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Journal Articles

Combined Targeting of STAT3 and STAT5: A Novel Approach to Overcome Drug Resistance in Ph + Cml

Karoline V Gleixner, MD, Mathias A Schneeweiss, MD, Harald Herrmann, MD, Katharina Blatt, MSc, PhD, Daniela Berger, Gregor Eisenwort, MD PhD, Georg Greiner, MD, Konstantin Byrgazov, PhD, Gregor Hoermann, Marina Konopleva, MD PhD, Islam Waliul, Patrick T Gunning, PhD, Hiroshi Maeda, PhD, Richard Moriggl, PhD, Michael W. Deininger, MD PhD, Thomas Lion, PhD, Michael Andreeff, MD PhD, Peter Valent, MD

Blood (2016) 128 (22): 4241.

https://doi.org/10.1182/blood.V128.22.4241.4241

Published: 2016

Journal Articles

Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction

Sagar Uttarkar, Emilie Dassé, Anna Coulibaly, Simone Steinmann, Anke Jakobs, Caroline Schomburg, Amke Trentmann, Joachim Jose, Peter Schlenke, Wolfgang E. Berdel, Thomas J. Schmidt, Carsten Müller-Tidow, Jon Frampton, Karl-Heinz Klempnauer

Blood (2016) 127 (9): 1173–1182.

https://doi.org/10.1182/blood-2015-09-668632

Published: 2016

Includes: Supplemental data

Journal Articles

Targeting Lon Protease Activity Promotes Growth Inhibition and Apoptosis in Acute Myeloid Leukemia Cell Lines

Serena De Matteis, BS, Silvia Carloni, BS, Roberta Napolitano, BS, Michele Zanoni, BS, Lara Gibellini, BS PhD, Alessandro Lucchesi, MD, Andrea Cossarizza, MD, Giovanni Martinelli, MD

Blood (2014) 124 (21): 5130.

https://doi.org/10.1182/blood.V124.21.5130.5130

Published: 2014

Journal Articles

Bernstein SH, Venkatesh S, Li M, et al. The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. Blood. 2012;119(14): 3321-3329 .

Blood (2014) 124 (9): 1539.

https://doi.org/10.1182/blood-2014-07-587428

Published: 2014

Journal Articles

A Plant Triterpenoid Avicin D Stimulates Adipocytic Differentiation of Bone Marrow Stromal Cells and Promotes Their Pro-Survival Effects On Acute Monoblastic Leukemia Cells

Yoko Tabe, MD, PhD, Linhua Jin, PhD, Saiko Kazuno, Tsutomu Fujimura, Hiromichi Matsushita, MD, PhD, Takashi Ueno, Michael Andreeff, MD, PhD, Jordan U. Gutterman, MD, Marina Konopleva, MD, PhD

Blood (2012) 120 (21): 4315.

https://doi.org/10.1182/blood.V120.21.4315.4315

Published: 2012

Journal Articles

The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives

Steven H. Bernstein, Sundararajan Venkatesh, Min Li, Jae Lee, Bin Lu, Shannon P. Hilchey, Kimberly M. Morse, Hollie M. Metcalfe, Jolanta Skalska, Michael Andreeff, Paul S. Brookes, Carolyn K. Suzuki

Blood (2012) 119 (14): 3321–3329.

https://doi.org/10.1182/blood-2011-02-340075

Published: 2012

Includes: Supplemental data

Journal Articles

Ursolic Acid Induced Apoptosis Involving Upregulation of Expression of PTEN Gene and Inactivation of PI3K/Akt Pathway in K562 Cells

Bin Wu, Rong Hu, Huihan Wang, Hongtao Wang, Rong Zhang, Wei Yang, Zhuogang Liu

Blood (2011) 118 (21): 4453.

https://doi.org/10.1182/blood.V118.21.4453.4453

Published: 2011

Journal Articles

The Heat Shock Protein 32 (Hsp32)/HO-1-Targeting Drug SMA-ZnPP and the Triterpenoid CDDO-Me Exert Synergistic Growth-Inhibitory Effects on TKI-Resistant Leukemic Cells in Ph+ CML

Karoline V. Gleixner, M.D., Harald Herrmann, M.D., Katharina Blatt, M.Sc., Winfried F Pickl, MD, Marina Konopleva, MD, PhD, Gahininath Y Bharate, Michael Andreeff, M.D., Ph.D., Hiroshi Maeda, MD, Peter Valent, M.D.

Blood (2011) 118 (21): 4414.

https://doi.org/10.1182/blood.V118.21.4414.4414

Published: 2011

Journal Articles

The Triterpenoid 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic Acid and Its Derivatives Inhibit Mitochondrial Lon Protease Activity: A Potential Novel Pathway for the Induction of Lymphoma Cell Death.

Steven H. Bernstein, MD, Bin Lin, PhD, Shannon Hilchey, PhD, N. Villaluna, L. Chen, K. Madura, Kim Morse, Hollie Metcalf, Michael Andreeff, MD, PhD, Paul S Brookes, PhD, Carolyn K Suzuki, PhD

Blood (2009) 114 (22): 414.

https://doi.org/10.1182/blood.V114.22.414.414

Published: 2009

Journal Articles

Pro-Apoptotic and Proliferative Effects of Bone Marrow Adipocytes on Myeloid Leukemia Cells.

Linhua Jin, PhD, Marina Konopleva, MD, PhD, Yixin Zhou, Akimichi Osaka, MD, PhD, Michael Andreeff, MD, PhD, Takashi Miida, MD, PhD, Yoko Tabe, MD, PhD

Blood (2009) 114 (22): 4572.

https://doi.org/10.1182/blood.V114.22.4572.4572

Published: 2009

Journal Articles

Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo

Rodger E. Tiedemann, Jessica Schmidt, Jonathan J. Keats, Chang-Xin Shi, Yuan Xiao Zhu, Stephen E. Palmer, Xinliang Mao, Aaron D. Schimmer, A. Keith Stewart

Blood (2009) 113 (17): 4027–4037.

https://doi.org/10.1182/blood-2008-09-179796

Published: 2009

Includes: Supplemental data

Journal Articles

Identification of a Potent Natural Triterpenoid Inhibitor of Proteosome Chymotrypsin-Like Activity and NF-κB with Specific Anti-Myeloma Activity in Vitr o and in Vivo

Rodger E. Tiedemann, MBChB, PhD, FRACP, FRCPA, Jonathan J Keats, PhD, Jessica Schmidt, BS, Chang-Xin Shi, Yuan X Zhu, PhD, Xinliang Mao, MD, PhD, Aaron D. Schimmer, Keith Stewart, MD

Blood (2008) 112 (11): 3679.

https://doi.org/10.1182/blood.V112.11.3679.3679

Published: 2008

Journal Articles

Cucurbitacin D Upregulates Fetal Hemoglobin Expression in K562 Cells and Human Erythroid Progenitors.

Hongtao Xing, PhD, Siwei Zhang, M.Phil., H. Phillip Koeffler, M.D., Ming Chiu Fung, Ph.D.

Blood (2007) 110 (11): 3833.

https://doi.org/10.1182/blood.V110.11.3833.3833

Published: 2007

Journal Articles

Preferential Inhibition of Malignant Cell Growth by CDDO in Waldenström Macroglobulinemia.

Sherine F. Elsawa, PhD, Anne J. Novak, Ph.D., Marina Konopleva, M.D., Ph.D., Michael Andreeff, M.D., Ph.D., Thomas E. Witzig, M.D., Stephen M. Ansell, M.D., Ph.D.

Blood (2006) 108 (11): 2528.

https://doi.org/10.1182/blood.V108.11.2528.2528

Published: 2006

Journal Articles

Triterpenoids Display Single Agent Activity in a Mouse Model of CLL/SBL.

Christina L. Kress, BS, Marina Konopleva, Ph.D., Maryla Krajewska, M.D., Vanesa Martinez-Garcia, B.S., Sophie Lefebvre, Ph.D., Marc L. Hyer, Ph.D., Teresa McQueen, B.S., Michael Andreeff, Ph.D., John C. Reed, MD,Ph.D, Juan Zapata, Ph.D.

Blood (2006) 108 (11): 2530.

https://doi.org/10.1182/blood.V108.11.2530.2530

Published: 2006

Journal Articles

Therapeutic Potential of a Desert Plant Triterpenoid Molecule for Polycythemia Vera.

Amos S. Gaikwad, PhD, Jordan U. Gutterman, MD, Josef T. Prchal, MD

Blood (2006) 108 (11): 3635.

https://doi.org/10.1182/blood.V108.11.3635.3635

Published: 2006

Journal Articles

Chemical Library Screening Identifies Novel Inhibitors of Cyclin D2 ( CCND2) Transactivation That Selectively Induce Apoptosis in Multiple Myeloma Cells.

Rodger E. Tiedemann, MD, PhD, Xinliang Mao, PhD, Chng-Xin Shi, PhD, Yuan Xiao Zhang, PhD, Stephen Palmer, Craig B. Reeder, MD, Aaron Schimmer, MD, Keith Stewart, MD

Blood (2006) 108 (11): 3421.

https://doi.org/10.1182/blood.V108.11.3421.3421

Published: 2006

Journal Articles

The Role of Apoptotic Inducing Factor (AIF) in Acute Myeloid Leukemia (AML).

Rui-Yu Wang, MD, PhD, Bing Z. Carter, PhD, Twee Tsao, Wendy Schober, Teresa McQueen, BS, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD

Blood (2005) 106 (11): 2369.

https://doi.org/10.1182/blood.V106.11.2369.2369

Published: 2005

Journal Articles

CDDO Increases Translation of CCAAT Enhancer Binding Protein alpha To Induce Granulocytic Differentiation.

Steffen Koschmieder, MD, Francesco D′Alo′, MD, Hanna Radomska, PhD, Susumu Kobayashi, MD, PhD, Elena Levantini, PhD, Nanjoo Suh, PhD, Michael B. Sporn, MD, Annalisa Di Ruscio, MD, Maria Teresa Voso, MD, Wolfgang E. Berdel, MD, Carsten Müller-Tidow, MD, Hubert Serve, MD, Daniel G. Tenen, MD

Blood (2005) 106 (11): 2458.

https://doi.org/10.1182/blood.V106.11.2458.2458

Published: 2005

Journal Articles

Mechanisms and Activity of PPARγ-Active Triterpenoids CDDO and CDDO-Me in Leukemias.

Marina Konopleva, MD, PhD, Ismael Samudio, PhD, Twee Tsao, Steven M. Kornblau, MD, Yue-Xi Shi, Teresa McQueen, BS, Rooha Contractor, Michael B. Sporn, MD, Colin J. Meyer, MD, Warren Huff, Stephen H. Safe, PhD, Hagop Kantarjian, MD, Michael Andreeff, MD, PhD

Blood (2005) 106 (11): 2460.

https://doi.org/10.1182/blood.V106.11.2460.2460

Published: 2005

NARROW

Combined Targeting of STAT3 and STAT5: A Novel Approach to Overcome Drug Resistance in Ph + Cml

Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction

Targeting Lon Protease Activity Promotes Growth Inhibition and Apoptosis in Acute Myeloid Leukemia Cell Lines

Bernstein SH, Venkatesh S, Li M, et al. The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. Blood. 2012;119(14): 3321-3329 .

A Plant Triterpenoid Avicin D Stimulates Adipocytic Differentiation of Bone Marrow Stromal Cells and Promotes Their Pro-Survival Effects On Acute Monoblastic Leukemia Cells

The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives

Ursolic Acid Induced Apoptosis Involving Upregulation of Expression of PTEN Gene and Inactivation of PI3K/Akt Pathway in K562 Cells

The Heat Shock Protein 32 (Hsp32)/HO-1-Targeting Drug SMA-ZnPP and the Triterpenoid CDDO-Me Exert Synergistic Growth-Inhibitory Effects on TKI-Resistant Leukemic Cells in Ph+ CML

The Triterpenoid 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic Acid and Its Derivatives Inhibit Mitochondrial Lon Protease Activity: A Potential Novel Pathway for the Induction of Lymphoma Cell Death.

Pro-Apoptotic and Proliferative Effects of Bone Marrow Adipocytes on Myeloid Leukemia Cells.

Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo

Identification of a Potent Natural Triterpenoid Inhibitor of Proteosome Chymotrypsin-Like Activity and NF-κB with Specific Anti-Myeloma Activity in Vitr o and in Vivo

Cucurbitacin D Upregulates Fetal Hemoglobin Expression in K562 Cells and Human Erythroid Progenitors.

Preferential Inhibition of Malignant Cell Growth by CDDO in Waldenström Macroglobulinemia.

Triterpenoids Display Single Agent Activity in a Mouse Model of CLL/SBL.

Therapeutic Potential of a Desert Plant Triterpenoid Molecule for Polycythemia Vera.

Chemical Library Screening Identifies Novel Inhibitors of Cyclin D2 ( CCND2) Transactivation That Selectively Induce Apoptosis in Multiple Myeloma Cells.

The Role of Apoptotic Inducing Factor (AIF) in Acute Myeloid Leukemia (AML).

CDDO Increases Translation of CCAAT Enhancer Binding Protein alpha To Induce Granulocytic Differentiation.

Mechanisms and Activity of PPARγ-Active Triterpenoids CDDO and CDDO-Me in Leukemias.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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