Issue Archive
Table of Contents
INSIDE BLOOD
Aiming at WM with both barrels blocked
Proteasome inhibition has proven to be a successful therapeutic strategy in B-cell malignancies including WM. In this issue of Blood, Roccaro and colleagues report preclinical studies, providing the rationale for clinical investigation of a novel orally available proteasome inhibitor in this disease.1
Proteomics unravels platelet function
In this issue of Blood, Schulz and colleagues report promising findings using differential proteomics as a discovery tool to identify functionally important proteins in platelet activation. The authors identify several proteins that change in abundance upon platelet activation. These findings implicate several novel pathomechanisms relevant to platelet activation and identify novel potential therapeutic targets for platelet inhibition.1
The TREC to less CMV after UCBT
In this issue of Blood, Brown and colleagues demonstrate the importance of thymic recovery and T-cell reconstitution in CMV-specific immunity after allogeneic UCB transplantation.
REVIEW ARTICLES
CLINICAL TRIALS AND OBSERVATIONS
Optimizing patient selection for myeloablative allogeneic hematopoietic cell transplantation in chronic myeloid leukemia in chronic phase
Brief Report
GENE THERAPY
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenström macroglobulinemia
MYELOID NEOPLASIA
Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation
TRANSPLANTATION
Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis
VASCULAR BIOLOGY
CORRESPONDENCE
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Cover Image
Cover Image
The binding domains of spectrin (top) and ankyrin (middle) form a complex (bottom), which is responsible for linking the cell membrane to the cytoskeleton. The structure of this complex and biophysical insights into the basis for some hereditary elliptocytosis-related mutations are discussed in this issue. See the article by Ipsaro and Mondragóaon beginning on page 4093.
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