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Journal Articles

Targeting the Activating Mutations of NOTCH1 in T-Cell Lymphoblastic Leukemia with a New SERCA Inhibitor CAD204520

Matteo Marchesini, PhD, Andrea Gherli, Anna Montanaro, Samuel Kitara, Claudia Sorrentino, Luca Pagliaro, Anne-Marie Lund Winter, Chiara Rompietti, Donatella Stilli, Federica Rizzi, Kimberly Stegmaier, MD, Paolo Sportoletti, William Dalby-Brown, Giovanni Roti
Journal: Blood
Blood (2019) 134 (Supplement_1): 407.
https://doi.org/10.1182/blood-2019-125616
Published: 2019
Journal Articles

RIG-I Activation Is Critical for Responsiveness to Checkpoint Blockade

Simon Heidegger, MD, Alexander Wintges, Florian Stritzke, Katja Steiger, Paul-Albert Koenig, Thomas Engleitner, Julius Clemens Fischer, Vladimir Makarov, Christof Winter, Roland Rad, Marcel R.M. van den Brink, MD PhD, Jürgen Ruland, Florian Bassermann, MD PhD, Timothy Chan, Tobias Haas, MD, Hendrik Poeck, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 624.
https://doi.org/10.1182/blood-2019-128724
Published: 2019
Journal Articles

A Phase 1 First-in-Human Study of the Anti-CD38 Dimeric Fusion Protein TAK-169 for the Treatment of Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM) Who Are Proteasome Inhibitor (PI)- and Immunomodulatory Drug (IMiD)-Refractory, Including Pts Relapsed/Refractory (R/R) or Naïve to Daratumumab (dara)

Shaji K. Kumar, MD, Robert F. Cornell, MD MS, Ola Landgren, MD PhD, Sikander Ailawadhi, MD, Jack P Higgins, PhD, Erin K Willert, Roger Waltzman, MD MBA, Jianchang Lin, PhD, Yuhong Zhang, Anya R Lublinsky, Ajeeta B Dash, PhD, Michael Hanley, Divya Manoharan, Morgan Leichter, Sean Ottinger, Richard J Labotka, John Newcomb, Alexander Vorog, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1867.
https://doi.org/10.1182/blood-2019-125629
Published: 2019
Journal Articles

Developing a Novel Anti-Bcma CAR-T for Relapsed or Refractory Multiple Myeloma

Xin Yao, PhD, Shigui Zhu, PhD, Jiaqi Huang, PhD, Xiaoyan Qu, MD PhD, Judy Zhu, MD, Yutian Wei, MS, Liping Lan, MS, Xiaoteng LV, MS, Junfeng Wu, PhD, Rirfei Wang, MS, Dingzhu Yang, Chengxiao Zheng, MD, DiJun Zhao, MS, Lei Fan, MD PhD, Fei Huang, Hua Lu, MD PhD, Chaocan Zhang, MS, Cheng Chen, PhD, Yanfeng Li, MS, Jiaqiang Ren, MD PhD, Li Zhang, MD, Michael Humphries, MD, Jianyong Li, MD, Yihong Yao, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 50.
https://doi.org/10.1182/blood-2019-125372
Published: 2019
Journal Articles

Oral Azacitidine and Cedazuridine Approximate Azacitidine Efficacy in a Murine Model

Haley E. Ramsey, PhDMSc, Maria Arrate, MSc, Londa Fuller, Agnieszka E. Gorska, MSc, Kelli Boyd, DVM, PhD, Melissa A. Fischer, MSc, PhD, Aram Oganesian, PhD, Mohammad Azab, MD, Michael R. Savona, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1376.
https://doi.org/10.1182/blood-2019-125899
Published: 2019
Journal Articles

A Phase 1b/2 Study of TAK-981, a First-in-Class Sumoylation Inhibitor, in Combination with Rituximab in Patients with Relapsed/Refractory (r/r) CD20-Positive Non-Hodgkin Lymphoma (NHL)

Sarit Assouline, MD, Amitkumar Mehta, MD, Paolo F Caimi, MD, Bingxia Wang, PhD, Chirag Patel, Mi-Sook Kim, Dennis Huszar, Allison J Berger, PhD, Sharon Friedlander, Alejandro Gomez-Pinillos, Igor Proscurshim
Journal: Blood
Blood (2019) 134 (Supplement_1): 1593.
https://doi.org/10.1182/blood-2019-128773
Published: 2019
Journal Articles

Alliance A041701 - a Randomized Phase 2/3 Study of Conventional Chemotherapy +/- Uproleselan (GMI-1271) in Older Adults with Acute Myeloid Leukemia (AML) Receiving Intensive Induction Chemotherapy

Geoffrey L. Uy, MD, Jun Yin, PhD, Heidi D. Klepin, MD, Shira Dinner, MD, Anthony J. Jaslowski, MD, Stephen A. Strickland, MD, Jane L. Liesveld, MD, John C. Byrd, MD, Richard M. Stone, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1366.
https://doi.org/10.1182/blood-2019-127142
Published: 2019
Journal Articles

A Novel Class of Bifunctional Immunotherapeutic That Exploits a Universal Antibody Binding Terminus (uABT) to Recruit Endogenous Antibodies to Cell Expressing CD38 Demonstrate In Vivo efficacy in Three Distinct Animal Models

Anna Bunin, PhD, Katy McGrath, BS, Ann Marie Rossi, MS, Matthew Welsch, PhD, Christian Vidal, PhD, David Trinh, BA, David Spiegel, MD, PhD, Luca Rastelli, PhD, Enrique Alvarez, DVM
Journal: Blood
Blood (2019) 134 (Supplement_1): 1820.
https://doi.org/10.1182/blood-2019-130838
Published: 2019
Journal Articles

Cord Blood Regulatory T Cells Prevent Mutiple Myeloma Progression By Suppressing Inflammation

Mitsutaka Nishimoto, MD PhD, Ke Zeng, MD PhD, Meixian Huang, Mi-Ae Lyu, PhD, Nina D. Shah, MD, Swaminathan P. Iyer, MD, Robert Z. Orlowski, MD, PhD, Simrit Parmar, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 3095.
https://doi.org/10.1182/blood-2019-128418
Published: 2019
Journal Articles

Host and Tumor Factor XII Drive Ovarian Cancer Maintenance and Progression

Evi X Stavrou, MD, Kara L. Bane, M.Sc., Peronne Joseph, M.Sc., Anil Belur Nagaraj, PhD, Analisa Difeo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2384.
https://doi.org/10.1182/blood-2019-125862
Published: 2019
Journal Articles

Mutation of the CD28 Co-Stimulatory Domain Confers Enhanced CAR T Cell Function

Justin C. Boucher, PhD, Gongbo Li, PhD MBBS, Hiroshi Kotani, MD PhD, Maria Cabral, Dylan Morrissey, Sae Bom Lee, Kristen Spitler, Nolan Beatty, Bishwas Shrestha, PhD, Bin Yu, Aslamuzzaman Kazi, Xuefeng Wang, PhD, Said Sebti, PhD, Marco L. Davila, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 248.
https://doi.org/10.1182/blood-2019-122954
Published: 2019
Journal Articles

TNB-486, a Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills CD19-Positive Tumor Cells with Minimal Cytokine Secretion

Harbani Malik, PhD, Ben Buelow, MD PhD, Udaya Rangaswamy, PhD, Aarti Balasubramani, Andrew Boudreau, Kevin Dang, Laura Davison, PhD, Shelley Force Aldred, Katherine Marie Harris, MD, Suhasini Iyer, PhD, Brett Jorgensen, PhD, Duy Pham, MBA, Kirthana Prabhakar, Ute Schellenberger, PhD, Harshad Ugamraj, Nathan Trinklein, PhD, Wim Van Schooten, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4070.
https://doi.org/10.1182/blood-2019-123226
Published: 2019
Journal Articles

TJC4, a Differentiated Anti-CD47 Antibody with Novel Epitope and RBC Sparing Properties

Zhen Meng, PhD, Zhengyi Wang, PhD, Bingshi Guo, PhD, Wei Cao, PhD, Huaqiong Shen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4063.
https://doi.org/10.1182/blood-2019-122793
Published: 2019
Journal Articles

FT819: Translation of Off-the-Shelf TCR-Less Trac-1XX CAR-T Cells in Support of First-of-Kind Phase I Clinical Trial

Chiawei Chang, Sjoukje Van Der Stegen, PhD, Mandal Mili, PhD, Raedun Clarke, PhD, Yi-Shin Lai, PhD, Alec Witty, PhD, Pieter Lindenbergh, Bi-Huei Yang, PhD, Mushtaq Husain, PhD, Helena Shaked, PhD, Brian Groff, Laurel Stokely, Ramzey Abujarour, PhD, Tom Lee, PhD, Hui-Yi Chu, PhD, Mochtar Pribadi, PhD, Jason ORourke, PhD, Alma Gutierrez, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4434.
https://doi.org/10.1182/blood-2019-130584
Published: 2019
Journal Articles

A Phase I/II Study of NMS-03592088, a FLT3, KIT and CSF1R Inhibitor, in Patients with Relapsed or Refractory AML or CMML

Marina Ciomei, Lucia Zanetta, Federico Lussana, MD, Erika Ravelli, MD, Francesco Fiorentini, Roberta Bosotti, Elena Ardini, Andrea Lombardi Borgia, Romana Pulci, Rosalinda Gatto, Alessandro Di Sanzo, Elena Colajori, MD, Cristina Davite, Arturo Galvani, Frank Xiaodong Gan, Giuseppe Rossi, Matteo Giovanni Della Porta, MD, Roberto Cairoli, MD, Alessandro Rambaldi, MD, Antonella Isacchi
Journal: Blood
Blood (2019) 134 (Supplement_1): 3855.
https://doi.org/10.1182/blood-2019-121954
Published: 2019
Journal Articles

NKTR-255, a Polymer-Conjugated IL-15 Enhances Antibody-Dependent Cellular Cytotoxicity Mediated By NK Cells in a B Cell Lymphoma Model

Takahiro Miyazaki, Saul Kivimäe, Marlene Hennessy, Rhoneil Pena, Phi Quach, Andrew Moffet, Wildaliz Nieves, Ping Zhang, Mario Q. Marcondes, MD PhD, Loui Madakamutil, Jonathan Zalevsky
Journal: Blood
Blood (2019) 134 (Supplement_1): 5302.
https://doi.org/10.1182/blood-2019-127771
Published: 2019
Journal Articles

Preclinical Development of an Anti-CD38 Antibody-Drug Conjugate for Treatment of Hematological Malignancies

Lingna Li, PhD, Wenyong Tong, PhD, Megan Lau, BS, Katherine Fells, PhD, Tong Zhu, PhD, Yingqing Sun, PhD, Ernest Kovacs, PhD, Alisher Khasanov, PhD, Zheng Yan, PhD, Dalun Deng, PhD, Ken Takeshita, MD, Gunnar F. Kaufmann, PhD, Henry Ji, PhD, Hui Li, PhD, Hong Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5621.
https://doi.org/10.1182/blood-2019-132062
Published: 2019
Journal Articles

Preclinical Development of a Bcma Targeting Antibody-Drug Conjugate with Novel Payload for Multiple Myeloma Therapy

Andrew Hau, PhD, Tong Zhu, PhD, Rengang Wang, PhD, Megan Lau, BS, Lingna Li, PhD, Xiaoqing Li, PhD, Yingqing Sun, PhD, Ernest Kovacs, PhD, Alisher Khasanov, PhD, Dalun Deng, PhD, Zheng Yan, PhD, Robert D. Knight, MD, Gunnar F. Kaufmann, PhD, Henry Ji, PhD, Hui Li, PhD, Hong Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5623.
https://doi.org/10.1182/blood-2019-132080
Published: 2019
Journal Articles

Arsenic Trioxide Synergistically Enhances the Antileukemia Activity of Bcl-2 Inhibitor ABT-199 in Acute Myeloid Leukemia

Sha Liu, Lin Chen, MD, Xiaojiao Wang, Ruihua Mi, Qingsong Yin, Ruihua Fan, Xudong Wei, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2555.
https://doi.org/10.1182/blood-2019-129543
Published: 2019
Journal Articles

A Phase 3 Randomized Study (PRIMULA) of the Epigenetic Combination of Pracinostat, a Pan-Histone Deacetylase (HDAC) Inhibitor, with Azacitidine (AZA) in Patients with Newly Diagnosed Acute Myeloid Leukemia (AML) Unfit for Standard Intensive Chemotherapy (IC)

Guillermo Garcia-Manero, MD, Maciej Kaźmierczak, Chun Yew Fong, MBBS,PhDFRACP,FRCPA, Pau Montesinos, MD PhD, Adriano Venditti, Silvia Mappa, MD, Riccardo Spezia, Lionel Ades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2652.
https://doi.org/10.1182/blood-2019-125924
Published: 2019