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Journal Articles

Statins Potentiate Aminopeptidase Inhibitor (pro)Drug Activity in Acute Myeloid Leukemia Cells

Jacqueline Cloos, PhD, Godefridus J Peters, PhD, Marjon Al, BSc, Yehuda G Assaraf, PhD, Lixia Wang, PhD, Jack W. Singer, MD, Jorge E. Cortes, MD, Gert J. Ossenkoppele, MD PhD, Gerrit Jansen, PhD

Blood (2018) 132 (Supplement 1): 3945.

https://doi.org/10.1182/blood-2018-99-114447

Published: 2018

Journal Articles

Alloantigen-Activated Human T-Cells Increase Extracellular Fatty Acid Uptake and Intracellular Lipid Metabolism during Xenogeneic Gvhd

Hirofumi Nakano, MD, Kazuya Sato, MD PhD, Hiroko Hayakawa, PhD, Kiyomi Mashima, MD, Daisuke Minakata, MD, Kaoru Morita, MD PhD, Ryoko Yamasaki, MD, Masahiro Ashizawa, MD, Chihiro Yamamoto, MD PhD, Kaoru Hatano, MD PhD, Shin-ichiro Fujiwara, MD PhD, Iekuni Oh, MD PhD, Ken Ohmine, MD PhD, Kazuo Muroi, MD PhD, Yoshinobu Kanda, MD PhD

Blood (2018) 132 (Supplement 1): 3320.

https://doi.org/10.1182/blood-2018-99-110011

Published: 2018

Journal Articles

Metabolic Reprogramming of Myeloid Cells in Response to Factors of "Emergency" Myelopoiesis By Myeloid-Specific PD-1 Ablation, Regulates Myeloid Lineage Fate Commitment and Anti-Tumor Immunity

Laura Strauss, PhD, Jessica D Weaver, PhD, Rinku Pal, MS, John Asara, PhD, Nikolaos Patsoukis, PhD, Vassiliki A Boussiotis, MD PhD

Blood (2018) 132 (Supplement 1): 14.

https://doi.org/10.1182/blood-2018-99-117438

Published: 2018

Journal Articles

Atorvastatin Restored the CD4 + T Cell Homeostasis By Regulating the Axis of Effector T Cells and Regulatory T Cells in Immune Thrombocytopenia

Pengcheng Xu, Yajing Zhao, BA, MD, Ming Hou, MD, Panpan Han

Blood (2018) 132 (Supplement 1): 132.

https://doi.org/10.1182/blood-2018-99-114690

Published: 2018

Journal Articles

Statins Enhance the Efficacy of BH3 Mimetics in Multiple Myeloma

Dennis Juarez, BS, David Alexander Fruman, PhD, Angela G. Fleischman, MD PhD, Elizabeth Brem, MD, Grace Diep, Undergraduate, Falisha Nguyen, Undergraduate

Blood (2018) 132 (Supplement 1): 1989.

https://doi.org/10.1182/blood-2018-99-120205

Published: 2018

Journal Articles

Statin Use Is Associated with Decreased Mortality in Multiple Myeloma— a SEER Medicare Study

Shivaprasad Manjappa, MD, Mark A. Fiala, BS, Pavan Kumar Bhamidipati, MBBS, MD, Keith E. Stockerl-Goldstein, MD, Mark A. Schroeder, MD, Armin Ghobadi, MD, Ravi Vij, MDMBA, Tanya M. Wildes, MDMSCI

Blood (2017) 130 (Supplement 1): 1860.

https://doi.org/10.1182/blood.V130.Suppl_1.1860.1860

Published: 2017

Journal Articles

Upregulated Cholesterol Biosynthesis Is a Biomarker for Isolated Central Nervous System Relapse in Acute Lymphoblastic Leukaemia

Antony Cousins, Elke Markert, Matilda Degn, PhD, Orianne Olivares, Yasar Mehmood Yousafzai, MBBS,PhD, Saeeda Bhatti, PhD, Pawel Herzyk, Alison M. Michie, PhD BSc, Kjeld Schmiegelow, MD DMSc, Eyal Gottlieb, PhD, Christina Halsey

Blood (2017) 130 (Supplement 1): 3992.

https://doi.org/10.1182/blood.V130.Suppl_1.3992.3992

Published: 2017

Journal Articles

Effects of Isoprenoid Biosynthetic Pathway Inhibition on Glucose Uptake in Myeloma Cells

Kaitlyn M. Dykstra, PhD, Sarah A. Holstein, MD PhD

Blood (2016) 128 (22): 3300.

https://doi.org/10.1182/blood.V128.22.3300.3300

Published: 2016

Journal Articles

Immune Checkpoint Blockade Combinations As Promising Strategy for Cancer Immunotherapy in Multiple Myeloma Patients

Barbara Castella, PhD, Myriam Foglietta, MD, Patrizia Sciancalepore, MD, Ezio Tripoli, PharmD, Mario Boccadoro, MD, Massimo Massaia, MD

Blood (2016) 128 (22): 2059.

https://doi.org/10.1182/blood.V128.22.2059.2059

Published: 2016

Journal Articles

ATP-Binding-Cassette A1 Regulates Extracellular Isopentenyl Pyrophosphate Release and Vγ9Vδ2 T-Cell Activation By Dendritic Cells

Patrizia Sciancalepore, MD, Barbara Castella, PhD, Chiara Riganti, MD, Myriam Foglietta, MD, Joanna Kopecka, PhD, Francesco Novelli, Giorgia Mandili, Ezio Tripoli, PharmD, Nico Mitro, Donatella Caruso, Mario Boccadoro, MD, Massimo Massaia, MD

Blood (2016) 128 (22): 3709.

https://doi.org/10.1182/blood.V128.22.3709.3709

Published: 2016

Journal Articles

Statins Potentiate the Cytotoxic Effect of ABT-199 in Diffuse Large B Cell Lymphoma

David A. Fruman, PhD, Jong-Hoon Scott Lee, B.S., Thanh-Trang T Vo, PhD, Shruti Bhatt, PhD, Jonathan H. Schatz, MD, Anthony Letai, MD PhD

Blood (2016) 128 (22): 3969.

https://doi.org/10.1182/blood.V128.22.3969.3969

Published: 2016

Journal Articles

The Hypoxia-Inducible Factor-1alpha Is Constitutively Upregulated in TP53 Disrupted CLL Cells: A Potential Target to Overcome Fludarabine Resistance

Valentina Griggio, Ms, Candida Vitale, MD, Chiara Riganti, MD, Joanna Kopecka, PhD, Michele Dal Bo, Davide Rossi, MD PhD, Gabriele Pozzato, MD, Luca Laurenti, MD, Francesco Zallio, MD, Monia Marchetti, MD PhD, Marina Ruggeri, Paola Omedè, Giovanni Del Poeta, Pr, MD, Valter Gattei, MD, Gianluca Gaidano, MD PhD, Mario Boccadoro, MD, Massimo Massaia, MD, Marta Coscia, MD PhD

Blood (2015) 126 (23): 2925.

https://doi.org/10.1182/blood.V126.23.2925.2925

Published: 2015

Journal Articles

A Novel Class of Geranylgeranyl Diphosphate Synthase Inhibitors: Structure-Activity Relationships of Homoisoprenoid Triazoles in Myeloma Cells

Veronica S. Wills, B.S., Cheryl Allen, BS, Ella J. Born, B.A., Xiang Zhou, B.S., David F. Wiemer, PhD, Sarah A Holstein, MD PhD

Blood (2014) 124 (21): 2156.

https://doi.org/10.1182/blood.V124.21.2156.2156

Published: 2014

Journal Articles

The Mevalonate Metabolic Pathway and the CXCL12/CXCR4 Axis Reciprocally Interact and Are Implicated in Fludarabine Resistance of Chronic Lymphocytic Leukemia Cells

Candida Vitale, MD, Valentina Griggio, MS, Chiara Riganti, MD, Ivana Campia, PhD, Marta Robino, MD, Micol Rigoni, PhD, Patrizia Sciancalepore, MD, Myriam Foglietta, MD PhD, Barbara Castella, PhD, Mario Boccadoro, MD, Massimo Massaia, Marta Coscia, MD PhD

Blood (2014) 124 (21): 833.

https://doi.org/10.1182/blood.V124.21.833.833

Published: 2014

Journal Articles

Vgamma9Vdelta2 T Cells-Based Immunotherapy Targeting BTN3 Molecules in Acute Myeloid Leukemia

Daniel Olive, MD, PhD, Audrey Benyamine, MD, Aude Le Roy, Rémy Castellano, PhD, Julie Gertner-Dardenne, Norbert Vey, MDPhD

Blood (2014) 124 (21): 3726.

https://doi.org/10.1182/blood.V124.21.3726.3726

Published: 2014

Journal Articles

Potential Involvement of Physiological TCR Gamma Delta Clones in Immune Surveillance of Preleukemic Cells

Olga Zimmermannova, Marketa Zaliova, Anthony V. Moorman, Eva Fronkova, MD, PhD, Jan Stary, Jan Trka, Tomas Kalina, Jan Zuna

Blood (2014) 124 (21): 3775.

https://doi.org/10.1182/blood.V124.21.3775.3775

Published: 2014

Journal Articles

Interim Analysis Of Zoledronic Acid and Interleukin-2 Therapy To Expand Tumoricidal γδ T Cells In Vivo In Patients With Refractory Neuroblastoma

Joseph G Pressey, MD, Adams Julia, BSN, RN, David Kelly, MD, Lawrence S. Lamb, Jr., PhD

Blood (2013) 122 (21): 2029.

https://doi.org/10.1182/blood.V122.21.2029.2029

Published: 2013

Journal Articles

The Mevalonate Pathway and Downstream Signal Transducers As Therapeutic Targets to Overcome Multidrug Resistance in Chronic Lymphocytic Leukemia (CLL)

Marta Coscia, MD, PhD, Micol Rigoni, PhD, Chiara Riganti, MD, Candida Vitale, MD, Ivana Campia, PhD, Valentina Griggio, PhD, Myriam Foglietta, MD, Barbara Castella, PhD, Patrizia Sciancalepore, MD, Maria Elisa Canepari, MD, Marta Robino, Daniela Drandi, PhD, Marco Ladetto, MD, Amalia Bosia, MD, Mario Boccadoro, MD, Massimo Massaia, MD

Blood (2012) 120 (21): 3881.

https://doi.org/10.1182/blood.V120.21.3881.3881

Published: 2012

Journal Articles

Targeting Rab Geranylgeranylation Disrupts Myeloma-Stromal Cell Interactions

Moaaz Soliman, Ella J. Born, BA, Sara V. Hartman, BS, Sarah A. Holstein, MD, PhD

Blood (2012) 120 (21): 1354.

https://doi.org/10.1182/blood.V120.21.1354.1354

Published: 2012

Journal Articles

Dysfunctional Vγ9Vδ2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells

Marta Coscia, Candida Vitale, Silvia Peola, Myriam Foglietta, Micol Rigoni, Valentina Griggio, Barbara Castella, Daniela Angelini, Sabina Chiaretti, Chiara Riganti, Anna Guarini, Daniela Drandi, Marco Ladetto, Amalia Bosia, Robin Foà, Luca Battistini, Mario Boccadoro, Jean-Jacques Fournié, Massimo Massaia

Blood (2012) 120 (16): 3271–3279.

https://doi.org/10.1182/blood-2012-03-417519

Published: 2012

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Statins Potentiate Aminopeptidase Inhibitor (pro)Drug Activity in Acute Myeloid Leukemia Cells

Alloantigen-Activated Human T-Cells Increase Extracellular Fatty Acid Uptake and Intracellular Lipid Metabolism during Xenogeneic Gvhd

Metabolic Reprogramming of Myeloid Cells in Response to Factors of "Emergency" Myelopoiesis By Myeloid-Specific PD-1 Ablation, Regulates Myeloid Lineage Fate Commitment and Anti-Tumor Immunity

Atorvastatin Restored the CD4 + T Cell Homeostasis By Regulating the Axis of Effector T Cells and Regulatory T Cells in Immune Thrombocytopenia

Statins Enhance the Efficacy of BH3 Mimetics in Multiple Myeloma

Statin Use Is Associated with Decreased Mortality in Multiple Myeloma— a SEER Medicare Study

Upregulated Cholesterol Biosynthesis Is a Biomarker for Isolated Central Nervous System Relapse in Acute Lymphoblastic Leukaemia

Effects of Isoprenoid Biosynthetic Pathway Inhibition on Glucose Uptake in Myeloma Cells

Immune Checkpoint Blockade Combinations As Promising Strategy for Cancer Immunotherapy in Multiple Myeloma Patients

ATP-Binding-Cassette A1 Regulates Extracellular Isopentenyl Pyrophosphate Release and Vγ9Vδ2 T-Cell Activation By Dendritic Cells

Statins Potentiate the Cytotoxic Effect of ABT-199 in Diffuse Large B Cell Lymphoma

The Hypoxia-Inducible Factor-1alpha Is Constitutively Upregulated in TP53 Disrupted CLL Cells: A Potential Target to Overcome Fludarabine Resistance

A Novel Class of Geranylgeranyl Diphosphate Synthase Inhibitors: Structure-Activity Relationships of Homoisoprenoid Triazoles in Myeloma Cells

The Mevalonate Metabolic Pathway and the CXCL12/CXCR4 Axis Reciprocally Interact and Are Implicated in Fludarabine Resistance of Chronic Lymphocytic Leukemia Cells

Vgamma9Vdelta2 T Cells-Based Immunotherapy Targeting BTN3 Molecules in Acute Myeloid Leukemia

Potential Involvement of Physiological TCR Gamma Delta Clones in Immune Surveillance of Preleukemic Cells

Interim Analysis Of Zoledronic Acid and Interleukin-2 Therapy To Expand Tumoricidal γδ T Cells In Vivo In Patients With Refractory Neuroblastoma

The Mevalonate Pathway and Downstream Signal Transducers As Therapeutic Targets to Overcome Multidrug Resistance in Chronic Lymphocytic Leukemia (CLL)

Targeting Rab Geranylgeranylation Disrupts Myeloma-Stromal Cell Interactions

Dysfunctional Vγ9Vδ2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells

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