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Amit U. Sinha
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Journal Articles

A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML

Shiva Bamezai, Alex Jose Pulikkottil, Tribhuwan Yadav, Naidu M. Vegi, Julia Mueller, Jasmin Mark, Tamoghna Mandal, Kristin Feder, Susann Ihme, Chenlin Song, Reinhild Rosler, Sebastian Wiese, Jessica I. Hoell, Andreas Kloetgen, Aly Karsan, Ankita Kumari, Luke Wojenski, Amit U. Sinha, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Elisa Donato, Andreas Trumpp, Elisabeth Kruse, Stephan Hamperl, Lee Zou, Vijay P. S. Rawat, Christian Buske
Journal: Blood
Blood (2023) 142 (1): 90–105.
https://doi.org/10.1182/blood.2022018651
Published: 2023
Includes: Supplemental data
Journal Articles

Targeting Meningeoma-1 Driven AML through Epigenetic Modulation of the Cell of Origin

Simone Riedel, PhD, Kathrin M Bernt, MD, Jessica Haladyna, BA, Matthew Bezzant, Brett Stevens, PhD, Daniel A. Pollyea, MD MS, Amit U. Sinha, PhD, Scott A. Armstrong, MD PhD, Qi Wei, PhD, Craig T. Jordan, PhD, Tobias Neff, MD
Journal: Blood
Blood (2014) 124 (21): 838.
https://doi.org/10.1182/blood.V124.21.838.838
Published: 2014
Journal Articles

Regulation Of Normal and Malignant Hoxa Gene Expression Through Higher H3K79 Methylated States

Aniruddha J Deshpande, Ph.D, Liying Chen, Ph.D., Amit U. Sinha, PhD, Nan Zhu, PhD, David Chen, Ph.D., Jenny Chang, Andrei V. Krivtsov, PhD, Kathrin Bernt, MD, James E Bradner, MD, Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2492.
https://doi.org/10.1182/blood.V122.21.2492.2492
Published: 2013
Journal Articles

Myeloid Leukemia Cells With MLL partial Tandem Duplication Are Sensitive To Pharmacological Inhibition Of The H3K79 Methyltransferase DOT1L

Michael W.M. Kühn, MD, Michael Hadler, MSc, Scott R. Daigle, PhD, Chun-Wei Chen, PhD, Amit U. Sinha, PhD, Andrei V. Krivtsov, PhD, Edward J. Olhava, PhD, Michael A. Caligiuri, MD, James E Bradner, MD, Roy M. Pollock, PhD, Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1256.
https://doi.org/10.1182/blood.V122.21.1256.1256
Published: 2013
Journal Articles

Genome-Wide RNAi Screen Identifies The Mechanistic Role For DOT1L In MLL -Rearranged Leukemia

Chun-Wei David Chen, Ph.D., Amit U. Sinha, PhD, Jun Qi, Ph.D., Aniruddha J Deshpande, Ph.D., Nan Zhu, PhD, Richard Koche, Ph.D., Rowena Eng, Jenny Chang, William C. Hahn, MD, PhD, James E Bradner, MD, Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 598.
https://doi.org/10.1182/blood.V122.21.598.598
Published: 2013
Journal Articles

Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l

Aniruddha J. Deshpande, Liying Chen, Maurizio Fazio, Amit U. Sinha, Kathrin M. Bernt, Deepti Banka, Stuart Dias, Jenny Chang, Edward J. Olhava, Scott R. Daigle, Victoria M. Richon, Roy M. Pollock, Scott A. Armstrong
Journal: Blood
Blood (2013) 121 (13): 2533–2541.
https://doi.org/10.1182/blood-2012-11-465120
Published: 2013
Includes: Supplemental data
Journal Articles

MLL-AF6 Mediated Transformation Is Dependent On the H3K79 Methyl-transferase Dot1l

Aniruddha J Deshpande, Liying Chen, Maurizio Fazio, Amit U. Sinha, Kathrin M Bernt, MD, Deepti Banka, Stuart Dias, Edward J Olhava, PhD, Scott R Daigle, Victoria M Richon, PhD, Roy M Pollock, PhD, Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3502.
https://doi.org/10.1182/blood.V120.21.3502.3502
Published: 2012
Journal Articles

The Interaction Between DOT1L and AF10 Is Required for H3K79 Dimethylation and MLL-AF9 Leukemia

Aniruddha J Deshpande, Liying Chen, Kathrin M Bernt, MD, Stuart Dias, Deepti Banka, Amit U. Sinha, David Chen, Natalie Punt, James E. Bradner, M.D., Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 401.
https://doi.org/10.1182/blood.V120.21.401.401
Published: 2012
Journal Articles

Haploinsufficiency of Dnmt1 Impairs Leukemia Stem Cell Function Through Derepression of Bivalent Chromatin Domains,

Jennifer J. Trowbridge, PhD, Amit U. Sinha, Scott A. Armstrong, MD, PhD, Stuart H. Orkin, MD
Journal: Blood
Blood (2011) 118 (21): 3459.
https://doi.org/10.1182/blood.V118.21.3459.3459
Published: 2011
Journal Articles

Cell of Origin Influences Leukemia Stem Cell Phenotype.

Andrei V. Krivtsov, PhD, Amit U. Sinha, Matthew C. Stubbs, PhD, Andrew Kung, MD, PhD, Scott Armstrong, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 3459.
https://doi.org/10.1182/blood.V114.22.3459.3459
Published: 2009
Journal Articles

β-Catenin Determines Developmental Stage Specific Transformation by Hox Genes.

Yingzi Wang, PhD, Andrei V. Krivtsov, PhD, Amit U. Sinha, PhD, Trista North, PhD, Wolfram Goessling, MD, PhD, Leonard I. Zon, MD, Scott Armstrong, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 385.
https://doi.org/10.1182/blood.V114.22.385.385
Published: 2009