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Issue Archive

Volume 1, Issue 20
September 12 2017
Blood Advances Cover Image for Volume 1, Issue 20

Table of Contents

STIMULUS REPORTS

Severe reduction of free-form ADAMTS13, unbound to von Willebrand factor, in plasma of patients with HELLP syndrome
Yoko Yoshida,Masanori Matsumoto,Hideo Yagi,Ayami Isonishi,Kazuya Sakai,Masaki Hayakawa,Yuji Hori,Toshiyuki Sado,Hiroshi Kobayashi,Yoshihiro Fujimura
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In vitro evidence of complement activation in transplantation-associated thrombotic microangiopathy
Seth J. Rotz,Nathan Luebbering,Bradley P. Dixon,Eleni Gavriilaki,Robert A. Brodsky,Christopher E. Dandoy,Sonata Jodele,Stella M. Davies
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Glycoprotein Ibα inhibitor (CCP-224) prevents neutrophil-platelet aggregation in sickle cell disease
Maritza A. Jimenez,Enrico M. Novelli,Gray D. Shaw,Prithu Sundd
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CLINICAL TRIALS AND OBSERVATIONS

Graphical abstract for: Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease;
Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease
Clinical Trials & Observations
Joshua J. Field,Elaine Majerus,Victor R. Gordeuk,Michel Gowhari,Carolyn Hoppe,Matthew M. Heeney,Maureen Achebe,Alex George,Hillary Chu,Brian Sheehan,Maneka Puligandla,Donna Neuberg,Gene Lin,Joel Linden,David G. Nathan
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HEMATOPOIESIS AND STEM CELLS

Graphical abstract for: Twist1 regulates embryonic hematopoietic differentiation through binding to <em>Myb</em> and <em>Gata2</em> promoter regions;
Twist1 regulates embryonic hematopoietic differentiation through binding to Myb and Gata2 promoter regions
Kasem Kulkeaw,Tomoko Inoue,Tadafumi Iino,Kenzaburo Tani,Koichi Akashi,Nancy A. Speck,Yoichi Nakanishi,Daisuke Sugiyama
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Graphical abstract for: RUNX1 regulates site specificity of DNA demethylation by recruitment of DNA demethylation machineries in hematopoietic cells;
RUNX1 regulates site specificity of DNA demethylation by recruitment of DNA demethylation machineries in hematopoietic cells
Takahiro Suzuki,Yuri Shimizu,Erina Furuhata,Shiori Maeda,Mami Kishima,Hajime Nishimura,Saaya Enomoto,Yoshihide Hayashizaki,Harukazu Suzuki
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IMMUNOBIOLOGY AND IMMUNOTHERAPY

Graphical abstract for: Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets;
Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets
Anne Zufferey,Edwin R. Speck,Kellie R. Machlus,Rukhsana Aslam,Li Guo,Mark J. McVey,Michael Kim,Rick Kapur,Eric Boilard,Joseph E. Italiano, Jr,John W. Semple
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LYMPHOID NEOPLASIA

Graphical abstract for: Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL;
Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL
Kathryn G. Roberts,Yung-Li Yang,Debbie Payne-Turner,Wenwei Lin,Jacob K. Files,Kirsten Dickerson,Zhaohui Gu,Jack Taunton,Laura J. Janke,Taosheng Chen,Mignon L. Loh,Stephen P. Hunger,Charles G. Mullighan
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Graphical abstract for: Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex;
Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex
Clinical Trials & Observations
Alyssa I. Clay-Gilmour,Theresa Hahn,Leah M. Preus,Kenan Onel,Andrew Skol,Eric Hungate,Qianqian Zhu,Christopher A. Haiman,Daniel O. Stram,Loreall Pooler,Xin Sheng,Li Yan,Qian Liu,Qiang Hu,Song Liu,Sebastiano Battaglia,Xiaochun Zhu,AnneMarie W. Block,Sheila N. J. Sait,Ezgi Karaesmen,Abbas Rizvi,Daniel J. Weisdorf,Christine B. Ambrosone,David Tritchler,Eva Ellinghaus,David Ellinghaus,Martin Stanulla,Jacqueline Clavel,Laurent Orsi,Stephen Spellman,Marcelo C. Pasquini,Philip L. McCarthy,Lara E. Sucheston-Campbell
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Graphical abstract for: Cumulative incidence, risk factors, and management of atrial fibrillation in patients receiving ibrutinib;
Cumulative incidence, risk factors, and management of atrial fibrillation in patients receiving ibrutinib
Clinical Trials & Observations
Tracy E. Wiczer,Lauren B. Levine,Jessica Brumbaugh,Jessica Coggins,Qiuhong Zhao,Amy S. Ruppert,Kerry Rogers,Anli McCoy,Luay Mousa,Avirup Guha,Nyla A. Heerema,Kami Maddocks,Beth Christian,Leslie A. Andritsos,Samantha Jaglowski,Steven Devine,Robert Baiocchi,Jennifer Woyach,Jeffrey Jones,Michael Grever,Kristie A. Blum,John C. Byrd,Farrukh T. Awan
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Graphical abstract for: Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways;
Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways
Sheryl M. Gough,Liat Goldberg,Marbin Pineda,Robert L. Walker,Yuelin J. Zhu,Sven Bilke,Yang Jo Chung,Joseph Dufraine,Subhadip Kundu,Elad Jacoby,Terry J. Fry,Susanna Fischer,Renate Panzer-Grümayer,Paul S. Meltzer,Peter D. Aplan
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Graphical abstract for: Bone marrow sites differently imprint dormancy and chemoresistance to T-cell acute lymphoblastic leukemia;
Bone marrow sites differently imprint dormancy and chemoresistance to T-cell acute lymphoblastic leukemia
Xavier Cahu,Julien Calvo,Sandrine Poglio,Nais Prade,Benoit Colsch,Marie-Laure Arcangeli,Thierry Leblanc,Arnaud Petit,Frederic Baleydier,Andre Baruchel,Judith Landman-Parker,Christophe Junot,Jerome Larghero,Paola Ballerini,Eric Delabesse,Benjamin Uzan,Francoise Pflumio
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MYELOID NEOPLASIA

Graphical abstract for: EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT;
EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT
Akil A. Merchant,Aparna Jorapur,Amy McManus,Ren Liu,Valery Krasnoperov,Parvesh Chaudhry,Mohan Singh,Lisa Harton,Mary Agajanian,Miriam Kim,Timothy J. Triche, Jr,Brian J. Druker,Jeffrey W. Tyner,Parkash S. Gill
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Graphical abstract for: Loss of mDia1 causes neutropenia via attenuated CD11b endocytosis and increased neutrophil adhesion to the endothelium;
Loss of mDia1 causes neutropenia via attenuated CD11b endocytosis and increased neutrophil adhesion to the endothelium
Yang Mei,Gong Feng,Nina Rahimi,Baobing Zhao,Jingxin Zhang,Lan Cao,Jing Yang,Juehua Gao,Yihua Chen,Ronen Sumagin,William A. Muller,Ling Zhang,Peng Ji
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Graphical abstract for: Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBPα to prevent Trib1-driven acute myeloid leukemia;
Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBPα to prevent Trib1-driven acute myeloid leukemia
Ikuko Nakamae,Jun-ya Kato,Takashi Yokoyama,Hidenori Ito,Noriko Yoneda-Kato
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Graphical abstract for: Impact of genomic alterations on outcomes in myelofibrosis patients undergoing JAK1/2 inhibitor therapy;
Impact of genomic alterations on outcomes in myelofibrosis patients undergoing JAK1/2 inhibitor therapy
Clinical Trials & Observations
Jay Y. Spiegel,Caroline McNamara,James A. Kennedy,Tony Panzarella,Andrea Arruda,Tracy Stockley,Mahadeo Sukhai,Mariam Thomas,Justyna Bartoszko,Jenny Ho,Nancy Siddiq,Dawn Maze,Aaron Schimmer,Andre Schuh,Hassan Sibai,Karen Yee,Jamie Claudio,Rebecca Devlin,Mark D. Minden,Suzanne Kamel-Reid,Vikas Gupta
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COMMENTARY

Neurologic event–free survival demonstrates a benefit for SCID patients diagnosed by newborn screening
Clinical Trials & Observations
Christopher C. Dvorak,Jennifer M. Puck,Justin T. Wahlstrom,Morna Dorsey,Alexis Melton,Morton J. Cowan
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  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Lack of inhibition of platelet-neutrophil aggregation in control peptide–treated sickle cell disease patient blood flowing through microfluidic flow channels presenting a combination of P-selectin, ICAM-1, and interleukin-8. Freely flowing platelets (round green objects) are shown nucleating on arrested neutrophils (pink). The image was recorded with quantitative microfluidic fluorescence microscopy. See the article by Jimenez et al, which demonstrates that a glycoprotein Ibα antagonist (CCP-224) prevents platelet-neutrophil aggregation in blood of patients with sickle cell disease.

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