yasushi Soda, MD PhD, Ai Sugawara, B.Sc., Yoshie Miura, PhD, Takafumi Hiramoto, PhD, Maino Tahara, PhD, Yuto Takishima, M.S., Shohei Miyamoto, PhD, Makoto Takeda, MD PhD, Kenzaburo Tani, MD PhD

Blood (2019) 134 (Supplement_1): 5750.

https://doi.org/10.1182/blood-2019-131593

Published: 2019

Journal Articles

Interrogation of Individual CLL Loss-of-Function Lesions By CRISPR In Vivo Editing Reveals Common and Unique Pathway Alterations

Blood (2019) 134 (Supplement_1): 684.

https://doi.org/10.1182/blood-2019-127673

Published: 2019

Journal Articles

Three-D Models for Megakaryopoiesis and Platelet Production

Alessandra Balduini, MD

Blood (2019) 134 (Supplement_1): SCI-36.

https://doi.org/10.1182/blood-2019-121076

Published: 2019

Journal Articles

Ex vivo Engineering of Red Blood Cells

Jan Frayne, BsC, PhD, Deborah E Daniels, Jan Frayne, BsC PhD, Timothy J Satchwell, PhD, Joseph Hawksworth, BSc PhD, Belinda K Singleton, Tatyana N Andrienko, PhD, Marieangela C Wilson, Sabine Kupzig, Marjolein Meinders, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Ivan Ferrer Vicens, PhD MSc, BSc, Rebecca Griffiths, PhD, Nicola Cogan, Kongtana Trakarnsanga, MD PhD, David J. Anstee, PhD FRCPath, Ashley Mark Toye, PhD

Blood (2019) 134 (Supplement_1): SCI-5.

https://doi.org/10.1182/blood-2019-121117

Published: 2019

Journal Articles

Sensing and Sensibility: Programming Smarter Chimeric Antigen Receptor T Cells

Wendell Lim, PhD

Blood (2019) 134 (Supplement_1): SCI-24.

https://doi.org/10.1182/blood-2019-121120

Published: 2019

Journal Articles

Engineering High Affinity and Cleavage Resistant CD16 to Augment ADCC of Placental Hematopoietic Stem Cells-Derived Natural Killer Cells

Xuan Guo, PhD, Srinivas Somanchi, PhD, Rohit Mathur, PhD, Shuyang He, PhD, Qian Ye, PhD, Andrea Difiglia, BS, Salvatore Rotondo, MS, Hemlata Rana, MS, Weifang Ling, PhD, James Edinger, PhD, Robert Hariri, MD PhD, Xiaokui Zhang, PhD

Blood (2019) 134 (Supplement_1): 1576.

https://doi.org/10.1182/blood-2019-127009

Published: 2019

Journal Articles

Engineering CpG Deoxynucleotide-Conjugated Gold Nanoparticles for Enhanced Anti-Lymphoma Effects in an Immune Competent Lymphoma Model

Adam Yuh Lin, MD PhD, Jonathan Rink, PhD, Reem Karmali, MD, Colby Shad Thaxton, MD PhD, Leo I. Gordon, MD

Blood (2019) 134 (Supplement_1): 1577.

https://doi.org/10.1182/blood-2019-125308

Published: 2019

Journal Articles

Off-the-Shelf Natural Killer Cells with Multi-Functional Engineering Using a Novel Anti-CD19 Chimeric Antigen Receptor Combined with Stabilized CD16 and IL15 Expression to Enhance Directed Anti-Tumor Activity

Dan S Kaufman, MD PhD, Ryan Bjordahl, PhD, Huang Zhu, PhD, Robert Blum, Andres Bahena, Sajid Mahmood, PhD, Greg Bonello, PhD, Tom Lee, PhD, Bruce Walcheck, PhD, Frank Cichocki, PhD, Jeffrey S. Miller, MD, Bahram Valamehr, PhD

Blood (2018) 132 (Supplement 1): 4541.

https://doi.org/10.1182/blood-2018-99-113701

Published: 2018

Journal Articles

Robust Cell Selections and Depletions across Various Hematopoietic Cell Fractions on the Clinimacs Plus Instrument

Thejaswi Bikkani, MBBS, Katherine Li, Anusha Rao, Angela Pickett, Xiaobai Li, PhD, Minoo Battiwalla, MD, Richard W. Childs, MD, John Barrett, MD, Andre Larochelle, MD PhD, Elizabeth Kang, MD, David F. Stroncek, Sandhya R. Panch, MD MPH

Blood (2018) 132 (Supplement 1): 3818.

https://doi.org/10.1182/blood-2018-99-118582

Published: 2018

Journal Articles

Multiplex Human T Cell Engineering without Double-Strand Break Induction Using the Cas9 Base Editor System

Beau Webber, PhD, Cara-lin Lonetree, MS, Miechaleen Diers, Walker S Lahr, Kluesner Mitchell, Matthew J Johnson, PhD, Branden S Moriarity, PhD

Blood (2018) 132 (Supplement 1): 3495.

https://doi.org/10.1182/blood-2018-99-120372

Published: 2018

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Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells

Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity

Donor cell engineering with GSK3 inhibitor–loaded nanoparticles enhances engraftment after in utero transplantation

Engineering a Hematopoietic Stem Cell Niche By Revitalizing Mesenchymal Stem Cells with Five Transcription Factors

Engineering Naturally Occurring CD7 Negative Cells for the Immunotherapy of CD7 Positive Leukemia

Stringent Small Molecule Dose Requirements for the Optimal Expansion of Hematopoietic Stem Cells Revealed By Predictive Analytics and Xenotransplants

Next Generation CRISPR Gene-Edited and Off-the-Shelf Virus-Specific T-Cells for the Immunocompromised Patient

Combining CAR Engineering and CIS Checkpoint Deletion in NK Cells for the Treatment of B Cell Hematologic Malignancies

Integrated Single Cell Transcriptomics Defines an Engineered Niche Supporting Hematopoietic Stem Cell Development Ex Vivo

Ex vivo Engineering of Platelets

F-Deletion Non-Integrating Measles Virus Vector: A Promising Tool for T-Cell Engineering and Naive iPSCs Generation

Interrogation of Individual CLL Loss-of-Function Lesions By CRISPR In Vivo Editing Reveals Common and Unique Pathway Alterations

Three-D Models for Megakaryopoiesis and Platelet Production

Ex vivo Engineering of Red Blood Cells

Sensing and Sensibility: Programming Smarter Chimeric Antigen Receptor T Cells

Engineering High Affinity and Cleavage Resistant CD16 to Augment ADCC of Placental Hematopoietic Stem Cells-Derived Natural Killer Cells

Engineering CpG Deoxynucleotide-Conjugated Gold Nanoparticles for Enhanced Anti-Lymphoma Effects in an Immune Competent Lymphoma Model

Off-the-Shelf Natural Killer Cells with Multi-Functional Engineering Using a Novel Anti-CD19 Chimeric Antigen Receptor Combined with Stabilized CD16 and IL15 Expression to Enhance Directed Anti-Tumor Activity

Robust Cell Selections and Depletions across Various Hematopoietic Cell Fractions on the Clinimacs Plus Instrument

Multiplex Human T Cell Engineering without Double-Strand Break Induction Using the Cas9 Base Editor System

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American Society of Hematology

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American Society of Hematology

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