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Journal Articles

SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

Gaurav S Choudhary, PhD, Molly A Smith, PhD, Andrea Pellagatti, Tushar D Bhagat, PhD, Shanisha Gordon, Sanjay Pandey, PhD, Nishi Shah, MBBS, MPH, Srinivas Aluri, Robert N Booher, PhD, Murali Ramachandra, PhD, Maria Elena Samson, Kith Pradhan, PhD, Teresa V. Bowman, PhD, Manoj M Pillai, MD, Chandan Guha, MBBS, Amittha Wickrema, PhD, Britta Will, PhD, Aditi Shastri, MD, Ulrich G. Steidl, MD PhD, Jacqueline Boultwood, Daniel T. Starczynowski, PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 4224.
https://doi.org/10.1182/blood-2019-124458
Published: 2019
Journal Articles

The Clinical Association and Prognostic Impact of IL1RAP Expression in Patients with De Novo Acute Myeloid Leukemia

Chao-Hung Wei, MD, Cheng-Hong Tsai, MD, M.Sc., Jih-Luh Tang, MD, PhD, Yuan-Yeh Kuo, PhD, Feng-Ming Tien, MD, M.Sc, Chien-Chin Lin, MD, Mei-Hsuan Tseng, M.Sc., Yen-Ling Peng, Ming-Chih Liu, Chia-Wen Liu, Ming Yao, MD, Liang-In Lin, PhD, Wen-Chien Chou, MD, PhD, Chien-Yu Chen, PhD, Hsin-An Hou, Hwei-Fang Tien, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2705.
https://doi.org/10.1182/blood-2019-124657
Published: 2019
Journal Articles

Targeted Degradation of IRAK4 Protein Via Heterobifunctional Small Molecules for Treatment of MYD88 Mutant Lymphoma

Joseph Kelleher, PhD, Laurent Audoly, PhD, Veronica Campbell, Jesse Chen, PhD, Nan Ji, PhD, Hari Kamadurai, PhD, Henry Li, PhD, Christine Loh, PhD, Haojing Rong, PhD, Dominico Vigil, PhD, Matt Weiss, PhD, Karen Yuan, Yi Zhang, PhD, Nello Mainolfi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2953.
https://doi.org/10.1182/blood-2018-99-120148
Published: 2018
Journal Articles

Upregulation of Tissue Factor May Contribute to Thrombosis in Polycythemia Vera and Essential Thrombocythemia

Brandi Reeves, MD, Soo Jin Kim, MS, Jihyun Song, PhD, Radhika Gangaraju, MD, Rafal Pawlinski, PhD, Perumal Thiagarajan, MD, Victor R. Gordeuk, MD, Nigel S. Key, MBChB, FRCP, Josef T. Prchal, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2513.
https://doi.org/10.1182/blood-2018-99-117812
Published: 2018
Journal Articles

Combination of IRAK4 Inhibitor CA-4948 with BCL2 Inhibitor Venetoclax Induces Tumor Regression in an ABC-DLBCL Xenograft Model

Robert Booher, PhD, Steven Dellarocca, B.S., Ruzanna Atoyan, MD, Mylissa Borek, B.S., Maria Elena S. Samson, B.S., David Tuck, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1534.
https://doi.org/10.1182/blood.V130.Suppl_1.1534.1534
Published: 2017
Journal Articles

Toll-Like Receptors: Mechanism and Relation to Human Populations

Jane Freedman, MD
Journal: Blood
Blood (2016) 128 (22): SCI-46.
https://doi.org/10.1182/blood.V128.22.SCI-46.SCI-46
Published: 2016
Journal Articles

Cytokine-Mediated Inflammatory Pathways Promote Clonal Evolution and Disease Progression in Acute Myeloid Leukemia

Christopher O. Eden, BA, David K. Edwards, V, BA, BS, Christopher A. Eide, Elie Traer, MD, Jeffrey W. Tyner, Shannon K. McWeeney, Anupriya Agarwal
Journal: Blood
Blood (2016) 128 (22): 1688.
https://doi.org/10.1182/blood.V128.22.1688.1688
Published: 2016
Journal Articles

IL1RAP Antibodies Block IL1-Induced Expansion of Primitive CML Cells and Display Therapeutic Effects in Xenograft Models

Helena Ågerstam, Nils Hansen, Sofia Von Palffy, Carl Sandén, Kristian Reckzeh, Christine Karlsson, Henrik Lilljebjörn, Niklas Landberg, Maria Askmyr, Carl Högberg, Marianne Rissler, Kimmo Porkka, Hans Wadenvik, Satu Mustjoki, Johan Richter, MD, Marcus Järås, Thoas Fioretos
Journal: Blood
Blood (2016) 128 (22): 1118.
https://doi.org/10.1182/blood.V128.22.1118.1118
Published: 2016
Journal Articles

Upregulation of Thrombo-Inflammatory Pathways May Contribute to Increased Thrombotic Risk in Polycythemia Vera and Essential Thrombocythemia

Radhika Gangaraju, MD, Soo Jin Kim, MS, Jihyun Song, PhD, Sabina Swierczek, PhD, Perumal Thiagarajan, MD, Josef T. Prchal, MD
Journal: Blood
Blood (2016) 128 (22): 3143.
https://doi.org/10.1182/blood.V128.22.3143.3143
Published: 2016
Journal Articles

Parallel Transcriptional Analysis of Multiple Stem and Progenitor Populations Identifies Novel Commonly Dysregulated and Functionally Relevant Targets in AML

Laura Barreyro, Britta Will, PhD, Boris Bartholdy, Ph.D., Li Zhou, PhD, Tihomira I Todorova, B.A., Robert Stanley, Susana Ben-Neriah, Cristina Montagna, PhD, Samir Parekh, MD, Andrea Pellagatti, PhD, Jacqueline Boultwood, PhD, Elisabeth Paietta, PhD, Rhett P Ketterling, MD, Larry D Cripe, MD, Hugo F Fernandez, MD, Peter L. Greenberg, MD, Jacob M Rowe, MD, Martin S. Tallman, MD, Christian Steidl, MD, Constantine S. Mitsiades, MD, PhD, Amit Verma, MD, Ulrich Steidl, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1875.
https://doi.org/10.1182/blood.V120.21.1875.1875
Published: 2012
Journal Articles

Clinical and Genetic Risk Assessment for Overall Survival in Haematopoietic Stem Cell Transplantation (HSCT).

Anne M Dickinson, PhD, Kim F Pearce, CStat, Graham H Jackson, Matthew Collin, MD, PhD, Jean Norden, Ernst Holler, PhD, Heike Bickeboller, Yesilda Balavarca, Vanderson Rocha, Hans-Jochem Kolb, Alvaro Aubano, Ilona Hromadnikova, Petr Sedlacek, Alois Gratwohl
Journal: Blood
Blood (2009) 114 (22): 1189.
https://doi.org/10.1182/blood.V114.22.1189.1189
Published: 2009
Journal Articles

Association in Outcome of Advanced Multiple Myeloma with Polymorphisms of Inflammatory-Related Genes IL-1A, IL-1B, IL1RN, TNF-a and TNFRSF1B.

Gabriele Buda, Alessandro Martino, Enrico Orciuolo, Antonella Lupia, Sara Galimberti, Massimo Gentile, md, Marino Brunori, Fortunato Morabito, MD, Anna Maria Rossi, Mario Petrini, MD
Journal: Blood
Blood (2009) 114 (22): 1723.
https://doi.org/10.1182/blood.V114.22.1723.1723
Published: 2009
Journal Articles

Interleukin-1 Receptor Antagonist and Interleukin-1 beta: Different Roles in Patients with Chronic Lymphocytic Leukemia.

Zhong Zhang, MD, Susan O’Brien, M.D., Michael Keating, M.D., Iman Jilani, PhD, Hagop Kantarjian, M.D., Zeev Estrov, M.D., Alessandra Ferrajoli, M.D., Francis Giles, M.D., Maher Albitar, M.D.
Journal: Blood
Blood (2006) 108 (11): 4948.
https://doi.org/10.1182/blood.V108.11.4948.4948
Published: 2006
Journal Articles

Human B cells express two types of interleukin-1 receptors

D Benjamin, SK Dower
Journal: Blood
Blood (1990) 75 (10): 2017–2023.
https://doi.org/10.1182/blood.V75.10.2017.2017
Published: 1990