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Journal Articles

The Splicing Modulator GEX1A Exhibits Potent Anti-Leukemic Activity Both in Vitro and In Vivo through Inducing an MCL1 Splice-Switch in Pre-Clinical Models of Acute Myeloid Leukemia

Mark Sellin, Ryan Mack, Matthew C. Rhodes, Lei Zhang, PhD, Wei Wei, Peter Breslin, PhD, Stephanie Berg, DO, Suming Huang, PhD, Richard Taylor, PhD, Jiwang Zhang, MD

Blood (2019) 134 (Supplement_1): 2666.

https://doi.org/10.1182/blood-2019-132030

Published: 2019

Journal Articles

Targeted Delivery of Nanocarrier-Conjugated Doxorubicin to Widen the Therapeutic Window of the Most Active Drug in Lymphoma Therapeutics

Artavazd Arumov, BSc, Piumi Y. Liyanage, BS, Asaad Trabolsi, MD, Lingxiao Li, PhD, Evan R. Roberts, BS, Daniel Bilbao, PhD, Roger M. LeBlanc, PhD, Jonathan H. Schatz, MD

Blood (2019) 134 (Supplement_1): 4061.

https://doi.org/10.1182/blood-2019-122599

Published: 2019

Journal Articles

Harnessing the Epichaperome As a Therapeutic Approach in Multiple Myeloma

Eloisi Caldas Lopes, PhD, Tai Wang, PhD, David S Jayabalan, MSc, Tony Taldone, PhD, Jorge Monge, MD, Jorge Contreras, MD, Yip Winnie, Vicenta Trujillo, PhD, Panchal Palak, Nicholas Lombardi, Sharma Sahil, PhD, Digwal Chander, PhD, Morton Coleman, MD, Gabriela Chiosis, PhD, Ruben Niesvizky, MD, Monica L. Guzman, PhD

Blood (2019) 134 (Supplement_1): 4399.

https://doi.org/10.1182/blood-2019-125267

Published: 2019

Journal Articles

Identification of Tractable Drug-like eIF4Al Inhibitors with Potent Anti-Tumor Activity

Tyler A. Cunningham, BS, Derek Essegian, BS, MS, Stephan Schürer, PhD, Jonathan H. Schatz, MD

Blood (2019) 134 (Supplement_1): 5760.

https://doi.org/10.1182/blood-2019-130494

Published: 2019

Journal Articles

Inhibition of ATR Overcomes Chemotherapy Resistance in p53 Deficient Myeloma Cells

Louise Bouard, MDin training, Benoit Tessoulin, MD PhD, Géraldine Descamps, PhD, Cyrille Touzeau, MD PhD, Philippe Moreau, MD, Martine Amiot, PhD, Catherine Pellat-Deceunynck, PhD

Blood (2019) 134 (Supplement_1): 3109.

https://doi.org/10.1182/blood-2019-122547

Published: 2019

Journal Articles

A Systems Biology Approach to Identify Mechanisms of Therapy Resistance in Multiple Myeloma

Rafael Renatino Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Mark B. Meads, PhD, Priscilla Granados, Anders Berglund, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Ion Petre, PhD, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD

Blood (2018) 132 (Supplement 1): 3266.

https://doi.org/10.1182/blood-2018-99-118784

Published: 2018

Journal Articles

Effects of a Novel Orally Bioavailable Small Molecule (Imidazolyl Ethanamide Pentandioic Acid) on Acute Radiation Syndrome

Dirk Pleimes, MD, Vivienne Bunker, Michael Meyer, Maciej Czajkowski

Blood (2018) 132 (Supplement 1): 5089.

https://doi.org/10.1182/blood-2018-99-114490

Published: 2018

Journal Articles

Pharmacodynamical Modeling of Two-Way Synergistic Effect for High-Throughput Drug Combination Screening in an Ex Vivo Reconstruction of Bone Marrow Using Primary Multiple Myeloma Cells

Praneeth Reddy Sudalagunta, PhD, Rafael Renatino Canevarolo, PhD, Maria D Coelho Siqueira Silva, MSc, Mark B. Meads, PhD, Alex Tungesvik, MD, Gabriel De Avila, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD

Blood (2018) 132 (Supplement 1): 1919.

https://doi.org/10.1182/blood-2018-99-118978

Published: 2018

Journal Articles

Lessons from Nature: A Novel Class of TET Inhibitors for TET2 Mutant Associated Diseases

Yihong Guan, Anand D. Tiwari, PhD, Metis Hasipek, PhD, Dale Grabowski, BS, Yvonne Parker, Cassandra M. Hirsch, Amy C Graham, BS, MS, Yasunobu Nagata, Bartlomiej P. Przychodzen, Aziz Nazha, Daniel Lindner, MD PhD, Tomas Radivoyevitch, PhD, James G Phillips, PhD, Jaroslaw P. Maciejewski, Babal K. Jha

Blood (2018) 132 (Supplement 1): 4345.

https://doi.org/10.1182/blood-2018-99-117186

Published: 2018

Journal Articles

Systems Biology Analysis Identifies Targetable Vulnerability Networks to Proteasome Inhibitors in Multiple Myeloma

Mark B. Meads, PhD, Rafael Renatino Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Paula S. Oliveira, Dario M. Magaletti, Bin Fang, PhD, Maria D Coelho Siqueira Silva, MSc, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Ion Petre, PhD, John M. Koomen, PhD, Ariosto Siqueira Silva, PhD, Kenneth H. Shain, MD PhD

Blood (2018) 132 (Supplement 1): 950.

https://doi.org/10.1182/blood-2018-99-120269

Published: 2018

Journal Articles

Identification of a Compound Overcoming Drug Resistance of Myeloma Cells at Hypoxic Condition

Eri Fujii, MT, Yuki Inada, Misaki Kakoki, Nao Nishimura, MD, Shinya Endo, MD, Shiho Fujiwara, MD, Naoko Wada, MD, Yawara Kawano, MD PhD, Yutaka Okuno, MD, PhD, Toshiya Sugimoto, MT, Hiroyuki Hata, MD PhD

Blood (2017) 130 (Supplement 1): 5395.

https://doi.org/10.1182/blood.V130.Suppl_1.5395.5395

Published: 2017

Journal Articles

Low TFPI Mice in Models of Atherosclerosis and Endotoxemia

Thomas James Girard, George J. Broze, Jr., MD, Nina M Lasky, Kristin Grunz

Blood (2017) 130 (Supplement 1): 2336.

https://doi.org/10.1182/blood.V130.Suppl_1.2336.2336

Published: 2017

Journal Articles

Prostaglandin E2 Protects HSC from DNA Damage Induced By Ionizing Radiation By Preventing Generation of Reactive Oxygen Species and Histone Acetylation

Liqiong Liu, MD PhD, Andrea M Patterson, PhD, Hui Lin Chua, PhD, Carol Sampson, MS, Artur Plett, PhD, Hongge Li, PhD, Pratibha Singh, PhD, Christie M. Orschell, PhD, Louis M. Pelus, PhD

Blood (2017) 130 (Supplement 1): 1151.

https://doi.org/10.1182/blood.V130.Suppl_1.1151.1151

Published: 2017

Journal Articles

Impact of Bioflavonoid Exposure on DNA Damage Response and of Non-Homologous End Joining (NHEJ) Pathway Repair Proteins in Stem Cells

Anindita Ghosh, MBBS, MSc, Christine Richardson, PhD

Blood (2017) 130 (Supplement 1): 3796.

https://doi.org/10.1182/blood.V130.Suppl_1.3796.3796

Published: 2017

Journal Articles

Prostaglandin E 2 Prevents Apoptosis and Promotes Homeostasis of Hematopoietic Stem Cells after Lethal Irradiation through Alteration of p53 and TNF Signaling

Andrea M Patterson, PhD, Liqiong Liu, MD PhD, Christie M. Orschell, PhD, Louis M. Pelus, PhD

Blood (2017) 130 (Supplement 1): 3766.

https://doi.org/10.1182/blood.V130.Suppl_1.3766.3766

Published: 2017

Journal Articles

Cross-Talk between Cytokine and NF-ĸB Signaling in the CLL Microenvironment Can Affect Sensitivity for Venetoclax

Rachel Thijssen, Marco Haselager, Elaine Willmore, Simon Mackay, Arnon P. Kater, MD, Eric Eldering

Blood (2017) 130 (Supplement 1): 4306.

https://doi.org/10.1182/blood.V130.Suppl_1.4306.4306

Published: 2017

Journal Articles

The Marine Natural Compound Elatol Is a Novel Protein Translation Inhibitor with Potent Activity Against Aggressive Non-Hodgkin Lymphomas

Tara Peters, BA, Joseph Tillotson, PhD, Sarah C Wilmore, BSc, Alison Yeomans, PhD, Graham Packham, PhD, Eli Chapman, PhD, Jonathan H. Schatz, MD, Lingxiao Li, PhD

Blood (2017) 130 (Supplement 1): 4112.

https://doi.org/10.1182/blood.V130.Suppl_1.4112.4112

Published: 2017

Journal Articles

Identification of Target Pathways of Acquired IMiD and Proteasome Inhibitor Resistance in Multiple Myeloma

Mark B. Meads, PhD, Paula Oliveira, Bin Fang, Praneeth Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Tuan Nguyen, Allison Distler, Salah-Eddin Komrokji, Aunshka Collins, Hongyue Dai, PhD, John M. Koomen, Ariosto Siqueira Silva, PhD, Kenneth H Shain, MD PhD

Blood (2017) 130 (Supplement 1): 4411.

https://doi.org/10.1182/blood.V130.Suppl_1.4411.4411

Published: 2017

Journal Articles

MAGE-a Inhibits Apoptosis in Multiple Myeloma through Regulation of Bim and PUMA

Hearn Jay Cho, MD PhD, Anna Huo-Chang Mei, MS, Jami Fukui, MD, Kaity Tung, BS, Deepak Perumal, PhD, Violetta Leshchenko, PhD, Alessandro Lagana, PhD, Seunghee Kim-Schultze, PhD, Ajai Chari, Sundar Jagannath, MD, Samir Parekh, MD

Blood (2017) 130 (Supplement 1): 4332.

https://doi.org/10.1182/blood.V130.Suppl_1.4332.4332

Published: 2017

Journal Articles

Therapeutic Targeting of GLI1 in Acute Myeloid Leukemia

Metis Hasipek, PhD, Sayer Al-Harbi, PhD, James G Phillips, PhD, Bartlomiej P. Przychodzen, MSc, Alek Nielsen, BS, Yihong Guan, PhD, Dale Grabowski, BS, Phillip J Maciejewski, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Babal K Jha, PhD

Blood (2017) 130 (Supplement 1): 2654.

https://doi.org/10.1182/blood.V130.Suppl_1.2654.2654

Published: 2017

NARROW

The Splicing Modulator GEX1A Exhibits Potent Anti-Leukemic Activity Both in Vitro and In Vivo through Inducing an MCL1 Splice-Switch in Pre-Clinical Models of Acute Myeloid Leukemia

Targeted Delivery of Nanocarrier-Conjugated Doxorubicin to Widen the Therapeutic Window of the Most Active Drug in Lymphoma Therapeutics

Harnessing the Epichaperome As a Therapeutic Approach in Multiple Myeloma

Identification of Tractable Drug-like eIF4Al Inhibitors with Potent Anti-Tumor Activity

Inhibition of ATR Overcomes Chemotherapy Resistance in p53 Deficient Myeloma Cells

A Systems Biology Approach to Identify Mechanisms of Therapy Resistance in Multiple Myeloma

Effects of a Novel Orally Bioavailable Small Molecule (Imidazolyl Ethanamide Pentandioic Acid) on Acute Radiation Syndrome

Pharmacodynamical Modeling of Two-Way Synergistic Effect for High-Throughput Drug Combination Screening in an Ex Vivo Reconstruction of Bone Marrow Using Primary Multiple Myeloma Cells

Lessons from Nature: A Novel Class of TET Inhibitors for TET2 Mutant Associated Diseases

Systems Biology Analysis Identifies Targetable Vulnerability Networks to Proteasome Inhibitors in Multiple Myeloma

Identification of a Compound Overcoming Drug Resistance of Myeloma Cells at Hypoxic Condition

Low TFPI Mice in Models of Atherosclerosis and Endotoxemia

Prostaglandin E2 Protects HSC from DNA Damage Induced By Ionizing Radiation By Preventing Generation of Reactive Oxygen Species and Histone Acetylation

Impact of Bioflavonoid Exposure on DNA Damage Response and of Non-Homologous End Joining (NHEJ) Pathway Repair Proteins in Stem Cells

Prostaglandin E 2 Prevents Apoptosis and Promotes Homeostasis of Hematopoietic Stem Cells after Lethal Irradiation through Alteration of p53 and TNF Signaling

Cross-Talk between Cytokine and NF-ĸB Signaling in the CLL Microenvironment Can Affect Sensitivity for Venetoclax

The Marine Natural Compound Elatol Is a Novel Protein Translation Inhibitor with Potent Activity Against Aggressive Non-Hodgkin Lymphomas

Identification of Target Pathways of Acquired IMiD and Proteasome Inhibitor Resistance in Multiple Myeloma

MAGE-a Inhibits Apoptosis in Multiple Myeloma through Regulation of Bim and PUMA

Therapeutic Targeting of GLI1 in Acute Myeloid Leukemia

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American Society of Hematology

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American Society of Hematology

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