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Journal Articles

The Factor VIII Variant X5 Enhances Hemophilia a Gene Therapy Efficiency By Its Improved Secretion

Franziska Horling, PhD, Johannes Lengler, PhD, Wenjing Cao, PhD, Biao Dong, PhD, Bagirath Gangadharan, Maurus De La Rosa, PhD, Werner Hoellriegl, PhD, Birgit M Reipert, PhD, Friedrich Scheiflinger, Weidong Xiao, PhD, Hanspeter Rottensteiner

Blood (2019) 134 (Supplement_1): 3356.

https://doi.org/10.1182/blood-2019-126489

Published: 2019

Journal Articles

Co-Prevalence of Pre-Existing Immunity to Different Serotypes of Adeno-Associated Virus (AAV) in Adults with Hemophilia

Kavitha Rajavel, Mila Ayash-Rashkovsky, Ying Tang, Bagirath Gangadharan, Maurus de la Rosa, Bruce Ewenstein

Blood (2019) 134 (Supplement_1): 3349.

https://doi.org/10.1182/blood-2019-123666

Published: 2019

Journal Articles

Data Coming out of the Human Inhibitor PUP Study (HIPS) Reveal 4 Subgroups of Patients with Distinct Antibody Signatures

Blood (2018) 132 (Supplement 1): 3774.

https://doi.org/10.1182/blood-2018-99-115979

Published: 2018

Journal Articles

Longitudinal Antibody Signatures Following FVIII Replacement Therapy in Previously Untreated Patients with Severe Hemophilia Α- New Insights from the Hemophilia Inhibitor PUP Study (HIPS)

Bagirath Gangadharan, PhD, Birgit Reipert, Fritz Scheiflinger, PhD, Joel Bowen, Elizabeth Donnachie, PhD, Karin Fijn van Draat, Ralph A. Gruppo, MD, Jenny Klintman, MD PhD, Christoph Male, MD, Catherine E. McGuinn, MD, Shannon L. Meeks, MD, Michael Recht, MD PhD, Margaret V. Ragni, MD MPH, Hassan M. Yaish, MD, Amy D. Shapiro, MD, Donald L Yee, MD, Vlad Calin Radulescu, MD, Elena Santagostino, Deborah Brown, MD

Blood (2017) 130 (Supplement 1): 88.

https://doi.org/10.1182/blood.V130.Suppl_1.88.88

Published: 2017

Journal Articles

Appearance of High-Affinity Antibodies Precedes Clinical Diagnosis of FVIII Inhibitors - Preliminary Analysis from the Hemophilia Inhibitor PUP Study (HIPS)

Birgit M Reipert, PhD, Bagirath Gangadharan, PhD, Christoph J Hofbauer, PhD, Fritz Scheiflinger, PhD, Joel Bowen, Elizabeth Donnachie, PhD, Karen Fijvandraat, MD, Ralph A. Gruppo, MD, Jenny Klintman, MD PhD, Christoph Male, MD, Catherine E. McGuinn, MD, Shannon L. Meeks, MD, Michael Recht, MD PhD, M V Ragni, MD, Hassan M Yaish, Elena Santagostino, MD PhD, Deborah L Brown, MD

Blood (2016) 128 (22): 328.

https://doi.org/10.1182/blood.V128.22.328.328

Published: 2016

Journal Articles

Identification of T Cell Epitope of ADAMTS13 in Thrombotic Thrombocytopenic Purpura Patients

Laurent Gilardin, MD Master, Sandrine Delignat, Master, Bernard Maillere, PhD, Bagirath Gangadharan, PhD, Ivan Peyron, PhD, Mathieu Ing, Master, Nimesh Gupta, PhD, Yu Chun Lone, PhD, Agnes Veyradier, MD PhD, Jean-Baptiste Latouche, MD PhD, Srini Kaveri, PhD DVM, Paul Coppo, MD PhD, Sébastien Lacroix-desmazes, PhD

Blood (2015) 126 (23): 106.

https://doi.org/10.1182/blood.V126.23.106.106

Published: 2015

Journal Articles

A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function

Shannon L. Meeks, Courtney L. Cox, John F. Healey, Ernest T. Parker, Bhavya S. Doshi, Bagirath Gangadharan, Rachel T. Barrow, Pete Lollar

Blood (2012) 120 (12): 2512–2520.

https://doi.org/10.1182/blood-2012-02-412361

Published: 2012

Includes: Supplemental data

Journal Articles

Factor VIII Structure, Not Activity, Is the Primary Determinant of Immunogenicity in Hemophilia A and Combined Hemophilia A/Von Willebrand Disease Mice

Shannon L. Meeks, MD, Courtney Cox, M.S., John F. Healey, B.S., Ernest T Parker, B.A., Bagirath Gangadharan, MS, Rachel T. Barrow, BS, John (Pete) S. Lollar, III, M.D.

Blood (2011) 118 (21): 1187.

https://doi.org/10.1182/blood.V118.21.1187.1187

Published: 2011

Journal Articles

Development and Characterization of Recombinant Ovine Factor VIII

Philip M Zakas, Bagirath Gangadharan, MS, Graca Almeida-Porada, MD, PhD, Christopher D Porada, PhD, H. Trent Spencer, PhD, Christopher B Doering, PhD

Blood (2011) 118 (21): 1193.

https://doi.org/10.1182/blood.V118.21.1193.1193

Published: 2011

Journal Articles

Factor VIII Supplementation Improves Recombinant VIIa Initiated Thrombin Generation in Hemophilia A Inhibitor Patient Plasmas

Bhavya Doshi, Courtney Cox, M.S., Bagirath Gangadharan, MS, Christopher B Doering, PhD, Shannon L. Meeks, MD

Blood (2011) 118 (21): 28.

https://doi.org/10.1182/blood.V118.21.28.28

Published: 2011

Journal Articles

Differential Engagement of the Unfolded Protein Response by Human and Porcine Factor VIII

Harrison C. Brown, BBA, Bagirath Gangadharan, MS, Christopher Doering, PhD

Blood (2010) 116 (21): 2224.

https://doi.org/10.1182/blood.V116.21.2224.2224

Published: 2010

Journal Articles

Humanized High-Expression Factor VIII Encoding Lentiviral Vectors Efficiently Drive High-Level FVIII Expression in Murine and Human Hematopoietic Cells

Christopher Doering, Ph.D., Gabriela Denning, Ph.D., Keith Kerstann, Ph.D., Bagirath Gangadharan, Robert Keefe, Ph.D., Boro Dropolic, Ph.D., H. Trent Spencer, PhD

Blood (2008) 112 (11): 3543.

https://doi.org/10.1182/blood.V112.11.3543.3543

Published: 2008

Journal Articles

FVIII Tolerance Following Nonmyeloablative Transplantation of Hematopoietic Stem Cells Engineered To Encode a High-Expression Factor VIII Transgene in Hemophilia A Mice.

Lucienne M. Ide, BA, Bagirath Gangadharan, MS, Christopher Doering, PhD, H. Trent Spencer, PhD

Blood (2007) 110 (11): 2599.

https://doi.org/10.1182/blood.V110.11.2599.2599

Published: 2007

Journal Articles

Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens

Lucienne M. Ide, Bagirath Gangadharan, Kuang-Yueh Chiang, Christopher B. Doering, H. Trent Spencer

Blood (2007) 110 (8): 2855–2863.

https://doi.org/10.1182/blood-2007-04-082602

Published: 2007

Includes: Supplemental data

Journal Articles

Marrow-Derived Stromal Cells as Gene Transfer Vehicles in a Murine Model of Hemophilia A.

Christopher B. Doering, PhD, Bagirath Gangadharan, MS, H. Trent Spencer, PhD

Blood (2006) 108 (11): 5489.

https://doi.org/10.1182/blood.V108.11.5489.5489

Published: 2006

Journal Articles

Post-Transplantation Immunosuppression Facilitates Sustained Expression of Porcine Factor VIII after Reduced-Intensity Transplantation of Genetically-Modified Stem Cells.

Lucienne M. Ide, Bagirath Gangadharan, K.Y. Chiang, MD,PhD, Christopher Doering, PhD, H. Trent Spencer, PhD

Blood (2006) 108 (11): 3280.

https://doi.org/10.1182/blood.V108.11.3280.3280

Published: 2006

Journal Articles

Restoration of Porcine Factor VIII Procoagulant Activity to Hemophilia A Mice with Pre-Existing Immunity to Human Factor VIII.

Christopher B. Doering, PhD, Bagirath Gangadharan, MS, Hillary Z. Dukart, H. Trent Spencer, PhD

Blood (2006) 108 (11): 3284.

https://doi.org/10.1182/blood.V108.11.3284.3284

Published: 2006

Journal Articles

High-level expression of porcine factor VIII from genetically modified bone marrow–derived stem cells

Bagirath Gangadharan, Ernest T. Parker, Lucienne M. Ide, H. Trent Spencer, Christopher B. Doering

Blood (2006) 107 (10): 3859–3864.

https://doi.org/10.1182/blood-2005-12-4961

Published: 2006

Journal Articles

High-Level Expression of Porcine Factor VIII from Murine Mesenchymal Stem Cells.

Bagirath Gangadharan, M.Sc., H. Trent Spencer, Ph.D., Ernest T. Parker, B.S., Christopher B. Doering, Ph.D.

Blood (2004) 104 (11): 5281.

https://doi.org/10.1182/blood.V104.11.5281.5281

Published: 2004

NARROW

The Factor VIII Variant X5 Enhances Hemophilia a Gene Therapy Efficiency By Its Improved Secretion

Co-Prevalence of Pre-Existing Immunity to Different Serotypes of Adeno-Associated Virus (AAV) in Adults with Hemophilia

Data Coming out of the Human Inhibitor PUP Study (HIPS) Reveal 4 Subgroups of Patients with Distinct Antibody Signatures

Longitudinal Antibody Signatures Following FVIII Replacement Therapy in Previously Untreated Patients with Severe Hemophilia Α- New Insights from the Hemophilia Inhibitor PUP Study (HIPS)

Appearance of High-Affinity Antibodies Precedes Clinical Diagnosis of FVIII Inhibitors - Preliminary Analysis from the Hemophilia Inhibitor PUP Study (HIPS)

Identification of T Cell Epitope of ADAMTS13 in Thrombotic Thrombocytopenic Purpura Patients

A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function

Factor VIII Structure, Not Activity, Is the Primary Determinant of Immunogenicity in Hemophilia A and Combined Hemophilia A/Von Willebrand Disease Mice

Development and Characterization of Recombinant Ovine Factor VIII

Factor VIII Supplementation Improves Recombinant VIIa Initiated Thrombin Generation in Hemophilia A Inhibitor Patient Plasmas

Differential Engagement of the Unfolded Protein Response by Human and Porcine Factor VIII

Humanized High-Expression Factor VIII Encoding Lentiviral Vectors Efficiently Drive High-Level FVIII Expression in Murine and Human Hematopoietic Cells

FVIII Tolerance Following Nonmyeloablative Transplantation of Hematopoietic Stem Cells Engineered To Encode a High-Expression Factor VIII Transgene in Hemophilia A Mice.

Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens

Marrow-Derived Stromal Cells as Gene Transfer Vehicles in a Murine Model of Hemophilia A.

Post-Transplantation Immunosuppression Facilitates Sustained Expression of Porcine Factor VIII after Reduced-Intensity Transplantation of Genetically-Modified Stem Cells.

Restoration of Porcine Factor VIII Procoagulant Activity to Hemophilia A Mice with Pre-Existing Immunity to Human Factor VIII.

High-level expression of porcine factor VIII from genetically modified bone marrow–derived stem cells

High-Level Expression of Porcine Factor VIII from Murine Mesenchymal Stem Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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