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Journal Articles

A factor VIIIa–mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice

Henrik Østergaard, Jacob Lund, Per J. Greisen, Stine Kjellev, Anette Henriksen, Nikolai Lorenzen, Eva Johansson, Gustav Røder, Morten G. Rasch, Laust B. Johnsen, Thomas Egebjerg, Søren Lund, Henrik Rahbek-Nielsen, Prafull S. Gandhi, Kasper Lamberth, Mette Loftager, Lisbeth M. Andersen, Amalie C. Bonde, Fabian Stavenuiter, Daniel E. Madsen, Xun Li, Thomas L. Holm, Carsten D. Ley, Peter Thygesen, Haisun Zhu, Rong Zhou, Karina Thorn, Zhiru Yang, Mette B. Hermit, Jais R. Bjelke, Bjarne G. Hansen, Ida Hilden
Journal: Blood
Blood (2021) 138 (14): 1258–1268.
https://doi.org/10.1182/blood.2020010331
Published: 2021
Includes: Supplemental data
Journal Articles

Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer

Alexandre Slater, Ying Di, Joanne C. Clark, Natalie J. Jooss, Eleyna M. Martin, Fawaz Alenazy, Mark R. Thomas, Robert A. S. Ariëns, Andrew B. Herr, Natalie S. Poulter, Jonas Emsley, Steve P. Watson
Journal: Blood
Blood (2021) 137 (24): 3443–3453.
https://doi.org/10.1182/blood.2020009440
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies

Simon Timothy Abrams, PhD BSc, Ben Morton, MBChB, MD, Yasir Alhamdi, MBChB, PhD, Mohmad Alsabani, Zhenxing Cheng, Steven Lane, PhD, Ingeborg Welters, PhD, Guozheng Wang, MD PhD, Cheng-Hock Toh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 440.
https://doi.org/10.1182/blood-2019-128493
Published: 2019
Journal Articles

Mutations and Copy Number Gains of the BCL2 Family Members Mediate Resistance to Venetoclax in Multiple Myeloma (MM) Patients

Paola Neri, MD PhD, Ranjan Maity, PhD, Jean-Baptiste Alberge, Sarthak Sinha, BSc, Justin Donovan, Madison Kong, Fajer Hasan, Arzina Jaffer, Lawrence H. Boise, PhD, Nizar Bahlis, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 572.
https://doi.org/10.1182/blood-2019-127593
Published: 2019
Journal Articles

LOXO-305: Targeting C481S Bruton Tyrosine Kinase in Patients with Ibrutinib-Resistant CLL

Aishath S Naeem, PhD, Winnie I Nguy, Svitlana Tyekucheva, PhD, Stacey M. Fernandes, BS, Vanessa Rai, BS, Kevin Ebata, PhD, Eliana B. Gomez, PhD, Barb J. Brandhuber, PhD, Stephen M. Rothenberg, MD PhD, Jennifer R Brown, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 478.
https://doi.org/10.1182/blood-2019-124362
Published: 2019
Journal Articles

The Tissue Factor Pathway Inhibitor Gamma Knockout Mouse Is a Better Model Than the Wild Type Mouse for Studying Tissue Factor-Related Human Diseases

Thomas J. Girard, Nina M. Lasky, Dhanalakshmi S. Anbukumar, George J. Broze, Jr.
Journal: Blood
Blood (2019) 134 (Supplement_1): 484.
https://doi.org/10.1182/blood-2019-130360
Published: 2019
Journal Articles

Characterization of the Interaction between Tissue Factor Pathway Inhibitor α (TFPIα) and Factor V Species

Teodolinda Petrillo, PhD, Cornelis Van 't Veer, PhD, Rodney M. Camire, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 485.
https://doi.org/10.1182/blood-2019-130589
Published: 2019
Journal Articles

Factor VIIa Induces Biased Cytoprotective Signaling through the Cleavage of Protease Activated Receptor 1 at Canonical Arg41 Site

Vijay Kumar Reddy Kondreddy, MSc,PhD, Usha R. Pendurthi, PhD, Xiao Xu, John H. Griffin, PhD, L. Vijaya Mohan Rao, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 481.
https://doi.org/10.1182/blood-2019-124976
Published: 2019
Journal Articles

In Vitro Effects of the Novel Platelet αIIbβ3 Receptor Antagonist RUC-4 on the Verifynow Assays: Potential for Point-of-Care Monitoring of RUC-4 Therapy

Ohad S. Bentur, MD, Barry S. Coller, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 166.
https://doi.org/10.1182/blood-2019-124548
Published: 2019
Journal Articles

AUTO1, a Novel Fast Off CD19CAR Delivers Durable Remissions and Prolonged CAR T Cell Persistence with Low CRS or Neurotoxicity in Adult ALL

Claire Roddie, PhD MD, Maeve A O'Reilly, MBBCHBAO, Maria A V Marzolini, Leigh Wood, BA, Juliana Dias Alves Pinto, PhD, Mahnaz Abbasian, Ketki Vispute, Mark W. Lowdell, BSc, MSc, PhD FRCPath, Graham Wheeler, Joanna Olejnik, Bilyana Popova, Kim Champion, Alexia Gali, Yashma Pathak, Victoria Spanswick, Helen Lowe, John A. Hartley, PhD, Farzin Farzaneh, PhD, David C. Linch, Martin Pule, Karl S Peggs
Journal: Blood
Blood (2019) 134 (Supplement_1): 226.
https://doi.org/10.1182/blood-2019-131086
Published: 2019
Journal Articles

Highly Potent BTK Degradation Induced By NRX0492 As a Therapeutic Strategy for CLL

Deyi Zhang, PhD, Hailey Harris, Aileen Kelly, PhD, Daniel W Robbins, May Tan, Timothy Ingallinera, Neil Bence, Arthur T Sands, Sivasubramanian Baskar, Sarah E. M. Herman, Adrian Wiestner, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 174.
https://doi.org/10.1182/blood-2019-126921
Published: 2019
Journal Articles

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

Dipti Gupta, Samuel Lessard, PhD, Nancy Moore, Jicheng Duan, PhD, Yukio Nakamura, MD PhD, Feng-Chun Yang, MD PhD, Alexandra Hicks, PhD, David R. Light, PhD, Sriram Krishnamoorthy, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 210.
https://doi.org/10.1182/blood-2019-129479
Published: 2019
Journal Articles

DT2216, a BCL-XL Proteolysis Targeting Chimera (PROTAC), Is a Potent Anti T-Cell Lymphoma Agent That Does Not Induce Significant Thrombocytopenia

Yonghan He, MD, Raphael Koch, Vivekananda Budamagunta, Dongwen Lv, Sajid Khan, Xuan Zhang, Janet S Wiegand, Guangrong Zheng, David M. Weinstock, MD, Daohong Zhou
Journal: Blood
Blood (2019) 134 (Supplement_1): 303.
https://doi.org/10.1182/blood-2019-125820
Published: 2019
Journal Articles

Hemophilia A Inhibitor Subjects Show Unique PBMC Gene Expression Profiles That Include up-Regulated Innate Immune Modulators

Ahmad Faisal Karim, PhD, Anthony R. Soltis, PhD, Nadia P Ewing, MD, Clifton L. Dalgard, PhD, Matthew D. Wilkerson, PhD, Kathleen P. Pratt, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 160.
https://doi.org/10.1182/blood-2019-124855
Published: 2019
Journal Articles

HDAC8 Maintain Cytoskeleton Integrity Via Homologous Recombination and Represent a Novel Therapeutic Target in Multiple Myeloma

Zuzana Chyra, PhD, Maria Gkotzamanidou, MD PhD, Masood A. Shammas, PhD, Vassilis L. Souliotis, PhD, Yan Xu, MD, Mehmet K. Samur, PhD, Aaron B. Beeler, PhD, Roman Hajek, MD, Mariateresa Fulciniti, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4385.
https://doi.org/10.1182/blood-2019-130700
Published: 2019
Journal Articles

Statins Enhance Killing of Multiple Myeloma Cells By the BCL-2 Inhibitor Venetoclax and the MCL-1 Inhibitor S63845

David Fruman, PhD, Dennis Juarez, B.S., Grace Diep, Undergraduate, Falisha Nguyen, Undergraduate, Vikas A. Gupta, MD PhD, Lawrence H. Boise, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4413.
https://doi.org/10.1182/blood-2019-131218
Published: 2019
Journal Articles

The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma

Yurie Nagai, MD, Naoya Mimura, MD PhD, Ola Rizq, MD PhD, Yusuke Isshiki, MD PhD, Motohiko Oshima, PhD, Mohamed Rizk, BSc, MSc, Atsunori Saraya, Shuhei Koide, PhD, Yaeko Nakajima-Takagi, PhD, Makiko Miyota, Nagisa Oshima-Hasegawa, MD PhD, Shokichi Tsukamoto, MD PhD, Shio Mitsukawa, MD PhD, Yusuke Takeda, MD PhD, Chikako Ohwada, MD PhD, Masahiro Takeuchi, MD PhD, Tohru Iseki, MD PhD, Chiaki Nakaseko, MD PhD, Josephine Sheedy, BS, MSc, Marla Weetall, PhD, Atsushi Iwama, MD PhD, Emiko Sakaida, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4414.
https://doi.org/10.1182/blood-2019-122350
Published: 2019
Journal Articles

Acquired Dysfibrinogenemia Krakow III after Everolimus Therapy

Alona A. Merkulova, MA, Steven C. Mitchell, MA, Sergei Merkulov, PhD, Alisa S. Wolberg, PhD, Neerman-Arbez Marguerite, PhD, Alvin H. Schmaier, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4934.
https://doi.org/10.1182/blood-2019-131319
Published: 2019
Journal Articles

ETH-155008, a Novel Selective Dual Inhibitor of FLT3 and CDK4/6 in Preclinical Treatment of Acute Myeloid Leukemia

Changnian Liu, PhD MD, Bin Liu, MSc, Chunping Xu, PhD, Pan Zhang, Bin Li, Bin Ji, Bin Zhang, Qingjun Liu, PhD, James Zhang, MSc, Chengzhi Yu, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5141.
https://doi.org/10.1182/blood-2019-123589
Published: 2019
Journal Articles

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, G. David Roodman, MD PhD, Larry D. Cripe, MD, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Katie J Sargent, RN, Hamid Sayar, MD MSc, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5051.
https://doi.org/10.1182/blood-2019-124384
Published: 2019