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Sharon Friedlander
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Journal Articles

TAK-981, a First-in-Class SUMO-Activating Enzyme Inhibitor, Combined with Rituximab in Adult Patients (Pts) with CD20-Positive Relapsed/Refractory (R/R) Non-Hodgkin Lymphoma (NHL): Phase 1 Data

Sarit Assouline, Amitkumar Mehta, Tycel Phillips, Lapo Alinari, Alexey V. Danilov, Stéphane Doucet, Steven I. Park, Deborah Berg, Alejandro Gomez-Pinillos, Alonzo Martinez, Bo Chao, Allison J Berger, John Gibbs, Sharon Friedlander, Christine K. Ward, Igor Proscurshim, Brenda W. Cooper, Paolo F Caimi
Journal: Blood
Blood (2021) 138 (Supplement 1): 2488.
https://doi.org/10.1182/blood-2021-152225
Published: 2021
Journal Articles

A Randomized Phase 2 Study of Pevonedistat, Venetoclax, and Azacitidine Versus Venetoclax Plus Azacitidine in Adults with Newly Diagnosed Acute Myeloid Leukemia (AML) Who Are Unfit for Intensive Chemotherapy

Nicholas J. Short, MD, Farhad Sedarati, Dan Zhao, Olga Tsukurov, Sharon Friedlander, Douglas V. Faller
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
https://doi.org/10.1182/blood-2020-136968
Published: 2020
Journal Articles

A Phase 1b/2 Study of TAK-981, a First-in-Class Sumoylation Inhibitor, in Combination with Rituximab in Patients with Relapsed/Refractory (r/r) CD20-Positive Non-Hodgkin Lymphoma (NHL)

Sarit Assouline, MD, Amitkumar Mehta, MD, Paolo F Caimi, MD, Bingxia Wang, PhD, Chirag Patel, Mi-Sook Kim, Dennis Huszar, Allison J Berger, PhD, Sharon Friedlander, Alejandro Gomez-Pinillos, Igor Proscurshim
Journal: Blood
Blood (2019) 134 (Supplement_1): 1593.
https://doi.org/10.1182/blood-2019-128773
Published: 2019
Journal Articles

Selective inhibition of nuclear export with selinexor in patients with non-Hodgkin lymphoma

Clinical Trials & Observations
John Kuruvilla, Michael Savona, Rachid Baz, Paul Morten Mau-Sorensen, Nashat Gabrail, Ramiro Garzon, Richard Stone, Michael Wang, Lynn Savoie, Peter Martin, Ian Flinn, Meagan Jacoby, Thaddeus J. Unger, Jean-Richard Saint-Martin, Tami Rashal, Sharon Friedlander, Robert Carlson, Michael Kauffman, Sharon Shacham, Martin Gutierrez
Journal: Blood
Blood (2017) 129 (24): 3175–3183.
https://doi.org/10.1182/blood-2016-11-750174
Published: 2017
Includes: Supplemental data
Journal Articles

Synergistic Anti-Tumor Effect of KPT-8602, a Second Generation Selective Inhibitor of Nuclear Export (SINE) Compound, and Panobinostat, a Pan-Histone Deacetylase (HDAC) Inhibitor in Multiple Myeloma

Christian Argueta, PhD, Hua Chang, PhD, Trinayan Kashyap, MS, Sivan Elloul, PhD, Sharon Friedlander, PhD, Margaret S. Lee, PhD, Michael Kauffman, MD PhD, Sharon Shacham, PhD MBA, William Senapedis, PhD, Erkan Baloglu, PhD MBA
Journal: Blood
Blood (2016) 128 (22): 3298.
https://doi.org/10.1182/blood.V128.22.3298.3298
Published: 2016
Journal Articles

Selinexor and Low Dose Dexamethasone (Sd) in Patients with Lenalidomide, Pomalidomide, Bortezomib, Carfilzomib and Anti-CD38 Ab Refractory Multiple Myeloma (MM): STORM Study

Dan T. Vogl, MD, David Dingli, MD PhD FRCP, R. Frank Cornell, MD MS, Carol Ann Huff, MD, Sundar Jagannath, MD, Divaya Bhutani, Rachid Baz, MD, Ajay K Nooka, MD MPH, Joshua Richter, MD, Craig E. Cole, MD, Ravi Vij, Andrzej Jakubowiak, MD, Rafat Abonour, MD, Gary J. Schiller, MD, Terri L. Parker, MD, Luciano J. Costa, MD PhD, David Kaminetzky, MD, James Hoffman, MD, Andrew J. Yee, MD, Ajai Chari, MD, David S. Siegel, MD PhD, Rafael Fonseca, MD, Scott VanWier, Gregory Ahmann, Ilsel Lopez, Michael Kauffman, MD PhD, Sharon Shacham, PhD MBA, Jean-Richard Saint-Martin, Carla Picklesimer, Sharon Friedlander, PhD, Cassandra Choe-Juliak, MD, A. Keith Stewart, MBChB
Journal: Blood
Blood (2016) 128 (22): 491.
https://doi.org/10.1182/blood.V128.22.491.491
Published: 2016
Journal Articles

Combination of Selective Inhibitor of Nuclear Export (SINE) Compounds, Selinexor and KPT-8602, with Venetoclax (ABT-199) Displays Enhanced Activity in Leukemia and Large Cell Lymphoma

Melissa A. Fischer, PhD, Sharon Friedlander, PhD, Leah Hogdal, PhD, Pia Arrate, Hua Chang, PhD, Trinayan Kashyap, MS, Christian Argueta, PhD, Boris Klebanov, MA, MS, William Senapedis, PhD, Erkan Baloglu, PhD MBA, Margaret S. Lee, PhD, Sharon Shacham, PhD MBA, Michael R. Savona, MD
Journal: Blood
Blood (2016) 128 (22): 3949.
https://doi.org/10.1182/blood.V128.22.3949.3949
Published: 2016
Journal Articles

A Phase 1/2 Study of the Second Generation Selective Inhibitor of Nuclear Export (SINE) Compound, KPT-8602, in Patients with Relapsed Refractory Multiple Myeloma

R. Frank Cornell, MD MS, Adriana C Rossi, MD, MSc, Rachid Baz, MD, Craig C Hofmeister, Chaim Shustik, MD, Joshua R. Richter, MD, Christine Chen, MD, Dan T. Vogl, MD, Sharon Shacham, PhD MBA, Erkan Baloglu, PhD MBA, William Senapedis, PhD, Joel Ellis, PhD, Sharon Friedlander, PhD, Cassandra Choe-Juliak, MD, Christopher L Cubitt, PhD, Joel G Turner, PhD, Daniel Sullivan, MD MS, Michael Kauffman, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4509.
https://doi.org/10.1182/blood.V128.22.4509.4509
Published: 2016
Journal Articles

Selinexor-Induced Thrombocytopenia Results from the Inhibition of Megakaryocyte Progenitor Cells in the Early Stage of Megakaryopoiesis

Kellie R Machlus, PhD, Stephen Wu, Robert Carlson, PhD, Sharon Friedlander, PhD, Trinayan Kashyap, MSc, Ori Kalid, PhD, Eran Shacham, PhD, Tami Rashal, MD, Sharon Shacham, PhD MBA, Joseph E Italiano, PhD, Yosef Landesman, PhD
Journal: Blood
Blood (2014) 124 (21): 1458.
https://doi.org/10.1182/blood.V124.21.1458.1458
Published: 2014