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Betty S. Pace
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Journal Articles

Nrf2 sensitizes ferroptosis through l-2-hydroxyglutarate–mediated chromatin modifications in sickle cell disease

Caixia Xi, Junfeng Pang, Wenbo Zhi, Chang-Sheng S. Chang, Umapathy Siddaramappa, Huidong Shi, Anatoli Horuzsko, Betty S. Pace, Xingguo Zhu
Journal: Blood
Blood (2023) 142 (4): 382–396.
https://doi.org/10.1182/blood.2022018159
Published: 2023
Includes: Supplemental data
Journal Articles

BACH1 Inhibitor Hpp-D Mediates γ-Globin Gene Activation in Sickle Erythroid Progenitors

Chithra D Palani, Xingguo Zhu, Manickam Alagar, Otis C Attucks, Betty S. Pace
Journal: Blood
Blood (2022) 140 (Supplement 1): 2521–2522.
https://doi.org/10.1182/blood-2022-169980
Published: 2022
Journal Articles

MiRNA29B Induces Fetal Hemoglobin through Targeting DNMT3 and MYB in Vitro and In Vivo in Preclinical Townes Sickle Cell Mice

Ernestine Amos-Abanyie, Chithra Palani, Alana Smith, Qingqing Gu, Ugochi Ogu, Daniel Johnson, Umapathy N Siddaramappa, Betty S. Pace, Athena Starlard-Davenport
Journal: Blood
Blood (2022) 140 (Supplement 1): 2496–2497.
https://doi.org/10.1182/blood-2022-165597
Published: 2022
Journal Articles

Development of the Novel Cytosine Analog Aza-T-Dcyd (AB1) As a Fetal Hemoglobin Inducer to Treat Sickle Cell Disease.

Manickam Alagar, Biaoru Li, Santhosh Vadivelu, Robert Schaub, Chithra D. Palani, Betty S. Pace
Journal: Blood
Blood (2022) 140 (Supplement 1): 4957–4958.
https://doi.org/10.1182/blood-2022-169657
Published: 2022
Journal Articles

Early Effects of a Repurposed Therapeutic PB-04 in Beta Thalassemia Intermedia and in Transgenic Sickle Mice

Betty S. Pace, Seyed Mehdi Nouraie, Kevin H.M. Kuo, Sylvia Singer, Mayuko Takezaki, Biaoru Li, Aidan D Faller, Abdullah Kutlar, Susan P Perrine
Journal: Blood
Blood (2022) 140 (Supplement 1): 5360–5361.
https://doi.org/10.1182/blood-2022-169310
Published: 2022
Journal Articles

A randomized, placebo-controlled, double-blind trial of canakinumab in children and young adults with sickle cell anemia

Clinical Trials & Observations
David C. Rees, Yurdanur Kilinc, Selma Unal, Carlton Dampier, Betty S. Pace, Banu Kaya, Sara Trompeter, Isaac Odame, Johnny Mahlangu, Sule Unal, Julie Brent, Regine Grosse, Beng R. Fuh, Baba P. D. Inusa, Ariel Koren, Goksel Leblebisatan, Carina Levin, Elizabeth McNamara, Karin Meiser, Douglas Hom, Stephen J. Oliver
Journal: Blood
Blood (2022) 139 (17): 2642–2652.
https://doi.org/10.1182/blood.2021013674
Published: 2022
Includes: Supplemental data
Journal Articles

IMR-261, a Novel Oral Nrf2 Activator, Induces Fetal Hemoglobin in Human Erythroblasts, Reduces VOCs, and Ameliorates Ineffective Erythropoiesis in Experimental Mouse Models of Sickle Cell Disease and Beta-Thalassemia

Thiago Trovati Maciel, Caroline Carvalho, Rachel Rignault, Biree Andemariam, Betty S. Pace, Jennifer Isler OCain, Rahul Ballal
Journal: Blood
Blood (2021) 138 (Supplement 1): 853.
https://doi.org/10.1182/blood-2021-149528
Published: 2021
Journal Articles

The Benefits Trial of PB-04 to Evaluate Safety, PK, and Preliminary Efficacy in Inducing Fetal Globin Expression in Beta Thalassemia Intermedia and Sickle Cell Disease

Kevin H.M. Kuo, Sylvia Singer, Sujit Sheth, Hanny Al-Samkari, Gershwin Blyden, Lanetta Bronte-Hall, Betty S. Pace, Abdullah Kutlar, Franciscus A. Kuypers, Aidan D Faller, Seyed Mehdi Nouraie, Pramod Terse, Haksong Jin, Xin Xu, Asaf Alimardanov, Arthur J. Sytkowski, Sharie Haugabook, Susan P Perrine
Journal: Blood
Blood (2021) 138 (Supplement 1): 4159.
https://doi.org/10.1182/blood-2021-148909
Published: 2021
Journal Articles

Investigation of miRNA-29b As a Fetal Hemoglobin Inducer in Sickle Cell Disease

Athena Starlard-Davenport, Alana Smith, Qingqing Gu, Umapathy N Siddaramappa, Chithra Palani, Betty S. Pace
Journal: Blood
Blood (2021) 138 (Supplement 1): 2023.
https://doi.org/10.1182/blood-2021-153290
Published: 2021
Journal Articles

Salubrinal Mediated Fetal Hemoglobin Induction through the eIF2α-ATF4 Signaling Pathway

Nicole Hope Lopez, BS, Biaoru Li, MDPhD, Xingguo Zhu, PhD, Betty S. Pace, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
https://doi.org/10.1182/blood-2020-139969
Published: 2020
Journal Articles

Double-Blind, Randomized Study of Canakinumab Treatment in Pediatric and Young Adult Patients with Sickle Cell Anemia

David C Rees, Yurdanur Kilinc, MD, Selma Unal, Carlton Dampier, MD, Betty S. Pace, MD, Banu Kaya, MD, Sara Trompeter, MBChB BSc MRCPCH FRCPath MSc, Isaac Odame, Johnny N Mahlangu, MBBCH, MMed, FCPath, Sule Unal, MD, Julie Brent, MD, Regine Grosse, MD, Beng R. Fuh, MD, Baba PD Inusa, MD, Ariel Koren, MD, Carina Levin, MD PhD, Steven Mortier, Elizabeth McNamara, Yue Li, Stephen John Oliver, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 615.
https://doi.org/10.1182/blood-2019-123355
Published: 2019
Journal Articles

Downregulation of Cytoskeletal Protein Kazrin in Lung Endothelial Cells of Preclinical Sickle Cell Disease Mouse Model - Essential Role of Endothelial Barrier Function

Umapathy N Siddaramappa, PhD, Niren Patel, MBBS, Betty S. Pace, MD, Abdullah Kutlar, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2258.
https://doi.org/10.1182/blood-2019-130924
Published: 2019
Journal Articles

NRF2 Mediates Epigenetic Changes in DNA and Chromatin Structure to Regulate γ-Globin Gene Expression in a Human βYAC Transgenic Mouse Model

Xingguo Zhu, PhD, Alexander H. Ward, PhD, Caixia Xi, PhD, Betty S. Pace, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1053.
https://doi.org/10.1182/blood-2018-99-116438
Published: 2018
Journal Articles

Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model

Brief Report
Xingguo Zhu, Caixia Xi, Bobby Thomas, Betty S. Pace
Journal: Blood
Blood (2018) 131 (5): 558–562.
https://doi.org/10.1182/blood-2017-10-810531
Published: 2018
Includes: Supplemental data
Journal Articles

Loss of NRF2 Function Worsens the Pathophysiology of Sickle Cell Disease in a Transgenic Mouse Model

Xingguo Zhu, PhD, Betty S. Pace, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 960.
https://doi.org/10.1182/blood.V130.Suppl_1.960.960
Published: 2017
Journal Articles

Characterization of a HBB -Locus Fetal Chromatin Domain Region during Adult Erythropoiesis

Li Liu, PhD, Xingguo Zhu, PhD, Alexander Yu, PhD, Betty S. Pace, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2223.
https://doi.org/10.1182/blood.V130.Suppl_1.2223.2223
Published: 2017
Journal Articles

Salubrinal Mediated Fetal Hemoglobin Induction through the eIF2α-ATF4 Signaling Pathway

Nicole Hope Lopez, BS, Biaoru Li, MD PhD, Levi Makala, DVM, MBA, PhD, Betty S. Pace, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2235.
https://doi.org/10.1182/blood.V130.Suppl_1.2235.2235
Published: 2017
Journal Articles

Novel Conjugates of Butyrate and δ-Aminolevulinate Increase γ-Globin Gene Expression and Fetal Hemoglobin Synthesis in Erythroid Progenitors

Aluya R. Oseghale, BSc, Marjorie M. Johnson, BS, Xingguo Zhu, PhD, Abraham Nudelman, PhD, Ada Rephaeli, PhD, Betty S. Pace, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3511.
https://doi.org/10.1182/blood.V130.Suppl_1.3511.3511
Published: 2017
Journal Articles

Micro RNA Profiling to Identify Regulator of Fetal Hemoglobin Expression in Sickle Cell Disease

Biaoru Li, PhD, Christina M. Torres, BS, Mayuko Takezaki, MS, Cindy Neunert, MD MSCS, Abdullah Kutlar, MD, Betty S. Pace, MD
Journal: Blood
Blood (2014) 124 (21): 49.
https://doi.org/10.1182/blood.V124.21.49.49
Published: 2014
Journal Articles

Next Generation Clinical-Stage HbF Inducers Exhibit Multiple Molecular Actions In Vitro and In Vivo and Offer Personalized Therapeutic Regimens

Betty S. Pace, MD, Jose I Sangerman, PhD, Michael S Boosalis, PhD, Roman Wolf, DVM, Yan Dai, PhD, David H.K. Chui, MD, Levi Makala, PhD, DVM, Biadru Li, PhD, Douglas V Faller, MD, PhD, Susan P Perrine, MD
Journal: Blood
Blood (2013) 122 (21): 560.
https://doi.org/10.1182/blood.V122.21.560.560
Published: 2013