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Journal Articles

Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumors

Blood (2021) 137 (15): 2103–2113.

https://doi.org/10.1182/blood.2020007488

Published: 2021

Includes: Supplemental data

Journal Articles

Extended Mutational Profiling By MSK-IMPACT TM Identifies Mutations Predicting Thromboembolic Risk in Patients with Solid Tumor Malignancy

Andrew Dunbar, MD, Kelly Bolton, MD PhD, Sean M. Devlin, PhD, Francisco Sanchez-Vega, PhD, Jianjiong Gao, PhD, Jodi V. Mones, MD, Jonathan M. Wills, BA, Daniel Kelly, MS, Mirko Farina, MD, Sirish Kishore, MD, Krishna Juluru, MD, Neil Iyengar, MD, David M. Hyman, MD, Ahmet Zehir, PhD, Wungki Park, MD, Alok A Khorana, MD, Gerald A. Soff, MD, Simon Mantha, MDMPH

Blood (2019) 134 (Supplement_1): 633.

https://doi.org/10.1182/blood-2019-124242

Published: 2019

Journal Articles

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

Dipti Gupta, Samuel Lessard, PhD, Nancy Moore, Jicheng Duan, PhD, Yukio Nakamura, MD PhD, Feng-Chun Yang, MD PhD, Alexandra Hicks, PhD, David R. Light, PhD, Sriram Krishnamoorthy, PhD

Blood (2019) 134 (Supplement_1): 210.

https://doi.org/10.1182/blood-2019-129479

Published: 2019

Journal Articles

Identification of Deubiquitinase OTUD1 As a Novel Player in Resistance of Multiple Myeloma to Bortezomib

Alexander Vdovin, Tomas Jelinek, MD, Matous Hrdinka, PhD, Juli R. Bago, PhD, Tereza Sevcikova, Roman Hajek, Prof, MD PhD, Michal Simicek, PhD

Blood (2019) 134 (Supplement_1): 5526.

https://doi.org/10.1182/blood-2019-127930

Published: 2019

Journal Articles

How KEAP1 Deletion in Single Cell Mitigates Sickle Cell Pathology

Nadine Keleku Lukwete, PhD, Mikiko Suzuki, PhD, Harit Panda, Akihito Otsuki, PhD, Fumiki Katsuoka, PhD, Ritsumi Saitou, MD, Daisuke Saigusa, PhD, Akira Uruno, MD PhD, Masayuki Yamamoto, MD PhD

Blood (2018) 132 (Supplement 1): 2353.

https://doi.org/10.1182/blood-2018-99-110502

Published: 2018

Journal Articles

Alternative Overexpression of NRF2 or MYC Defines a Subgroup of Poor Prognosis Acute Myeloid Leukemia and Suggests a Novel Therapeutic Strategy By Combined Bromodomain Inhibition and Forced NRF2 Pathway Activation

Giorgia Simonetti, PhD, Samantha Bruno, Carmine Onofrillo, PhD, Cristina Papayannidis, Giovanni Marconi, Michele Cavo, MD, Lorenzo Montanaro, MD PhD, Giovanni Martinelli

Blood (2018) 132 (Supplement 1): 2639.

https://doi.org/10.1182/blood-2018-99-117429

Published: 2018

Journal Articles

Defective Autophagy Process and Increased ROS Formation in Primary Myelofibrosis

Guanfang Shi, PhD, Sreenath Kodali, MBBS, MD, Ching Wong, MD, Vladimir K. Gotlieb, MD, Jen-Chin Wang, MD

Blood (2018) 132 (Supplement 1): 3069.

https://doi.org/10.1182/blood-2018-99-112406

Published: 2018

Journal Articles

Inhibition of ROS-Induced Nrf2 Antioxidant Pathway Activation May Explain Synergy between Venetoclax and Hypomethylating Agents Against Acute Myeloid Leukemia

Le Xuan Truong Nguyen, PhD, Estelle Troadec, PhD, Arjun Kalvala, PhD, Dinh Hoa Hoang, Bachelor, Domenico Viola, BS, Stephen J. Forman, MD FACP, Guido Marcucci, MD, Vinod Pullarkat, MD MRCP

Blood (2017) 130 (Supplement 1): 1367.

https://doi.org/10.1182/blood.V130.Suppl_1.1367.1367

Published: 2017

Journal Articles

Modulation of Donor Graft By the Steroidal Lactone Withaferin A Alleviates Post-Transplant Acute GVHD Via Nrf-2 Independent T-Reg Induction

Vikram Gota, MD, Miten Mehta, PhD, Dievya Gohil, MSc, Dhruv Jha, M.Pharm, Rajiv Kumar, MBBS, MD DM, Beamon Agarwal, MD PhD, Deepak Sharma, PhD, Santosh Sandur, PhD, Navin Khattry, MD DM, Anuradha Majumdar, PhD

Blood (2017) 130 (Supplement 1): 3174.

https://doi.org/10.1182/blood.V130.Suppl_1.3174.3174

Published: 2017

Journal Articles

Nrf2 Regulates Sensitivity of Leukemias to Artemisinins

Jennifer Bai, BA, Xiaochun Chen, PhD, Curt I. Civin, MD

Blood (2016) 128 (22): 2324.

https://doi.org/10.1182/blood.V128.22.2324.2324

Published: 2016

Journal Articles

Genetic Sequencing of Adult T-Cell Leukemia/Lymphoma in the Caribbean Population Shows a Distinct Mutational Profile When Compared to the Japanese Cohort

Urvi A Shah, MD, B. Hilda Ye, PhD, Jeff Hall, PhD, Yanhua Wang, MD PhD, Ronald Rice, MD PhD, Rizwan Naeem, MD, Amara Gayathri Nandikolla, MD, Swati Goel, MD, Ioannis Mantzaris, MD, Aditi Shastri, MD, Olga Derman, MD, Noah Kornblum, MD, Ira Braunschweig, MD, Amit Verma, MD, Murali Janakiram, MD

Blood (2016) 128 (22): 1758.

https://doi.org/10.1182/blood.V128.22.1758.1758

Published: 2016

Journal Articles

Antisense Oligonucleotide Against Kelch-like Ech-Associated protein1 Ameliorates Liver Injury in Sickle Cell Mice

Margaret Nettleton, Luis E. Almeida, MD PhD, Sayuri Kamimura, Richard G Lee, PhD, Gene Hung, MD, Zena Quezado, MD

Blood (2016) 128 (22): 1294.

https://doi.org/10.1182/blood.V128.22.1294.1294

Published: 2016

Journal Articles

Dual Activation of NRF2 in Multiple Myeloma and Bone Marrow Mesenchymal Stromal Cells Regulates Chemotherapy Resistance

Yu Sun, MRes, Lyubov Zaitseva, BSc, PhD, Manar S Shafat, MSc, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhDBSc

Blood (2016) 128 (22): 3287.

https://doi.org/10.1182/blood.V128.22.3287.3287

Published: 2016

Journal Articles

Specific Deletion of Keap1 in Endothelial Cells or/and Macrophages of SCD Mice Induces Nrf2 to Protect Tissues Against Oxidative Insults

Nadine Keleku-Lukwete, MD PhD, Panda Harit, Eriko Naganuma, Mikiko Suzuki, PhD, Masayuki Yamamoto, MD PhD

Blood (2016) 128 (22): 2475.

https://doi.org/10.1182/blood.V128.22.2475.2475

Published: 2016

Journal Articles

Nrf2 Activation and Fetal Hemoglobin Induction in Sickle Cell Disease

Sriram Krishnamoorthy, Dipti Gupta, William E. Hobbs, MD PhD, Christine Loh, PhD, David R. Light, Robert Peters, PhD, Sarah Sturtevant, Betty Pace, MD, Yukio Nakamura, Brian Lucas, Benjamin F. Vieira

Blood (2016) 128 (22): 4840.

https://doi.org/10.1182/blood.V128.22.4840.4840

Published: 2016

Journal Articles

Dimethyl Fumarate Induces Fetal Hemoglobin in Sickle Cell Disease

Sriram Krishnamoorthy, PhD, Dipti Gupta, MS, Sarah Sturtevant, Biaoru Li, PhD, Levi C Makala, DVM, MBA, PhD, William E. Hobbs, MDPhD, David R. Light, PhD, Betty Pace, MD

Blood (2015) 126 (23): 410.

https://doi.org/10.1182/blood.V126.23.410.410

Published: 2015

Journal Articles

Keap1-Nrf2 System: Potential Role in Prevention of Sickle Cell Disease Organs Damages and Inflammation

Nadine Keleku-Lukwete, MD, Mikiko Suzuki, PhD, Akihito Otsuki, DDS, Kouhei Tsuchida, Saori Katayama, MD, Makiko Hayashi, Eriko Naganuma, Takashi Moriguchi, MDPhD, Osamu Tanabe, MDPhD, James Doug Engel, PhD, Masue Imaizumi, MDPhD, Masayuki Yamamoto, MD PhD

Blood (2015) 126 (23): 411.

https://doi.org/10.1182/blood.V126.23.411.411

Published: 2015

Journal Articles

Hemopexin Gene Therapy Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Cell Mice

Gregory M Vercellotti, Ping Zhang, PhD, Chunsheng Chen, PhD, Julia Nguyen, BS, Fuad Abdulla, DVM, Phong Nguyen, BS, Carlos Nowotny, Aman Irfanullah, Ann Smith, PhD, Clifford J. Steer, MD, John D. Belcher, PhD

Blood (2015) 126 (23): 412.

https://doi.org/10.1182/blood.V126.23.412.412

Published: 2015

Journal Articles

Comprehensive Quantitative Proteomic Profiling of the Pharmacodynamic Changes Induced By MLN4924 in Acute Myeloid Leukemia Cells Reveals Rational Targets for Combination Therapy

Valeria Visconte, PhD, Steffan T. Nawrocki, PhD, Kevin R. Kelly, MD PhD, Yingchun Han, MD, Anthony Possemato, Sean Beausoleil, Aziz Nazha, MD, Jaroslaw P. Maciejewski, MD PhD, Hetty E. Carraway, MD MBA, Anjali S. Advani, MD, Mikkael A. Sekeres, MD MS, Jennifer S. Carew, PhD

Blood (2015) 126 (23): 1271.

https://doi.org/10.1182/blood.V126.23.1271.1271

Published: 2015

Journal Articles

A Stress-Responsive Transcriptional Factor NRF2 Activates Hematopoietic Stem Cells

Murakami Shohei, PhD, Masayuki Yamamoto, MD PhD, Hozumi Motohashi, MD PhD

Blood (2015) 126 (23): 2351.

https://doi.org/10.1182/blood.V126.23.2351.2351

Published: 2015

NARROW

Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumors

Extended Mutational Profiling By MSK-IMPACT TM Identifies Mutations Predicting Thromboembolic Risk in Patients with Solid Tumor Malignancy

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

Identification of Deubiquitinase OTUD1 As a Novel Player in Resistance of Multiple Myeloma to Bortezomib

How KEAP1 Deletion in Single Cell Mitigates Sickle Cell Pathology

Alternative Overexpression of NRF2 or MYC Defines a Subgroup of Poor Prognosis Acute Myeloid Leukemia and Suggests a Novel Therapeutic Strategy By Combined Bromodomain Inhibition and Forced NRF2 Pathway Activation

Defective Autophagy Process and Increased ROS Formation in Primary Myelofibrosis

Inhibition of ROS-Induced Nrf2 Antioxidant Pathway Activation May Explain Synergy between Venetoclax and Hypomethylating Agents Against Acute Myeloid Leukemia

Modulation of Donor Graft By the Steroidal Lactone Withaferin A Alleviates Post-Transplant Acute GVHD Via Nrf-2 Independent T-Reg Induction

Nrf2 Regulates Sensitivity of Leukemias to Artemisinins

Genetic Sequencing of Adult T-Cell Leukemia/Lymphoma in the Caribbean Population Shows a Distinct Mutational Profile When Compared to the Japanese Cohort

Antisense Oligonucleotide Against Kelch-like Ech-Associated protein1 Ameliorates Liver Injury in Sickle Cell Mice

Dual Activation of NRF2 in Multiple Myeloma and Bone Marrow Mesenchymal Stromal Cells Regulates Chemotherapy Resistance

Specific Deletion of Keap1 in Endothelial Cells or/and Macrophages of SCD Mice Induces Nrf2 to Protect Tissues Against Oxidative Insults

Nrf2 Activation and Fetal Hemoglobin Induction in Sickle Cell Disease

Dimethyl Fumarate Induces Fetal Hemoglobin in Sickle Cell Disease

Keap1-Nrf2 System: Potential Role in Prevention of Sickle Cell Disease Organs Damages and Inflammation

Hemopexin Gene Therapy Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Cell Mice

Comprehensive Quantitative Proteomic Profiling of the Pharmacodynamic Changes Induced By MLN4924 in Acute Myeloid Leukemia Cells Reveals Rational Targets for Combination Therapy

A Stress-Responsive Transcriptional Factor NRF2 Activates Hematopoietic Stem Cells

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American Society of Hematology

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American Society of Hematology

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