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Journal Articles

Mammalian VPS45 orchestrates trafficking through the endosomal system

Laura Frey, Natalia Ziętara, Marcin Łyszkiewicz, Benjamin Marquardt, Yoko Mizoguchi, Monika I. Linder, Yanshan Liu, Florian Giesert, Wolfgang Wurst, Maik Dahlhoff, Marlon R. Schneider, Eckhard Wolf, Raz Somech, Christoph Klein

Blood (2021) 137 (14): 1932–1944.

https://doi.org/10.1182/blood.2020006871

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

Myeloid-Lineage Enhancers Drive Oncogene Synergy and Represent a Novel Therapeutic Target in CSF3R-CEBPA Mutant AML

Theodore Braun, MD PhD, Cody Coblentz, Sarah A Carratt, PhD BS, Mariam Okhovat, PhD, Amy Foley, MEng., Zachary Schonrock, BS, Kimberly Nevonen, Rhonda E. Ries, MA, Shannon K. McWeeney, PhD, Claus Nerlov, PhD, Soheil Meshinchi, MD PhD, Lucia Carbone, PhD, Brian J. Druker, Julia E. Maxson, PhD

Blood (2019) 134 (Supplement_1): 543.

https://doi.org/10.1182/blood-2019-124773

Published: 2019

Journal Articles

Improved Anti-Tumor Response of Chimeric Antigen Receptor T Cell (CART) Therapy after GM-CSF Inhibition Is Mechanistically Supported By a Novel Direct Interaction of GM-CSF with Activated Carts

Michelle J. Cox, Charles J. Kuhlmann, Rosalie M. Sterner, Reona Sakemura, MD PhD, Sutapa Sinha, PhD, Raphael Mwangi, MS, Nancy Scott, MS, Mehrdad Hefazi, MD, Omar Ahmed, Dale Chappell, Cameron Durrant, Claudia Manriquez Roman, Kendall J. Schick, Erin E. Tapper, Paulina Horvei, MD, Michael W. Ruff, MD, Sameer A. Parikh, MD, Neil E. Kay, MD, Saad S. Kenderian, MD

Blood (2019) 134 (Supplement_1): 3868.

https://doi.org/10.1182/blood-2019-129349

Published: 2019

Journal Articles

Understanding the Role of CSF3R and Runx1 Runt Homology Domain Missense Mutations in Leukemic Transformation of Hematopoietic Stem Cells

Malte U Ritter, Olga Klimenkova, Maksim Klimiankou, Amy E Schmidt, MDPhD, Carol Stocking, PhD, Lothar Kanz, Cornelia Zeidler, Daniel C. Link, MD, Karl Welte, Julia Skokowa, MDPhD

Blood (2018) 132 (Supplement 1): 1101.

https://doi.org/10.1182/blood-2018-99-118644

Published: 2018

Journal Articles

JAK2 V617F Dimerizes Homodimeric Cytokine Receptors Cytosolic Domains By Requiring Pseudokinase Domain Residues That Promote JAK2 Dimerization and Oncogenic Activity

Emilie Leroy, Thomas Balligand, MD, Stefan N Constantinescu, MD

Blood (2018) 132 (Supplement 1): 50.

https://doi.org/10.1182/blood-2018-99-111336

Published: 2018

Journal Articles

JAK2 R1063H Variant Enhances V617F Constitutive Signaling and Favors Development of Essential Thrombocythemia with Increased Hemoglobin and Neutrophils

Cristina Mambet, MD, Jean-Philippe Defour, BPharm, PhD, Olga Babosova, M.Sc., Emilie Leroy, Laura Necula, PhD, Oana Stanca, MD, Aurelia Tatic, MD, Daniel Coriu, MD, Monika Belickova, PhD, Barbora Kralova, MSc, Lucie Lanikova, PhD, Pascale Saussoy, Violaine Havelange, Carmen C. Diaconu, PhD, Vladimir Divoky, PhD, Stefan N Constantinescu, MD

Blood (2018) 132 (Supplement 1): 3066.

https://doi.org/10.1182/blood-2018-99-117019

Published: 2018

Journal Articles

Combinatorial CSF3R and RUNX1 Mutations Involved in the Leukemic Progression of Severe Congenital Neutropenia Confer a G-CSF-Dependent Premalignant State in Mice

Szabolcs Fatrai, PhD, Paulette van Strien, BSc, Julia Obenauer, MSc, BSc, M.M. Van den Heuvel-Eibrink, MD, Ivo Touw, PhD

Blood (2017) 130 (Supplement 1): 543.

https://doi.org/10.1182/blood.V130.Suppl_1.543.543

Published: 2017

Journal Articles

Effects of CSF3R mutations on Myeloid Differentiation and Proliferation of Hematopoietic Cells of Congenital Neutropenia Patients

Maksim Klimiankou, Benjamin Dannenmann, Anna Solovyeva, Regine Bernhard, Diana Amend, Cornelia Zeidler, Sabine Mellor-Heineke, MD, Lothar Kanz, Julia Skokowa, Karl Welte, MD PhD

Blood (2017) 130 (Supplement 1): 2278.

https://doi.org/10.1182/blood.V130.Suppl_1.2278.2278

Published: 2017

Journal Articles

Gfi1-Mediated Repression of C-Fos , Egr1 and Egr2 , and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis

Yangyang Zhang, MD, Nan Hu, PhD, Fan Dong, MD PhD

Blood (2017) 130 (Supplement 1): 3765.

https://doi.org/10.1182/blood.V130.Suppl_1.3765.3765

Published: 2017

Journal Articles

When Standard Markers Are Not Sufficient for Monitoring Minimal Residual Disease or Targeted Treatment: New Transcriptome Derived Flow Cytometry Markers for Switching B Cell Precursor Leukemias

Michaela Novakova, Alena Musilova, Lucie Slamova, Barbora Vakrmanova, Monika Brüggemann, Matthias Ritgen, Eva Fronkova, Tomas Kalina, Ondrej Hrusak, Jan Trka, Jan Stary, Martina Vaskova, Lucie Winkowska, Marketa Zaliova, Karel Fiser, Ester Mejstrikova

Blood (2017) 130 (Supplement 1): 3982.

https://doi.org/10.1182/blood.V130.Suppl_1.3982.3982

Published: 2017

Journal Articles

Unraveling a Novel Mechanism of RUNX1 Activity in Familial Platelet Disorder with Associated Myeloid Malignancy

Halah I. Alkadi, PhD candidate, Tatiana S. Karpova, PhD, Erika Mijin Kwon, PhD, Lisa J. Garrett, MS, Yongxing Gao, BS, Stephen Wincovitch, Anfal Alsadhan, MS, James J. Greene, PhD, David A. Ball, Linzhao Cheng, PhD, April D. Sorrell, MD, Paul P. Liu, MD PhD

Blood (2016) 128 (22): 2693.

https://doi.org/10.1182/blood.V128.22.2693.2693

Published: 2016

Journal Articles

Src-like Adaptor Protein Promotes the CD103 + dendritic Cell Homeostasis in the Lung

Namit Sharma, Pan Zhongda, Tracy Lauren Smith, Savar Kaul, Emilie Ernoult, Jane McGlade

Blood (2016) 128 (22): 1339.

https://doi.org/10.1182/blood.V128.22.1339.1339

Published: 2016

Journal Articles

Inv(16) AML Engrafts Human Cytokine Knock-in Mice

Philipp J Rauch, MD, Jana M Ellegast, MD, Larisa V Kovtonyuk, PhD, Ulrich Wagner, PhD, Rouven Müller, MD, Yasuyuki Saito, MD PhD, Nicole Wildner-Verhey van Wijk, PhD, Christine Fritz, Anahita Rafiei, PhD, Veronika Lysenko, Ewa Dudkiewicz, Davide Soldini, MD PhD, Jeroen S Goede, MD, Richard Flavell, PhD, Markus G Manz, MD

Blood (2016) 128 (22): 1078.

https://doi.org/10.1182/blood.V128.22.1078.1078

Published: 2016

Journal Articles

Optimization of CSF3R Mutation Detection in Severe Congenital Neutropenia and Cyclic Neutropenia Patients for Routine Diagnostics Using Next Generation Sequencing

Maksim Klimiankou, PhD, Cornelia Zeidler, MD, Sabine Mellor-Heineke, Ingeborg Steiert, Karin Haehnel, Karl Welte, MD PhD, Julia Skokowa, MD PhD

Blood (2016) 128 (22): 3685.

https://doi.org/10.1182/blood.V128.22.3685.3685

Published: 2016

Journal Articles

Mutations in the Splicosome Lead to Alternative Splicing of CSF3R in Promoting Myelodysplastic Syndromes

Frances Austin, MD, Hrishikesh M Mehta, PhD, Seth J. Corey, MD MPH, Chonghui Cheng, MD PhD

Blood (2016) 128 (22): 3897.

https://doi.org/10.1182/blood.V128.22.3897.3897

Published: 2016

Journal Articles

Mutations in the Spliceosome Lead to Alternative Splicing of CSF3R in Promoting Myelodysplastic Syndromes

Frances Austin, MD, Hrishikesh M Mehta, PhD, Chonghui Cheng, MD PhD, Seth Corey, MD MPH

Blood (2016) 128 (22): 1978.

https://doi.org/10.1182/blood.V128.22.1978.1978

Published: 2016

Journal Articles

Inhibition of the NAMPT-Triggered Deacetylation of HCLS1 Protein: A New Therapeutic Option in Chronic Myeloid Leukemia

Bardia Samareh, PhD, Inna Zimmer, Andrew Zikic, Olga Klimenkova, PhD, Houra Loghmani-Khouzani, PhD, Meinolf Suttorp, Prof. Dr., Lothar Kanz, Prof. Dr. MD, Karl Welte, Prof. Dr. MD, Julia Skokowa, Prof. Dr.

Blood (2015) 126 (23): 1001.

https://doi.org/10.1182/blood.V126.23.1001.1001

Published: 2015

Journal Articles

Restoration of CCAAT Enhancer Binding Protein Alpha P42 Overcomes Myeloid Differentiation Block and All-Trans Retinoic Acid Resistance in Human Acute Promyelocytic Leukemia NB4-R1 Cells

Limengmeng Wang, Haowen Xiao, Xing Zhang, Weichao Liao, Shan Fu, He Huang, MD PhD

Blood (2015) 126 (23): 1238.

https://doi.org/10.1182/blood.V126.23.1238.1238

Published: 2015

Journal Articles

MPL SV , a Unique MPN MPL Splice Variant, Provokes a Fulminant Myeloid Leukemia in a JAK2 V617F Transgenic Mouse Model of Polycythemia Vera

Jerry L. Spivak, MD, Donna Marie Williams, PhD, Zhizhuang Joe Zhao, PhD, Ophelia Rogers, Amy S. Duffield, MD PhD, W. David Hankins, PhD, Alison R Moliterno, MD

Blood (2015) 126 (23): 484.

https://doi.org/10.1182/blood.V126.23.484.484

Published: 2015

Journal Articles

Activation of C/EBPa Myeloid-Specific Transcription Factor By NAMPT/SIRT1-Triggered Deacetylation

Bardia Samareh, PhD, Masoud Nasri, M.Sc, Inna Zimmer, Olga Klimenkova, PhD, Leonie Keller, Lothar Kanz, Prof. Dr. MD, Karl Welte, Prof. Dr. MD, Julia Skokowa, Prof. Dr.

Blood (2015) 126 (23): 2199.

https://doi.org/10.1182/blood.V126.23.2199.2199

Published: 2015

NARROW

Mammalian VPS45 orchestrates trafficking through the endosomal system

Myeloid-Lineage Enhancers Drive Oncogene Synergy and Represent a Novel Therapeutic Target in CSF3R-CEBPA Mutant AML

Improved Anti-Tumor Response of Chimeric Antigen Receptor T Cell (CART) Therapy after GM-CSF Inhibition Is Mechanistically Supported By a Novel Direct Interaction of GM-CSF with Activated Carts

Understanding the Role of CSF3R and Runx1 Runt Homology Domain Missense Mutations in Leukemic Transformation of Hematopoietic Stem Cells

JAK2 V617F Dimerizes Homodimeric Cytokine Receptors Cytosolic Domains By Requiring Pseudokinase Domain Residues That Promote JAK2 Dimerization and Oncogenic Activity

JAK2 R1063H Variant Enhances V617F Constitutive Signaling and Favors Development of Essential Thrombocythemia with Increased Hemoglobin and Neutrophils

Combinatorial CSF3R and RUNX1 Mutations Involved in the Leukemic Progression of Severe Congenital Neutropenia Confer a G-CSF-Dependent Premalignant State in Mice

Effects of CSF3R mutations on Myeloid Differentiation and Proliferation of Hematopoietic Cells of Congenital Neutropenia Patients

Gfi1-Mediated Repression of C-Fos , Egr1 and Egr2 , and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis

When Standard Markers Are Not Sufficient for Monitoring Minimal Residual Disease or Targeted Treatment: New Transcriptome Derived Flow Cytometry Markers for Switching B Cell Precursor Leukemias

Unraveling a Novel Mechanism of RUNX1 Activity in Familial Platelet Disorder with Associated Myeloid Malignancy

Src-like Adaptor Protein Promotes the CD103 + dendritic Cell Homeostasis in the Lung

Inv(16) AML Engrafts Human Cytokine Knock-in Mice

Optimization of CSF3R Mutation Detection in Severe Congenital Neutropenia and Cyclic Neutropenia Patients for Routine Diagnostics Using Next Generation Sequencing

Mutations in the Splicosome Lead to Alternative Splicing of CSF3R in Promoting Myelodysplastic Syndromes

Mutations in the Spliceosome Lead to Alternative Splicing of CSF3R in Promoting Myelodysplastic Syndromes

Inhibition of the NAMPT-Triggered Deacetylation of HCLS1 Protein: A New Therapeutic Option in Chronic Myeloid Leukemia

Restoration of CCAAT Enhancer Binding Protein Alpha P42 Overcomes Myeloid Differentiation Block and All-Trans Retinoic Acid Resistance in Human Acute Promyelocytic Leukemia NB4-R1 Cells

MPL SV , a Unique MPN MPL Splice Variant, Provokes a Fulminant Myeloid Leukemia in a JAK2 V617F Transgenic Mouse Model of Polycythemia Vera

Activation of C/EBPa Myeloid-Specific Transcription Factor By NAMPT/SIRT1-Triggered Deacetylation

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American Society of Hematology

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