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Journal Articles

Preclinical Activity of the MPS1 Inhibitor S81694 in Acute Lymphoblastic Leukemia (ALL)

Anna Kaci, PhD, Emilie Adiceam, Melanie Dupont, Marine Garrido, Jeannig Berrou, Hanane Djamai, Andre Baruchel, Mike Burbridge, Claude Gardin, Herve Dombret, MD PhD, Thorsten Braun, MD

Blood (2019) 134 (Supplement_1): 2631.

https://doi.org/10.1182/blood-2019-125641

Published: 2019

Journal Articles

Pign Suppresses CIN and Leukemia Progression Via Regulation of the Spindle Assembly Checkpoint

Jeffrey J Pu, MD PhD, Emmanuel Kwame Teye, PhD, Shasha Lu, MD PhD, Yang Wenrui, MD, Fangyuan Chen, MD PhD, Thomas Abraham, PhD

Blood (2018) 132 (Supplement 1): 2792.

https://doi.org/10.1182/blood-2018-99-119977

Published: 2018

Journal Articles

FANCA Fine-Tunes Chromosome Segregation By Controlling BUBR1 K250 Acetylation at the Kinetochores

Zahi Abdul Sater, Richa Sharma, MD, Elizabeth Sierra Potchanant, PhD, Ying He, Grzegorz Nalepa, MDPhD

Blood (2016) 128 (22): 1040.

https://doi.org/10.1182/blood.V128.22.1040.1040

Published: 2016

Journal Articles

Impaired Spindle Assembly Checkpoint In Vivo Promotes MDS/AML in a Novel Mouse Model of Fanconi Anemia

Donna Cerabona, Zahi Abdul Sater, Elizabeth Sierra Potchanant, PhD, Ying He, Zejin Sun, MD PhD, Grzegorz Nalepa, MDPhD

Blood (2015) 126 (23): 1211.

https://doi.org/10.1182/blood.V126.23.1211.1211

Published: 2015

Journal Articles

A Double Strand Break during Telophase Is Repaired with Homologous Recombination Despite the Absence of an Available Sister Chromatid

Amit Patel, MBBS, PhD MRCP, MRCS, FRCPath, Luis Alcaide Aragon, PhD

Blood (2015) 126 (23): 2421.

https://doi.org/10.1182/blood.V126.23.2421.2421

Published: 2015

Journal Articles

Kinome-Wide shRNA Screen Reveals Functional Connections Between FANCA, Mitotic Centrosomes and the Spindle Assembly Checkpoint Tumor Suppressor Pathways

Richa Sharma, MD, Zahi Abdul Sater, Rikki Enzor, PhD, Ying He, Grzegorz Nalepa, MDPhD

Blood (2015) 126 (23): 3612.

https://doi.org/10.1182/blood.V126.23.3612.3612

Published: 2015

Journal Articles

Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice

Marianna Trakala, David Partida, María Salazar-Roa, María Maroto, Paulina Wachowicz, Guillermo de Cárcer, Marcos Malumbres

Blood (2015) 126 (14): 1707–1714.

https://doi.org/10.1182/blood-2015-03-634402

Published: 2015

Includes: Supplemental data

Journal Articles

FANCA Controls Mitotic Phosphosignaling Networks To Ensure Genome Stability During Cell Division

Rikki Enzor, Zahi Abdul Sater, Donna Cerabona, Zejin Sun, MD, PhD, Su-jung Park, PhD, Helmut Hanenberg, MD, D. Wade Clapp, MD, Grzegorz Nalepa, MD, PhD

Blood (2013) 122 (21): 801.

https://doi.org/10.1182/blood.V122.21.801.801

Published: 2013

Journal Articles

The Spindle Checkpoint Protein BubR1 Is Differentially Expressed in the Lymphatic and Myeloid Lineage and Is a Determinator of Response to Spindle Poisons

Dominik Schnerch, MD, Marie Follo, PhD, Andrea Schmidts, Julika Krohs, Julia Felthaus, Monika Engelhardt, MD, Ralph Wäsch

Blood (2011) 118 (21): 1407.

https://doi.org/10.1182/blood.V118.21.1407.1407

Published: 2011

Journal Articles

Pharicin a, a Novel Natural Compound That Induces Mitotic Arrest and Catastrophe of Cancer Cells by Perturbing Microtubule Dynamics and the Spindle Checkpoint

Guo-Qiang Chen, Wei Dai, Han-Zhang Xu, Dao Li

Blood (2008) 112 (11): 4723.

https://doi.org/10.1182/blood.V112.11.4723.4723

Published: 2008

Journal Articles

Unscheduled Sister-Chromatid-Separation in the Presence of Spindle Disruption in Acute Myelogenous Leukemia

Dominik Schnerch, Julia Felthaus, Monika Engelhardt, Ralph M. Waesch, MD

Blood (2008) 112 (11): 3114.

https://doi.org/10.1182/blood.V112.11.3114.3114

Published: 2008

Journal Articles

Mouse Hematopoietic Stem Cells, Unlike Human and Mouse Embryonic Stem Cells, Exhibit Checkpoint-Apoptosis Coupling.

Sara Rohrabaugh, Charlie Mantel, Hal E. Broxmeyer

Blood (2007) 110 (11): 3357.

https://doi.org/10.1182/blood.V110.11.3357.3357

Published: 2007

Journal Articles

Molecular Mechanisms of Spindle Checkpoint-Apoptosis Linkage and Karyotypic Stability in Stem Cells.

Charlie Mantel, Sara Rhorabough, Ying Guo, Man-Ryul Lee, Myung-Kwan Han, Kye-Seong Kim, Hal E. Broxmeyer

Blood (2007) 110 (11): 3361.

https://doi.org/10.1182/blood.V110.11.3361.3361

Published: 2007

Journal Articles

Spindle Checkpoint Insufficiency in Acute Myeloid Leukemia.

Dominik Schnerch, Julia Felthaus, Monika Engelhardt, MD, Ralph M. Waesch, MD

Blood (2007) 110 (11): 873.

https://doi.org/10.1182/blood.V110.11.873.873

Published: 2007

Journal Articles

A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy

Anita Boyapati, Ming Yan, Luke F. Peterson, Joseph R. Biggs, Michelle M. Le Beau, Dong-Er Zhang

Blood (2006) 109 (9): 3963–3971.

https://doi.org/10.1182/blood-2006-09-045583

Published: 2006

Includes: Supplemental data

Journal Articles

Spindle Checkpoint Insufficiency and Unscheduled APC-Dependent Proteolysis in Acute Myeloid Leukemia.

Dominik Schnerch, Julia Felthaus, Monika Engelhardt, Ralph M. Waesch

Blood (2006) 108 (11): 2082.

https://doi.org/10.1182/blood.V108.11.2082.2082

Published: 2006

Journal Articles

A t(8;21) Fusion Protein Disrupts the Spindle Checkpoint and Promotes Aneuploidy.

Anita Boyapati, PhD, Luke F. Peterson, PhD, Ming Yan, PhD, Michelle M. Le Beau, PhD, Dong-Er Zhang, PhD

Blood (2005) 106 (11): 1345.

https://doi.org/10.1182/blood.V106.11.1345.1345

Published: 2005

Journal Articles

Downregulation of Bub1 and a Defective Spindle Checkpoint in Acute Myeloid Leukemia.

Ralph Waesch, MD, Dominik Schnerch

Blood (2005) 106 (11): 2846.

https://doi.org/10.1182/blood.V106.11.2846.2846

Published: 2005

Journal Articles

Leukemic B Cells from CD38 Positive but Not CD38 Negative B-CLL Patients Express Heightened Levels of Cell Cycle Related Genes.

Brian T. Pittner, Ph.D., Renee C. Tschumper, Bruce W. Morlan, Karla V. Ballman, Ph.D., Neil E. Kay, M.D., Diane F. Jelinek, Ph.D.

Blood (2004) 104 (11): 4809.

https://doi.org/10.1182/blood.V104.11.4809.4809

Published: 2004

Journal Articles

BUBR1 deficiency results in abnormal megakaryopoiesis

Qi Wang, Tongyi Liu, Yuqiang Fang, Suqing Xie, Xuan Huang, Radma Mahmood, Gita Ramaswamy, Kathleen M. Sakamoto, Zbigniew Darzynkiewicz, Ming Xu, Wei Dai

Blood (2004) 103 (4): 1278–1285.

https://doi.org/10.1182/blood-2003-06-2158

Published: 2004

NARROW

Preclinical Activity of the MPS1 Inhibitor S81694 in Acute Lymphoblastic Leukemia (ALL)

Pign Suppresses CIN and Leukemia Progression Via Regulation of the Spindle Assembly Checkpoint

FANCA Fine-Tunes Chromosome Segregation By Controlling BUBR1 K250 Acetylation at the Kinetochores

Impaired Spindle Assembly Checkpoint In Vivo Promotes MDS/AML in a Novel Mouse Model of Fanconi Anemia

A Double Strand Break during Telophase Is Repaired with Homologous Recombination Despite the Absence of an Available Sister Chromatid

Kinome-Wide shRNA Screen Reveals Functional Connections Between FANCA, Mitotic Centrosomes and the Spindle Assembly Checkpoint Tumor Suppressor Pathways

Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice

FANCA Controls Mitotic Phosphosignaling Networks To Ensure Genome Stability During Cell Division

The Spindle Checkpoint Protein BubR1 Is Differentially Expressed in the Lymphatic and Myeloid Lineage and Is a Determinator of Response to Spindle Poisons

Pharicin a, a Novel Natural Compound That Induces Mitotic Arrest and Catastrophe of Cancer Cells by Perturbing Microtubule Dynamics and the Spindle Checkpoint

Unscheduled Sister-Chromatid-Separation in the Presence of Spindle Disruption in Acute Myelogenous Leukemia

Mouse Hematopoietic Stem Cells, Unlike Human and Mouse Embryonic Stem Cells, Exhibit Checkpoint-Apoptosis Coupling.

Molecular Mechanisms of Spindle Checkpoint-Apoptosis Linkage and Karyotypic Stability in Stem Cells.

Spindle Checkpoint Insufficiency in Acute Myeloid Leukemia.

A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy

Spindle Checkpoint Insufficiency and Unscheduled APC-Dependent Proteolysis in Acute Myeloid Leukemia.

A t(8;21) Fusion Protein Disrupts the Spindle Checkpoint and Promotes Aneuploidy.

Downregulation of Bub1 and a Defective Spindle Checkpoint in Acute Myeloid Leukemia.

Leukemic B Cells from CD38 Positive but Not CD38 Negative B-CLL Patients Express Heightened Levels of Cell Cycle Related Genes.

BUBR1 deficiency results in abnormal megakaryopoiesis

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American Society of Hematology

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ASH Publications

American Society of Hematology

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