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Journal Articles

N-glycan–mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP

Brief Report
Bogac Ercig, Nuno A. G. Graça, Kadri Kangro, Tom Arfman, Kanin Wichapong, Johana Hrdinová, Paul Kaijen, Floris P. J. van Alphen, Maartje van den Biggelaar, Karen Vanhoorelbeke, Agnès Veyradier, Paul Coppo, Chris Reutelingsperger, Gerry A. F. Nicolaes, Andres Männik, Jan Voorberg
Journal: Blood
Blood (2021) 137 (19): 2694–2698.
https://doi.org/10.1182/blood.2020007972
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

TTP: an open and shut (closed) case

Marie Scully
Journal: Blood
Blood (2020) 136 (3): 265–266.
https://doi.org/10.1182/blood.2020006444
Published: 2020
Journal Articles

Pharmacologic Normalization of Altered Transcriptome of SF3B1 Mutant Myeloid Neoplasia

Valeria Visconte, PhD, Vera Adema, PhD, Anand D. Tiwari, PhD, Cassandra M Kerr, MS, Hassan Awada, Bartlomiej Przychodzen, Allison Noe, Rachel Toth, Christina Snider, Yvonne Parker, Yuriy Fedorov, Drew Adams, Hetty E. Carraway, MD MBA, Anjali S. Advani, MD, Kevin R Kelly, MD PhD, Steffan T. Nawrocki, PhD, Jennifer S. Carew, PhD, Heesun J. Rogers, MD PhD, Daniel J. Lindner, Mikkael A. Sekeres, MD MS, James G Phillips, PhD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 564.
https://doi.org/10.1182/blood-2019-129189
Published: 2019
Journal Articles

CD70-Specific CAR T Cells Have Potent Activity Against Acute Myeloid Leukemia (AML) without HSC Toxicity

Tim Sauer, MD, Kathan Parikh, Sandhya Sharma, Bilal Omer, MD, Stephen Gottschalk, MD, Cliona M. Rooney, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1932.
https://doi.org/10.1182/blood-2019-125534
Published: 2019
Journal Articles

Phase 1/2 Study of AUTO3 the First Bicistronic Chimeric Antigen Receptor (CAR) Targeting CD19 and CD22 Followed By an Anti-PD1 in Patients with Relapsed/Refractory (r/r) Diffuse Large B Cell Lymphoma (DLBCL): Results of Cohort 1 and 2 of the Alexander Study

Kirit M. Ardeshna, MBBChir, Maria A V Marzolini, Jane Norman, MD, Muhammad Al-Hajj, Simon Thomas, PhD, Jim Faulkner, Ekaterini Kotsopoulou, Martin Pule, MD, Vijay G R Peddareddigari, Nushmia Z Khokhar, Maud Jonnaert, PhD, Robert Chen, MD, Wendy Osborne, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 246.
https://doi.org/10.1182/blood-2019-122724
Published: 2019
Journal Articles

Disruption of ADAMTS13-Autoantibody Complexes with an ADAMTS13 Spacer Domain As a Potential Therapeutic Strategy for Immune Thrombotic Thrombocytopenic Purpura

Konstantine Halkidis, MD PhD, X. Long Zheng, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 88.
https://doi.org/10.1182/blood-2019-125965
Published: 2019
Journal Articles

Enhancing the Effect of CLL-1 CAR T Cells with Interleukin-15 for Treatment of Acute Myeloid Leukemia

Pinar Ataca Atilla, MD, Haruko Tashiro, MD PhD, Mary Kathryn McKenna, PhD, Madhuwanti Srinivasan, Brian Wesley Simons, Alexandra McLean Stevens, MD PhD, Michele Redell, MD PhD, Maksim Mamonkin, PhD, Malcolm K. Brenner, MD PhD, Erden Atilla, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3912.
https://doi.org/10.1182/blood-2019-127953
Published: 2019
Journal Articles

Durable and Robust Fetal Globin Induction without Anemia in Rhesus Monkeys Following Autologous Hematopoietic Stem Cell Transplant with BCL11A Erythroid Enhancer Editing

Selami Demirci, PhD, Jing Zeng, MD, Yuxuan Wu, PhD, Naoya Uchida, MD, Jackson Gamer, Morgan Yapundich, Claire Drysdale, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, VMD, Anne H. Shen, Juan J. Haro-Mora, PhD, Alexis Leonard, MD, Tina Nassehi, Kevin Luk, Scot A. Wolfe, Cicera R. Lazzarotto, Shengdar Q. Tsai, PhD, Mitchell J. Weiss, MD, PhD, Daniel E. Bauer, MD PhD, John F. Tisdale, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4632.
https://doi.org/10.1182/blood-2019-129394
Published: 2019
Journal Articles

A New Flow-Based Assay to Assess Treatment Response in Congenital Thrombotic Thrombocytopenic Purpura

Ferras Alwan, Chiara Vendramin, Alice Taylor, Mari Thomas, PhD, Ri Liesner, Marie Scully, MD MRCP, FRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 2441.
https://doi.org/10.1182/blood-2018-99-115965
Published: 2018
Journal Articles

Simultaneous Targeting of CD19 and CD22: Phase I Study of AUTO3, a Bicistronic Chimeric Antigen Receptor (CAR) T-Cell Therapy, in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (r/r B-ALL): Amelia Study

Persis J Amrolia, FRCP, FRCPath, PhD, Robert Wynn, MD, Rachael Hough, MD BMBS, FRCP, FRCPath, Ajay Vora, MD, Denise Bonney, Paul Veys, MD PhD, Kanchan Rao, Robert Chiesa, Muhammad Al-Hajj, Shaun P Cordoba, PhD, Shimobi Onuoha, PhD, Ekaterini Kotsopoulou, Nushmia Z Khokhar, Martin Pule, PhD, Vijay G R Peddareddigari
Journal: Blood
Blood (2018) 132 (Supplement 1): 279.
https://doi.org/10.1182/blood-2018-99-118616
Published: 2018
Journal Articles

Chimeric Antigen Receptor T-Cells for the Treatment of Gamma-Delta T-Cell Malignancies

Paul Maciocia, BSc, MBChB, MRCP, Patrycja Wawrzyniecka, Leo Kassimatis, Martin Pule, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3338.
https://doi.org/10.1182/blood-2018-99-119774
Published: 2018
Journal Articles

Gene Editing of BTK in Acute Myeloid Leukaemia Using CRISPR-Cas9

Melanie Maerken, MS, BSc, David MacEwan, PhD, Nicholas Harper, PhD, Joseph R Slupsky, PhD, Adam Linley, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3952.
https://doi.org/10.1182/blood-2018-99-113804
Published: 2018
Journal Articles

JCARH125, Anti-BCMA CAR T-cell Therapy for Relapsed/Refractory Multiple Myeloma: Initial Proof of Concept Results from a Phase 1/2 Multicenter Study (EVOLVE)

Sham Mailankody, MBBS, Myo Htut, MD, Kelvin P. Lee, MD, William Bensinger, MD, Todd Devries, PhD, Julia Piasecki, BA, Safiyyah Ziyad, PhD, Michelle Blake, PhD, John Byon, MDPhD, Andrzej Jakubowiak, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 957.
https://doi.org/10.1182/blood-2018-99-113548
Published: 2018
Journal Articles

CAR T Cell Therapy Targeting G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D), a Novel Target for the Immunotherapy of Multiple Myeloma

Eric L. Smith, MD PhD, Kimberly Harrington, Mette Staehr, PhD, Reed Masakayan, MS, Jon Jones, BS, Thomas Long, PhD, Majid Ghoddusi, DVM, PhD, Terence J Purdon, MS, Trevor Do, Xiuyan Wang, PhD, Minh Pham, Jessica M Brown, Elizabeth Peguero, Carlos Fernández De Larrea, MD PhD, Pei Wang, PhD, Hong Liu, MD PhD, Yiyang Xu, PhD, Sarah Garrett, Steven Almo, PhD, Isabelle Riviere, PhD, Cheng Liu, PhD, Blythe Duke Sather, PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 589.
https://doi.org/10.1182/blood-2018-99-110471
Published: 2018
Journal Articles

Anti-CUB1 or Anti-Spacer Antibodies That Increase ADAMTS13 Activity Act By Allosterically Enhancing Metalloprotease Domain Function

An-Sofie Schelpe, Anastasis Petri, Nele Vandeputte, Hans Deckmyn, PhD, Simon F De Meyer, PhD, James TB Crawley, PhD, Karen Vanhoorelbeke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 23.
https://doi.org/10.1182/blood-2018-99-117061
Published: 2018
Journal Articles

Development of a Novel Class of Agents Targeting the RNA-Splicing Machinery in Myeloid Malignancies

Valeria Visconte, PhD, Bartlomiej P. Przychodzen, Vera Adema, PhD, Cassandra M. Hirsch, Allison Noe, Rachel Toth, Christina Snider, BA, Hassan Awada, MD, Amy C Graham, BS, MS, Yvonne Parker, Yuriy Fedorov, Drew Adams, Hetty E. Carraway, MD MBA, Anjali S. Advani, MD, Tomas Radivoyevitch, Heesun J. Rogers, MD PhD, Kevin R Kelly, MD PhD, Steffan T. Nawrocki, PhD, Jennifer S. Carew, PhD, Daniel Lindner, MD PhD, Richard A Padgett, Mikkael A. Sekeres, MD MS, James G Phillips, PhD, Jaroslaw P. Maciejewski
Journal: Blood
Blood (2018) 132 (Supplement 1): 211.
https://doi.org/10.1182/blood-2018-99-116411
Published: 2018
Journal Articles

Trph-222, a Novel Anti-CD22 Antibody Drug Conjugate (ADC), Has Signficant Anti-Tumor Activity in NHL Xenografts and Is Well Tolerated in Non-Human Primates

Ann Maclaren, PhD BS, Nancy Levin, PhD, Henry Lowman, PhD, Mohit Trikha, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4105.
https://doi.org/10.1182/blood.V130.Suppl_1.4105.4105
Published: 2017
Journal Articles

Hydrogen-Deuterium Exchange Plus Mass Spectrometry (HX-MS) Reveals a Novel Mechanism Underlying the pH-Dependent Regulation of ADAMTS13 Activity

Catherine B. Zander, PhD, Vikram G. Pillai, PhD, Leland Mayne, PhD, S. Walter Englander, PhD, X. Long Zheng, MD, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 238.
https://doi.org/10.1182/blood.V130.Suppl_1.238.238
Published: 2017
Journal Articles

Development of JCARH125: Optimization of a Fully Human Anti-Bcma CAR for Use in the Treatment of Multiple Myeloma

Kim Harrington, BS, Rebecca Wu, BS, Collin Hauskins, BS, Rupesh Amin, PhD, Thomas Long, PhD, Aye Chen, BA, Ayu Rahardjo, BS, Casey Thayer, BS, Garnet Navvaro, BS, Madelyn Myers, MS, Jon Jones, BS, Alex Baturevych, BS, Stan Morkowski, PhD, Ruth Salmon, PhD, Christopher J Bond, PhD, Mette Staehr, PhD, Terence J Purdon, MS, Reed Masakayan, MS, Cheng Liu, PhD, Hong Liu, MD PhD, Yiyang Xu, PhD, Pei Wang, PhD, Margot Pont, PhD, Damian J. Green, MD, Renier J. Brentjens, MD PhD, Eric L Smith, MDPhD, Blythe Duke Sather, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1813.
https://doi.org/10.1182/blood.V130.Suppl_1.1813.1813
Published: 2017
Journal Articles

Characterizing the United Kingdom Congenital Thrombotic Thrombocytopenic Purpura Population

Ferras Alwan, MBBS, Chiara Vendramin, Ri Liesner, Tina Dutt, Amanda Clark, Jayashree Motwani, Will Lester, Vickie McDonald, Rachel Rayment, Nichola Cooper, MA, MD MRCP, FRCPath, Richard Gooding, Hamish Lyall, Tina Biss, MD, Joost van Veen, Henry G Watson, John-Paul Westwood, Mari Thomas, Marie Scully
Journal: Blood
Blood (2017) 130 (Supplement 1): 3616.
https://doi.org/10.1182/blood.V130.Suppl_1.3616.3616
Published: 2017