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Journal Articles

Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis by using the new oral demethylating agent OR-2100

Tatsuro Watanabe, Satoshi Yamashita, Hiroshi Ureshino, Kazuharu Kamachi, Yuki Kurahashi, Yuki Fukuda-Kurahashi, Nao Yoshida, Naoko Hattori, Hideaki Nakamura, Akemi Sato, Atsushi Kawaguchi, Naoko Sueoka-Aragane, Kensuke Kojima, Seiji Okada, Toshikazu Ushijima, Shinya Kimura, Eisaburo Sueoka
Journal: Blood
Blood (2020) 136 (7): 871–884.
https://doi.org/10.1182/blood.2019003084
Published: 2020
Includes: Supplemental data
Journal Articles

Reversible DNA Hypermethylation of the Interleukin-15 (IL-15) Promoter Induces IL-15 Expression, Drives the Pathogenesis of T-Cell Large Granular Lymphocytic Leukemia and Provides a Potential Therapeutic Approach Using 5-Azacitidine

Jonathan E Brammer, MD, Amy E Boles, BS, Anthony Mansour, MD, Aharon G. Freud, MD PhD, Monique Mathé-Allainmat, Agnès Quéméner, Erwan Mortier, Pierluigi Porcu, MD, Anjali Mishra, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3776.
https://doi.org/10.1182/blood-2019-131174
Published: 2019
Journal Articles

Whole Genome Bisulfite Sequencing of 63 Primary AML Samples Identifies a Unique DNA Hypermethylation Signature for Mutant IDH1/2 Cases That Is Different from That of TET2 Mutant AML

Ellie Wilson, BS, Nichole Helton, Catrina Fronick, BS, Robert Fulton, MS, John S. Welch, MD PhD, Timothy J Ley, MD, David H Spencer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3755.
https://doi.org/10.1182/blood-2019-122340
Published: 2019
Journal Articles

The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies

Joseph L. Wiemels, PhD, Ivo S Muskens, Shaobo Li, Priyatama Pandey, Ritu Roy, PhD, Helen M Hansen, BSc, Kimberly D Siegmund, PhD, Beth A Mueller, PhD, Xiaomei Ma, PhD, Catherine Metayer, MD PhD, Adam J de Smith, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2510.
https://doi.org/10.1182/blood-2019-131455
Published: 2019
Journal Articles

Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in AML

Sagarajit Mohanty, MSc, Nidhi Jyotsana, PhD, Amit Sharma, PhD, Basem Othman, Arnold Kloos, PhD, Madhvi Mandhania, MSc, Renate Schottmann, Euan Ramsay, PhD, Hans- Peter Vornlocher, PhD, Arnold Ganser, MD, Felicitas Thol, MD, Michael Heuser, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2545.
https://doi.org/10.1182/blood-2019-123709
Published: 2019
Journal Articles

DNA Methylation Profiling of AML Reveals Epigenetic Subgroups with Distinct Clinical Outcome

Sebastian Vosberg, Paul Kerbs, MSc, Vindi Jurinovic, MSc, Klaus H. Metzeler, MD, Susanne Amler, PhD, Cristina Sauerland, Dennis Görlich, PhD, Wolfgang E. Berdel, MD, Jan Braess, MD, Wolfgang Hiddemann, MD PhD, Karsten Spiekermann, MD, Tobias Herold, MD, Philipp A. Greif, MD PD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2715.
https://doi.org/10.1182/blood-2019-130047
Published: 2019
Journal Articles

Significant Features of DNA Methylation at Bivalent Promotor and Repressed Polycomb Regions in Pediatric AML-the Jccg Study, JPLSG AML-05-

Genki Yamato, Tomoko Kawai, PhD, Norio Shiba, Yusuke Hara, Kentaro Ohki, MD PhD, Taeko Kaburagi, MD, Kenichi Yoshida, MD PhD, Yuichi Shiraishi, PhD, Satoru Miyano, PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Akira Shimada, MD PhD, Manabu Sotomatsu, MD PhD, Hirokazu Arakawa, MD PhD, Souichi Adachi, MD PhD, Takashi Taga, MD PhD, Keizo Horibe, MD PhD, Seishi Ogawa, MD PhD, Kenichiro Hata, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2739.
https://doi.org/10.1182/blood-2019-125025
Published: 2019
Journal Articles

Aberrant Regional DNA Hypermethylation As a Preventive and Therapeutic Target for Adult T-Cell Leukemia-Lymphoma

Tatsuro Watanabe, PhD, Hiroshi Ureshino, MD, Yuki Kurahashi, Yuki Fukuda-Kurahashi, Satoshi Yamashita, PhD, Toshikazu Ushijima, MD PhD, Seiji Okada, MD PhD, Eisaburo Sueoka, MD PhD, Shinya Kimura, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4175.
https://doi.org/10.1182/blood-2018-99-117536
Published: 2018
Journal Articles

Tight Regulation of H3K79 Methylation Levels in KMT2A -Rearranged AML

Molly C. Kingsley, BS, Simone Stefanie Riedel, PhD, Hongbo Michael Xie, PhD, Sally P. Stabler, MD, Taylor Pastuer, BA, Kathrin M. Bernt, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3884.
https://doi.org/10.1182/blood-2018-99-114784
Published: 2018
Journal Articles

Association of Clinical Epidemiologic Exposures and Overall Survival with Genome-Wide DNA Methylation Profiles in Acute Myeloid Leukemia: Analysis of the Mayo Clinic AML Epidemiology Cohort

César J. Torres-Gutierrez, BS, Michael G. Heckman, Ryan A. Hlady, Rhett P. Ketterling, Lisa Z. Sproat, Kathryn E. Pearce, Elizabeth R. Lesser, Nancy N. Diehl, Laura E. Finn, Liuyan Jennifer Jiang, Keith D. Robertson, James R. Cerhan, MD PhD, James M. Foran, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3987.
https://doi.org/10.1182/blood-2018-99-119386
Published: 2018
Journal Articles

Epigenetic Profiles of Primary Endothelial Cells from Patients with Low VWF Levels

Christopher J. Ng, MD, Alice Liu, BS, Katrina J. Ashworth, MS, Kenneth L. Jones, PhD, Jorge Di Paola, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 983.
https://doi.org/10.1182/blood-2018-99-116719
Published: 2018
Journal Articles

Selective Pressure from Chemotherapy Drives Convergent Evolution in Relapsing and Refractory AML across Age Groups

Timothy Junius Triche, Jr., PhD, Benjamin K. Johnson, PhD, Lyong Heo, MS, Yizhou Peter Huang, BS, Rhonda E. Ries, MA, Hamid Bolouri, PhD, Jason E. Farrar, MD, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2609.
https://doi.org/10.1182/blood-2018-99-119323
Published: 2018
Journal Articles

Polycomb Group Proteins Recruit TET1 to Remove Aberrant DNA Methylation in Murine Embryonic Stem Cells

Yong Lei, PhD, Margaret A. Goodell, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2571.
https://doi.org/10.1182/blood-2018-99-116841
Published: 2018
Journal Articles

Integrated Analysis of Global DNA Methylation and Transcription Reveals a Leukemia Subtype with Extreme Hypermethylation Associated with Silencing of Regulators of Differentiation

Claudia Gebhard, PhD, Roger Mulet-Lazaro, B.Sc., Lucia Schwarzfischer, Dagmar Glatz, Margit Nuetzel, Daniel Heudobler, MD, Sandra Pohl, Wolfgang Herr, MD, Gerhard Ehninger, MD, Claudia Erpelinck-Verschueren, B.Sc., Stanley van Herk, B.Sc., B.J. Wouters, Christian Thiede, MD, Ruud Delwel, PhD, Michael Rehli, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2608.
https://doi.org/10.1182/blood-2018-99-118521
Published: 2018
Journal Articles

Signaling Pathways of Mutant IDH1 Independent of R-2-Hydroxyglutarate

Charu Gupta, Michelle Maria Araujo Cruz, PhD, Nidhi Jyotsana, PhD, Amit Sharma, PhD, Ramya Goparaju, PhD, Kerstin Görlich, Renate Schottmann, Eduard Struys, PhD, Erwin E Jansen, Felicitas Thol, MD, Arnold Ganser, MD, Michael Heuser, MD, Anuhar Chaturvedi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2617.
https://doi.org/10.1182/blood-2018-99-110159
Published: 2018
Journal Articles

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

Asumi Yokota, PhD, Lulu Zhang, PhD, Xiaomei Yan, MD PhD, Xiaomin Feng, MD PhD, Lijun Wen, MS, George Freudiger, Maria Rife, Ally Woeste, Yoshihiro Hayashi, MD PhD, Gang Huang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1311.
https://doi.org/10.1182/blood-2018-99-112529
Published: 2018
Journal Articles

Single-Cell Methylome and Transcriptome High-Resolution Maps Define the Effects of Epigenetic Modifiers on the Landscape of Hematopoietic Differentiation

Franco Izzo, PhD, Asaf Poran, Stanley Chun-Wei Lee, PhD, Ronan Chaligne, PhD, Federico Gaiti, PhD, Steven Kothen-Hill, MS, Rafael Schulman, BS, Michelle Ki, Kenigsberg Ephraim, PhD, Omar Abdel-Wahab, MD, Dan A. Landau, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 559.
https://doi.org/10.1182/blood.V130.Suppl_1.559.559
Published: 2017
Journal Articles

Branched Chain Amino Acid Catabolism Restricts Alpha-Ketoglutarate Levels Resembling IDH mut -Driven DNA Hypermethylation in AML Stem Cells

Simon Raffel, MD, Mattia Falcone, Niclas Kneisel, Jenny Hansson, Wei Wang, Christoph Lutz, MD, Gernot Poschet, Yannic Nonnenmacher, Patrizia Jensen, Claudia Scholl, MD, Stefan Fröhling, MD, Sibylle Cocciardi, MSc, Patrick Wuchter, MD, Christian Thiede, MD, Anne Floercken, Joerg Westermann, MD, Gerhard Ehninger, Karsten Hiller, Rüdiger Hell, Carl Herrmann, Anthony D. Ho, Jeroen Krijgsveld, Bernhard Radlwimmer, Andreas Trumpp, Prof, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 472.
https://doi.org/10.1182/blood.V130.Suppl_1.472.472
Published: 2017
Journal Articles

Preferential In Vitro and In Vivo Induction of Endogenous Retrovirus Transcription from a Monoallelic Chromosome 7q in Decitabine (DAC) Treated AML Blasts

Gabriele Greve, Dietmar Pfeifer, Sina Bengel, Michael Lübbert
Journal: Blood
Blood (2017) 130 (Supplement 1): 2612.
https://doi.org/10.1182/blood.V130.Suppl_1.2612.2612
Published: 2017
Journal Articles

Hypermethylation of GADD45A Defines a Methylation Profile Distinct to Mutant IDH1/2 , and Correlates with More Aggressive AML

Saumya E Samaraweera, PhD, Francine E. Garrett-Bakelman, MD PhD, Yaseswini Neelamraju, Michelle Perugini, PhD, Debora A. Casolari, PhD, Diana Iarossi, Sarah C Bray, PhD, Caroline Sheridan, Tak C Lee, M.S., Ing Soo Tiong, MBChB, Silke Danner, Nik Cummings, BSc, Monica L. Guzman, PhD, Gail J. Roboz, Luen Bik To, MBBS, FRACP, FRCPA, PhD, Andrew Wei, Christopher E. Mason, PhD, Christopher Y. Park, MD PhD, Ross L. Levine, MD, Martin Carroll, MD, Michael W. Becker, MD, Ian D Lewis, MBBS, PhD FRACP, FRCPA, Ari Melnick, MD, Richard D'Andrea, PhD
Journal: Blood
Blood (2016) 128 (22): 2877.
https://doi.org/10.1182/blood.V128.22.2877.2877
Published: 2016