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Volume 3, Issue 14

July 23 2019

In this Issue

STIMULUS REPORTS
CLINICAL TRIALS AND OBSERVATIONS
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
RED CELLS, IRON, AND ERYTHROPOIESIS
TRANSPLANTATION
GLOBAL ADVANCES

STIMULUS REPORTS

α4β1 integrin associates with VEGFR2 in CLL cells and contributes to VEGF binding and intracellular signaling

Alejandra Gutiérrez-González,Noemí Aguilera-Montilla,Estefanía Ugarte-Berzal,Elvira Bailón,Isabel Cerro-Pardo,Clara Sánchez-Maroto,Lara García-Campillo,José A. García-Marco,Angeles García-Pardo

View Articletitled, α4β1 integrin associates with VEGFR2 in CLL cells and contributes to VEGF binding and intracellular signaling

Supplemental data

Fetal hemoglobin does not inhibit Plasmodium falciparum growth

Natasha M. Archer,Nicole Petersen,Manoj T. Duraisingh

View Articletitled, Fetal hemoglobin does not inhibit Plasmodium falciparum growth

CLINICAL TRIALS AND OBSERVATIONS

Tisagenlecleucel in relapsed/refractory diffuse large B-cell lymphoma patients without measurable disease at infusion
Clinical Trials & Observations

Michael R. Bishop,Richard T. Maziarz,Edmund K. Waller,Ulrich Jäger,Jason R. Westin,Joseph P. McGuirk,Isabelle Fleury,Harald Holte,Peter Borchmann,Christopher del Corral,Ranjan Tiwari,Özlem Anak,Rakesh Awasthi,Lida Pacaud,Vadim V. Romanov,Stephen J. Schuster

View Articletitled, Tisagenlecleucel in relapsed/refractory diffuse large B-cell lymphoma patients without measurable disease at infusion

Challenges and approaches to implementing master/basket trials in oncology
Clinical Trials & Observations

Amy Burd,Richard L. Schilsky,John C. Byrd,Ross L. Levine,Vassiliki A. Papadimitrakopoulou,Roy S. Herbst,Mary W. Redman,Brian J. Druker,David R. Gandara

View Articletitled, Challenges and approaches to implementing master/basket trials in oncology

HEMATOPOIESIS AND STEM CELLS

The splicing factor Sf3b1 regulates erythroid maturation and proliferation via TGFβ signaling in zebrafish

Adriana De La Garza,Rosannah C. Cameron,Varun Gupta,Ellen Fraint,Sara Nik,Teresa V. Bowman

View Articletitled, The splicing factor Sf3b1 regulates erythroid maturation and proliferation via TGFβ signaling in zebrafish

Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Safety and feasibility of virus-specific T cells derived from umbilical cord blood in cord blood transplant recipients
Clinical Trials & Observations

Allistair A. Abraham,Tami D. John,Michael D. Keller,C. Russell Y. Cruz,Baheyeldin Salem,Lauren Roesch,Hao Liu,Fahmida Hoq,Bambi J. Grilley,Adrian P. Gee,Hema Dave,David A. Jacobsohn,Robert A. Krance,Elizabeth. J. Shpall,Caridad A. Martinez,Patrick J. Hanley,Catherine M. Bollard

View Articletitled, Safety and feasibility of virus-specific T cells derived from umbilical cord blood in cord blood transplant recipients

Supplemental data

In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease

Sarah Morin-Zorman,Christian Wysocki,Jieqing Zhu,Hongmei Li,Sylvain Zorman,Catherine Matte-Martone,Edwina Kisanga,Jennifer McNiff,Dhanpat Jain,David Gonzalez,David M. Rothstein,Fadi G. Lakkis,Ann Haberman,Warren D. Shlomchik

View Articletitled, In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease

Supplemental data

Assessment of TCR signal strength of antigen-specific memory CD8⁺ T cells in human blood

Hanchih Wu,Ashley Witzl,Hideki Ueno

View Articletitled, Assessment of TCR signal strength of antigen-specific memory CD8+ T cells in human blood

Supplemental data

IgA levels at diagnosis predict for infections, time to treatment, and survival in chronic lymphocytic leukemia
Clinical Trials & Observations

Ganchimeg Ishdorj,Erin Streu,Pascal Lambert,Harbhajan S. Dhaliwal,Salaheddin M. Mahmud,Spencer B. Gibson,Versha Banerji,Aaron J. Marshall,James B. Johnston

View Articletitled, IgA levels at diagnosis predict for infections, time to treatment, and survival in chronic lymphocytic leukemia

Supplemental data

LYMPHOID NEOPLASIA

Dual-action CXCR4-targeting liposomes in leukemia: function blocking and drug delivery

Catriona McCallion,Anna D. Peters,Andrew Booth,Karen Rees-Unwin,Julie Adams,Raisa Rahi,Alain Pluen,Claire V. Hutchinson,Simon J. Webb,John Burthem

View Articletitled, Dual-action CXCR4-targeting liposomes in leukemia: function blocking and drug delivery

Supplemental data

Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma

Ajinkya Patil,Mark Manzano,Eva Gottwein

View Articletitled, Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma

Supplemental data

MYELOID NEOPLASIA

Distinct clinical and biological implications of CUX1 in myeloid neoplasms

Mai Aly,Zubaidah M. Ramdzan,Yasunobu Nagata,Suresh K. Balasubramanian,Naoko Hosono,Hideki Makishima,Valeria Visconte,Teodora Kuzmanovic,Vera Adema,Aziz Nazha,Bartlomiej P. Przychodzen,Cassandra M. Kerr,Mikkael A. Sekeres,Mohamed E. Abazeed,Alain Nepveu,Jaroslaw P. Maciejewski

View Articletitled, Distinct clinical and biological implications of CUX1 in myeloid neoplasms

Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

Siyang Hao,Jie Xiang,Dai-Chen Wu,James W. Fraser,Baiye Ruan,Jingwei Cai,Andrew D. Patterson,Zhi-Chun Lai,Robert F. Paulson

View Articletitled, Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

Supplemental data

TRANSPLANTATION

A critical role of the Gas6-Mer axis in endothelial dysfunction contributing to TA-TMA associated with GVHD

Miki Furukawa,Xintao Wang,Hiroshi Ohkawara,Masahiko Fukatsu,Lobna Alkebsi,Hiroshi Takahashi,Kayo Harada-Shirado,Akiko Shichishima-Nakamura,Satoshi Kimura,Kazuei Ogawa,Takayuki Ikezoe

View Articletitled, A critical role of the Gas6-Mer axis in endothelial dysfunction contributing to TA-TMA associated with GVHD

Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes
Clinical Trials & Observations

J. B. Langenhorst,C. van Kesteren,E. M. van Maarseveen,T. P. C. Dorlo,S. Nierkens,C. A. Lindemans,M. A. de Witte,A. van Rhenen,R. Raijmakers,M. Bierings,J. Kuball,A. D. R. Huitema,J. J. Boelens

View Articletitled, Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes

Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation
Clinical Trials & Observations

Max Jan,Matthew J. Leventhal,Elizabeth A. Morgan,Jordan C. Wengrod,Anwesha Nag,Samantha D. Drinan,Bruce M. Wollison,Matthew D. Ducar,Aaron R. Thorner,Scott Leppanen,Jane Baronas,Jonathan Stevens,William J. Lane,Natasha Kekre,Vincent T. Ho,John Koreth,Corey S. Cutler,Sarah Nikiforow,Edwin P. Alyea, III,Joseph H. Antin,Robert J. Soiffer,Jerome Ritz,R. Coleman Lindsley,Benjamin L. Ebert

View Articletitled, Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation

Supplemental data

Randomized controlled study of ECP with methoxsalen as first-line treatment of patients with moderate to severe cGVHD
Clinical Trials & Observations

Madan Jagasia,Christof Scheid,Gérard Socié,Francis Ayuketang Ayuk,Johanna Tischer,Michele L. Donato,Árpád Bátai,Heidi Chen,Sheau-Chiann Chen,Thomas Chin,Henri Boodée,Ghaith Mitri,Hildegard T. Greinix

View Articletitled, Randomized controlled study of ECP with methoxsalen as first-line treatment of patients with moderate to severe cGVHD

Supplemental data

GLOBAL ADVANCES

Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif
Clinical Trials & Observations Global Advances

Peixun Zhou,Alex E. Blain,Alexander M. Newman,Masood Zaka,George Chagaluka,Filbert R. Adlar,Ugonna T. Offor,Casey Broadbent,Lewis Chaytor,Amber Whitehead,Amy Hall,Hettie O’Connor,Susan Van Noorden,Irvin Lampert,Simon Bailey,Elizabeth Molyneux,Chris M. Bacon,Simon Bomken,Vikki Rand

View Articletitled, Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif

Supplemental data

Cover Image

Cover Image

COVER FIGURE
Laser deconvolution microscopy demonstrates uptake of CXCR4-targeted fluorescent green liposomes into the cytoplasm of chronic lymphocytic leukemia lymphocytes after 3 hours of incubation in vitro. Nuclei are stained blue with DAPI. See the article by McCallion et al.
Front Matter
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Table of Contents

STIMULUS REPORTS

α4β1 integrin associates with VEGFR2 in CLL cells and contributes to VEGF binding and intracellular signaling

Fetal hemoglobin does not inhibit Plasmodium falciparum growth

CLINICAL TRIALS AND OBSERVATIONS

Tisagenlecleucel in relapsed/refractory diffuse large B-cell lymphoma patients without measurable disease at infusion
Clinical Trials & Observations

Challenges and approaches to implementing master/basket trials in oncology
Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

The splicing factor Sf3b1 regulates erythroid maturation and proliferation via TGFβ signaling in zebrafish

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Safety and feasibility of virus-specific T cells derived from umbilical cord blood in cord blood transplant recipients
Clinical Trials & Observations

In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease

Assessment of TCR signal strength of antigen-specific memory CD8⁺ T cells in human blood

IgA levels at diagnosis predict for infections, time to treatment, and survival in chronic lymphocytic leukemia
Clinical Trials & Observations

LYMPHOID NEOPLASIA

Dual-action CXCR4-targeting liposomes in leukemia: function blocking and drug delivery

Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma

MYELOID NEOPLASIA

Distinct clinical and biological implications of CUX1 in myeloid neoplasms

RED CELLS, IRON, AND ERYTHROPOIESIS

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

TRANSPLANTATION

A critical role of the Gas6-Mer axis in endothelial dysfunction contributing to TA-TMA associated with GVHD

Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes
Clinical Trials & Observations

Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation
Clinical Trials & Observations

Randomized controlled study of ECP with methoxsalen as first-line treatment of patients with moderate to severe cGVHD
Clinical Trials & Observations

GLOBAL ADVANCES

Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif
Clinical Trials & Observations Global Advances

Email alerts

ASH Publications

American Society of Hematology

Issue Archive

Table of Contents

STIMULUS REPORTS

CLINICAL TRIALS AND OBSERVATIONS

Tisagenlecleucel in relapsed/refractory diffuse large B-cell lymphoma patients without measurable disease at infusion Clinical Trials & Observations

Challenges and approaches to implementing master/basket trials in oncology Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Safety and feasibility of virus-specific T cells derived from umbilical cord blood in cord blood transplant recipients Clinical Trials & Observations

IgA levels at diagnosis predict for infections, time to treatment, and survival in chronic lymphocytic leukemia Clinical Trials & Observations

LYMPHOID NEOPLASIA

MYELOID NEOPLASIA

RED CELLS, IRON, AND ERYTHROPOIESIS

TRANSPLANTATION

Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes Clinical Trials & Observations

Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation Clinical Trials & Observations

Randomized controlled study of ECP with methoxsalen as first-line treatment of patients with moderate to severe cGVHD Clinical Trials & Observations

GLOBAL ADVANCES

Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif Clinical Trials & Observations Global Advances

Cover Image

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Tisagenlecleucel in relapsed/refractory diffuse large B-cell lymphoma patients without measurable disease at infusion
Clinical Trials & Observations

Challenges and approaches to implementing master/basket trials in oncology
Clinical Trials & Observations

Safety and feasibility of virus-specific T cells derived from umbilical cord blood in cord blood transplant recipients
Clinical Trials & Observations

IgA levels at diagnosis predict for infections, time to treatment, and survival in chronic lymphocytic leukemia
Clinical Trials & Observations

Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes
Clinical Trials & Observations

Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation
Clinical Trials & Observations

Randomized controlled study of ECP with methoxsalen as first-line treatment of patients with moderate to severe cGVHD
Clinical Trials & Observations

Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif
Clinical Trials & Observations Global Advances