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Journal Articles

Very long chain fatty acid metabolism is required in acute myeloid leukemia

Matthew Tcheng, Alessia Roma, Nawaz Ahmed, Richard W. Smith, Preethi Jayanth, Mark D. Minden, Aaron D. Schimmer, David A. Hess, Kristin Hope, Kevin A. Rea, Tariq A. Akhtar, Eric Bohrnsen, Angelo D’Alessandro, Al-Walid Mohsen, Jerry Vockley, Paul A. Spagnuolo
Journal: Blood
Blood (2021) 137 (25): 3518–3532.
https://doi.org/10.1182/blood.2020008551
Published: 2021
Includes: Supplemental data
Journal Articles

A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML

Bo-Rui Chen, Anagha Deshpande, Karina Barbosa, Maria Kleppe, Xue Lei, Narayana Yeddula, Pablo Sánchez Vela, Alexandre Rosa Campos, Robert J. Wechsler-Reya, Anindya Bagchi, Soheil Meshinchi, Connie Eaves, Irmela Jeremias, Torsten Haferlach, David A. Frank, Ze’ev Ronai, Sumit Chanda, Scott A. Armstrong, Peter D. Adams, Ross L. Levine, Aniruddha J. Deshpande
Journal: Blood
Blood (2021) 137 (24): 3403–3415.
https://doi.org/10.1182/blood.2020009023
Published: 2021
Includes: Supplemental data
Journal Articles

Unique Regulatory Pathways Dictate the Translational Program in Hematopoietic Stem and Progenitor Cells

Harold K. Elias, MD, Christina Spevak, PhD, Lavanya Kannan, PhD, Mohamed A.E. Ali, MD PhD, Gaelle H Martin, PhD, Shanmugapriya Selvaraj, MS, William S Eng, Guangjie Zhao, BS, Amanda Ernlund, PhD, Vinagolu Rajasekhar, PhD, Carolien M Woolthuis, MD PhD, Robert J Schneider, PhD, Christopher Y. Park, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1180.
https://doi.org/10.1182/blood-2019-131333
Published: 2019
Journal Articles

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Takeshi Fujino, MD, Susumu Goyama, MD PhD, Yuki Sugiura, PhD, Daichi Inoue, MD PhD, Satoshi Yamasaki, PhD, Akiko Matsumoto, Naru Sato, MD, Hironobu Morinaga, PhD, Shiori Shikata, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, PhD, Shuhei Asada, MD PhD, Tsuyoshi Fukushima, MD PhD, Hiroaki Honda, MD PhD, Emi K Nishimura, MD PhD, Tatsuhiro Shibata, MD PhD, Makoto Suematsu, MD PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 821.
https://doi.org/10.1182/blood-2019-127904
Published: 2019
Journal Articles

Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Peng Huang, PhD, Jennifer A. Yano, BA, Jeremy D. Grevet, PhD, Osheiza Abdulmalik, DVM, Cheryl A Keller, PhD, Ross C. Hardison, PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3557.
https://doi.org/10.1182/blood-2019-125664
Published: 2019
Journal Articles

Venous Thromboembolism Prophylaxis in Acute Medically Ill Patients: A Retrospective Cohort Study

Anat Gafter-Gvili, MD, Genady Drozdinsky, Oren Zusman, MD, Shiri Kushnir, Leonard Leibovici, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3678.
https://doi.org/10.1182/blood-2019-124495
Published: 2019
Journal Articles

Pharmacological Increase of Hb-O 2 Affinity with a Voxelotor Analog Does Not Decrease Brain Tissue pO 2 or Limit O 2 Extraction in Brain Tissues of Sickle Cell Mice

Kobina Dufu, PhD, Alfredo Lucas, MS, Cynthia Rodrigues Muller, PhD, Alexander T Williams, MS, Xinchun Zhang, MS, Peter Rademacher, PhD, Carsten Alt, MSc, PhD, Donna Oksenberg, PhD, Pedro Cabrales, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3564.
https://doi.org/10.1182/blood-2019-129282
Published: 2019
Journal Articles

Next-Generation FVIII Mimetic Shows Superior Effect in a FIX- and Fx-Humanized Mouse Model In Vivo

Carsten Dan Ley, PhD, Thomas Lindebo Holm, PhD, Daniel Elenius, PhD, Heidi Lindgreen Holmberg, PhD, Jais Rose Bjelke, PhD, Mette Loftager, PhD, Mette B Hermit, PhD, Ida Hilden, Stine L Kjellev, PhDDVM
Journal: Blood
Blood (2019) 134 (Supplement_1): 3631.
https://doi.org/10.1182/blood-2019-128159
Published: 2019
Journal Articles

Potency Equated Porcine and Bovine Mucosal Heparin Are Bioequivalent in Terms of Biochemical and Pharmacological Effects

Nausheen Baig, Ahmed Kouta, Fakiha Siddiqui, Ambar Farooqui, Debra Hoppensteadt, PhD, Walter Jeske, PhD, Omer Iqbal, MD, Cassie Bacher, Sharan Krishnappan, Jawed Fareed, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3665.
https://doi.org/10.1182/blood-2019-126075
Published: 2019
Journal Articles

Reversible TET Inhibitor As a Hematopoietic Stem Cell Booster: A Novel Strategy to Improve Stem Cell Function

Sunisa Kongkiatkamon, Yihong Guan, PhD, Anand Tiwari, Phillip J Maciejewski, Dale Grabowski, BS, Sergei Vatolin, PhD, Vera Adema, PhD, Cassandra M Kerr, MS, Yasunobu Nagata, MD PhD, Milo Co, Christina Snider, Hassan Awada, Jibran Durrani, Yvonne Parker, Daniel J. Lindner, Mikkael A. Sekeres, MD MS, Valeria Visconte, PhD, James G Phillips, PhD, Jaroslaw P. Maciejewski, MD PhD, Babal K. Jha, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2472.
https://doi.org/10.1182/blood-2019-129056
Published: 2019
Journal Articles

PKR-like Endoplasmic Reticulum Kinase Mediates Apoptosis Induced By Pharmacological AMP-Activated Protein Kinase Activation in Acute Myeloid Leukemia

Laury Poulain, PhD, Adrien Grenier, MD PhD, Johanna Mondesir, MD, Arnaud Jacquel, PhD, Claudie Bosc, Lucille Stuani, PhD, Rudy Birsen, MD, Sarah Mouche, Justine Decroocq, MD, Fetta Mazed, PhD, Benoit Viollet, PhD, Patrick Auberger, PhD, Pierre Sujobert, MD PhD, Didier Bouscary, MD PhD, Jean-Emmanuel Sarry, PhD, Jerome Tamburini, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2552.
https://doi.org/10.1182/blood-2019-123364
Published: 2019
Journal Articles

Mitochondrial Activity Identifies a Transcriptionally and Functionally Distinct Subset of Aged HSCs with Lineage-Balanced Output

Els Mansell, PhD, Valgardur Sigurdsson, PhD, Elitza Deltcheva, PhD, John Brown, PhD, Chela James, PhD, Kenichi Miharada, PhD, Shamit Soneji, PhD, Jonas Larsson, MD PhD, Tariq Enver, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2480.
https://doi.org/10.1182/blood-2019-124001
Published: 2019
Journal Articles

Pharmacologic Normalization of Altered Transcriptome of SF3B1 Mutant Myeloid Neoplasia

Valeria Visconte, PhD, Vera Adema, PhD, Anand D. Tiwari, PhD, Cassandra M Kerr, MS, Hassan Awada, Bartlomiej Przychodzen, Allison Noe, Rachel Toth, Christina Snider, Yvonne Parker, Yuriy Fedorov, Drew Adams, Hetty E. Carraway, MD MBA, Anjali S. Advani, MD, Kevin R Kelly, MD PhD, Steffan T. Nawrocki, PhD, Jennifer S. Carew, PhD, Heesun J. Rogers, MD PhD, Daniel J. Lindner, Mikkael A. Sekeres, MD MS, James G Phillips, PhD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 564.
https://doi.org/10.1182/blood-2019-129189
Published: 2019
Journal Articles

Pharmacological Inhibition of the RNA m 6 a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Konstantinos Tzelepis, Etienne De Braekeleer, PhD MSc, Eliza Yankova, PhD, Justyna Rak, PhD, Demetrios Aspris, MSc, Ana Filipa Domingues, PhD, Richard Fosbeary, Alan Hendrick, PhD, Dan Leggate, PhD, Yaara Ofir-Rosenfeld, PhD, Alexandra Sapetschnig, PhD, Cristina Pina, MDDPhil, Mark Albertella, PhD, Wesley Blackaby, PhD, Oliver Rausch, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Tony Kouzarides, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 403.
https://doi.org/10.1182/blood-2019-127962
Published: 2019
Journal Articles

Pharmacological Inhibition of Nemo-like Kinase Rescues mTOR-Mediated Translation and Primes Progenitors for Leucine-Stimulated Erythroid Expansion in Pre-Clinical Models of Diamond Blackfan Anemia

Mark C Wilkes, PhD, Jacqueline D Mercado, Mallika Saxena, Jun Chen, MD PhD, Kavitha Siva, PhD, Hee-Don Chae, PhD, Minyoung Youn, PhD, Ethan Patrick Wentworth, Kevin Jung, Ryan Sathianathen, Hiral Patel, Bertil Glader, MD PhD, Anupama Narla, MD, Claire E Repellin, PhD, Hanna T Gazda, MD PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 455.
https://doi.org/10.1182/blood-2019-129570
Published: 2019
Journal Articles

Pharmacologic Activation of Aldehyde Metabolism to Protect Hematopoietic Stem Cells (HSC) in Murine Models of Fanconi Anemia (FA)

Jennifer Tsai, MD, Kelsey R. Logas, MS, Lauren D. Van Wassenhove, PhD, Beruh Dejene, BS, Che-Hong Chen, PhD, Daria Mochly-Rosen, PhD, Kenneth I. Weinberg, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 105.
https://doi.org/10.1182/blood-2019-124439
Published: 2019
Journal Articles

DNMT3A R882 Alters the Epigenome of Hematopoietic Cells

Amanda M Smith, PhD, Taylor LaValle, BS, Shamika Ketkar, PhD, Sai Mukund Ramakrishnan, MS, Christopher A Miller, PhD, Timothy J Ley, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 112.
https://doi.org/10.1182/blood-2019-129003
Published: 2019
Journal Articles

Activated but Not Quiescent Hematopoietic Stem Cells Rely Readily on Glycolysis As Their Main Source of Energy

Tasleem Arif, PhD, Raymond Liang, PhD, Maio Lin, Msc, Svetlana Kalmikova, Msc, Artem Kasianov, PhD, Vijay Menon, PhD, Dmitri Papatsenko, PhD, Saghi Ghaffari, PhD MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 271.
https://doi.org/10.1182/blood-2019-129099
Published: 2019
Journal Articles

Autophagy in Endothelial Cells Regulates Their Hematopoiesis Supporting Ability

Yuan Kong, MD PhD, Xie-Na Cao, Zhong-Shi Lyu, PhD, Xiao-Dong Mo, Qi Wen, MD, Hong-Yan Zhao, MD, Yu-Hong Chen, Yu Wang, Ying-Jun Chang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang
Journal: Blood
Blood (2019) 134 (Supplement_1): 4425.
https://doi.org/10.1182/blood-2019-122227
Published: 2019
Journal Articles

Pharmacological Inhibition of MAP2K7 Induces Apoptosis and Cell Cycle Arrest in T-Cell Acute Lymphoblastic Leukemia

Taylor J Chen, BS, Ye Shen, PhD, Cory Seth Bridges, BS, Chun Shik Park, PhD, Jacob J. Junco, PhD, Karen R. Rabin, MD PhD, H. Daniel Lacorazza, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3889.
https://doi.org/10.1182/blood-2019-129127
Published: 2019