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Issue Archive

Volume 131, Issue 5
February 1 2018
Issue Cover

Table of Contents

EDITORIAL

Introduction to a review series on hematologic disease at older age
Clinical Trials & Observations
Bob Löwenberg
View Articletitled, Introduction to a review series on hematologic disease at older age

BLOOD COMMENTARIES

CLINICAL TRIALS AND OBSERVATIONS
Opening a can of worms in AL progression
Clinical Trials & Observations
Angela Dispenzieri
View Articletitled, Opening a can of worms in AL progression
THROMBOSIS AND HEMOSTASIS
Removal of destructive brain-borne microdust
Ton Lisman
View Articletitled, Removal of destructive brain-borne microdust

REVIEW SERIES

Aging of hematopoietic stem cells
Gerald de Haan,Seka Simone Lazare
View Articletitled, Aging of hematopoietic stem cells
DNA damage responses and p53 in the aging process
Hui-Ling Ou,Björn Schumacher
View Articletitled, DNA damage responses and p53 in the aging process
Age-related clonal hematopoiesis
Clinical Trials & Observations
Liran I. Shlush
View Articletitled, Age-related clonal hematopoiesis
Anemia at older age: etiologies, clinical implications, and management
Clinical Trials & Observations
Reinhard Stauder,Peter Valent,Igor Theurl
View Articletitled, Anemia at older age: etiologies, clinical implications, and management
Frailty and the management of hematologic malignancies
Clinical Trials & Observations
Gregory A. Abel,Heidi D. Klepin
View Articletitled, Frailty and the management of hematologic malignancies

CLINICAL TRIALS AND OBSERVATIONS

Presentation and outcome with second-line treatment in AL amyloidosis previously sensitive to nontransplant therapies
Clinical Trials & Observations
Giovanni Palladini,Paolo Milani,Andrea Foli,Marco Basset,Francesca Russo,Stefano Perlini,Giampaolo Merlini
View Articletitled, Presentation and outcome with second-line treatment in AL amyloidosis previously sensitive to nontransplant therapies
Supplemental data

GENE THERAPY

Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections
Miriam Hetzel,Adele Mucci,Patrick Blank,Ariane Hai Ha Nguyen,Jan Schiller,Olga Halle,Mark-Philipp Kühnel,Sandra Billig,Robert Meineke,Daniel Brand,Vanessa Herder,Wolfgang Baumgärtner,Franz-Christoph Bange,Ralph Goethe,Danny Jonigk,Reinhold Förster,Bernhard Gentner,Jean-Laurent Casanova,Jacinta Bustamante,Axel Schambach,Ulrich Kalinke,Nico Lachmann
View Articletitled, Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals
Felicia A. Tucci,Simo Kitanovski,Patricia Johansson,Ludger Klein-Hitpass,Alisan Kahraman,Jan Dürig,Daniel Hoffmann,Ralf Küppers
View Articletitled, Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model
Brief Report
Xingguo Zhu,Caixia Xi,Bobby Thomas,Betty S. Pace
View Articletitled, Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model
Supplemental data

THROMBOSIS AND HEMOSTASIS

Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice
Yuan Zhou,Wei Cai,Zilong Zhao,Tristan Hilton,Min Wang,Jason Yeon,Wei Liu,Fangyi Zhang,Fu-Dong Shi,Xiaoping Wu,Perumal Thiagarajan,Min Li,Jianning Zhang,Jing-fei Dong
View Articletitled, Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice
Supplemental data

LETTERS TO BLOOD

Isolated myeloperoxidase expression in pediatric B/myeloid mixed phenotype acute leukemia is linked with better survival
Clinical Trials & Observations
Sunil S. Raikar,Sunita I. Park,Traci Leong,David L. Jaye,Frank G. Keller,John T. Horan,William G. Woods
View Articletitled, Isolated myeloperoxidase expression in pediatric B/myeloid mixed phenotype acute leukemia is linked with better survival
Supplemental data
Isolated myelosarcoma is characterized by recurrent NFE2 mutations and concurrent preleukemic clones in the bone marrow
Vladimir Lazarevic,Christina Orsmark-Pietras,Henrik Lilljebjörn,Louise Pettersson,Marianne Rissler,Anna Lübking,Mats Ehinger,Gunnar Juliusson,Thoas Fioretos
View Articletitled, Isolated myelosarcoma is characterized by recurrent <em>NFE2</em> mutations and concurrent preleukemic clones in the bone marrow
Supplemental data
Hepatic Smad7 overexpression causes severe iron overload in mice
Dilay Lai,Feng Teng,Seddik Hammad,Julia Werle,Thorsten Maas,Andreas Teufel,Martina U. Muckenthaler,Steven Dooley,Maja Vujić Spasić
View Articletitled, Hepatic <em>Smad7</em> overexpression causes severe iron overload in mice
Supplemental data

BLOOD WORK

A “foamy” mastocytosis case
Rathana Kim,Ludovic Lhermitte
View Articletitled, A “foamy” mastocytosis case

ERRATUM

Crump M, Neelapu SS, Farooq U, et al. Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study. Blood. 2017;130(16):1800-1808.
View Articletitled, Crump M, Neelapu SS, Farooq U, et al. Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study. <em>Blood</em>. 2017;130(16):1800-1808.
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