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Fiona C Brown
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Journal Articles

BAX Mutated Clonal Hematopoiesis Arises Following Treatment with the BCL2 Inhibitor Class of Therapeutics across a Range of Hematological and Non-Hematological Neoplasms

Ing Soo Tiong, Tamia Nguyen, Charis Teh, Chong Chyn Chua, Sarah Ftouni, Thomas E Lew, Fiona C. Brown, Donia Moujalled, Christine Muttiah, Daniel Gray, Mary Ann Anderson, Philip A. Thompson, Constantine S. Tam, John F. Seymour, Sarah-Jane Dawson, Andrew H. Wei, Geoffrey Lindeman, Piers Blombery
Journal: Blood
Blood (2023) 142 (Supplement 1): 2688.
https://doi.org/10.1182/blood-2023-180386
Published: 2023
Journal Articles

Venetoclax Has Potent Efficacy in NPM1 mutated AML with Acquired Resistance Associated with Either Perturbed Pro-Survival Signalling or NPM1 wild-Type Populations

Chong Chyn Chua, Natasha Anstee, Christoffer Flensburg, Charis Teh, Adam Ivey, Noorul Amin, Rachel Thijssen, Stefan K. Bohlander, Purvi M. Kakadia, Zhen Xu, Chun Yew Fong, Stephen Ting, Sun Loo, Ing Soo Tiong, Daniel Gray, Shaun Fleming, Nadia Davidson, Andrew W. Roberts, Ian Majewski, Andrew H. Wei, Fiona C. Brown
Journal: Blood
Blood (2023) 142 (Supplement 1): 423.
https://doi.org/10.1182/blood-2023-185321
Published: 2023
Journal Articles

Direct, Potent, and TP53-Independent Activity of Sting Agonists Against Acute Myeloid Leukaemia Enhances Venetoclax Efficacy In Vivo

Yin Yuan, Sarah T Diepstraten, Fiona C. Brown, Veronique Litalien, Andreas Strasser, Gemma L Kelly, Andrew W. Roberts, Andrew H. Wei
Journal: Blood
Blood (2023) 142 (Supplement 1): 4163.
https://doi.org/10.1182/blood-2023-179698
Published: 2023
Journal Articles

Is BCL-xL the Achilles' heel of AEL and AMKL?

Fiona C. Brown, Andrew H. Wei
Journal: Blood
Blood (2023) 141 (13): 1505–1506.
https://doi.org/10.1182/blood.2022019246
Published: 2023
Journal Articles

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia

Clinical Trials & Observations
Donia M. Moujalled, Fiona C. Brown, Chong Chyn Chua, Michael A. Dengler, Giovanna Pomilio, Natasha S. Anstee, Veronique Litalien, Ella Thompson, Thomas Morley, Sarah MacRaild, Ing S. Tiong, Rhiannon Morris, Karen Dun, Adrian Zordan, Jaynish Shah, Sebastien Banquet, Ensar Halilovic, Erick Morris, Marco J. Herold, Guillaume Lessene, Jerry M. Adams, David C. S. Huang, Andrew W. Roberts, Piers Blombery, Andrew H. Wei
Journal: Blood
Blood (2023) 141 (6): 634–644.
https://doi.org/10.1182/blood.2022016090
Published: 2023
Includes: Supplemental data
Journal Articles

The AP-1/ETS Transcription Factor Network Regulates Stem Cell Quiescence and Chemotherapy Resistance in Acute Myeloid Leukemia

Sumiko Takao, Victor Morell, Fiona C. Brown, Richard Koche, Alex Kentsis
Journal: Blood
Blood (2022) 140 (Supplement 1): 8682–8683.
https://doi.org/10.1182/blood-2022-165325
Published: 2022
Journal Articles

Pharmacological Reduction of Mitochondrial Iron in AML Triggers a BAX/BAK Dependent Non-Canonical Cell Death Synergistic with Venetoclax

Sylvain Garciaz, Sebastian Müller, Andrew Guirguis, Fiona C. Brown, Yih-Chih Chan, Mathilde Poplineau, Kevin Tran, Kah-Lok Chan, Laura MacPherson, Brian Liddicoat, Enid Y. N. Lam, Tatiana Cañeque, Marian L. Burr, Veronique Litalien, Giovanna Pomilio, Estelle Duprez, David C.S. Huang, Sarah-Jane Dawson, Georg Ramm, Andrew G. Cox, Kristin K. Brown, Andrew H. Wei, Kate McArthur, Raphael Rodriguez, Mark A. Dawson
Journal: Blood
Blood (2021) 138 (Supplement 1): 267.
https://doi.org/10.1182/blood-2021-145424
Published: 2021
Journal Articles

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Rachel Thijssen, Sarah T. Diepstraten, Donia Moujalled, Edward Chew, Christoffer Flensburg, Melissa X. Shi, Michael A. Dengler, Veronique Litalien, Sarah MacRaild, Maoshan Chen, Natasha S. Anstee, Boris Reljić, Sarah S. Gabriel, Tirta M. Djajawi, Chris D. Riffkin, Brandon J. Aubrey, Catherine Chang, Lin Tai, Zhen Xu, Thomas Morley, Giovanna Pomilio, Claudia Bruedigam, Axel Kallies, David A. Stroud, Ashish Bajel, Ruth M. Kluck, Steven W. Lane, Marie Schoumacher, Sébastien Banquet, Ian J. Majewski, Andreas Strasser, Andrew W. Roberts, David C. S. Huang, Fiona C. Brown, Gemma L. Kelly, Andrew H. Wei
Journal: Blood
Blood (2021) 137 (20): 2721–2735.
https://doi.org/10.1182/blood.2020010167
Published: 2021
Includes: Supplemental data
Journal Articles

Acquired Mutations in BAX Confer Resistance to BH3 Mimetics in Acute Myeloid Leukemia

Donia M Moujalled, PhD, Fiona C Brown, PhD, Giovanna Pomilio, Natasha S Anstee, PhD, Veronique Litalien, Ella R Thompson, PhD BSc, Thomas Morley, Sarah MacRaild, Chong C Chua, MBBS, BMedSc, SéBastien Banquet, PhD, Maia Chanrion, Ana-Leticia Maragno, PhD, Marie Schoumacher, Marco J Herold, PhD, Guillaume Lessene, PhD, Olivier Geneste, PhD, David C.S. Huang, MBBS MRCP PhD, Andrew W Roberts, MBBS, Piers Blombery, MBBS, Andrew Wei, MBBS,PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7–8.
https://doi.org/10.1182/blood-2020-136872
Published: 2020
Journal Articles

Targeting Aurora Kinase B with AZD2811 Enhances Venetoclax Activity in TP53-Mutant AML

Fiona C Brown, Jelena Urosevic, Urszula Polanska, Jan Cosaert, MD PhD, J. Elizabeth Pease, PhD, Giovanna Pomilio, Veronique Litalien, Jon Travers, PhD, Andrew H. Wei
Journal: Blood
Blood (2019) 134 (Supplement_1): 3930.
https://doi.org/10.1182/blood-2019-129564
Published: 2019
Journal Articles

Peptidomimetic Blockade of MYB in Acute Myeloid Leukemia

Kavitha Ramaswamy, MD, Lauren Forbes, Fiona C Brown, PhD, Richard Koche, PhD, Tatyana Gindin, MDPhD, Gerard Minuesa, PhD, Michael G. Kharas, PhD, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD, Eric Still, Elisa de Stanchina, PhD, Randi Isenhart, Guangwu Guo, Birgit Knoechel, MDPhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3945.
https://doi.org/10.1182/blood.V128.22.3945.3945
Published: 2016
Journal Articles

Aberrant Phosphorylation of MEF2C Is Dispensable for Hematopoiesis, and Induces Chemotherapy Resistance and Susceptibility to MARK Kinase Inhibition Therapy in Acute Myeloid Leukemia

Fiona C Brown, PhD, Eric Still, Paolo Cifani, PhD, Casie Reed, Scott Ficarro, PhD, Jie He, PhD, Richard Koche, PhD, Patrick Bhola, PhD, Peter Romanienko, PhD, Willie Mark, PhD, Andrei V. Krivtsov, PhD, Anthony Letai, MD PhD, Nathanael Gray, PhD, Jarrod Marto, PhD, Scott A. Armstrong, MD PhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2016) 128 (22): 436.
https://doi.org/10.1182/blood.V128.22.436.436
Published: 2016
Journal Articles

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model

Fiona C. Brown, Ashlee J. Conway, Loretta Cerruti, Janelle E. Collinge, Catriona McLean, James S. Wiley, Ben T. Kile, Stephen M. Jane, David J. Curtis
Journal: Blood
Blood (2015) 126 (26): 2863–2870.
https://doi.org/10.1182/blood-2014-10-609362
Published: 2015
Includes: Supplemental data
Journal Articles

Heterozygous Mutation Of Dynamin 2 Expands The Pool Of IL-7 Responsive Leukemic Stem Cells In T-Cell Acute Lymphoblastic Leukemia

David J. Curtis, M.D., Ph.D., Fiona C. Brown, BSc, Michael Collett, BSc, Sarah E. Lucas, BSc, Jesslyn Saw, Phillip J. Robinson, PhD, Cedric Stevens Tremblay
Journal: Blood
Blood (2013) 122 (21): 613.
https://doi.org/10.1182/blood.V122.21.613.613
Published: 2013
Journal Articles

A Novel DNM2 Mutation Displaying Embryonic Lethality and Impaired Transferrin Uptake Identified in a Mouse ENU Mutagenesis Screen for Genes Perturbing Erythropoiesis

Fiona C Brown, BSc, Michael Collett, BSc, Phillip J Robinson, PhD, James C Whisstock, PhD, Douglas J. Hilton, Benjamin T. Kile, Stephen M Jane, FRACP, FRCPA, MBBS, PhD, David J. Curtis, M.D., Ph.D.
Journal: Blood
Blood (2012) 120 (21): 608.
https://doi.org/10.1182/blood.V120.21.608.608
Published: 2012