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Journal Articles

The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Manasa K. Nayak, Madankumar Ghatge, Gagan D. Flora, Nirav Dhanesha, Manish Jain, Kathleen R. Markan, Matthew J. Potthoff, Steven R. Lentz, Anil K. Chauhan

Blood (2021) 137 (12): 1658–1668.

https://doi.org/10.1182/blood.2020007140

Published: 2021

Includes: Supplemental data

Journal Articles

Alpha-Dystroglycan Supports Platelet Aggregation and Thrombus Formation

Yiming Wang, MD PhD, Reid C. Gallant, MSc, Miguel A. D. Neves, PhD MSc, Xi Lei, MSc, Sahil Gupta, MSc, Rodrigo Coelho, BSc, Tatianna Wong, MSc, Ronald D. Cohn, MD, Kevin P. Campbell, PhD, Heyu Ni, MD MSc, PhD

Blood (2019) 134 (Supplement_1): 11.

https://doi.org/10.1182/blood-2019-131521

Published: 2019

Journal Articles

Targeting Myeloid-Cell Specific Integrin α9β1 Inhibits Arterial Thrombosis in Mice

Nirav Dhanesha, PhD, Manasa K Nayak, PhD, Prakash Doddapattar, PhD, Anil K Chauhan, PhD

Blood (2019) 134 (Supplement_1): 3581.

https://doi.org/10.1182/blood-2019-127006

Published: 2019

Journal Articles

Targeting Metabolic Enzyme Pyruvate Kinase M2: A Novel Strategy to Inhibit Platelet Function and Arterial Thrombosis

Manasa K Nayak, PhD, Madankumar Ghatge, PhD, Nirav Dhanesha, PhD, Gagan D Flora, PhD, Manish Jain, PhD, Omar Rodriguez, MD BS, Kathleen Markan, PhD, Mathhhew Potthoff, PhD, Steven R. Lentz, MD PhD, Anil K Chauhan, PhD

Blood (2019) 134 (Supplement_1): 1056.

https://doi.org/10.1182/blood-2019-129027

Published: 2019

Journal Articles

Platelet CD36 Promotes ERK5 and Caspase-Dependent Procoagulant Phosphatidylserine Externalization and In Vivo Fibrin Formation in Dyslipidemia

Moua Yang, PhD, Andaleb Kholmukhamedov, MD, Marie L Schulte, PhD, Brian C Cooley, PhD, Na'il O Scoggins, Jeremy P. Wood, PhD, Scott J Cameron, MDPhD, Craig Morrell, DVM, PhD, Shawn M. Jobe, MD PhD, Roy L. Silverstein, MD

Blood (2018) 132 (Supplement 1): 867.

https://doi.org/10.1182/blood-2018-99-111204

Published: 2018

Journal Articles

Manipulating Metabolic Plasticity By Targeting Pyruvate Kinase M2 in Platelets Inhibits Arterial Thrombosis

Manasa Nayak, PhD, Nirav Dhanesha, PhD, Manish Jain, PhD, Anil Chauhan, PhD

Blood (2018) 132 (Supplement 1): 868.

https://doi.org/10.1182/blood-2018-99-112704

Published: 2018

Journal Articles

Optimization of Clot Formation Under Blood Flow in a Tissue Engineered Blood Vessel

Elena Kistanova, MA, Maria M Aleman, PhD, Yasuteru Sano, PhD, Fumitaka Shimizu, PhD, Takashi Kanda, PhD, Joe Salas, PhD

Blood (2017) 130 (Supplement 1): 2304.

https://doi.org/10.1182/blood.V130.Suppl_1.2304.2304

Published: 2017

Journal Articles

Inhibition of Neutrophil Extracellular Trap Release through the Disruption of PAD4 Leads to Decreased Neutrophil and Platelet Accumulation at Sites of Venular Vascular Injury in a Murine Model of Heparin-Induced Thrombocytopenia

Kandace Gollomp, MD, Vincent Hayes, Ian Johnston, BS, Minna Kim, Guohua Zhao, Lubica Rauova, MD PhD, Mortimer Poncz, MD

Blood (2017) 130 (Supplement 1): 2268.

https://doi.org/10.1182/blood.V130.Suppl_1.2268.2268

Published: 2017

Journal Articles

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

Lacramioara Ivanciu, PhD, Jeffrey Crosby, PhD, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brett P. Monia, PhD, Robert J. Davidson, BS, Rodney M Camire, PhD

Blood (2017) 130 (Supplement 1): 364.

https://doi.org/10.1182/blood.V130.Suppl_1.364.364

Published: 2017

Journal Articles

Inhibition of Protein Disulfide Isomerase Ameliorates Vaso-Occlusion and Thrombosis in a Mouse Model of Sickle Cell Disease

Chao Fang, PhD, Anish V. Sharda, MBBS, MPH, Lin Lin, PhD, Robert C. Flaumenhaft, MD PhD, Bruce Furie, MD

Blood (2017) 130 (Supplement 1): 442.

https://doi.org/10.1182/blood.V130.Suppl_1.442.442

Published: 2017

Journal Articles

Gα 13 Switch Region 2 Relieves Talin Autoinhibition to Activate Platelet αIIbβ3 Integrin

James Schiemer, BS, Andrew Bohm, PhD, Glenn Merrill-Skoloff, PhD, Robert C. Flaumenhaft, MD PhD, Guy Le Breton, PhD, Athar Chishti, PhD

Blood (2016) 128 (22): 712.

https://doi.org/10.1182/blood.V128.22.712.712

Published: 2016

Journal Articles

Extracellular Protein Disulfide Isomerase Regulates Vitronectin during the Initiation of Thrombus Formation

Chao Fang, PhD, Sheryl R. Bowley, PhD, Barbara C. Furie, PhD, Bruce Furie, MD

Blood (2016) 128 (22): 15.

https://doi.org/10.1182/blood.V128.22.15.15

Published: 2016

Journal Articles

Dysfunctional Endothelium Drives a Pre-DIC State in Endotoxemia

Karen E.P. De Ceunynck, PhD, Sarah J. Higgins, PhD, Sharjeel A. Chaudhry, B.S., Samir Parikh, MD PhD, Robert C. Flaumenhaft, MD PhD

Blood (2016) 128 (22): 3725.

https://doi.org/10.1182/blood.V128.22.3725.3725

Published: 2016

Journal Articles

A Chemical APC Mimetic Protects Endothelium from Thromboinflammatory Injury

Karen E.P. De Ceunynck, PhD, Christian G. Peters, PhD, Sharjeel A. Chaudhry, B.S., Abhishek Jain, PhD, Sarah J. Higgins, PhD, Omozuanvbo Aisiku, PhD, Jennifer Fitch-Tewfik, PhD, Christopher Dockendorff, PhD, Samir Parikh, MD PhD, Donald E. Ingber, PhD, Robert C. Flaumenhaft, MD PhD

Blood (2016) 128 (22): 3835.

https://doi.org/10.1182/blood.V128.22.3835.3835

Published: 2016

Journal Articles

An Antibody to Tissue Factor Pathway Inhibitor (TFPI) Restores Hemostasis after the Onset of Bleeding in Hemophilic a Mouse Injury Models

Reema Jasuja, Amey Barakat, John E. Murphy, Debra D Pittman

Blood (2016) 128 (22): 3761.

https://doi.org/10.1182/blood.V128.22.3761.3761

Published: 2016

Journal Articles

Stimulated Platelets but Not Endothelium Generate Thrombin Via a Factor XIIa-Dependent Mechanism Requiring Phosphatidylserine Exposure

Pavan K. Bendapudi, MD, Karen Deceunynck, PhD, Secil Koseoglu, PhD, Roelof Hendrik Bekendam, MD, Shauna D Mason, Jon Kenniston, Robert C. Flaumenhaft, MD PhD

Blood (2016) 128 (22): 258.

https://doi.org/10.1182/blood.V128.22.258.258

Published: 2016

Journal Articles

A Targeted Photochemical Microfluidic Vascular Injury Model for in Vitro Thrombosis Studies: Usage in Heparin-Induced Thrombocytopenia (HIT)

Ian Johnston, BS, Vincent M Hayes, BS, Douglas B. Cines, Mortimer Poncz, MD

Blood (2015) 126 (23): 212.

https://doi.org/10.1182/blood.V126.23.212.212

Published: 2015

Journal Articles

Noncovalent stabilization of the factor VIII A2 domain enhances efficacy in hemophilia A mouse vascular injury models

Lilley Leong, Derek Sim, Chandra Patel, Katherine Tran, Perry Liu, Elena Ho, Thomas Thompson, Peter J. Kretschmer, Hironao Wakabayashi, Philip J. Fay, John E. Murphy

Blood (2015) 125 (2): 392–398.

https://doi.org/10.1182/blood-2014-02-555656

Published: 2015

Includes: Supplemental data

Journal Articles

Regulation of Protein Disulfide Isomerase By S-Nitrosylation Controls Its Function during Thrombus Formation

Roelof H Bekendam, MD, Gopal Srila, MD, Pavan K Bendapudi, MD, James R Dilks, Lin Lin, PhD, Sheryl Bowley, PhD, Jack Stopa, PhD, Mingdong Huang, PhD, Bruce Furie, MD, Kevin Croce, MD/ PhD, Robert Flaumenhaft, MD/ PhD

Blood (2014) 124 (21): 93.

https://doi.org/10.1182/blood.V124.21.93.93

Published: 2014

Journal Articles

A Subcutaneously Administered RNAi Therapeutic (ALN-AT3) Targeting Antithrombin for Treatment of Hemophilia: Interim Phase 1 Study Results in Healthy Volunteers and Patients with Hemophilia a or B

Benny Sorensen, MD PhD, Tim Mant, MD, Akin Akinc, PhD, Amy Simon, MD, Lauren Melton, Christian Lynam, Andrew Strahs, PhD, Alfica Sehgal, PhD, Renta Hutabarat, PhD, Prasoon Chaturvedi, PhD, Scott Barros, PhD, Akshay Vaishnaw, MD PhD, Aln-AT Investigators

Blood (2014) 124 (21): 693.

https://doi.org/10.1182/blood.V124.21.693.693

Published: 2014

NARROW

The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Alpha-Dystroglycan Supports Platelet Aggregation and Thrombus Formation

Targeting Myeloid-Cell Specific Integrin α9β1 Inhibits Arterial Thrombosis in Mice

Targeting Metabolic Enzyme Pyruvate Kinase M2: A Novel Strategy to Inhibit Platelet Function and Arterial Thrombosis

Platelet CD36 Promotes ERK5 and Caspase-Dependent Procoagulant Phosphatidylserine Externalization and In Vivo Fibrin Formation in Dyslipidemia

Manipulating Metabolic Plasticity By Targeting Pyruvate Kinase M2 in Platelets Inhibits Arterial Thrombosis

Optimization of Clot Formation Under Blood Flow in a Tissue Engineered Blood Vessel

Inhibition of Neutrophil Extracellular Trap Release through the Disruption of PAD4 Leads to Decreased Neutrophil and Platelet Accumulation at Sites of Venular Vascular Injury in a Murine Model of Heparin-Induced Thrombocytopenia

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

Inhibition of Protein Disulfide Isomerase Ameliorates Vaso-Occlusion and Thrombosis in a Mouse Model of Sickle Cell Disease

Gα 13 Switch Region 2 Relieves Talin Autoinhibition to Activate Platelet αIIbβ3 Integrin

Extracellular Protein Disulfide Isomerase Regulates Vitronectin during the Initiation of Thrombus Formation

Dysfunctional Endothelium Drives a Pre-DIC State in Endotoxemia

A Chemical APC Mimetic Protects Endothelium from Thromboinflammatory Injury

An Antibody to Tissue Factor Pathway Inhibitor (TFPI) Restores Hemostasis after the Onset of Bleeding in Hemophilic a Mouse Injury Models

Stimulated Platelets but Not Endothelium Generate Thrombin Via a Factor XIIa-Dependent Mechanism Requiring Phosphatidylserine Exposure

A Targeted Photochemical Microfluidic Vascular Injury Model for in Vitro Thrombosis Studies: Usage in Heparin-Induced Thrombocytopenia (HIT)

Noncovalent stabilization of the factor VIII A2 domain enhances efficacy in hemophilia A mouse vascular injury models

Regulation of Protein Disulfide Isomerase By S-Nitrosylation Controls Its Function during Thrombus Formation

A Subcutaneously Administered RNAi Therapeutic (ALN-AT3) Targeting Antithrombin for Treatment of Hemophilia: Interim Phase 1 Study Results in Healthy Volunteers and Patients with Hemophilia a or B

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American Society of Hematology

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ASH Publications

American Society of Hematology

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