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Journal Articles

Overexpression of the Signaling Integrator Gab2 Accelerates AML Development in Mice with Dnmt3a R878H and Npm1 cA Mutations

Michael H. Kramer, Stephanie Richardson, Yang Li, Nichole Helton, Daniel George, Michelle Cai, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley

Blood (2023) 142 (Supplement 1): 2752.

https://doi.org/10.1182/blood-2023-175053

Published: 2023

Journal Articles

Mechanisms of PML::Rara and GATA2 Protein Interactions in Hematopoietic Cells

Casey Katerndahl, Olivia Rogers, Nichole Helton, Sai Mukund Ramakrishnan, Christopher A Miller, Ziheng Xu, Sridhar N Srivatsan, Timothy J Ley

Blood (2023) 142 (Supplement 1): 2758.

https://doi.org/10.1182/blood-2023-181291

Published: 2023

Journal Articles

Rapid and Accurate Remethylation of Dnmt3a Deficient Hematopoietic Cells with Restoration of DNMT3A Activity

Yang Li, Haley Abel, Michelle Cai, Taylor Lavalle, Tiankai Yin, Nichole Helton, Amanda Smith, Christopher A Miller, Timothy J Ley

Blood (2023) 142 (Supplement 1): 4124.

https://doi.org/10.1182/blood-2023-180255

Published: 2023

Journal Articles

Reduced Subclone Diversity in Clonal Cytopenia of Undetermined Significance Compared to Myelodysplastic Syndrome

Monique Chavez, Sridhar N Srivatsan, Christopher A Miller, Andrew J. Menssen, Ajay Khanna, Jin Shao, Catrina Fronick, Robert Fulton, Sharon E Heath, Constantine Logothetis, Tasha Burton, Victoria Donaldson, Claudia Cabrera, Raya Saba, Kiran R. Vij, Eric J. Duncavage, Meagan Jacoby, Matthew J. Walter

Blood (2023) 142 (Supplement 1): 2696.

https://doi.org/10.1182/blood-2023-189591

Published: 2023

Journal Articles

Re-Sensitization of Allogeneic T Cell Resistant Murine AML with Pegylated IFN-Gamma

Ezhilarasi Chendamarai, Julie K. Ritchey, Leah Gehrs, Michael P. Rettig, Sai Mukund Ramakrishnan, Christopher A Miller, George Cox, Lana Anderson, Timothy J Ley, John F. DiPersio

Blood (2022) 140 (Supplement 1): 7345–7346.

https://doi.org/10.1182/blood-2022-167415

Published: 2022

Journal Articles

ITK Inhibitor Induces Dose-Dependent Th1 Skewing in Normal T Cells and Is Active in Refractory T Cell Lymphomas

Yuqin Song, Ning Ding, Dok Hyun Yoon, John C. Reneau, Ryan A. Wilcox, Won Seog Kim, Youn H. Kim, Michael S. Khodadoust, Tatyana A. Feldman, Costas K. Yannakou, Pratyush Giri, Jonathan E Brammer, Lih-Yun Hsu, Hongwei Yuan, Erik Verner, Suresh Mahabhashyam, Richard A. Miller

Blood (2022) 140 (Supplement 1): 8857–8859.

https://doi.org/10.1182/blood-2022-159177

Published: 2022

Journal Articles

Nucleolar Stress Plays a Key Role in the Pathogenesis of T Cell Acute Lymphoblastic Leukemia

Joseph R. Krambs, Kimberly B. Johansson, Isabelle Genter, Sai Mukund Ramakrishnan, Christopher A Miller, Daniel C. Link

Blood (2022) 140 (Supplement 1): 5891–5892.

https://doi.org/10.1182/blood-2022-158717

Published: 2022

Journal Articles

A Comprehensive Reassessment of the Direct DNA Binding Sites of PML-Rara within the Genomes of Primary Hematopoietic Progenitor Cells, and Their Effects on Chromatin Structure and Gene Expression

Casey D.S. Katerndahl, Olivia R.S. Rogers, Sai Mukund Ramakrishnan, Christopher A Miller, Nichole M Helton, Mieke Hoock, Timothy J Ley

Blood (2022) 140 (Supplement 1): 5858–5859.

https://doi.org/10.1182/blood-2022-167204

Published: 2022

Journal Articles

Proteomic and phosphoproteomic landscapes of acute myeloid leukemia

Michael H. Kramer, Qiang Zhang, Robert Sprung, Ryan B. Day, Petra Erdmann-Gilmore, Yang Li, Ziheng Xu, Nichole M. Helton, Daniel R. George, Yiling Mi, Peter Westervelt, Jacqueline E. Payton, Sai M. Ramakrishnan, Christopher A. Miller, Daniel C. Link, John F. DiPersio, Matthew J. Walter, R. Reid Townsend, Timothy J. Ley

Blood (2022) 140 (13): 1533–1548.

https://doi.org/10.1182/blood.2022016033

Published: 2022

Includes: Supplemental data

Journal Articles

DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults

Margaret A. Ferris, Amanda M. Smith, Sharon E. Heath, Eric J. Duncavage, Matthew Oberley, David Freyer, Robert Wynn, Sofia Douzgou, John M. Maris, Anne F. Reilly, Melinda D. Wu, Florence Choo, Roel B. Fiets, Saskia Koene, David H. Spencer, Christopher A. Miller, Marwan Shinawi, Timothy J. Ley

Blood (2022) 139 (3): 461–464.

https://doi.org/10.1182/blood.2021014052

Published: 2022

Includes: Supplemental data

Journal Articles

Analysis of the Proteomes of Primary, De Novo Acute Myeloid Leukemia Cells from Adults

Michael H Kramer, Qiang Zhang, Robert W. Sprung, Petra Erdmann-Gilmore, Daniel R George, Nichole M Helton, Sharon E Heath, Jacqueline E. Payton, Peter Westervelt, Christopher A Miller, Matthew J. Walter, Daniel C. Link, John F. DiPersio, R Reid Townsend, Timothy J Ley

Blood (2021) 138 (Supplement 1): 3427.

https://doi.org/10.1182/blood-2021-148819

Published: 2021

Journal Articles

Dnmt3a Inactivation Leads to Slow DNA Methylation Loss in Murine Hematopoietic Cells In Vivo

Amanda M Smith, Angela Maria Verdoni, Shamika Ketkar, Elizabeth Leight, David Y Chen, Sai Mukund Ramakrishnan, Christopher A Miller, Haley J Abel, Timothy J Ley

Blood (2021) 138 (Supplement 1): 1087.

https://doi.org/10.1182/blood-2021-150558

Published: 2021

Journal Articles

Adverse Outcomes in Acute Myeloid Leukemia Are Associated with Tumor Cell-Mediated Immunosuppression

Blood (2021) 138 (Supplement 1): 800.

https://doi.org/10.1182/blood-2021-148645

Published: 2021

Journal Articles

Tumor suppressor function of Gata2 in acute promyelocytic leukemia

Casey D. S. Katerndahl, Olivia R. S. Rogers, Ryan B. Day, Michelle A. Cai, Timothy P. Rooney, Nichole M. Helton, Mieke Hoock, Sai Mukund Ramakrishnan, Sridhar Nonavinkere Srivatsan, Lukas D. Wartman, Christopher A. Miller, Timothy J. Ley

Blood (2021) 138 (13): 1148–1161.

https://doi.org/10.1182/blood.2021011758

Published: 2021

Includes: Supplemental data

Journal Articles

Molecular Profiling of Decitabine Response in MDS and AML Patients

Pawan Kumar Upadhyay, PhD, Jeremy Beales, MS, Nakul Kumar Shah, MD, Christopher A Miller, PhD, Allegra A Petti, PhD, Daniel C. Link, MD, Timothy J Ley, MD, John Welch, MDPhD

Blood (2020) 136 (Supplement 1): 40.

https://doi.org/10.1182/blood-2020-141292

Published: 2020

Journal Articles

Cpi-818, an Oral Interleukin-2-Inducible T-Cell Kinase Inhibitor, Is Well-Tolerated and Active in Patients with T-Cell Lymphoma

Michael S. Khodadoust, MD PhD, Tatyana A. Feldman, MD, Dok Hyun Yoon, Costas K. Yannakou, MBBS (Hons), FRACP, FRCPA, Dejan Radeski, MBBS, FRACP, FRCPA, Youn H. Kim, MD, Neha Mehta-Shah, MD, Amit Khot, MBBS, MD MRCP, FRCPath, FRACP, Ryan A. Wilcox, MD, Won Seog Kim, MD PhD, Steven M. Horwitz, MD, Joseph J. Buggy, PhD, Andrew Hotson, PhD, Craig M. Hill, PhD, Brian Munneke, PhD, Suresh Mahabhashyam, MD, Richard A. Miller, MD, James W. Janc, PhD, Mehrdad Mobasher, MDMPH

Blood (2020) 136 (Supplement 1): 19–20.

https://doi.org/10.1182/blood-2020-137782

Published: 2020

Journal Articles

The ITK Inhibitor Cpi-818 Blocks Activation of T Cells from Autoimmune Lymphoproliferative Syndrome (ALPS) Patients and Is Active in a Murine Model of ALPS

V. Koneti Koneti Rao, MD FRCPA, Patrick P. Ng, PhD, Craig M. Hill, PhD, Richard A. Miller, MD, Joseph J. Buggy, PhD, James W. Janc, PhD

Blood (2020) 136 (Supplement 1): 36–37.

https://doi.org/10.1182/blood-2020-137631

Published: 2020

Journal Articles

Signaling Gene Mutations Are Characterized By Diverse Patterns of Expansion and Contraction during Progression from MDS to Secondary AML

Andrew J Menssen, BA, Ajay Khanna, Christopher A Miller, PhD, Gue Su Chang, PhD, Jin J Shao, Sridhar Nonavinkere Srivatsan, MS, Joshua Robinson, Michelle O'Laughlin, Catrina Fronick, BS, Robert Fulton, MS, Kimberly J Brendel, Sharon E Heath, Peter Westervelt, MDPhD, John F. DiPersio, MD PhD, Daniel C. Link, MD, Meagan A. Jacoby, Eric Duncavage, MD, Timothy J Ley, MD, Matthew J. Walter, MD

Blood (2020) 136 (Supplement 1): 2–3.

https://doi.org/10.1182/blood-2020-140394

Published: 2020

Journal Articles

Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia

Melat T. Gebru, Jennifer M. Atkinson, Megan M. Young, Lijun Zhang, Zhenyuan Tang, Zhenqiu Liu, Pinyi Lu, Christopher M. Dower, Longgui Chen, Charyguly Annageldiyev, Arati Sharma, Yuka Imamura Kawasawa, Zhongming Zhao, Barbara A. Miller, David F. Claxton, Hong-Gang Wang

Blood (2020) 136 (9): 1067–1079.

https://doi.org/10.1182/blood.2019003124

Published: 2020

Includes: Supplemental data

Journal Articles

Comprehensive Genomic Profiling of 104 Rare Histiocytic and Dendritic Cell Neoplasms Reveals Shared and Distinct Targetable Genomic Alterations

Lucas R. Massoth, MD, Yin P. Hung, MD, PhD, Judith A. Ferry, MD, Robert P. Hasserjian, MD, Abner Louissaint, Jr., MD PhD, Meagan Montesion, PhD, Ethan S. Sokol, PhD, Dean C. Pavlick, Nikunj Shah, Natalie Danziger, Jonathan Keith Killian, MD,PhD, Eric A. Severson, MD, PhD, MMSc, Daniel Duncan, MD, Julia A. Elvin, MD, PhD, Vincent A. Miller, MD, Jeffrey S. Ross, MD, Jo-Anne Vergilio, MD, Lawrence R. Zukerberg, MD, Erik A. Williams, MD

Blood (2019) 134 (Supplement_1): 2541.

https://doi.org/10.1182/blood-2019-123729

Published: 2019

NARROW

Overexpression of the Signaling Integrator Gab2 Accelerates AML Development in Mice with Dnmt3a R878H and Npm1 cA Mutations

Mechanisms of PML::Rara and GATA2 Protein Interactions in Hematopoietic Cells

Rapid and Accurate Remethylation of Dnmt3a Deficient Hematopoietic Cells with Restoration of DNMT3A Activity

Reduced Subclone Diversity in Clonal Cytopenia of Undetermined Significance Compared to Myelodysplastic Syndrome

Re-Sensitization of Allogeneic T Cell Resistant Murine AML with Pegylated IFN-Gamma

ITK Inhibitor Induces Dose-Dependent Th1 Skewing in Normal T Cells and Is Active in Refractory T Cell Lymphomas

Nucleolar Stress Plays a Key Role in the Pathogenesis of T Cell Acute Lymphoblastic Leukemia

A Comprehensive Reassessment of the Direct DNA Binding Sites of PML-Rara within the Genomes of Primary Hematopoietic Progenitor Cells, and Their Effects on Chromatin Structure and Gene Expression

Proteomic and phosphoproteomic landscapes of acute myeloid leukemia

DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults

Analysis of the Proteomes of Primary, De Novo Acute Myeloid Leukemia Cells from Adults

Dnmt3a Inactivation Leads to Slow DNA Methylation Loss in Murine Hematopoietic Cells In Vivo

Adverse Outcomes in Acute Myeloid Leukemia Are Associated with Tumor Cell-Mediated Immunosuppression

Tumor suppressor function of Gata2 in acute promyelocytic leukemia

Molecular Profiling of Decitabine Response in MDS and AML Patients

Cpi-818, an Oral Interleukin-2-Inducible T-Cell Kinase Inhibitor, Is Well-Tolerated and Active in Patients with T-Cell Lymphoma

The ITK Inhibitor Cpi-818 Blocks Activation of T Cells from Autoimmune Lymphoproliferative Syndrome (ALPS) Patients and Is Active in a Murine Model of ALPS

Signaling Gene Mutations Are Characterized By Diverse Patterns of Expansion and Contraction during Progression from MDS to Secondary AML

Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia

Comprehensive Genomic Profiling of 104 Rare Histiocytic and Dendritic Cell Neoplasms Reveals Shared and Distinct Targetable Genomic Alterations

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American Society of Hematology

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American Society of Hematology

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