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Alexander J. Silver
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Journal Articles

DNMT3A R882H Exhibits Greater Inflammatory Potential Than R882C in Primary Hematopoietic Stem and Progenitor Cell Knock-in Model and Population Data

Alexander J Silver, Donovan J Brown, Caitlyn Vlasschaert, Pawan Bhat, Fabio Puddu, Joseph C Van Amburg, Matthew T Villaume, Melissa A Fischer, Maria P Arrate, Yu Wang, Jamie Scotcher, Kristy Stengel, Brianna Nicole Smith, Brian Sharber, Chad R Potts, Mark Consugar, Jonathan Brett Heimlich, Yaomin Xu, P. Brent Ferrell, Jr., Alexander G. Bick, Michael R. Savona
Journal: Blood
Blood (2023) 142 (Supplement 1): 815.
https://doi.org/10.1182/blood-2023-187244
Published: 2023
Journal Articles

Clonal Hematopoiesis and Inflammation in the Vasculature (CHIVE), a Prospective, Longitudinal Clonal Hematopoiesis Cohort and Biorepository

Jonathan Heimlich, Morgan Shannon, Sydney Olson, Alexander J Silver, Ariana Debevec, Zachary Copeland, Caitlyn Vlasschaert, Christina Snider, Ashwin Kishtagari, Donovan J Brown, Travis Spaulding, Manasa R Bhatta, Kelly Pugh, Shannon S Stockton, Jessica Ulloa, Yaomin Xu, Muhamed Baljevic, Sanjay Mohan, Javid J. Moslehi, Eiman Jahangir, Brent Ferrell, Jr., David Slosky, Alexander G. Bick, Michael R. Savona
Journal: Blood
Blood (2023) 142 (Supplement 1): 5594.
https://doi.org/10.1182/blood-2023-189808
Published: 2023
Journal Articles

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets

Caitlyn Vlasschaert, Taralynn Mack, J. Brett Heimlich, Abhishek Niroula, Md Mesbah Uddin, Joshua Weinstock, Brian Sharber, Alexander J. Silver, Yaomin Xu, Michael Savona, Christopher Gibson, Matthew B. Lanktree, Michael J. Rauh, Benjamin L. Ebert, Pradeep Natarajan, Siddhartha Jaiswal, Alexander G. Bick
Journal: Blood
Blood (2023) 141 (18): 2214–2223.
https://doi.org/10.1182/blood.2022018825
Published: 2023
Includes: Supplemental data
Journal Articles

Combined Single-Cell Transcriptomics and Mitochondrial Lineage Tracing Identify IL-6 Signaling Responses in TET2 Clonal Hematopoiesis of Indeterminate Potential

Pawan Bhat, J. Brett Heimlich, Alyssa Parker, Matthew T. Jenkins, Chad R. Potts, Jessica Ulloa, Alexander J. Silver, Donovan J. Brown, Peter Van Galen, Michael R. Savona, Alexander G. Bick, Brent Ferrell
Journal: Blood
Blood (2022) 140 (Supplement 1): 2891–2892.
https://doi.org/10.1182/blood-2022-167850
Published: 2022
Journal Articles

Primary HSPC-Derived Monocytes with DNMT3A p.R882H Exhibit Activated Myeloid Cell Gene Signatures

Alexander J. Silver, Donovan J. Brown, Maria P. Arrate, Yu Wang, Melissa A. Fischer, Pawan Bhat, J. Brett Heimlich, Alexander G. Bick, P. Brent Ferrell, Yaomin Xu, Michael R. Savona
Journal: Blood
Blood (2022) 140 (Supplement 1): 2885–2886.
https://doi.org/10.1182/blood-2022-170803
Published: 2022
Journal Articles

Integrating Mosaic Chromosomal Alterations and Single-Nucleotide Variants to Predict Evolution of Clonal Hematopoiesis

Ashwin Kishtagari, MA Wasay Khan, Yajing Li, Cosmin Bejan, Naimisha Marneni, Alexander J. Silver, Kelly von Beck, Travis Spaulding, Shannon Stockton, Christina A. Snider, Kelly Pugh, Andrew Sochacki, Dixon Dorand, Taralynn Mack, Caitlyn Vlasschaert, Brent Ferrell, Yaomin Xu, Michael R. Savona, Alexander G. Bick
Journal: Blood
Blood (2022) 140 (Supplement 1): 2868–2870.
https://doi.org/10.1182/blood-2022-170957
Published: 2022
Journal Articles

Lactate Utilization Provides a Metabolic Escape to Resist the Antileukemic Activity of BET Inhibition in Acute Myeloid Leukemia

Andrew J. Monteith, Haley E. Ramsey, Dalton Greenwood, Maria P. Arrate, Londa Fuller, Agnieszka E. Gorska, Alexander J. Silver, Donovan J. Brown, Sarah D. Olmstead, Jackson Watke, Matthew J. Stubbs, Jeffrey C. Rathmell, Michael R. Savona
Journal: Blood
Blood (2022) 140 (Supplement 1): 8709–8710.
https://doi.org/10.1182/blood-2022-164701
Published: 2022
Journal Articles

Loss-of-Function Mutations in Dnmt3a and Tet2 Lead to Accelerated Atherosclerosis and Convergent Macrophage Phenotypes in Mice

Philipp J. Rauch, MD, Alexander J. Silver, BA, Jk Gopakumar, BA, Marie McConkey, PhD, Eti Sinha, BS, Maia Fefer, BS, Eugenia Shvartz, BS, Galina Sukhova, PhD, Peter Libby, MD, Benjamin L. Ebert, MDPhD, Siddhartha Jaiswal, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 745.
https://doi.org/10.1182/blood-2018-99-118288
Published: 2018
Journal Articles

PPM1D -truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

Josephine D. Kahn, Peter G. Miller, Alexander J. Silver, Rob S. Sellar, Shruti Bhatt, Christopher Gibson, Marie McConkey, Dylan Adams, Brenton Mar, Philipp Mertins, Shaunt Fereshetian, Karsten Krug, Haoling Zhu, Anthony Letai, Steven A. Carr, John Doench, Siddhartha Jaiswal, Benjamin L. Ebert
Journal: Blood
Blood (2018) 132 (11): 1095–1105.
https://doi.org/10.1182/blood-2018-05-850339
Published: 2018
Includes: Supplemental data
Journal Articles

Thrombosis in Myeloproliferative Neoplasms Is Linked to Increased Neutrophil Extracellular Trap (NET) Formation

Ofir Wolach, MD, Rob S Sellar, MD, Kimberly Martinod, PhD, Marie E. McConkey, PhD, Alexander J. Silver, B.S., Ryan Chappell, Richard M. Stone, MD, Martha Wadleigh, MD, David P Steensma, MD, Daniel J. DeAngelo, MD PhD, Ilene Galinsky, MSN, ANPc, Rebekka K. Schneider, MD, Robert F. Padera, MD PhD, Ann Mullally, MD, Denisa D. Wagner, PhD, Benjamin L. Ebert, MD PhD
Journal: Blood
Blood (2016) 128 (22): 633.
https://doi.org/10.1182/blood.V128.22.633.633
Published: 2016
Journal Articles

PPM1D Truncating Mutations Confer Chemotherapy Resistance in Hematopoietic Stem Cells, Which Is Reversible By PPM1D Inhibition

Josephine Kahn, MD, Alexander J. Silver, B.S., Philipp Mertins, PhD, Steven Carr, PhD, Siddhartha Jaiswal, MD PhD, Benjamin L. Ebert, MD PhD
Journal: Blood
Blood (2016) 128 (22): 740.
https://doi.org/10.1182/blood.V128.22.740.740
Published: 2016