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Journal Articles

Hemostatic Effect of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X in an Acquired Hemophilia A Model

Atsushi Muto, Takehisa Kitazawa, DVM, Kazutaka Yoshihasi, DVM, PhD, Minako Takeda, DVM, Tetsuhiro Soeda, PhD, Tomoyuki Igawa, PhD, Zenjiro Sampei, Yuichiro Sakamoto, Yukiko Okuyama-Nishida, PhD, Hiroyuki Saito, Yoshiki Kawabe, PhD, Midori Shima, MD, PhD, Akira Yoshioka, MD, PhD, Kunihiro Hattori, PhD

Blood (2012) 120 (21): 42.

https://doi.org/10.1182/blood.V120.21.42.42

Published: 2012

Journal Articles

Prevention of Inhibitor Development Using Apoptosis-Induced FVIII Producing ES Cells.

Shogo Kasuda, Yoshihiko Sakurai, Kohei Tatsumi, Tomohiro Takeda, Atsushi Kubo, Katsuhiko Hatake, Akira Yoshioka, Midori Shima

Blood (2008) 112 (11): 3381.

https://doi.org/10.1182/blood.V112.11.3381.3381

Published: 2008

Journal Articles

Functional imaging of shear-dependent activity of ADAMTS13 in regulating mural thrombus growth under whole blood flow conditions

Yasuaki Shida, Kenji Nishio, Mitsuhiko Sugimoto, Tomohiro Mizuno, Masaaki Hamada, Seiji Kato, Masanori Matsumoto, Kazuo Okuchi, Yoshihiro Fujimura, Akira Yoshioka

Blood (2008) 111 (3): 1295–1298.

https://doi.org/10.1182/blood-2007-09-110700

Published: 2008

Journal Articles

Identification of a Protein S-Interactive Site on the Factor VIII A2 Domain.

Masahiro Takeyama, MD, Keiji Nogami, MD, PhD, Tetsuhiro Soeda, Akira Yoshioka, MD, PhD, Midori Shima, MD, PhD

Blood (2007) 110 (11): 2684.

https://doi.org/10.1182/blood.V110.11.2684.2684

Published: 2007

Journal Articles

Localization of Factor VIII Interactive Site within Plasmin/Plasminogen Which Is Responsible for Plasmin-Catalyzed Activation/Inactivation of Factor VIII.

Katsumi Nishiya, MD, Keiji Nogami, M.D., Kiyotaka Okada, M.D., Osamu Matsuo, M.D., Masahiro Takeyama, M.D., Kenichi Ogiwara, M.D., Ichiro Tanaka, M.D., Akira Yoshioka, M.D., Midori Shima, M.D.

Blood (2007) 110 (11): 1759.

https://doi.org/10.1182/blood.V110.11.1759.1759

Published: 2007

Journal Articles

Role of the Direct Interaction between Factor VIII C2 and Factor IXa Gla Domain in the Factor Xase Complex.

Tetsuhiro Soeda, Keiji Nogami, MD, PhD, Masahiro Takeyama, MD, Kenichi Ogiwara, MD, Kazuhiko Tomokiyo, PhD, Yoichi Sakata, MD, PhD, Akira Yoshioka, MD, PhD, Midori Shima, MD, PhD

Blood (2007) 110 (11): 2687.

https://doi.org/10.1182/blood.V110.11.2687.2687

Published: 2007

Journal Articles

Identification of a Thrombin-Interactive Site within Factor VIII A2 Domain Responsible for the Cleavage at Arg372.

Keiji Nogami, MD, PhD, Midori Shima, MD,PhD, Evgueni L. Saenko, PhD, Masahiro Takeyama, MD, Kohei Tatsumi, MD, Yuri Fujita, MD, Ichiro Tanaka, MD,PhD, Akira Yoshioka, MD,PhD

Blood (2006) 108 (11): 1710.

https://doi.org/10.1182/blood.V108.11.1710.1710

Published: 2006

Journal Articles

Protein S Down-Regulates Factor VIIIa by Competing with Factor IXa.

Masahiro Takeyama, MD, Keiji Nogami, MD.PhD, Kohei Tatsumi, MD, Yuri Fujita, MD, Ichiro Tanaka, MD,PhD, Akira Yoshioka, MD,PhD, Midori Shima, MD,PhD

Blood (2006) 108 (11): 1714.

https://doi.org/10.1182/blood.V108.11.1714.1714

Published: 2006

Journal Articles

Characterization of an Anti-Factor VIII Monoclonal Antibody with A1 and A3 Epitopes Which Increases Factor VIII Activity.

Masahiro Takeyama, MD, Keiji Nogami, MD,PhD, Tetsuhiro Soeda, phD, Tsukasa Suzuki, phD, Kunihiro Hattori, phD, Kohei Tatsumi, MD, Yuri Fujita, MD, Ichiro Tanaka, MD.PhD, Akira Yoshioka, MD,PhD, Midori Shima, MD,PhD

Blood (2006) 108 (11): 1702.

https://doi.org/10.1182/blood.V108.11.1702.1702

Published: 2006

Journal Articles

Establishment of ES Cells Secreting Human Factor VIII for Hemophilia A-Targeted Cell Therapy.

Shogo Kasuda, MD, Yoshihiko Sakurai, M.D.,Ph.D., Atsushi Kubo, M.D.,Ph.D., Midori Shima, M.D.,Ph.D., Gordon Keller, Ph.D., Akira Yoshioka, M.D.,Ph.D.

Blood (2006) 108 (11): 1012.

https://doi.org/10.1182/blood.V108.11.1012.1012

Published: 2006

Journal Articles

Identification of a Plasmin-Interactive Site in the Factor VIII Light Chain Responsible for Proteolytic Cleavage at Lys36 in the A1 Domain.

Keiji Nogami, MD, PhD, Midori Shima, MD,PhD, Masahiro Takeyama, MD, Kohei Tatsumi, MD, Yuri Fujita, MD, Evgueni L. Saenko, PhD, Ichiro Tanaka, MD,PhD, Akira Yoshioka, MD,PhD

Blood (2006) 108 (11): 1709.

https://doi.org/10.1182/blood.V108.11.1709.1709

Published: 2006

Journal Articles

Mechanisms of Plasmin-Catalyzed Inactivation of the Factor VIII.

Keiji Nogami, MD, PhD, Midori Shima, MD, PhD, Tomoko Matsumoto, Katsumi Nishiya, MD, Masahiro Takeyama, MD, Kohei Tatsumi, MD, Ichiro Tanaka, MD, PhD, Akira Yoshioka, MD, PhD

Blood (2005) 106 (11): 1017.

https://doi.org/10.1182/blood.V106.11.1017.1017

Published: 2005

Journal Articles

Identification of a Plasmin-Interactive Site within the A2 Domain of the Factor VIII Heavy Chain.

Keiji Nogami, MD, PhD, Midori Shima, MD, PhD, Katsumi Nishiya, MD, Evgueni L. Saenko, PhD, Masahiro Takeyama, MD, Kohei Tatsumi, MD, Ichiro Tanaka, MD, PhD, Akira Yoshioka, MD, PhD

Blood (2005) 106 (11): 1018.

https://doi.org/10.1182/blood.V106.11.1018.1018

Published: 2005

Journal Articles

von Willebrand Factor Protects Ca 2+ -Dependent Structure of the Factor VIII Light Chain.

Masahiro Takeyama, MD, Midori Shima, MD, PhD, Keiji Nogami, MD, PhD, Masahiro Okuda, PhD, Yoshihiko Sakurai, MD, PhD, Kohei Tatsumi, MD, Tomohiro Takeda, Ichiro Tanaka, MD, PhD, Akira Yoshioka, MD, PhD

Blood (2005) 106 (11): 1008.

https://doi.org/10.1182/blood.V106.11.1008.1008

Published: 2005

Journal Articles

An Essential Role of Factor VIII-Mediated Hemostasis in the Absence of von Willebrand Factor.

Yoshihiko Sakurai, MD, PhD, Midori Shima, MD, PhD, Shogo Kasuda, MD, Shoko Omura, MD, Masahiro Takeyama, MD, Hiroshi Suzuki, MD, Yuichiro Imai, MD, Akira Yoshioka, MD, PhD

Blood (2004) 104 (11): 3101.

https://doi.org/10.1182/blood.V104.11.3101.3101

Published: 2004

Journal Articles

Inhibition of PAR4 Signaling in Ethanol-Attenuation of Platelet Function.

Shogo Kasuda, MD, Yoshihiko Sakurai, MD, PhD, Midori Shima, MD, PhD, Masahiro Takeyama, MD, Katsuhiko Hatake, MD, PhD, Akira Yoshioka, MD, PhD

Blood (2004) 104 (11): 3892.

https://doi.org/10.1182/blood.V104.11.3892.3892

Published: 2004

Journal Articles

Mural thrombus generation in type 2A and 2B von Willebrand disease under flow conditions

Mitsuhiko Sugimoto, Hideto Matsui, Tomohiro Mizuno, Shizuko Tsuji, Shigeki Miyata, Masanori Matsumoto, Michio Matsuda, Yoshihiro Fujimura, Akira Yoshioka

Blood (2003) 101 (3): 915–920.

https://doi.org/10.1182/blood-2002-03-0944

Published: 2003

Journal Articles

Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow

Hideto Matsui, Mitsuhiko Sugimoto, Tomohiro Mizuno, Shizuko Tsuji, Shigeki Miyata, Michio Matsuda, Akira Yoshioka

Blood (2002) 100 (10): 3604–3610.

https://doi.org/10.1182/blood-2002-02-0508

Published: 2002

Journal Articles

A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C–catalyzed inactivation

Keiji Nogami, Midori Shima, Katsumi Nishiya, Kazuya Hosokawa, Evgueni L. Saenko, Yoshihiko Sakurai, Masaru Shibata, Hiroshi Suzuki, Ichiro Tanaka, Akira Yoshioka

Blood (2002) 99 (11): 3993–3998.

https://doi.org/10.1182/blood.V99.11.3993

Published: 2002

Journal Articles

Circulating factor VIII immune complexes in patients with type 2 acquired hemophilia A and protection from activated protein C–mediated proteolysis

Keiji Nogami, Midori Shima, John C. Giddings, Kazuya Hosokawa, Masanori Nagata, Seiki Kamisue, Hiroshi Suzuki, Masaru Shibata, Evgueni L. Saenko, Ichiro Tanaka, Akira Yoshioka

Blood (2001) 97 (3): 669–677.

https://doi.org/10.1182/blood.V97.3.669

Published: 2001

NARROW

Hemostatic Effect of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X in an Acquired Hemophilia A Model

Prevention of Inhibitor Development Using Apoptosis-Induced FVIII Producing ES Cells.

Functional imaging of shear-dependent activity of ADAMTS13 in regulating mural thrombus growth under whole blood flow conditions

Identification of a Protein S-Interactive Site on the Factor VIII A2 Domain.

Localization of Factor VIII Interactive Site within Plasmin/Plasminogen Which Is Responsible for Plasmin-Catalyzed Activation/Inactivation of Factor VIII.

Role of the Direct Interaction between Factor VIII C2 and Factor IXa Gla Domain in the Factor Xase Complex.

Identification of a Thrombin-Interactive Site within Factor VIII A2 Domain Responsible for the Cleavage at Arg372.

Protein S Down-Regulates Factor VIIIa by Competing with Factor IXa.

Characterization of an Anti-Factor VIII Monoclonal Antibody with A1 and A3 Epitopes Which Increases Factor VIII Activity.

Establishment of ES Cells Secreting Human Factor VIII for Hemophilia A-Targeted Cell Therapy.

Identification of a Plasmin-Interactive Site in the Factor VIII Light Chain Responsible for Proteolytic Cleavage at Lys36 in the A1 Domain.

Mechanisms of Plasmin-Catalyzed Inactivation of the Factor VIII.

Identification of a Plasmin-Interactive Site within the A2 Domain of the Factor VIII Heavy Chain.

von Willebrand Factor Protects Ca 2+ -Dependent Structure of the Factor VIII Light Chain.

An Essential Role of Factor VIII-Mediated Hemostasis in the Absence of von Willebrand Factor.

Inhibition of PAR4 Signaling in Ethanol-Attenuation of Platelet Function.

Mural thrombus generation in type 2A and 2B von Willebrand disease under flow conditions

Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow

A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C–catalyzed inactivation

Circulating factor VIII immune complexes in patients with type 2 acquired hemophilia A and protection from activated protein C–mediated proteolysis

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American Society of Hematology

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American Society of Hematology

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